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Natarajan Muthusamy, DVM, PhD


410 W 12th Ave
Columbus, OH 43210

Phone: (614) 293-7406

Email: muthusamy.1@osu.edu

 

Current OSU Appointment

Professor, Hematology

 

Advising Narrative

Danielle Chappelle (2011 - Present):



- 2012 Pelotonia Undergraduate Fellowship

- 2012 The American Society of Hematology Abstract achievement award

- 2013 Biological Sciences Alumni Society Scholarship



Presenter regional, national or international conferences

Postdoctoral / Researcher Advising

I have been actively involved in day to day mentoring activities including supervision, and advice in planning and execution of experiments, data analysis, interpretations, writing manuscripts and grant applications, preparation of research materials for poster and oral presentations at local, National and International meetings. As part of advising I introduce the trainees to peer scientists at scientific meetings. Although the list below limits to the postdoctoral fellows trained by me during the past 5 years I also trained two additional PDFs Dr. Ramadevi Raghunandan PhD (currrently at the Laboratory of Stem Cell Biology, FDA) and Dr. Mohamed Bayoumy M.D (currently at King Faisal Hospital, Saudi Arabia) prior to this time window. The following section includes list of clinical (MD) and Postdoctoral fellows (PhD) to whom I serve(d) as advisor or co-advisor with Dr. John Byrd MD.

Research Funding

My research efforts are built on the "Team Science " approach. In this context my research and mentoring activities are oriented toward cross-training graduate students from diverse disciplines including Colleges of Medicine, Pharmacy, Engineering and Veterinary Medicine. This is truly reflected in the graduate students I have co-advised with the faculty members from each of these colleges. This team effort has led to several high profile publications and grants in which the participating faculty members have contributed as co-senior authors in publications and/or "Multiple PIs" in grant applications. Most importantly this formula has allowed us to create a unique environment for training interdisciplinary researchers in Translational Medicine.

Noteworthy Graduate Narrative

Doctoral Students:



Rebekah Browning (2010 - Present):



- 2010 The Ohio State University Board of Trustees Student Recognition Award

- 2010 The American Society of Hematology Trainee Research Award

- 2010 The Ohio State University Comprehensive Cancer Center Annual Scientific Meeting 2nd Place Immunity Poster

- 2009 The American Society of Hematology Travel Award

- 2008-2010 HHMI Fellowship Recipient

- National Cancer Institute National Research Service

Award grant number 1F30CA174232-01

Project title: Combination therapies with interleukin-21

in chronic lymphocytic leukemia

4/1/2013-3/31/2016



Presenter at departmental/college, regional and national conferences; co-author of 1 published paper; winner of research award; recipient of research award.



Rajeswaran Mani (2009 - Present):



- 2012 OSU College of Medicine Research Day Travel Award

- 2011 The American Society of Hematology Travel Award

- 2011 Nominee, College of Veterinary Medicine - HHMI International Fellow award

- 2011 The American Society of Hematology Abstract Achievement Award



Presenter at departmental/college forums; presenter at regional, national or international conferences; co-author of 4 published paper.



Kyle Beckwith (2011 - present):



- 2012 The American Society of Hematology Travel Award

- 2012 The American Society of Hematology Oral Presentation

- 2011 Pelotonia Medical Student Fellowship



Presenter at department/college forums; presenter at local and national conferences;co-author of 1 published paper and one first authored manuscript in review.



Yi-Cheng Mao (2009 - present):



- 2012 Recipient of the Betty Ann Hoener Award to top pharmaceutics graduate student

- 2011 AAPS APQ Section Travel Award

NSF Nanoscale Science and Engineering Center fellowship



Presenter at departmental/college forums; presenter at regional, national or international conferences; co-author of 6 published papers 3 of which as first author.



Sarwish Rafiq (2007-2012):



Presenter at departmental/college forums; presenter at regional and national conferences; co-author of 5 published papers 3 of which as first author.



Bo Yu (2007-2010):



Presenter at departmental/college forums; presenter at regional, national or international conferences; co-author of 13 published papers 3 of which as first author.



Qing Liu (2006 - 2009):



Presenter at departmental/college forums; presenter at regional and national conferences; author/co-author of 5 published papers; winner of research awards



Fellows:



Farrukh Awan (2007 - 2009):



Presenter at departmental/college forums; presenter at regional and national conferences, author/co-author of 1 published paper; recipient of grants or scholarships for research; ASCO Young Investigator Award



Aruna Gowda (2007 - 2009):



Presenter at departmental/college forums; presenter at regional, national or international conferences; author/co-author of 4 published papers; winner or research award; recipient of grants or scholarships for research.



Post Doctorate:



Jason Dubovsky (2011 - present):



- 2011 T32 Post Doctoral Fellow

- 2012 The American Society of Hematology Oral Presentation

- 2013 American Cancer Society Post doctoral Fellowship



Presenter at departmental/college forums; presenter at regional, national or international conferences; Winner of ASH award and ACS grants, First author of 2 published papers one of which is a plenary paper in Blood.



Rosa Lapalombella (2006 - 2011):



- 2007 The American Society of Hematology Travel Award

- 2009 The American Society of Hematology Oral Presentation

- 2009 Comprehensive Cancer Center Annual Meeting Abstract Award

- 2009 The American Society of Hematology Travel Award



Presenter departmental/college forums; presenter at regional, national or international conferences; author/co-author of 11 published papers; winner of research awards/grants.

Biographical

Following basic training in veterinary medicine in India, I pursued my PhD training in Molecular Immunology at the University of Kentucky. My dissertation research focused on understanding signaling cross-talk in B lymphocytes. Following my post-doctoral training in the areas of T cell development using transgenic and embryonic stem cell technologies at the Howard Hughes Medical Institute and the University of Chicago, I joined and established the first Embryonic Stem Cell facility at then Columbus Children's Hospital (now Nationwide Children's Hospital) and the OSU Comprehensive Cancer Center. To pursue my interest in B and T lymphoid biology and translational sciences I joined the Division of Hematology in 2004. Since then my research has focused on translating basic findings for clinical applications through partnerships with physician scientists, medicinal chemists, pharmaco analytical and nanoformulation experts at OSU. One of my major goals is to train the next generation of physician scientists and basic researchers in the area of translational research and medicine.

Academic Advising

2009 - present Rajeswaran Mani The Ohio State University.
2009 - present Rajeswaran Mani The Ohio State University.
2009 - present Rajeswaran Mani The Ohio State University.
2009 - present Rajeswaran Mani The Ohio State University.
2010 - present Rebekah Browning The Ohio State University.
2010 - present Rebekah Browning The Ohio State University.
2010 - present Rebekah Browning The Ohio State University.
2010 - present Rebekah Browning The Ohio State University.
2010 - present Rebekah Browning The Ohio State University.
2011 - present Kyle Beckwith The Ohio State University.
2011 - present Danielle Chappelle The Ohio State University.
2011 - present Kyle Beckwith The Ohio State University.
2011 - present Kyle Beckwith The Ohio State University.
2011 - present Kyle Beckwith The Ohio State University.
2011 - present Jason Dubovsky The Ohio State University.
2012 - present Emily McWilliams The Ohio State University.
2012 - present Priscilla Do The Ohio State University.
2012 - present Zhiliang Xie The Ohio State University.
2012 - present Chi-Ling Chiang The Ohio State University.
2012 - present Priscilla Do The Ohio State University.
2012 - present Priscilla Do The Ohio State University.
2012 - present Emily McWilliams The Ohio State University.
2012 - present Emily McWilliams The Ohio State University.
2012 - present Priscilla Do The Ohio State University.
2012 - present Chi-ling Chiang The Ohio State University.
2012 - present Priscilla Lee The Ohio State University.
2012 - present Nisitha Sengottuvelu The Ohio State University.
2012 - present Chi-Ling Chiang The Ohio State University.
2012 - present Dhevamaalini Murugham The Ohio State University.
2012 - present Deborah Stephens The Ohio State University. Graduated 2007.
2013 - present Jennifer Yang The Ohio State University.
2013 - present Aaron Victor The Ohio State University.
2013 - present Nerisha Roach American Society of Hematology.
1998 Jon Eisengard, The Ohio State University. Graduated 2001.
1999 Jeffrey Sall The Ohio State University. Graduated 2003.
1999 - 2000 Maria Luz The Ohio State University.
1998 - 2001 Ramadevi Raghunandhan The Ohio State University.
2000 - 2002 Mohamed Bayoumy The Ohio State University. Graduated 2002.
2002 Nicholas Kin The Ohio State University. Graduated 2005.
1998 - 2003 Hui-Chen Chen The Ohio State University. Graduated 2003.
1998 - 2003 Hui-Chen Chen The Ohio State University. Graduated 2003.
1998 - 2003 Hui-Chen Chen The Ohio State University. Graduated 2003. Role for cyclic Adenosine monophosphate (cAMP) response element binding proteins in B lymphocyte development and functional maturation
2000 - 2003 Uma Sankar The Ohio State University.
2001 - 2003 Uma Sankar The Ohio State University. Graduated 2003.
1999 - 2004 Wei Ding The Ohio State University.
1999 - 2004 Wei Ding The Ohio State University. Graduated 2004.
1999 - 2004 K Usha Avinashilingam University For women. Graduated 2004.
2000 - 2004 Joung-Woo Hong The Ohio State University. Graduated 2004.
2000 - 2004 Carl Eugene The Ohio State University. Graduated 2004.
2000 - 2004 Seung Jae The Ohio State University. Graduated 2004.
2000 - 2004 Carl Eugene The Ohio State University.
2000 - 2004 Joung-Woo Hong The Ohio State University. Graduated 2004.
2000 - 2004 Seung Jae The Ohio State University. Graduated 2004.
2002 - 2004 Butch Stanley The Ohio State University.
2003 - 2004 Hao-Tian Zhao The Ohio State University. Graduated 2004.
2003 - 2004 Blaine Washington The Ohio State University.
2004 Amritraj Nair The Ohio State University.
2004 Hao-Tian Zhao The Ohio State University.
2000 - 2005 Ian Fisher The Ohio State University. Graduated 2005.
2000 - 2005 Ian Fisher The Ohio State University. Graduated 2005. Role of Ets-2 in Lymphocyte Development, function and survival
2002 - 2005 Hajime Hiraragi The Ohio State University. Graduated 2005.
2003 - 2005 Frank Frissora The Ohio State University. Graduated 2005. Ets-1 deficiency in the mouse is associated with accumulation of B220+, Mac-1+ B-1 cells resulting in splenomegaly and elevated serum IgM
2003 - 2005 Frank Frissora The Ohio State University. Ets-1 deficiency in the mouse is associated with accumulation of B220+, Mac-1+ B-1 cells resulting in splenomegaly and elevated serum IgM
2005 Lee Silverman The Ohio State University.
2004 - 2006 Xhaobin Zhao The Ohio State University. Graduated 2006.
2004 - 2006 Xhaobin Zhao The Ohio State University. Graduated 2006.
2004 - 2006 Xhaobin Zhao The Ohio State University. Graduated 2006.
2004 - 2007 Xiaobin Zhao The Ohio State University. Graduated 2007.
2004 - 2007 Xiaobin Zhao The Ohio State University. Graduated 2007.
2006 - 2007 Julie Roda The Ohio State University.
2007 Xiaobin Zhao The Ohio State University. Graduated 2007.
2006 - 2008 Aruna Gowda The Ohio State University. Graduated 2005.
2006 - 2009 Qing Liu The Ohio State University. Graduated 2008.
2006 - 2009 Qing Liu The Ohio State University. Graduated 2008.
2006 - 2009 Qing Liu The Ohio State University. Graduated 2009.
2006 - 2009 Qing Liu The Ohio State University. Graduated 2008.
2007 - 2009 Farrukh Awan The Ohio State University.
2008 - 2009 Li-Yuan Bai The Ohio State University.
2007 - 2010 Bo Yu The Ohio State University. Graduated 2010.
2007 - 2010 Bo Yu The Ohio State University. Graduated 2011.
2007 - 2010 Bo Yu The Ohio State University. Graduated 2010.
2010 Brindha Narayanan The Ohio State University.
2006 - 2011 Rosa Lapalombella The Ohio State University. Graduated 2006.
2006 - 2011 Georgia Triantafillou The Ohio State University. Graduated 2010.
2006 - 2011 Georgia Triantafillou The Ohio State University. Graduated 2010.
2006 - 2011 Georgia Triantafillou The Ohio State University. Graduated 2011.
2007 - 2011 Justin Staubli The Ohio State University. Graduated 2012.
2008 - 2011 Alan Smith The Ohio State University. Graduated 2011.
2011 Joseph Sweeney Fordham University.
2007 - 2012 Sarwish Rafiq The Ohio State University. Graduated 2012.
2007 - 2012 Sarwish Rafiq The Ohio State University. Graduated 2012.
2007 - 2012 Sarwish Rafiq The Ohio State University. Graduated 2012.
2007 - 2012 Sarwish Rafiq The Ohio State University. Graduated 2012.
2007 - 2012 Justin Staubli The Ohio State University.
2009 - 2012 YiCheng Mao The Ohio State University. Graduated 2012.
2009 - 2012 Yi Cheng The Ohio State University. Graduated 2012.
2009 - 2012 Yi Cheng The Ohio State University. Graduated 2012.
2009 - 2012 YiCheng Mao The Ohio State University. Graduated 2012.
 

