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Alison Walker, MD


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320 W 10th Ave
Columbus, OH 43210

Phone: (614) 293-9869

Email: walker.1088@osu.edu

 

Current OSU Appointments

Assistant Professor-Clinical, Hematology

Physician, FGP-Hematology

 

Academic Advising

Preceptor: Internal Medicine Clinc- 4 hrs. 1/18/11Resident morning report preceptor- 1/12/11 & 11/17/10

Certifications

1997 - present New York State Pharmacy: New York State Medical Board
2005 - present New York State Medicine: New York State Medical Board
2005 - present Internal Medicine: American Board of Internal Medicine
2008 - present Ohio Sate Medical License: State Medical Board of Ohio
2008 - present Hematology: American Board of Internal Medicine
2009 - present Medical Oncology: American Board of Internal Medicine
 

Clinical Services

09/01/2008 Outpatient Clinic Serivce (James Cancer Hospital, Hematology)
11/01/2008 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
12/01/2008 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
02/01/2009 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
03/01/2009 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
05/01/2009 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
06/01/2009 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
09/01/2009 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
10/01/2009 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
03/01/2010 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
05/01/2010 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
09/01/2010 Hematology II/ Acute Leukemia Service (The James Cancer Hospital)
07/01/2011 Hematology II/Acute Leukemia Service (The James Cancer Hospital)
08/01/2011 Hematology II/Acute Leukemia Service (The James Cancer Hospital)
11/01/2011 Hematology II/Acute Leukemia Service (The James Cancer Hospital)
01/01/2012 Hematology II/Acute Leukemia Service (The James Cancer Hospital)
08/01/2012 Hematology II/Acute Leukemia Service (The James Cancer Hospital)
11/01/2012 Hematology II/Acute Leukemia Service (James Cancer Hospital)

Degrees

1997 B.S., State University of New York College at Buffalo

2002 M.D., University of Rochester

 

Honors

1992 - 1997 Deans List.
1993 Phi Eta Sigma freshman Honor Society.
1993 Golden Key National Honor Society.
1996 Rho Chi Pharmaceutical Honor Society.
1997 Robert H. Ritz Award.
1997 Merck Award.
2007 American Society of Hematology Clinical Research Training Institute.
2009 K-12 Award. NIH/NCI.
2010 ASH-AMFDP Award. ASH.
2010 Certificate of Excellence. The Ohio State Medical Center.
2011 Med I/II Integrated Pathway Program faculty recognition award.
2013 - present Who's who in Black Columbus. The Ohio State University.
 

Journal Articles

Walker AR, Rothberg PG, Liesveld JL. "A case of JAK2 positive essential thrombocythemia 16.5 years after autologous marrow transplantation for AML.." Bone Marrow Transplantation. Vol. 39, (January 2007.): 725-726.

Walker AR, Kleiner A, Rich L, Conners C., Fisher R. I., Anolik J., Friedberg J. W.. "Profound hypogammaglobulinemia 7 years after treatment for indolent lymphoma.." Cancer Invest.. Vol. 4, no. 26. (May 2008.): 431-433.

Walker AR, Komrokji R, Ifthikharuddin J, Messina P., Mulford D., Becker M., Friedberg J., Oliva J., Phillips G., Liesveld J. L., Abboud C.. "Phase I study of Cladribine, Cytarabine (Ara-C), Granylocyte Colony Stimulating Factor (G-CSF) (CLAG Regimen) and Simultaneous Escalating Doses of Imatinib Mesylate (Gleevac) in Relapsed/Refactory AML.." Leuk Res. Vol. 12, no. 32. (January 2008.): 1830-1836.

Blum W, Garzon R, Klisovic RB, Schwind S, Walker AR, Geyer S., Liu S., Havelange V., Becker H., Schaaf L., Mickle J., Devine H., Kefauver C., Devine S. M., Chan K. K., Heerema N. A., Bloomfield C. D., Grever M. R., Byrd J. C., Villalona-Calero M., Croce C. M., Marcucci G.. "Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine." Proc Natl Acad Sci USA. Vol. 16, no. 107. (April 2010.): 7473-7478.

