Jordi B. Torrelles, PhD

Assistant Professor, Internal Medicine, Center for Microbial Interface Biology

E-mail: Jordi.torrelles@osumc.edu

Torrelles JB, Chatterjee D., Lonca, J., Manterola, JM., Ausina, V. and Brennan, PJ. (2000). Serovars of Mycobacterium avium complex isolated from AIDS and non-AIDS patients in Spain. Journal of Applied Microbiology, 88, 266-279.
 
 Fisher K, Chatterjee D, Torrelles JB, Brennan PJ, Kaufmann SHE and Schaible UE. (2001). Mycobacterial lysocardiolipin is exported from phagosomes upon cleavage of cardiolipin by a macrophage-derived lysosomal phospholipase A2. Journal of Immunology, 15, 2187-2192.

 Escuyer VE, Lety MA, Torrelles JB, Frehel C, McNeil MR, Brennan PJ and Chatterjee D. (2001). The role of embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan. Journal of Biological Chemistry, 276, 48854-48862.

 Torrelles JB, Ellis D, Osborne T, Hoefer A, Orme IM, Chatterjee D, BrennanPJ and Cooper A (2002). Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104. Tuberculosis, 82, 293-300.

 Rhoades E, Hsu F-F, Torrelles JB, Turk J, Chatterjee D, and Russell DG (2003). Characterization of mycobacterial glycolipids released within host macrophages. Molecular Microbiology, 48, 875-888.

 Zhang N*, Torrelles JB*, McNeil MR, Escuyer VE, Brennan PJ, Khoo K-H, and Chatterjee D (2003). The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region. Molecular Microbiology, 50, 69-76. (*Equal Authorship)

 Torrelles JB*, Khoo K-H*, Sieling PA, Modlin RL, Zhang N, Marques AM, Rithner CD, Brennan PJ, and Chatterjee D (2004). Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol drug-resistant strains of Mycobacterium tuberculosis. Detailed characterization of the arabinan and mannan structural motifs. Journal of Biological Chemistry, 279, 41227-41239. (*Equal Authorship)

 Berg S, Starbuck J, Torrelles JB, Vissa VD, Crick DC, Chatterjee D, Brennan PJ (2005). Roles of conserved proline and glycosyltransferase motifs of EmbC in biosynthesis of lipoarabinomannan. Journal of Biological Chemistry, 280, 5651-5663.

 Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, and Modlin RL (2005) The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: Implications for host responses against immunologically related pathogens. Journal of Immunology, 174, 2637-2644.

 Kang PB, Azad AK, Torrelles JB, Kaufman TM, Beharka A, Tibesar E, Desjardin LE, Schlesinger LS (2005). The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. Journal of Experimental Medicine, 202, 987-999.

 McCarthy TR*, Torrelles JB*, Macfarlane AS, Katawczik M, Kutzbach B, Desjardin LE, Clegg S, Goldberg JB, Schlesinger LS (2005). Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages. Molecular Microbiology 58, 774-790. (*Equal Authorship)

 Hall-Stoodley L, Watts G, Crowther JE, Balapogal A, Torrelles JB, Robison-Cox J, Bargatze RF, Harmsen AG, Crouch EC, and Schlesinger LS (2006). Mycobacterium tuberculosis Binding to human surfactant proteins A and D, fibronectin and small airway epithelial cells under shear. Infection and Immunity, 74, 3587-3596.

 Torrelles JB, Azad AK, and Schlesinger LS (2006). Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors. Journal of Immunology, 177, 1805-1816.

 Lee A, Wu SW, Scherman MS, Torrelles JB, Chatterjee D, McNeil MR and Khoo K-H (2006). Sequencing of oligoarabinosyl units released from mycobacterial arabinogalactan and lipoarabinomannan by endogenous arabinanase: Identification of distinctive and novel structural motifs. Biochemistry, 45, 15817-15828.

 Wittkowski M, Mittelstädt J, Brandau S, Reiling N, Lindner B, Torrelles JB, Brennan PJ, Holst O (2007). Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity. Journal of Biological Chemistry, 282, 19103-19112.

 Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, Kang P, Hill PJ, Brennan PJ, Chatterjee D, Belisle JT, Musser JM, and Schlesinger LS (2008). Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan. Journal of Biological Chemistry 283: 31417 - 31428.

 Azad AK, Torrelles JB, and Schlesinger LS. (2008). Mutation in DC-SIGN cytoplasmic triacidic cluster motif attenuates the receptor in both phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells. Journal of Leukocyte Biology 84: 1594-1603.