Books

Muthusamy N.. Differential Regulation of B lymphocyte activation mediated through surface immunoglobulin and Lyb2 molecules. Ann Arbor: U.M.I.Ann Arbor., January 1992.

 

Chapters in Books

Wu H, Muthusamy N and Bondada S. "CD72 in Choi." In Encyclopedia of Signaling Molecules. -. January 0.

Subbarao B, Baluyut A and Muthusamy N. "Funtionally important B cell surface molecules." In T cell dependent and independent B cell activation. Edited by E.C. Snow. -. Boston, US|USA: C.R.C Press Inc., January 1990.

Chen H-C, Frissora F, Muthusamy N. "A Transgenic Approach to Define the Role of Cyclic AMP Response Element Binding Proteins in B Cells." In Proceeding of 10th International Congress of Immunology, New Delhi, India. Edited by Monduzze Editore. -. Stockholm: IIC, January 1998.

Zhao XB, Muthusamy N, Byrd JC and Lee RJ. "Folate receptor-targeted liposomes for cancer therapy." In Nanotechnology for cancer therapeutics. Edited by Amiji MA. -. Boca Raton: CRC press Inc., January 2006.

 

Conferences

Muthusamy N, aka Natarajan, M, Udhayakumar V, Krishnaraj K, Muthukkaruppan, VR. "Antibody response to outer membrane proteins of Salmonella typhimurium." In Frontiers in Immuology. (April 1984). Abstract-.

Chen HC, Frissora F, Muthusamy N. "A transgenic approach to define the role of cyclic AMP response element binding proteins in B cells." In 10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2. (January 1998). 131-136.

Muthusamy N, Rajgolikar G, Gronostajski R. "RAG-2 deficient blastocyst complementation analysis reveal an essential role for NF-IA transcription factor in T cells." In PEDIATRIC RESEARCH. (April 2000). 251A-251A.

Frissora F, Chen HC, Durbin J, Muthusamy N. "Antigen receptor induced cAMP response element binding activity in murine B cells is negatively regulated by IFN-gamma." In PEDIATRIC RESEARCH. (April 2000). 17A-17A.

Fisher,I,B; Ostrowski,M; Oshima,R,G; Muthusamy,N. "In vivo and in vitro approaches to define the role of Ets-2 in B lymphocyte development and function." In PEDIATRIC RESEARCH. (April 2000). 16A-16A.

Chen HC, Muthusamy N. "Differential regulation of stem cell antigen-1 (Ly-6A/E) expression during murine B cell activation." In PEDIATRIC RESEARCH. (April 2000). 16A-16A.

Muthusamy N, Rajgolikar G, Butz KG, Chen HC, Frissora F, Gronostajski RM. "Blastocyst complementation analysis reveal a role for NF-1A transcription factor in T cell activation." In FASEB JOURNAL. (March 2001). A1197-A1197.

Chen HC, Muthusamy N. "Differential role for CREB transcription factor in regulation of B-1 and B-2B cell development in mice." In FASEB JOURNAL. (March 2002). A1246-A1246.

Muthusamy N, Chen H-C, Bayoumy M. "Role of cyclic AMP binding protein-1 in B lymphocyte and osteoclast development and function-lessons from a transgenic mouse model." In PEDIATRIC RESEARCH. (April 2002). 254A-254A.

Fisher IB, Ostrowski M, Muthusamy N. "Transgenic mice over-expressing a non-phosphorylatable Ets-2 transcription factor reveal an increase in thymocyte cell death." In PEDIATRIC RESEARCH. (April 2002). 11A-11A.

Bayoumy M, Muthusamy N. "Timing of addition of M-CSF, TNF and ODF determine dfficient in-vitro osteoclastogenesis from bone marrow derived stem cells." In PEDIATRIC RESEARCH. (April 2002). 254A-254A.

Girish R, Muthusamy N, Kenneth BG, Chen HC, Frissora F, Gronostajski RM. "Nuclear factor I-A transcription factor is essential for activation of thymocytes and mature T cells in mice." In PEDIATRIC RESEARCH. (April 2003). 16A-16A.

Frissora F, Chen H-C, Durbin J, Bondada S, Muthusamy N. "Cross-talk between the STAT-1/CREB signaling pathway in IFN-gamma mediated negative regulation of B cell growth." In PEDIATRIC RESEARCH. (April 2003). 16A-16A.

Fisher IB, Ostrowski M, Muthusamy N. "Ets-2T72A thymocyte developmental defects are rescued by over-expression of Bcl-2." In PEDIATRIC RESEARCH. (April 2003). 16A-16A.

Chen H-C, Muthusamy N. "Cyclic AMP response element binding protein plays a critical role in early development and functional maturation of B lymphocytes in mice." In PEDIATRIC RESEARCH. (April 2003). 293A-293A.

Zhao X BB, Biswas S, Mone A, Ledbetter J, Ledbetter MH, Grosmaire L, Espling E, Cheney C, Young D, Lee RJ, Muthusamy N, Byrd JC. "Novel anti-CD37 small modular immunopharmaceutical (SMIP) induces B-cell-specific, caspase-independent apoptosis in human CLL cells.." In BLOOD. (November 2004). 689A-689A.

Muthusamy N, Chen H-C, Frissora F, Byrd JC. "Generation and analysis of transgenic mice reveal a role for CRE binding proteins in multiple stages of B cell development, functional maturation, proliferation and apoptosis." In BLOOD. (November 2004). 883A-883A.

Biswas S, Mone AP, Sen CK, Muthusamy N, Byrd JC. "Arsenic trioxide and ascorbic acid enhances the cytotoxicity of Hu1D10 towards CLL cells.." In BLOOD. (November 2004). 948A-948A.

Gowda AC, Zhao XB, Cheney C, Mehter N, Lozanski G, Lin TS, Guster S, Drachman JG, Muthusamy N, Byrd JC. "Humanized anti CD-40 antibody SGN-40 effectively induces cytotoxicity against chronic lymphocytic leukemia (CLL) cells through antibody mediated cytotoxicity and demonstrates modest biologic evidence of CD40 activation." In BLOOD. (November 2005). 832A-832A.

Johnson AJ, EdwardsR, Smith LL, Lucas DM, Croce CM, Muthusamy N, Chen C-S, Liu Z-F, Chan K, Grever MR, Byrd JC. "The TCL-1 transgenic mouse is an effective tool for pre-clinical drug development in chronic lymphocytic leukemia." In BLOOD. (November 2005). 20A-20A.

Liu Qi, Zhao X, Frissora F, Ma Y, Santhanam R, Perrotti D, Chen C-S, Dalton JT, Byrd JC, Muthusamy N. "FTY720 (2-amino-2-[2-(4-octylphenyl) ethyl] propane 1, 3-diol hydrochloride), mediates cytotoxicity through caspase independent and protein phosphatase 2A dependent mechanisms in chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.." In BLOOD. (November 2006). 594A-594A.

Lapalombella R, Zhao XB, Grosmaire L, Ledbetter JA, Muthusamy N, Byrd JC. "CD37-SMIP (TM) drug induced caspase independent cellular cytotoxicity is associated with activation of phosphotyrosine-mediated signaling events in primary chronic lymphocytic leukemia (CLL) B cells.." In BLOOD. (November 2006). 595A-595A.

Zhao XB, Trupti J, Lapalombella R, Cheney C, Gowda A, Hayden-Ledbetter MS, Baum PR, Lin TS, Jarjoura D, Lehman A, Lee RJ, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC. "NK cells contribute significantly to the innate immune effector role of CD37-Specific SMIP in CLL and NHL.." In BLOOD. (November 2006). 44A-44A.

Santhanam R, Neviani P, Eiring A, Oaks J, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Marcucci G, Gambacorti C, Roy D-C, Caligiuri MA, Bloomfield CD, Chen ,C-S, Byrd JC, Perrotti D. "FTY720, a new and alternative strategy for treating blast crisis CML and Ph-1 ALL patients.." In BLOOD. (November 2006). 89A-89A.

Joshi T, Ganesan LP, Chcney C, Muthusamy N, Byrd JC, Ostrowski MC, Tridandapani S. "A critical role for Akt in macrophage cytotoxicity to antibody-coated tumor cells." In FASEB JOURNAL. (April 2007). A184-A184.

Roda JM, Gowda A, Hussain R, Ramanunmi A, Lehman A, Kindsvogel W, Carson WE, Muthusamy N, Byrd JC. "IL-21 promotes apoptosis through induction of the BH3 only protein bim and enhacnes direct and innate immune-promoted death of chronic lymphocytic leukemia cells." In BLOOD. (November 2007). 917A-917A.