Blum W, Klisovic RB, Becker H, Yang X, Rozewski DM, Phelps MA, Garzon R, Walker A , et al.. "Dose escalation of lenalidomide in relapsed or refractory acute leukemias.." J Clin Oncol.. Vol. 28, (January 2010.): 4919-4925.

Walker A, Marcucci G.. "Prognostic factos in acute myeloid leukemia with normal karyotype." Haematologica. Vol. 96, no. 5. (January 2011.): 640-643.

KH Metzeler, Walker AR, S Geyer, R Garzon, RB Klisovic, CD Bloomfield, W Blum, and G Marcucci. "DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia." Leukemia. Vol. 26, (January 2011.): 1106-1107.

Walker,Alison; Marcucci,Guido. "Impact of molecular prognostic factors in cytogenetically normal acute myeloid leukemia at diagnosis and relapse." HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. Vol. 96, no. 5. (May 2011.): 640-643.

Hickey C J., Schwind S, Radomska H S., Dorrance AM, Santhanam R, Mishra A, Wu Y, Alachkar H, Maharry K, Nicolet D, Mrózek K, Walker A,. Eiring A M, Whitman S P, Becker H, Perrotti D, Wu L, Zhao X, Fehniger T A, Vij R, Byrd J C., Blum W, Lee L, Caligiuri M A, Bloomfield CD, Garzon R, Marcucci G. "Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein upregulates expression of the anti-leukemic microRNA-181a in acute myeloid leukemia.." Blood. Vol. 10.1182, (October 2012.): 2012-05.

Pearlly Yan, David Frankhouser, Mark Murphy, Hok-Hei Tam, Benjamin Rodriguez, John Curfman, Michael Trimarchi, Susan Geyer, Yue-Zhong Wu, Susan P. Whitman, Klaus Metzeler, Alison Walker, Rebecca Klisovic, Samson Jacob, Michael R. Grever, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon, William Blum, Michael A. Caligiuri, Ralf Bundschuh, Guido Marcucci. "Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia.." Blood. Vol. 120(12), (July 2012.): 2466-74.

Mims A, Walker AR, Huang X, Sun J, Wang H, Santhanam R, Dorrance AM, Walker C, Hoellerbauer P, Tarighat SS, Chan KK, Klisovic RB, Perrotti D, Caligiuri MA, Byrd JC, Chen CS, Lee LJ, Jacob S, Mrozek K, Bloomfield CD, Blum W, Garzon R, Schwind S, Marcucci G.. "Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: A novel epigenetic-targeting approach in acute myeloid leukemia.." Leukemia. Vol. doi: 10.1038, (November 2012.): leu.2012.342-.

Racke F, Cole C, Walker AR, Jones J, Heerema NA. ". Therapy-related pro-B cell acute lymphoblastic leukemia: report of two patients with MLL amplification." Cancer Genetics. Vol. 0, (December 2012.): 0-.

Walker A, Marcucci G. "Molecular prognostic factors in cytogenetically normal acute myeloid leukemia.." Expert Rev Hematol.. Vol. 5(5), (October 2012.): 547-58.

Wang H, Chen P, Wang J, Santhanam R, Aimiuwu J, Saradhi UV, Liu Z, Schwind S, Mims A, Byrd JC, Grever MR, Villalona-Calero MA, Klisovic R, Walker A, Garzon R, Blum W, Chan KK, Marcucci G. "In Vivo Quantification of Active Decitabine-Triphosphate Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia.." AAPS J. Vol. Doi: 10.1208/S12248-012-9427-5, (November 2012.): 1-8.

Tallman M, Chung S, Damon L, Marcucci G, Walker A, Madhava B. "75-year-old woman with Thoracic Spinal Cord Compression and Chloroma (Granulocytic Sarcoma).." Seminars in Oncology. Vol. 39, (December 2012.): e37-e46.

Blum,William; Schwind,Sebastian; Tarighat,Somayeh,S; Geyer,Susan; Eisfeld,Ann-Kathrin; Whitman,Susan; Walker,Alison; Klisovic,Rebecca; Byrd,John,C; Santhanam,Ramasamy; Wang,Hongyan; Curfman,John,P; Devine,Steven,M; Jacob,Samson; Garr,Celia; Kefauver,Cheryl; Perrotti,Danilo; Chan,Kenneth,K; Bloomfield,Clara,D; Caligiuri,Michael,A; Grever,Michael,R; Garzon,Ramiro; Marcucci,Guido. "Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia." BLOOD. Vol. 119, no. 25. (June 2012.): 6025-6031.

