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Jesse Kwiek, PhD
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Home > Directory > Faculty > Jesse Kwiek, PhD

Jesse J. Kwiek, PhD                                   

Assistant Professor, Internal Medicine and The Department of Microbiology, Center for Microbial Interface Biology


1008 BRT
460 W. 12th Ave.
Columbus, OH 43210
Phone: (614) 292-3256
Kwiek.2@osu,edu

Jesse Kwiek, Ph.D., is an Assistant Professor of Internal Medicine with a joint appointment in the Department of Microbiology

Research Focus

Prevention of HIV-1 mother-to-child transmission (MTCT) has been successfully implemented in the developed world, where the annual incidence of MTCT has been reduced to less than 2%; for example, in 2005, the USA reported 86 cases of perinatally acquired HIV. However, in the developing world, HIV-1 MTCT remains a serious public health problem, with approximately 530,000 children newly HIV-1 infected in 2006 (http://www.unaids.org/). Approximately 20% of all MTCT occurs in utero, and although many countries are scaling up programs to provide single-dose nevirapine prophylaxis (http://www.globalfundatm.org/), this treatment will not reduce in utero MTCT.

The Kwiek lab seeks to better understand the molecular biology and epidemiology of in utero HIV-1 MTCT. This will be accomplished, in collaboration with colleagues at both The Ohio State University and The Malawi College of Medicine, by addressing the following questions:

1. Are specific HIV-1 envelope genotypes or phenotypes associated with HIV-1 MTCT?

2. Does the placenta represent a unique HIV-1 compartment?

3. Where does HIV-1 localize in the placenta?

4. Do transmitted HIV-1 envelope genes have enhanced tropism against primary placental trophoblasts?

Education

B.S., Biochemistry, University of Rochester, 1995
United States Peace Corps, Malawi, 1995-6
Ph.D., Pharmacology, University of Virginia, 2003

Post-doctoral Training

Epidemiology, UNC-Chapel Hill  2007

Links

Recent Publications

Center for Microbial Interface Biology


Department of Internal Medicine http://www.internalmedicine.osu.edu

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