Lapalombella R, Zhao XB, Baum PR, Ledbetter JA, Muthusamy N, Byrd JC. "Role of CD37(SMIP) a novel engineered small modular immunopharmaceutical in the treatment of CLL." In BLOOD. (November 2007). 246A-246A.

Roda JM, Lapalombella R, Baiocchi R, Zhukocsky E, Desjarlais J, Muthusamy N, Byrd JC. "Pre-clinical activity of a novel Fc gamma RIIIa engineered CD19 monoclonal antibody in B cell chronic lymphocytic leukemia and acute lymphoblastic leukemia." In BLOOD. (November 2007). 695A-695A.

Garzon R, Liu S, Fabbri M, Liu Z, Pang J, Muthusamy N, Blum W, Chan K, Byrd JC, Croce CM, Marcucci G. "MicroRNA (miRNA)-29b targets DNMT3A and B and induces re-expression of the hypermethylated ESR1 and p15 genes in acute myeloid leukemia (AML).." In BLOOD. (November 2007). 220A-220A.

Jin Y, Yu B, Liu S, Zhang X, Lapalombella R, Triantafillou G, Pang J, Muthusamy N, Lee LJ, Byrd JC, Marcucci G, Lee RJ. "BIOT 305-Targeted delivery of oligonucleotides for antileukemia therapy using multifunctional immunolipopolyplex nanocarriers." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (August 2008). Abstract 236-.

Alinari L, Hertlein E, Goldenberg DM, Lapalombella R, Yan F, Zhang X, Lucas DM, Muthusamy N, Byrd JC, Baiocchi RA. "Combination Anti-CD74 (Milatuzumab) and CD20 (Rituximab) Monoclonal Antibody Therapy Has in Vitro and in Vivo Activity in Mantle Cell Lymphoma." In BLOOD. (November 2008). 327-327.

Maddocks K, Lapalombella R, Blum KA, Blum W, Fischer BB, Muthusamy N, Moran ME, Holtzapfel D, Byrd JC, Johnson AJ, Andritsos L. "Preliminary Results of a Phase I Study of Lenalidomide in Relapsed Chronic Lymphocytic Leukemia.." In BLOOD. (November 2009). 1339-1339.

Hertlein EK, Triantafillou G, Hessler J, Zhang X, Jarjoura D, Lucas DM, Lee RJ, Muthusamy N, Goldenberg DM, Byrd JC. "Immunoliposomes Incorporated with Humanized Monoclonal Antibody, Milatuzumab, Induce Cell Death in CLL by Retention of the CD74 Receptor On the Surface of B Cells." In BLOOD. (November 2009). 301-301.

Butchar JP, Mehta P, Justiniano SE, Guenterberg KD, Kanneganti T-D, Amer A, Muthusamy N, Jarjoura D, Marsh CB, Carson WE, Byrd JC, Tridandapani S. "TLR7/8 Differentially Regulates Fc gamma Receptor Expression and Function." In BLOOD. (November 2009). 1391-1392.

Browning RL, Wang S-H, Ramanunni A, Muthusamy N, Byrd JC. "Transcriptional up-Regulation of IL-21 Receptor-alpha On CLL Cells by CpG685 through An NF-kappa B Mediated Pathway Provides a Rationale for Combination Strategies with IL-21.." In BLOOD. (November 2009). 1079-1079.

Bai L-Y, Ma Y, Kulp SK, Wang S-H, Chiu C-F, Frissora F, Mo X, Jarjoura D, Byrd JC, Chen C-S, Muthusamy N. "OSU-DY7, a Novel D-Tyrosinol Derivative, Mediates Cytotoxicity in Chronic Lymphocytic Leukemia and Lymphoblastic Lymphoma through p38 Mitogen-Activated Protein Kinase Pathway.." In BLOOD. (November 2009). 1453-1453.

Andritsos L, Furman RR, Flinn IW, Foreno-Torres A, Flynn JM, Muthusamy N, Rafiq S, Stromatt S, Byrd JC. "A Phase 1 Trial of TRU-016, An Anti-CD37 Small Modular Immunopharmaceutical (SMIP (TM)) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity.." In BLOOD. (November 2009). 1330-1330.

Byrd,J,C; Lapalombella,R; Ramanunni,A; Andritsos,L,A; Flynn,J,M; Baum,P; Thompson,P; Muthusamy,N. "Effect of CD37 small modular immuno-pharmaceutical (SMIP) on direct apoptosis in chronic lymphocytic leukemia cells via transcriptional up-regulation of the BH3 family member BIM." In JOURNAL OF CLINICAL ONCOLOGY. (May 2009). Abstract-.

Xie Z, Liu Z, Muthusamy N, Byrd JC, Yamada K, Chan K. "A Validated Ultra-sensitive Hybridization-ELISA FOR Quantification of CpG685 on Plasma and Cell Lysate and its preclinical Pharmacokinetics in Mice." In AAPS Journal. (October 2009). Annual Meeting Abstract-.

Baum,P,R; Cerveny,C; GORDON,B; Nilsson,C; Wiens,J; Rafiq,S; Lapalombella,R; Muthusamy,N; Byrd,J,C; Wahl,A. "Evaluation of the effect of TRU-016, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non-Hodgkin's lymphoma." In JOURNAL OF CLINICAL ONCOLOGY. (May 2009). Abstract-.

Rafiq S, Cheney C, Thompson PA, Siadak T, Algate P, Cerveny C, Byrd JC, Muthusamy N. "Glycovariant CD37 Small Modular Immuno-Pharmaceutical (Tru-ADhanCe (TM) SMIP) Promotes Enhanced Natural Killer Cell Mediated Cytotoxicity against Primary Chronic Lymphocytic Leukemia Cells.." In BLOOD. (November 2009). 693-693.

Awan F, Lapalombella R, Trotta R, Butchar JP, Yu B, Benson D, Cheney C, Mo X, Lehman A, Jones JA, Flynn JM, Jarjoura D, Baiocchi RA, Desjarlais J, Tridandapani S, Caligiuri MA, Muthusamy N, Byrd JC. "CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody." In BLOOD. (November 2009). 1435-1435.

Alinari L, Liu Q, Chen C-S, Yan F, Dalton JT, Lapalombella Rosa, Zhang X, Lin T, Byrd J, Baiocchi RA, Muthusamy N. "FTY720 Demonstrates Promising in-Vitro and in-Vivo Pre-Clinical Activity by Down-Modulation of Cyclin D1 and Pakt in Mantle Cell Lymphoma." In BLOOD. (November 2009). 1436-1436.

Alinari L, Christian B, Yu B, Shin J, Hertlein EK, Lapalombella R, Yan F, Lesinski G, Zhang X, Lozanski G, Muthusamy N, Goldenberg DM, Byrd JC, Baiocchi RA. "Co-Treatment with Milatuzumab (Anti-CD74 mAb) and Rituximab (Anti-CD20 mAb) Results in the Induction of Mantle Cell Lymphoma Cell Death That Is Dependent On Actin Polymerization and Inhibition of NF-Kb.." In BLOOD. (November 2009). 675-675.

Rafiq S, Cheney C Lozanski G, Lapalombella R, Mo X, Siadak A, Jarjoura D, Byrd JC, Muthusamy N. "GlycoVariant Anti-CD37 Small Modular Immuno-Pharmaceutical Exhibits Superior Natural Killer Cell Mediated Cytotoxicity Against Chronic Lymphocytic Leukemia Cells at Low Concentrations and Low Antigen Density." In BLOOD. (November 2010). 770-770.

Yu B, Mao Y, Bai L-Y, Herman SEM, Ramanunni A, Jin Y, Mo X, Cheney C, Chan KK, Jarjoura D, Marcucci G,Lee R, Lee LJ, Byrd JC, Muthusamy N. "Liposomal Targeted Delivery Overcome Immunostimulatory Effects of Oligonucleotide Based Therapy In Chronic Lymphocytic Leukemia." In BLOOD. (November 2010). 630-631.

Herman SEM, Lapalombella R, Jones JA, Andritsos L, Gordon AL, Ramanunni A, Lannutti B, Muthusamy N, Byrd JC, Johnson AJ. "Lenalidomide-Dependent Activation of the Phosphatidylinositol 3-kinase-delta Pathway Is Antagonized by CAL-101 In Chronic Lymphocytic Leukemia.." In BLOOD. (November 2010). 760-761.

Rafiq S, Butchar JP, Cheney C, Mo X, Jarjoura D, Tridandapani S, Muthusamy N, Byrd JC. "Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties." In BLOOD. (November 2011). 1588-1588.

Mani R, Frissora F, Chen C-S, Byrd JC, Muthusamy N. "OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase." In BLOOD. (November 2011). 1069-1070.

Lapalombella R, Ramanunni A, Yeh Y-Y, Wang L, Jha S, Staubli J, Herman SEM, Andritsos LA, Jones JA, Flynn JM, Mo X, Johnson AJ, Thompson P, Algate PA, Stromatt S, Freitas MA, Muthusamy N, Byrd JC. "Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals." In BLOOD. (November 2011). 284-285.

Gupta P, Goldenberg DM, Rossi EA, Cardillo TM, Byrd JC, Muthusamy N, Furman RR, Chang C-H. "Juxtaposing CD20 and CD74 with Novel Bispecific Antibodies Evokes Potent Cytotoxicity in Mantle Cell Lymphoma (MCL)." In BLOOD. (November 2011). 275-275.

Alinari L, Mahoney E, Patton JT, Zhang X, Huynh L, Earl CT, Mani R, Mao Y, Yu B, Towns WH, Chen C-S, Goldenberg DM, Blum KA, Byrd JC, Muthusamy N, Ibba M, Baiocchi RA. "FTY720 Increases CD74 Expression and Sensitizes Mantle Cell Lymphoma Cells to Milatuzumab-Mediated Cell Death." In BLOOD. (November 2011). 275-276.

Huang X, Schwind S, Yu B, Pang J, Santhanam R, Chan KK, Garzon R, Blum W, Bloomfield CD, Liu S, Perrotti D, Lee RJ, Byrd JC, Muthusamy N, Lee LJ, Marcucci G. "Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML)." In Blood. (December 2011). Abstract 81-.

Jaglowski SM, Vasu S, Geyer S, Bingman A, Elder P, Yu J, Blum W, Klisovic RB, Penza S, Efebera YA, Hofmeister CC, Benson DM, Muthusamy N, Devine SM, Andritsos LA, Lozanski G. "Immune Reconstitution At Days 30 and 100 Following Allogeneic Stem Cell Transplant and Association with Subsequent Development of Chronic Graft-Versus-Host Disease." In BLOOD. (November 2012). Abstract-.

Dubovsky JA, Beckwith K, Woyach JA, Jaglowski SM,Samantha M, Hessler J, Chang BY, Larkin K, Stefanovski MR, Frissora FW, Smith LL, Smucker KA, Flynn JM, Jones JA, Andritsos LA, Maddocks K, Lehman A, Furman RR, Sharman J, Mishra S, Caligiuri MA, Buggy J, Muthusamy N, Johnson AJ, Byrd JC. "Ibrutinib Is an Irreversible Molecular Inhibitor of Interleukin-2 Inducible Kinase: Expanding Therapeutic Potential and Modulating a Th1 Selective Pressure in CD4 T-Cells." In BLOOD. (November 2012). Abstract-.