Ranganathan,Parvathi; Yu,Xueyan; Na,Caroline; Santhanam,Ramasamy; Shacham,Sharon; Kauffman,Michael; Walker,Alison; Klisovic,Rebecca; Blum,William; Caligiuri,Michael; Croce,Carlo,M; Marcucci,Guido; Garzon,Ramiro. "Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia.." Blood. Vol. 120, no. 9. (August 2012.): 1765-1773.

Walker,Alison; Mrozek,Krzysztof; Kohlschmidt,Jessica; Rao,Kathleen,W; Pettenati,Mark,J; Sterling,Lisa,J; Marcucci,Guido; Carroll,Andrew,J; Bloomfield,Clara,D. "New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: Cancer and leukemia group B 8461." GENES CHROMOSOMES & CANCER. Vol. 52, no. 4. (April 2013.): 385-401.

Mims,A; Walker,A,R; Huang,X; Sun,J; Wang,H; Santhanam,R; Dorrance,A,M; Walker,C; Hoellerbauer,P; Tarighat,S,S; Chan,K,K; Klisovic,R,B; Perrotti,D; Caligiuri,M,A; Byrd,J,C; Chen,C-S; Lee,L,James; Jacob,S; Mrozek,K; Bloomfield,C,D; Blum,W; Garzon,R; Schwind,S; Marcucci,G. "Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia." LEUKEMIA. Vol. 27, no. 4. (April 2013.): 871-878.

Huang,Xiaomeng; Schwind,Sebastian; Yu,Bo; Santhanam,Ramasamy; Wang,Hongyan; Hoellerbauer,Pia; Mims,Alice; Klisovic,Rebecca; Walker,Alison,R; Chan,Kenneth,K; Blum,William; Perrotti,Danilo; Byrd,John,C; Bloomfield,Clara,D; Caligiuri,Michael,A; Lee,Robert,J; Garzon,Ramiro; Muthusamy,Natarajan; Lee,Ly,James; Marcucci,Guido. "Targeted Delivery of microRNA-29b by Transferrin-Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia." CLINICAL CANCER RESEARCH. Vol. 19, no. 9. (May 2013.): 2355-2367.

Walker,Alison,R; Klisovic,Rebecca; Johnston,Jeffrey,S; Jiang,Yao; Geyer,Susan; Kefauver,Cheryl; Binkley,Philip; Byrd,John,C; Grever,Michael,R; Garzon,Ramiro; Phelps,Mitch,A; Marcucci,Guido; Blum,Kristie,A; Blum,William. "Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia." LEUKEMIA & LYMPHOMA. Vol. 54, no. 9. (September 2013.): 1996-2002.

Walker A, Marcucci G. "Introduction: Genetics and Classification of AML. Targeted Therapy of Acute Myeloid Leukemias.." In press. -.

 