Heerema NA, Briedenbach H, Miller C, McFaddin A, Haudenshield S, Muthusamy N, Byrd JC. "Dicentric Chromosomes Are Frequent in Chronic Lymphocytic Leukemia (CLL)." In CYTOGENETIC AND GENOME RESEARCH. (January 2012). 330-330.

Motiwala T, Zanesi N, Roy S, Mustafa M, Kutay H, You J, Frissora F, Lu Y, Muthusamy N, Freitas M, Croce CM, Jacob ST. "Analysis of the in vivo tumor suppressive potential of PTPROt (truncated protein tyrosine phosphatase receptor-type O) in CLL using a transgenic mouse model." In Cancer Research. (April 2012). Abstract 1351-.

Dubovsky JA, Andritsos LA, Blum W, Johnson AJ, Muthusamy N, Byrd JC. "Immunoglobulin reactivity analysis of chronic lymphocytic leukemia patients unveils Lymphocyte Cytosolic Protein 1 (LCP1) as a novel CLL exosome antigen." In Cancer Research. (April 2012). Abstract # 509-.

Beckwith KA, Frissora FW, Stefanovski MR, Deckert J, Croce CM, Mo X, Jarjoura D, Byrd JC, Muthusamy N. "A Transgenic Mouse Model of Aggressive B-Cell Malignancy for Evaluating Anti-Human CD37 Therapeutics." In BLOOD. (November 2012). Abstract #188-.

Vasu S, Jaglowski SM, Geyer S, Bingman A, Elder PY,Yu J, Andritsos LA, Blum W, Klisovic RB, Penza S, Efebera YA, Hofmeister CC, Benson DM, Muthusamy N, Devine SM, Lozanski G. "Differential Distribution of Activated Innate and Adaptive Immune Subsets in G-CSF Mobilized Hematopoietic Stem Cell Allografts May Influence Incidence of Acute (aGVHD) and Chronic Graft-Versus-Host Disease (cGVHD)." In BLOOD. (November 2012). Abstract-.

Butchar JP, Shah P, Patel H, Fatehchand K, Rafiq S, Cheney C, Vasilakos JP, Muthusamy N, Byrd JC, Tridandapani S. "TLR7/8 Agonists Overcome the Suppression of Fc gamma R Activity in Monocytes From Chronic Lymphocytic Leukemia Patients." In BLOOD. (November 2012). Abstract-.

Huang X, Schwind S, Eisfeld A-K, Jin Y, Yu B, Hickey C, Pang J, Ramasamy S, Chan KK, Perrotti D, Muthusamy N, Byrd JC, Blum W, Bloomfield C, Liu S, Garzon R, Lee R, Lee L, Marcucci G. "Synthetic microRNA (miR)-181a nanoparticles (NP) target RAS and sensitize cells to daunorubicin (DNR) in acute myeloid leukemia (AML)." In Cancer Research. (April 2012). Abstract 111-.

Vasu S, Jaglowski SM Geyer S, Bingman A, Elder P, Yu J, Andritsos LA, Blum W, Klisovic RB, Penza S, Efebera YA, Hofmeister CC, Benson DM, Muthusamy N, Devine SM, Lozanski G. "Differential Distribution of Activated Innate and Adaptive Immune Subsets in G-CSF Mobilized Hematopoietic Stem Cell Allografts May Influence Incidence of Acute (aGVHD) and Chronic Graft-Versus-Host Disease (cGVHD)." In BLOOD. (November 2012). Abstract-.

Rafiq S, Butchar JP, Cheney C, Mo X, Trotta R, Caligiuri M, Jarjoura D, Tridandapani S, Muthusamy N, Byrd JC. "Comparative Assessment of Clinically Utilized CD20-Directed Antibodies in Chronic Lymphocytic Leukemia Cells Reveals Divergent NK Cell, Monocyte, and Macrophage Properties." In JOURNAL OF IMMUNOLOGY. (March 2013). 2702-2711.

Mani R, Frissora F, Mao Y, Chiang C-L, Mo X, Jarjoura D, Baskar S, Rader C, Lee R, Lee LJ, Chen C-S, Byrd JC, Muthusamy N. "OSU-2S: a novel non-immunosuppressive FTY720 derivative mediates potent cytotoxic activity through PKC dependent phosphorylation of tumor suppressor SHP1 and down modulation of Tcl1 oncogene in chronic lymphocytic leukemia." In JOURNAL OF IMMUNOLOGY. (May 2013). Abstract-.

Natarajan G, Dubovsky J, Satoskar A, Muthusamy N, Johnson AJ, Byrd JC. "Ibrutinib (PCI-32765) administration modulates a Th1 dominated immune response during cutaneous leishmaniasis infection." In JOURNAL OF IMMUNOLOGY. (May 2013). Abstract-.

Muthusamy N, Mao Y, Frissora F, Mani R, Wang J, Wu Y, Yu B, Baskar S, Rader C, Phelphs M, Chen C-S, Lee RL, Byrd JC. "ROR1 directed delivery of FTY720 derivative OSU-2S mediates potent cytotoxic activity against chronic lymphocytic leukemia but not normal B cells in-vitro and in ROR1 expressing transgenic CLL mouse model in-vivo." In JOURNAL OF IMMUNOLOGY. (May 2013). Abstract-.

 

Degrees

1982 D.V.M., Madras Veterinary College

1992 Ph.D., University of Kentucky

 

Editorial Activities

2000 - present Journal of Immunology
2006 - present Blood
2008 - present Cancer Research
2008 - present Journal of Leukocyte Biology
2009 - present Current Medicinal Chemistry
2010 - present Journal of Postgenomics: Drug & Biomarker Development -Member Editorial Board
2011 - present PLoS One
2011 - present Therapeutic Delivery
2011 - present Molecular Medicine
2011 - present Leukemia and Lymphoma
2011 - present Leukemia
2011 - 2013 Metabolomics: Open Access
2012 - present Dataset Papers in Medicine
2012 - present Conference Papers in Medicine
2013 - present Nanomedicine
 

Honors

1986 - 1991 Research Assistantship. University of Kentucky.
1987 Teaching Assistantship. University of Kentucky.
1991 - present Graduate Student Research Award. University of Kentucky (Provided funding for a summer research in NIH).
1998 American Association of Immunologists. Travel Award to the 10th Int’l. Congress of Immunology New Delhi, India Nov1-7. 10th Inernational Congress of Immunology.
1998 ‘Free Communication Merit Award’. 10th International Congress of Immunology New Delhi, India Nov1-7,1998. International Congress of Immunology.
2001 - present ‘Heroes of Hope’ Award. American Cancer Society (Heroes of Hope initiative honors cancer researchers whose work exemplifies the mission of the American Cancer Society).
2001 American Association of Immunologists. Junior Faculty Certificate of appreciation and Travel Award, FASEB Meeting, Orlando, FL. American Association of Immunologists.
2001 American Association of Immunologists. Travel Award to the 11th International Congress of Immunology, Stockholm, Sweden. 11th Internatinal Congress of Immunology.
2012 - present Elected Member. Henry Kunkel Society (The Henry Kunkle society is a vibrant society that supports the common goals of promoting research focused on the immunologic basis of human disease. The induction into this prestigious society is through nomination and acceptance of new members with significant accomplishments in immunologic basis of human disease, by current distinguished Henry Kunkel Society members. The current members include distinguished immunologists around the world).
 

Journal Articles

Muthusamy N (aka Natarajan M), Udhayakumar V, Krishnaraju K, Muthukkaruppan V. "Role of outer membrane proteins in immunity against murine salmonellosis--1. Antibody response to crude outer membrane proteins of Salmonella typhimurium.." Comparative Immunology, Microbiology And Infectious Diseases. Vol. 8, no. 1. (January 1985.): 9-.

Goud SN, Muthusamy N, Subbarao B. "Differential responses of B cells from the spleen and lymph node to TNP-Ficoll.." Journal Of Immunology. Vol. 140, no. 9. (May 1988.): 2925-.

Nagarkatti PS; Seth A; Nagarkatti M; Muthusamy N; Rychlik B; Subbarao B. "A specific defect in the proliferative capacity of B cells from old mice stimulated with autoreactive T cells.." Cellular Immunology. Vol. 120, no. 1. (April 1989.): 102-.

Muthusamy N, Baluyut AR, Subbarao B. "Differential regulation of surface Ig- and Lyb2-mediated B cell activation by cyclic AMP. I. Evidence for alternative regulation of signaling through two different receptors linked to phosphatidylinositol hydrolysis in murine B cells.." Journal Of Immunology. Vol. 147, no. 8. (October 1991.): 2483-.

Muthusamy N, Bondada S. "Differential regulation of surface immunoglobulin and Lyb2 mediated B cell activation: II. cAMP dependent (prostaglandin E2) and independent (IFN-gamma) mechanisms of regulation of B lymphocyte activation.." International Immunology. Vol. 5, no. 8. (August 1993.): 949-.

Muthusamy N, Barton K, Leiden JM. "Defective activation and survival of T cells lacking the Ets-1 transcription factor.." Nature. Vol. 377, no. 6550. (October 1995.): 639-.

Barton K, Muthusamy N, Chanyangam M, Fischer C, Clendenin C, Leiden JM. "Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB.." Nature. Vol. 379, no. 6560. (January 1996.): 81-.

Su GH, Chen HM, Muthusamy N, Garrett-Sinha LA, Baunoch D, Tenen DG, Simon MC. "Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.." The EMBO Journal. Vol. 16, no. 23. (December 1997.): 7118-.

Muthusamy N, Leiden JM. "A protein kinase C-, Ras-, and RSK2-dependent signal transduction pathway activates the cAMP-responsive element-binding protein transcription factor following T cell receptor engagement.." The Journal Of Biological Chemistry. Vol. 273, no. 35. (August 1998.): 22841-.

Barton K, Muthusamy N, Fischer C, Ting CN, Walunas TL, Lanier LL, Leiden JM. "The Ets-1 transcription factor is required for the development of natural killer cells in mice.." Immunity. Vol. 9, no. 4. (October 1998.): 555-.

Venkataraman C, Muthusamy N, Muthukkumar S, Bondada S. "Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes.." Journal Of Immunology. Vol. 160, no. 7. (April 1998.): 3322-.

Bayoumy M, Sankar U, Muthusamy N. "Role of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis of bone marrow derived stem cells.." Indian Journal Of Experimental Biology. Vol. 40, no. 9. (September 2002.): 995-.

Allen CE, Muthusamy N, Weisbrode SE, Hong JW, Wu LC. "Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC.." Genes, Chromosomes & Cancer. Vol. 35, no. 4. (December 2002.): 287-.

Ding W, Albrecht B, Kelley RE, Muthusamy N, Kim SJ, Altschuld RA, Lairmore MD. "Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells.." Journal Of Virology. Vol. 76, no. 20. (October 2002.): 10374-.

Chen HC, Frissora F, Durbin JE, Muthusamy N. "Activation induced differential regulation of stem cell antigen-1 (Ly-6A/E) expression in murine B cells.." Cellular Immunology. Vol. 225, no. 1. (September 2003.): 42-.

Frissora F, Chen HC, Durbin J Bondada S, Muthusamy N. "IFN-gamma-mediated inhibition of antigen receptor-induced B cell proliferation and CREB-1 binding activity requires STAT-1 transcription factor.." European Journal Of Immunology. Vol. 33, no. 4. (April 2003.): 907-.

Muthusamy N, Park DJ, Rho HW, Rhee SG, Subbarao B. "Impaired antigen receptor induced calcium mobilization in a phospholipase C-gamma1 deficient B cell line.." Immunology Letters. Vol. 90, no. 2-3. (December 2003.): 203-.

Johnson AJ, Lucas DM, Muthusamy N, Smith LL, Edwards RB, De Lay MD, Croce CM, Grever MR, Byrd JC. "Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia.." Blood. Vol. 108, no. 4. (August 2006.): 1334-.

Chen HC, Byrd JC, Muthusamy N. "Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival.." Journal Of Immunology. Vol. 176, no. 4. (February 2006.): 2208-.

Allen CE, Richards J, Muthusamy N, Auer H, Liu Y, Robinson ML, Barnard JA, Wu LC. "Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.." Gene Expression. Vol. 14, no. 2. (January 2007.): 83-.

Opavsky R, Tsai SY, Guimond M, Arora A, Opavska J, Becknell B, Kaufmann M, Walton NA, Stephens JA, Fernandez SA, Muthusamy N, Felsher DW, Porcu P, Caligiuri MA, Leone G. "Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.." Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 104, no. 39. (September 2007.): 15400-.

Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, Druker BJ, Cortes J, Marcucci G, Chen CS, Verrills NM, Roy DC, Caligiuri MA, Bloomfield CD, Byrd JC, Perrotti D. "FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.." The Journal Of Clinical Investigation. Vol. 117, no. 9. (September 2007.): 2408-.

Zhao XB, Muthusamy N, Byrd JC, Lee RJ. "Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes.." Journal Of Pharmaceutical Sciences. Vol. 96, no. 9. (September 2007.): 2424-.

Saini SS, Farrugia W, Muthusamy N, Ramsland PA, Kaushik AK. "Structural evidence for a new IgG1 antibody sequence allele of cattle.." Scandinavian Journal Of Immunology. Vol. 65, no. 1. (January 2007.): 32-.

Zhao X, Lapalombella R; Joshi T, Cheney C, Gowda A, Hayden-Ledbetter MS, Baum PR, Lin TS, Jarjoura D, Lehman A, Kussewitt D, Lee RJ, Caligiuri MA, Tridandapani S,Muthusamy N, Byrd JC. "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical.." Blood. Vol. 110, no. 7. (October 2007.): 2569-.

Lapalombella R, Zhao X, Triantafillou G, Yu B, Jin Y, Lozanski G, Cheney C, Heerema N, Jarjoura D, Lehman A, Lee LJ, Marcucci G, Lee RJ, Caligiuri MA, Muthusamy N, Byrd JC. "A novel Raji-Burkitt's lymphoma model for preclinical and mechanistic evaluation of CD52-targeted immunotherapeutic agents.." Clinical Cancer Research. Vol. 14, no. 2. (January 2008.): 569-.

Liu Q, Farley KL, Johnson AJ, Muthusamy N, Hofmeister CC, Blum KA, Schaaf LJ, Grever MR, Byrd JC, Dalton JT, Phelps MA. "Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.." Therapeutic Drug Monitoring. Vol. 30, no. 5. (October 2008.): 620-.

Lapalombella R, Yu B, Triantafillou G, Liu Q, Butchar JP, Lozanski G, Ramanunni A, Smith LL, Blum W, Andritsos L, Wang DS, Lehman A, Chen CS, Johnson AJ, Marcucci G, Lee RJ, Lee LJ, Tridandapani S, Muthusamy N, Byrd JC. "Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells.." Blood. Vol. 112, no. 13. (December 2008.): 5180-.

Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, Muthusamy N, Byrd JC. "FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.." Blood. Vol. 111, no. 1. (January 2008.): 275-.

Zhao X, Wu J, Muthusamy N, Byrd JC, Lee RJ. "Liposomal coencapsulated fludarabine and mitoxantrone for lymphoproliferative disorder treatment.." Journal Of Pharmaceutical Sciences. Vol. 97, no. 4. (April 2008.): 1508-.

Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS. "FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.." Cancer Research. Vol. 68, no. 4. (February 2008.): 1204-.

Nagaleekar VK, Diehl SA, Juncadella I, Charland C, Muthusamy N, Eaton S, Haynes L, Garrett-Sinha LA, Anguita J, Rincón M. "IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program.." Journal Of Immunology. Vol. 181, no. 12. (December 2008.): 8315-.

Gowda A, Roda J, Hussain SR, Ramanunni A, Joshi T, Schmidt S, Zhang X, Lehman A, Jarjoura D, Carson WE, Kindsvogel W, Cheney C, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC. "IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro.." Blood. Vol. 111, no. 9. (May 2008.): 4723-.

Joshi T, Ganesan LP, Cheney C, Ostrowski MC, Muthusamy N, Byrd JC, Tridandapani S. "The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma.." PLoS ONE. Vol. 4, no. 1. (January 2009.): e4208-.

Lapalombella R, Gowda A, Joshi T, Mehter N, Cheney C, Lehman A, Chen CS, Johnson AJ, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC. "The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia.." British Journal Of Haematology. Vol. 144, no. 6. (March 2009.): 848-.

Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G. "MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.." Blood. Vol. 113, no. 25. (June 2009.): 6411-.

Yang X, Koh CG, Liu S, Pan X, Santhanam R, Yu B, Peng Y, Pang J, Golan S, Talmon Y, Jin Y, Muthusamy N, Byrd JC, Chan KK, Lee LJ, Marcucci G, Lee RJ. "Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.." Molecular Pharmaceutics. Vol. 6, no. 1. (January 2009.): 221-.

Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima RG, Leone G, Ostrowski MC. "Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis.." Blood. Vol. 114, no. 5. (July 2009.): 1123-.

Leshchenko VV, Kuo PY, Shaknovich R, Yang DT, Gellen T, Petrich A, Yu Y, Remache Y, Weniger MA, Rafiq S, Suh KS, Goy A, Wilson W, Verma A, Braunschweig I, Muthusamy N, Kahl BS, Byrd JC, Wiestner A, Melnick A, Parekh S. "Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.." Blood. Vol. 116, no. 7. (August 2010.): 1025-1034.

Liu Q, Alinari L, Chen CS, Yan F, Dalton JT, Lapalombella R, Zhang X, Mani R, Lin T, Byrd JC, Baiocchi RA, Muthusamy N. "FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma.." Clinical Cancer Research. Vol. 16, no. 12. (June 2010.): 3182-.

Biswas S, Zhao X, Mone AP, Mo X, Vargo M, Jarjoura D, Byrd JC, Muthusamy N. "Arsenic trioxide and ascorbic acid demonstrate promising activity against primary human CLL cells in vitro.." Leukemia Research. Vol. 34, no. 7. (July 2010.): 925-931.

Lapalombella R, Andritsos L, Liu Q, May SE, Browning R, Pham LV, Blum KA, Blum W, Ramanunni A, Raymond CA, Smith LL, Lehman A, Mo X, Jarjoura D, Chen CS, Ford R Jr, Rader C, Muthusamy N, Johnson AJ, Byrd JC. "Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway.." Blood. Vol. 115, no. 13. (April 2010.): 2619-.

Gowda A, Ramanunni A, Cheney C, Rozewski D, Kindsvogel W, Lehman A, Jarjoura D, Caligiuri M, Byrd JC, Muthusamy N. "Differential effects of IL-2 and IL-21 on expansion of the CD4+ CD25+ Foxp3+ T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia.." Mabs. Vol. 2, no. 1. (January 2010.): 35-.

Butchar JP, Mehta P, Justiniano SE, Guenterberg KD, Kondadasula SV, Mo X, Chemudupati M, Kanneganti TD, Amer A, Muthusamy N, Jarjoura D, Marsh CB, Carson WE 3rd, Byrd JC, Tridandapani S. "Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy.." Clinical Cancer Research. Vol. 16, no. 7. (April 2010.): 2065-.

Lesinski GB, Carson WE, Repasky EA, Wei WZ, Kalinski P, Lotze MT, June CH, Petros W, Muthusamy N, Olencki T. "Meeting report: The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3); Immune Suppression and the Tumor Microenvironment, Columbus, Ohio; March 1-2, 2010.." Journal Of Immunotherapy. Vol. 33, no. 7. (September 2010.): 659-.

Jin Y, Liu S, Yu B, Golan S, Koh CG, Yang J, Huynh L, Yang X, Pang J, Muthusamy N, Chan KK, Byrd JC, Talmon Y, Lee LJ, Lee RJ, Marcucci G. "Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia.." Molecular Pharmaceutics. Vol. 7, no. 1. (February 2010.): 196-.

Zhao XB, Muthusamy, N, Byrd JC, Lee RJ. "Erratum: Cholesterol as a bilayer anchor for PEGylation and targeting ligant in folate-receptor targeted liposomes." J Pham Sci. Vol. 99, (January 2010.): 4753-.

Awan FT, Lapalombella R, Trotta R, Butchar JP, Yu B, Benson DM Jr, Roda JM, Cheney C, Mo X, Lehman A, Jones J, Flynn J, Jarjoura D, Desjarlais JR, Tridandapani S, Caligiuri MA, Muthusamy N, Byrd JC. "CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody.." Blood. Vol. 115, no. 6. (February 2010.): 1204-.

Chan KK, Liu Z, Xie Z, Chiu M, Wang H, Chen P, Dunkerson S, Chiu M, Liu S, Triantafillou G, Garzon R, Croce CM, Byrd JC, Muthusamy N, Marcucci G. "A novel ultrasensitive hybridization-based ELISA method for 2-methoxyphosphorothiolate microRNAs and its in vitro and in vivo application.." The AAPS Journal. Vol. 12, no. 4. (December 2010.): 556-.

Jaglowski SM, Alinari L, Lapalombella R, Muthusamy N, Byrd JC. "The clinical application of monoclonal antibodies in chronic lymphocytic leukemia.." Blood. Vol. 116, no. 19. (November 2010.): 3705-.

Koh CG, Zhang X, Liu S, Golan S, Yu B, Yang X, Guan J, Jin Y, Talmon Y, Muthusamy N, Chan KK, Byrd JC, Lee RJ, Marcucci G, Lee LJ. "Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing.." Journal Of Controlled Release. Vol. 141, no. 1. (January 2010.): 62-.

Hertlein E, Triantafillou G, Sass EJ, Hessler JD, Zhang X, Jarjoura D, Lucas DM, Muthusamy N, Goldenberg DM, Lee RJ, Byrd JC. "Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells.." Blood. Vol. 116, no. 14. (October 2010.): 2554-.