Reference Works

December 2006 Abbound, C, Walker AR, Komorokji, R. et al.."Phase I study of cladribine, cytarabine (Ara-C), Granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating does of imantinib mesylate (Gleevac) in relapsed/refactory AML." Washington D.C..
January 2009 Blum W, Klisovic R, Walker AR, et al.."Epigenetic targeting via transcriptional inhibition of DNA methyltransferase: a Phase 1 studay of Bortezomib in Comination with 5-azacytidine in Adults with relapsed or refactory Acute Myeloid Leukemia." New Orleans.
January 2009 Chen P, Blum W, Aimiuwu J, Upadhyayula V, Liu Z, Lui S, Pang J, Walker AR, et al.."Quantification of Intracelluar Decitabine-Triphosphate with A Novel, Highly Sensitive and Specfic LC-MS/MS Assay in Acute Myeloid Leukemia Patients Treated with Low Dose Decitabine" New Orleans.
January 2009 Chandler J, Klisovic R, Phelps M, Walker AR et al.."Phase I Studay of Lenalidomide in Acute Myeloid Leukemia: Remissions Post-allogeneic relapse of Acute Myeloid Leukemia" New Orleans.
January 2010 Blum W, Klisovic B, Garzon R, Walker A , et al.."Phase 1 Trial of Decitabine and Bortezomib in High Risk Acute Myeloid Leukemia (AML)." Orlando.
January 2010 Gojo I, Walker A , Cooper M, et al.."Phase II Study of the Cyclin-Dependent Kinase (CDK) Inhibitor Dinaciclib (SCH 727965) In Patients with Advanced Acute Leukemias." Orlando.
January 2011 Walker AR,Metzeler Klaus H, Geyer Susan, et al.."Impact of DNMT3A Mutations on Clinical Response to the Hypomethylating Agent Decitabine in Older Patients (pts) with Acute Myeloid Leukemia (AML)" San Diego.
April 2012 Alice S. Mims, Alison R. Walker, Hongyan Wang, Xiaomeng Huang, Ramasamy Santhanam, Pia Hoellerbauer, Somayeh Tarighat, Kenneth K. Chan, Rebecca B. Klisovic, Danilo Perrotti, Michael A. Caligiuri, John C. Byrd, Ching-Shih Chen, William Blum, Ramiro Garzon, Sebastian Schwind, Guido Marcucci."AR-42, a Histone Deacetylase Inhibitor, increases microRNA-29b and sensitizes cells to decitabine treatment: a novel epigenetic-targeting approach in Acute Myeloid Leukemia" Chicago.
April 2012 Schwind S, Blum W, Liu S, Tarighat S, Geyer S, Klisovic R, Eisfeld A, Walker A, Whitman S, Ramasamy S, Wu Y, Jacob S, Caligiuri M, Grever M, Perrotti D, Byrd J, Bloomfield C, Garzon R, Marcucci G."The Combination of Bortezomib (BOR) and Decitabine (DEC): a Phase I Trial in Patients (Pts) with Acute Myeloid Leukemia (AML) targeting FLT3 expression" Chicago.

Presentations

"MDS- myelodysplastic syndromes." Presented at ASH Review, Columbus, OH. (January 2009)

"MDS- myelodysplastic syndromes." Presented at ASH Review, Columbus, OH. (January 2010)

"Careers in Medicine." Presented at DIVE, Columbus, OH. (March 2010)

"MDS- myelodysplastic syndromes." Presented at Fellows Science and Clinical Lecture Series, Columbus, OH. (May 2010)

"APL - Acute Promyelocytic Leukemia." Presented at Fellows Science and Clinical Lecture Series, Columbus, OH. (November 2010)

"Impact of Mutations on Clinical Response to the Hypomethylating Agent Decitabine in Older Patients with Acute Myeloid Leukemia.." Presented at American Society of Hematology, San Diego, CA. (December 2011)

"Approach to the patient with cytopenias." Presented at 2011 Department of Internal Medicine Conference, Columbus, OH. (December 2011)

"Clinical Skills Center." Presented at Canady Conference for Future Doctors and Dentists, Columbus, OH. (April 2011)

"DNMT Mutations and Response to Decitabine." Presented at CALGB, Chicago, IL. (September 2011)

"Targeting the Expression of Mutated genes encoding Tyrosine Kinases in Acute Myeloid Leukemia." Presented at Harold Amos Medical Faculty Development Program, New Orleans, LA. (October 2011)

"Impact of DNMT3A Mutations in AML patients treated with Decitabine." Presented at CALGB, Chicago, IL. (November 2011)

 

Professional Activities

2009 - present CDK Acute Leukemia Advisory Board. Schering-Plough. Short Hills, NJ.
2009 - present Dicussing Myeloid Diseases. It's All About Health Radio Show.
2011 - present Free Clinic. Columbus, OH.
2011 - present ARNO Advisory Board Meeting. Arno Therapeutics. New York City, NY.
2011 - present Community Day. OSU Medical Center. Columbus, OH.
2000 - 2002 Hospice.
- 2012 Health Seminar Speaker. Friendship Missionary Baptist Church. Columbus, OH.
- 2012 Myelodysplastic Syndrome Broadcast. WBNS/TV-10.
- 2012 The Black History Month Program.
- 2012 TKI vs. imatinib for first line treatment in CML. HemOnc Today Newspaper.
- 2012 MDS Awareness. WCMH/TV-4.
- 2012 Doctor Day Hotline.