Alinari L, Yu B, Christian BA, Yan F, Shin J, Lapalombella R, Hertlein E, Lustberg ME, Quinion C, Zhang X, Lozanski G, Muthusamy N, Prætorius-Ibba M, O'Connor OA, Goldenberg DM, Byrd JC, Blum KA, Baiocchi RA. "Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma.." Blood. Vol. 117, no. 17. (April 2011.): 4530-.

Herman SE, Lapalombella R, Gordon AL, Ramanunni A, Blum KA, Jones J, Zhang X, Lannutti BJ, Puri KD, Muthusamy N, Byrd JC Johnson AJ. "The role of phosphatidylinositol 3-kinase-{delta} in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.." Blood. Vol. 117, no. 16. (April 2011.): 4323-.

Muthusamy N, Breidenbach H, Andritsos L, Flynn J, Jones J, Ramanunni A, Mo X, Jarjoura D, Byrd JC, Heerema NA. "Enhanced detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide in combination with pokeweed mitogen and phorbol myristate acetate.." Cancer Genetics. Vol. 204, no. 2. (February 2011.): 77-.

Alinari L, Mahoney E, Patton J, Zhang X, Huynh L, Earl CT, Mani R, Mao Y, Yu B, Quinion C, Towns WH, Chen CS, Goldenberg DM, Blum KA, Byrd JC, Muthusamy N, Prætorius-Ibba M0, Baiocchi RA. "FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.." Blood. Vol. 118, no. 26. (December 2011.): 6893-.

Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS. "Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.." Hepatology. Vol. 53, no. 6. (June 2011.): 1943-.

Muthusamy N, Chen HC, Rajgolikar G, Butz KG, Frissora FW, Gronostajski RM. "Recombination activation gene-2-deficient blastocyst complementation analysis reveals an essential role for nuclear factor I-A transcription factor in T-cell activation.." International Immunology. Vol. 23, no. 6. (June 2011.): 385-.

Bai LY, Ma Y, Kulp SK, Wang SH, Chiu CF, Frissora F, Mani R, Mo X, Jarjoura D, Byrd JC, Chen CS, Muthusamy N. "OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway.." British Journal Of Haematology. Vol. 153, no. 5. (June 2011.): 623-.

Lapalombella R, Wang L, Ramanunni A, Yeh Y-Y, Jha S, Staubli J, Herman SEM, Johnson AJ, Andritsos L, Jones J, Flynn J, Thompson P, Alfate P, Stromatt S, Jarjoura D, Mo X, Wang D, Chen C-S, Lozanski G, Tridandapani S, Freitas MA, Muthusamy N, Byrd JC. "Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals." Cancer Cell. Vol. 21, no. 5. (May 2012.): 694-708.

Timmerman JM, Byrd JC, Andorsky DJ, Yamada RE, Kramer J, Muthusamy N, Hunder N, Pagel JM. "A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders.." Clinical Cancer Research. Vol. 18, no. 20. (October 2012.): 5752-5760.

Gupta P, Goldenberg DM, Rossi EA, Cardillo TM, Byrd JC,Muthusamy N, Furman RR, Chang C-H. "Dual-targeting immunotherapy of lymphoma: Potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas.." Blood. Vol. 119, no. 16. (April 2012.): 3767-78.

Wang H, Chiu M, Xie Z, Chiu M, Liu Z, Chen P, Liu S, Byrd JC, Muthusamy N, Garzon R, Croce C, Marcucci G, Chan KK. "Synthetic MicroRNA Cassette Dosing: Pharmacokinetics, Tissue Distribution and Bioactivity." Molecular Pharmaceutics. Vol. 9, no. 6. (June 2012.): 1638-1644.

Fisher IB, Ostrowski M, Muthusamy N. "Role for Ets-2(Thr-72) Transcription Factor in Stage-specific Thymocyte Development and Survival." Journal of Biological Chemistry. Vol. 287, no. 8. (February 2012.): 5199-5210.

Rafiq S, Cheney C, Mo X, Jarjoura D, Muthusamy N, Byrd JC. "XmAb-5574 antibody demonstrates superior antibody-dependent cellular cytotoxicity as compared with CD52- and CD20-targeted antibodies in adult acute lymphoblastic leukemia cells." Leukemia. Vol. 26, no. 7. (July 2012.): 1720-1722.

Rafiq S, Siadak A, Butchar JP, Cheney C, Lozanski G, Jacob NK, Lapalombella R, McGourty J, Moledor M, Lowe R, Setter B, Jones J, Flynn JM, Andritsos L, Devine S, Mo X, Jarjoura D, Tridandapani S, Algate P, Byrd JC, Muthusamy N. "Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies.." mAbs. Vol. 5, no. 5. (September 2013.): 723-735.

Justiniano SE, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda JM, Mo X,Cheney C,Hertlein E, Eubank TD, Marsh C, Muthusamy N, Butchar JP, Byrd JC, Tridandapani S. "Fc? Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies.." Journal of Biological Chemistry. Vol. 288, no. 37. (September 2013.): 26800-26809.

Baskar S, Muthusamy N. "Antibody-based therapeutics for the treatment of human B cell malignancies." Current Allergy Asthma Rep. Vol. 13, no. 1. (February 2013.): 33-43.

Rafiq S, Butchar JP, Cheney C, Mo X, Trotta R, Caligiuri M, Jarjoura D, Tridandapani S, Muthusamy N, Byrd JC.. "Comparative Assessment of Clinically Utilized CD20-Directed Antibodies in Chronic Lymphocytic Leukemia Cells Reveals Divergent NK Cell, Monocyte, and Macrophage Properties." Journal of Immunology. Vol. 190, no. 6. (March 2013.): 2702-11.

Yu B, Mao Y, Yuan Y, Yue C, Wang X, Mo X, Jarjoura D, Paulaitis ME, Lee RJ, Byrd JC, Lee LJ, Muthusamy N. "Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells." BIOMATERIALS. Vol. 34, no. 26. (August 2013.): 6185-6193.

Huang X, Schwind S, Yu B, Santhanam R, Wang H, Hoellerbauer P, Mims A, Klisovic RB, Walker A, Chan KK, Blum W, Perrotti D, Byrd JC, Bloomfield CD, Caligiuri MA, Lee RJ, Garzon R, Muthusamy N, Lee LJ, Marcucci G. "Targeted Delivery of microRNA-29b by Transferrin Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia." Clinical Cancer Research. Vol. in press, (March 2013.): epub ahead of press-.

Mao Y, Triantafillou G, Hertlein E, Towns WH, Stefanovski M, Mo X, Jarjoura D, Phelps MA, Marcucci G, Lee LJ, Goldenberg DM, Lee RJ, John BC, Muthusamy N. "Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carrier for Therapeutic Delivery in CD74+ B-Cell Malignancies." Clinical Cancer Research. Vol. 19, no. 2. (January 2013.): 347-56.

Raghunandan R , Frissora F and Muthusamy N. "Modulation of Ets-1 expression in B lymphocytes is dependent on the antigen receptor mediated activation signals and cell cycle status." Scandavian Journal of Immunology. Vol. 77, no. 2. (February 2013.): 75-83.

Yu B, Mao Y, Bai L-Y, Herman SEM, Ramanunni A, Mo X, Jin Y, Cheney C, Chan KK, Jarjoura D, Marcucci G, Lee RJ, Byrd JC, Lee LJ, Muthusamy N. "Targeted Nanoparticle Delivery Overcomes Off-Target Immunostimulatory Effects of Oligonucleotides and Improves Therapeutic Efficacy." Blood. Vol. 121, no. 1. (January 2013.): 136-47.

Wu, Y, Kwak, KJ, Agarwal, K, Marras, A, Wang, C, Mao, Y, Huang, X, Ma, J, Yu, B, Lee, RJ, Vachani, A, Marcucci, G, Byrd, JC, Muthusamy, N, Otterson, G, Huang, K, Castro, CE, Paulaitis, ME, Nana-Sinkam, SP, Lee, LJ. "Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons." Anal Chem.. -.

 

Reference Works

January 1987 Goud, Sn, Muthusamy N and Subbarao, B.."Differential abilities of lymph node and splenic B cell response to TNP-Ficoll" . : 5215
January 1988 Subbarao, B, Udhayakumar, V, Muthusamy, N, Cross, RA, Seth, M, Nagarkatti, M and Nagarkatti, P."Abnormalities of intrinsic B and T lymphocyte function in old mice. 5th International symposium on infections in the immuno compromised host." .
January 1988 Subbarao, B, Muthusamy, N, Seth, A, Nagarkatti, M and Nagarkatti, P."A specific defect in the ability if B-lymphocytes from old mice to proliferate in response to stimulation with an auto reactive T cell clone" . : A1664
January 1989 Baluyut, AR, Muthusamy, N and Subbarao, B."The role of surface Ia molecules in B cell activation." Berlin.
January 1989 Muthusamy, N, Govindarajulu, U, Waller, WE, Baluyut, AR and Subbarao, B."Differential effects of cAMP on anti-u and anti-Lyb2 mediated B cell activation" Miami.
January 1990 Muthusamy, N, Baluyut, AR and Subbarao, B."Differential regulation of B lymphocyte responses." .
January 1990 Muthusamy, N, Baluyut, AR and Subbarao, B."Differential regulation of surface IgM and Lyb2 mediated B cell activation-evidence for alternative mechanisms of inositol triphosphate generation in murine B cells" New ORleans.
January 1991 Muthusamy, N and Subbarao, B."Triggering of murine B-lymphocytes via Lyb2 surface molecules results in a rapid induction of tyrosine phosphorylation" Atlanta.
January 1991 Muthusamy, N and Subbarao, B."Differential regulation of early signaling in B-lymphocytes by cAMP" .
January 1992 Muthusamy, N, Park, DJ, Rho, HW, Rhee, SG and Subbarao, B."Differential expression of phospholipase C isozymes in murine B-lymphocytes" Anaheim.
January 1992 Muthusamy, N, and Subbarao, B."Cyclic AMP dependent and independent mechanisms of prostaglandin E2 and interferon- mediated regulation of B cell activation through IgM and Lyb2 receptors" Budapest.
January 1992 Subbarao, B and Muthusamy, N.."Differential regulation of surface Immunoglobulin and Lyb2 mediated B cell activation. II. CAMP dependent and independent mechanisms of PGE2 and IFN-γ mediated regulation of B lymphocyte activation" Anaheim.
January 1994 Muthusamy, N, Barton, K, Clendenin, C, Chanyangam, M and Leiden, JM."Expression of dominant negative CREB transgene results in a severe defect in murine T cell activation" .
January 1997 Su, GH, Chen, H-M, Muthusamy, N, Tenens, DG and Simon, MC."Disruption of the gene encoding Sip-B, an EST protein causes defective B cell receptor mediated responses -B lymphocytes in Health and Disease" Steamboat Springs.
January 1997 Muthusamy, N, Barton, K, Fisher, C. and Leiden, JM."Role of Ets-1 transcription factors in lymphocyte development and function" San Francisco.
January 1998 Xie, E, Barr, F, Muthusamy, N, Qualman S and Durbin, J."The Role of Pax3-FKHR fusion gene in the development of Alveolar Rhabdomyosarcoma" .
January 1998 Chen, H-C, Frissora, F and Muthusamy, N."A Transgenic Approach to Define the Role of cyclic AMP Response Element Binding Proteins in B Cells" .
January 1998 Chen, H-C, Frissora, F and Muthusamy, N."Generation of Transgenic Mice to Define the Role of Cyclic AMP Response Element Binding Proteins in B Cells." Put-in-Bay.
June 1998 Frissora F, Chen H-C, Muthusamy N."Characterization of Antigen Receptor Induced B lymphocyte Growth Inhibition by INFN-y" Columbus.
January 1998 Rajgolikar, G, Weslow-Schmidt, J, Robinson, M, O'Dorisio, S and Muthusamy, N.."Generation of Gene Targeted Mutant Mice" Newark.
January 1998 Rajgolikar, G, Weslow-Schmidt, J, Robinson, M, O'Dorisio, S and Muthusamy, N."Generation of Gene Targeted Mutant Mice at CHRF" .
December 1998 Chen H-C, Frissora F, Muthusamy N."Generation of Transgenic Mice to Define the Role of Cyclic AMP Response Element Binding Proteins in B Cells" Newark.
January 1998 Muthusamy, N, Frissora, F and Leiden, JL."A Protein Kinase C, Ras, and Rsk-2-Dependent Phosphorylation of CREB Transcription Factor by T Cell Antigen Receptor Stimulation" Put-in-Bay.
January 1998 Frissora, F, Chen, H-C and Muthusamy, N.."Characterization of Antigen Receptor Induced B lymphocyte Growth Inhibition by IFN-γ" .
January 2000 Frissora, F, Chen, H-C, Durbin, J, Bondada, S, Muthusamy, N."Antigen receptor induced CREB signaling pathway in murine B cells is negatively regulated by IFNγ" Columbus.
January 2000 Fisher, IB, Muthusamy, N."In vivo and In vitro Approaches to Define the Role of Ets-2 Lymphocyte Development and Function" Columbus.
January 2000 Chen, H-C, Muthusamy, N."A Transgenic mouse model reveals a role for CREB Transcription Factor in normal development of Bone Marrow and Peritoneal B cells." Columbus.
January 2001 Fisher, IB, Ostrowski, M and Muthusamy, N."Transgenic mice overexpressing a non-phosphorylatable Ets-2 transcription factor reveal defective development of T cells in the thymus." Baltimore.
January 2001 Muthusamy, N and Chen, H-C."Role of cyclic AMP response element binding proteins in B cell development -Lessons from a transgenic mouse model" Baltimore.
January 2001 Muthusamy, N and Chen, H-C."Role of cyclic AMP response element binding proteins in hematopoiesis-Lessons from transgenic mouse models" .
January 2001 Chen, H-C and Muthusamy, N."A transgenic approach defines a differential role for CREB transcription factor in B-1 and B-2 B cell development in Mice. Abstract" Columbus.
January 2001 Chen, H-C and Muthusamy, N."A transgenic approach defines a differential role for cyclic AMP response element binding proteins in B-1 and B-2 B cell development." Baltimore.
January 2002 Natarajan, A, Frissora, F, Chen, H-C, Raghunandan, R, Kusewitt, D, and Muthusamy, N."Analysis of splenocyte population in mice deficient in Ets-1 reveal selective expansion of macrophages, erythrocytes and B-1 B cells" Dublin.
January 2002 Muthusamy, N,Rajgolikar, G., Butz,KG, Chen, HC, Frissora, F and Gronostajski, R."Recombination Activation Gene-2 deficient Blastocyst Complementation Analysis Reveals an Essential Role for Nuclear Factor I-A Transcription Factor in T cell Activation" Chicago.
January 2002 Muthusamy N, Bayoumy, M and Chen-HC."Transcriptional control of osteoclast development and function by cyclic AMP binding protein- Lessons from a transgenic mouse model." San Francisco.
January 2002 Washington, B, Frissora, F, Fisher, IB, and Muthusamy, N."Targeted gene deletion in mice reveals an essential role for Ets-1 transcription factor in T cell proliferation and survival" Dublin.
January 2002 Frissora, F., Chen, HC., Durbin, J, Bondada, S and Muthusamy, N."Cross-talk between the STAT-1/CREB signaling pathway in IFN- mediated negative regulation of B cell growth" Chicago.
January 2002 Fisher, I and Muthusamy, N."Transgenic Mice Over-Expressing a Phosphomutant Ets-2 Reveal An Increase in Thymocyte Cell Death." Dublin.
January 2002 Fisher, I and Muthusamy, N."Transgenic Mice Over-Expressing a Phosphomutant Ets-2 Reveal An Increase in Thymocyte Cell Death" Chicago.
January 2002 Chen-HC and Muthusamy, N."A Transgenic model reveals a role for CREB transcription factor in B cell development and differentiation" Chicago.
January 2002 Chen, H-C, Muthusamy, N.."Differential role for CREB-1 transcription factor in regulation of B-1 and B-2 B cell development in mice" Dublin.
January 2002 Chen, H-C and Muthusamy, N."Differential role for CREB transcription of B-1 and B-2 B cell development in mice" .
January 2002 Chen, H-C and Muthusamy, N."Differential role for CREB transcription of B-1 and B-2 B cell development in mice." Newark.
January 2005 Zhao XB, Carolyn C, Gowda A, Ledbetter J, Ledbetter M, Baum P, Grosmaire L, Espling E, Young D, Lin T, Lee RJ, Caligiuri M, Muthusamy N, Byrd JC."Novel anti-CD37 small modular immunopharmaceutical (SMIP) demonstrated promising preclinical activity" Toronto.
January 2005 Opavsky, R., Tsai S.Y., Sharma, N., Guimond, G., Arora, A., Opavska, J Trikha, P., Maiti, B.,Wu, L., Becknell., B., Kaufmann, M., Walton, N., Stephens, JA., Fernandez, S.A., Muthusamy N., Felsher, Caligiuri, MA., and Leone, G."Novel E2F2B isoform functions as tumor suppressor in myc induced T cell lymphomagenesis" .
January 2006 Zhao XB, Cheney C, Gowda A, Ledbetter J, Ledbetter MH, Baum P, Grosmaire L, Espling E, Young D, Lee RJ, Caligiuri MA, Muthusamy N, Byrd JC."CD37 Directed Single Chain Fv-Ig Demonstrates Promising Preclinical Activity against Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia" . : 276 (#1169)
January 2006 Muthusamy, N., Grabenstatter, J., Frissora, F., Liu, Q., Biswas, S., Chen, C.S and Byrd J.C.."Thiazolidinedione derivativE 5-[4-(6-allyoxy-2,5,7,8-tetramethyl-chroman-2-yl-methoxy)-benzylidene]-2,4-thiazolidinedione mediateS apoptosis in B cell lines and B cells from Chronic lymphocytic leukemia patients by cyclin D1 independent mechanism" Washington. : 1161 (#4942)
January 2007 R Lapalombella, Zhao XB, Ledbetter JA, Baum P, Muthusamy N, Byrd JC.."Role of a novel CD37-specific engineered small modular immunopharmaceutica (SMIPTM) drug in the treatment of CLL" London.
January 2007 Gowda AC, Ramanunni A, Cheney C, Roda J, Kindsvogel W, Henderson D, Pallavur S, Carson W, Muthusamy N and Byrd JC.."IL-21 enhances chemoimmunotherapy mediated death of chronic lymphocytic leukemia cells" . : 7094
January 2007 Nagaleekar VK, Diehl S, Juncadella I, Charland C, Garrett-Sinha LA, Muthusamy N, Anguita J, Rincón M."Ets1-dependent IP3R3 expression in naïve CD4+ T cells is required for cytokine gene expression" Miami Beach. : 22
January 2007 Muthusamy N, Gowda AC, Ramanunni A, Cheney C, Roda J, Kindsvogel W, Henderson D, Pallavur S, Carson W, and Byrd JC."IL-21 enhances chemoimmunotherapy mediated death of chronic lymphocytic leukemia cells" London.
August 2008 Yan J,Yu B, Liu S, Zhang X, Lapalombella R, Triantafillou G, Pang X, Muthusamy N, James JL, Byrd JC, Marcucci G, Lee RJ."BIOT 305-Targeted delivery of oligonucleotides for antileukemia therapy using multifunctional immunolipopolyplex nanocarriers" Washington DC.
October 2011 Muthusamy N, Yu B, Mao Y, Bai L-Y, Herman SEM, Ramanunni A, Mo X, Yan J, Cheney C, Chan KK, Jarjoura D, Marcuci G, Lee RJ, Byrd JC, Lee LJ."Targeted Nanoparticle Delivery Overcomes Off-Target Immunostimulatory Effects of Eligonucleotides and Improves Therapeutic Efficiacy" Houston.

Inventions and Patents

Chen C-S, Kulp SK, Wang D, Byrd JC, Muthusamy N. "FTY720-DERIVED ANTICANCER AGENTS." Filed November 2011.

Byrd JC, Perrotti D, Chen C-S, Dalton JT, Frissora F, Zhao X, Liu Q, Muthusamy N. "Therapeutic agents for the treatment of lymphoid malignancies." Filed November 2012.

Cheney C, He S, Marcucci G, Muthusamy N. "Anti-CD33 Antibody Therapy in Combination with Azanucleoside and Immunemodulatory Agents for AML." Filed July 2013.

Perrotti D, Neviani P, Ramasamy S, Byrd JC, Marcucci H, Muthusamy N, Chen C-S. "Therapeutic Agents for the Treatment of Leukemia." Filed March 2006.

Byrd JC, Muthusamy N, Lee RJ; Lee JL, Lapalombella R, Yu B. "Methods and Compositions for Delivering Therapeutic Agents in the Treatment of B-Cell Related Disorders." Filed July 2009.

Byrd JC, Chen C-S, Kulp S,Muthusamy N, Wang D. "FTY720-Derived Anticancer Agents." Filed November 2010.

 

Presentations

"History of Major Histocompatibility Complex." Presented at Short Term Training Course on Hybridoma Technology, IN|IND. (January 1985)

"Differential effects of cAMP and on anti-IgM and anti-Lyb2 mediated B cell activation." Presented at Mid West Immunology Conference, St. Louis. (January 1988)

"Differential effects of cAMP on anti-IgM and anti-Lyb2 mediated B cell activation." Presented at FASEB Meeting, New Orleans. (January 1989)

"Differential effects of cAMP on anti-u and anti-Lyb2 mediated B cell activation." Presented at Mid West Immunology Conference, St. Louis. (January 1989)

"Evidence for alternative signal transduction mechanisms in murine B cells." Presented at MidWest Immunology Conference, St. Louis. (January 1989)

"Differential regulation of B lymphocyte activation mediated through the surface receptors on murine B lymphocytes." Presented at Invited Speaker Series, Ann Arbor. (January 1991)

"Role of Lyb2 in B cell activation- a comparison with the antigen receptor mediated triggering of murine B lymphocytes.." Presented at Invited Speaker Series, Oklahoma. (January 1991)

"Regulation of early signaling in B lymphocytes." Presented at Section on Signal Transduction, National Heart, Blood and Lung Institute - NIH, Bethesda, MD. (January 1991)

"Differential regulation of early signaling in B lymphocytes." Presented at Cancer Institute Seminar Series, Amsterdam, NL|NLD. (January 1992)

"Role of Ets-1 and CREB transcription factors in lymphocyte development and function: A gene targeting and Transgenic approach.." Presented at Visiting Speaker Series, Knoxville. (January 1996)

"Role of Ets-1 and CREB transcription factors in lymphocyte development and function.." Presented at Visiting Seminar Speaker Series, Gaithersberg. (January 1996)

"Role of Ets-1 and CREB transcription factors in lymphocyte development and function: A gene targeting and Transgenic Approach." Presented at Invited Speaker, Columbus. (March 1997)

"Role of Ets-1 and CREB transcription factors in lymphocyte development and function: A gene targeting and Transgenic approach." Presented at Visiting Speaker Seminar Series, Knoxville. (March 1997)

"Role of Ets-1 and CREB transcription factors in lymphocyte development and function: A gene targeting and Transgenic Approach." Presented at MVIMG Department seminar series, Columbus. (January 1998)

"Generation of murine models to study regulation of B lymphocyte development and functions.." Presented at OSU Molecular Biology Program, Columbus. (January 1998)

"Role of Ets-1 and CREB transcription factors in lymphocyte development and function: A gene targeting and Transgenic Approach." Presented at Department seminar, Columbus. (May 1998)

"Generation of murine models to study regulation of B lymphocyte development and functions." Presented at OSU Molecular Biology Program, Columbus. (May 1998)

"Genetic Approaches in Immunology.." Presented at Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, IN|IND. (November 1998)

"A Transgenic Approach to Define the Role of Cyclic AMP Response Element Binding Proteins in B Cells.." Presented at The Tenth International Congress of Immunology, New Delhi, IN|IND. (November 1998)

"Genetic approaches to define lymphocyte development and function in mice." Presented at Dept. of Veterinary BioSciences Research Seminar Series, Columbus. (April 1999)

"Transgenic approach to define the role of cyclic AMP response element binding proteins in lymphocytes.." Presented at Immunology Seminar Program Sponsored by OSU College of Medicine and Pathology, Columbus. (January 1999)

"Transcriptional regulation of lymphocyte development and function." Presented at Departmental Seminar Series, Lexington. (January 2000)

"Role of cyclic AMP response element binding proteins in B cell development -Lessons from a transgenic mouse model.." Presented at Keystone Symposia on B cells biology in diseases, . (January 2001)

"Genetic approaches to define transcriptional control of lymphocyte development and function in mice.." Presented at Departmental Seminar, East Lansing, MI. (January 2001)

"Blastocyst complementation analysis reveal a role for NF-1A transcription factor in T cell activation." Presented at FASEB/American Association of Immunologists Meeting, Orlando. (January 2001)

"Role of cyclic AMP response element binding proteins in B cell development -Lessons from a transgenic mouse model.." Presented at Keystone Symposia on B cells biology in diseases, . (April 2001)

"Blastocyst complementation analysis reveal a role for NF-1A transcription factor in T cell activation." Presented at 2001 FASEB/American Association of Immunologists meeting, Orlando. (April 2001)

"Genetic analysis of lymphocyte development and function: Lessons from transgenic and gene targeted mouse models.." Presented at College of Veterinary Medicine-Pathobiology Seminar Series, Ontario, CA|CAN. (May 2002)

"Cyclic AMP response element binding proteins in developmental and functional maturation of B lymphocytes." Presented at Immunology Seminar Program Sponsored by OSU College of Medicine and Pathology, Columbus, OH. (October 2004)

"Recent Developments in Cancer Management and research." Presented at National Workshop Avinahsilingam Home Science University, Coimbatore, IN|IND. (December 2006)

"FTY720, a novel therapeutic agent in B cell malignanices." Presented at Christian Medical College Reseach Seminars, Vellore, IN|IND. (December 2006)

"Recent Developments in Cancer Management and reseach." Presented at National Workshop on Recent Developments in Cancer Management and reseach- Avinahsilingam�, Coimbatore, IN|IND. (January 2006)

"Ets proteins in lymphocyte development and maturation." Presented at Immunology Seminar Program Sponsored by OSU College of Medicine and Pathology, Columbus, OH. (February 2006)

"FTY720, a novel therapeutic agent in B cell malignanices." Presented at Invited Speaker, Chennai, IN|IND. (January 2007)

"Differential role for CREB transcription factor in multiple stages of B-cell development and functional maturation." Presented at The Babraham Institute, Cambridge, England, GB|GBR. (June 2007)

"Towards development of a novel therapeutic agent for B cell malignancies." Presented at Immunology Seminar Program Sponsored by OSU College of Medicine and Pathology, . (February 2007)

"Towards development of novel agents for leukemia and lymphoma: Immunology meets pharmacy and Medicine- A Team Science experience at OSU." Presented at Immunology Seminar Program Sponsored by OSU College of Medicine and Pathology., Columbus, OH. (October 2008)

"IL-21 - The new cytokine on the block for CLL." Presented at The 12th Annual Meeting of the Translational Research Cancer Center Consotrium (TRC3), Philadelphia, Pensylvania. (March 2009)

"Senior leadership committee on building a bridge with US universities." Presented at Avinasilingam University, Coimbatore, IN|IND. (December 2011)

"Prospects for Targeted Nanoparticle Delivery in B Cell malignancies." Presented at 4th International Conference on Translational Cancer Research: Recent Developments in Cancer Prevention, Udaipur, Rajasthan, IN|IND. (December 2011)

"Therapeutic Antibodies: A Decade of Design." Presented at 15th Annual International Congress on Hematologic Malignancies: Focus on Leukemias, Lymphomas and Myeloma, Whistler, BC, CA|CAN. (February 2011)

"Study of CD37 and Mouse Models." Presented at Chronic lymphocytic leukemia Research Consortium -Annual Meeting, LaJolla, California. (February 2012)

"Tetraspanin CD37 mediates Transducton of survival and Apoptotic signals i B Cells." Presented at The Henry Kunkle Society an IMPAM Meeting, Berlin, DE|DEU. (June 2012)

"A dual signaling role for CD37 tetraspanin CD37 in B cells - a tale of two tails." Presented at Boehringer Ingelhiem Scientific meeting, Vienna, AT|AUT. (June 2012)

"Dual Sgnaling role for Tetraspanin CD37 in B cells - a tale of two tails." Presented at 5th European Conference on Tetraspanins, Amsterdam, NL|NLD. (September 2012)

"CD37 tetraspanin – a novel therapeutic target in B cell malignancies." Presented at Immunology Seminar Program Sponsored by OSU College of Medicine and Pathology, Columbus, . (September 2012)

"CD37 Tetraspanin - a therapeutic target in B-cell malignancies." Presented at Departmental Seminar University of Nebraska Medical Center, Omaha, NE, US|USA. (February 2013)

"CD37 Tetraspanin as a Therapeutic Target for B-Cell Malignancies." Presented at The Henry Kunkel Society Annual Meeting, New York, NY, US|USA. (April 2013)

 

Professional Activities

2006 - present Patient Sevices. James Volunteering services.
2007 - present Fundraising and educational activities. Leukemia Lymphoma Society.
2011 - present Research Mentor to Sumuthira Vasu, MBBS, Assistant Professor of Medicine. The Ohio State University. Columbus, Ohio.
2012 - present Translational Research Program Grant Reviewer. Leukemia & Lymphoma Society. New York, NY.
2012 - present Member of Mentorship Team- Jennifer A. Woyach, MD. The Ohio State University. Columbus, Ohio.
2012 - present Research Mentor to Samantha Jaglowski, MD, MPH, Assistant Professor of Medicine. The Ohio State University. Columbus, Ohio.
2001 - 2003 Review of Grant Application. Susan G. Komen Breast Cancer Foundation. Dallas, TX.
2003 Review of Grant applications. Cancer Research UK.
2013 Review of Grant Applications. National Science Center.
2013 Scholarship Review. The Ohio State University, College of Medicine. Columbus, OH.
2013 Review of Grant Applications. The Ohio State University Comprehensive Cancer Center's Intramural Research Program. Columbus, OH.
 

Unpublished Works

Shah P, Elavazhagan S, Patel H, Fatehchand K, Cheney C, Muthusamy N, Vasilakos JP, Matthews MA, Hershberg RM, Byrd JC, Tridandapani S, Butchar JP. TLR7/8 agonists aid in reversing FcγR suppression and enhance antibody-mediated clearance of B-CLL cells. March 2013.

Yu B , Mao Y, Yuan Y, Yue C, Wang X, Mo X, Jarjoura D, Paulaitis M, Lee RJ, Byrd, JC, Lee LJ, Muthusamy N. Dual-ligand immunoliposomes improves the cross-linking induced apoptosis and targeting drug delivery efficiency to B chronic lymphocytic leukemia cells. April 2013.

Mao Y, Frissora FW, Wang J, Zhao Y, Wu Y, Mani R, Yu B, Baskar S, Phelps MA, Chen C-S, Rader C, Lee RJ, Byrd JC, Lee LJ, Muthusamy N. ROR1 directed delivery of therapeutic small molecule OSU-2S mediates potent cytotoxic activity against chronic lymphocytic leukemic but not normal B cells in vitro and in ROR1 expressing CLL transgenic mouse model in-vivo.

Mani R, Frissora FW, Mao Y, Chiang C-l, Mo X, Jarjoura D, Baskar S, C Rader, Lee RJ, Lee LJ, Chen C-S, Byrd JC, Muthusamy N. OSU-2S, a novel non-immunosuppressive FTY720 derivative mediates potent cytotoxic activity through PKC dependent phosphorylation of tumor suppressor SHP1 and down modulation of TCL1 oncogene in chronic lymphocytic leukemia.

Dubovsky JA, Chappell DL, Andritsos LA, Flynn JM, Jones JA, Byrd JC, Muthusamy N. Lymphocyte cytosolic protein 1 (LCP1) is a membrane associated tumor-antigen in chronic lymphocytic leukemia with functional relevance in CXCL12 migration. July 2013.

Wu, Y, Kwak K J, Agarwal K, Marras A, Wang C, Mao Y, Huang X, Ma J, Yu B, Lee R, Vachani A, Marcucci G, Byrd JC, Muthusamy N, Otterson G, Huang K, Castro C, Paulaitis M, Nana-Sinkam S, Lee L.. Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons".. October 2013.

Li X, Jarjoura D, Muthusamy N. Testing the “Direct Control” Hypothesis in Target Modulation Experiments. January 2011.

Fisher IB and Muthusamy N. Role of Ets-2Thr-72 transcription factor in B220+ Bone marrow B lymphocytes. January 2012.