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Ramiro Garzon, MD


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-2518

Email: garzon.2@osu.edu

 

Current OSU Appointments

Associate Professor, Hematology

Physician, FGP-Hematology

 

Advising Narrative

Catherine Heaphy (Former research assistant in my lab): 3 peer review manuscripts (one as first co-author in Blood), 2 reviews and several abstracts at international meetings. Currently in Univ of Indiana nursing school.



Nicole Stauffer (Former research assistant in my lab): 2 peer review manuscripts, several abstracts at international meetings ( 1 abstract as first name and presenter at ASH (oral presentation. Currently at Boston University, Phd immunology .



Caroline NA (Former research assistant in my lab): 2 peer review manuscripts, several abstracts at international meetings. Currently at Robert Wood Johnson New Jersey University, medical school, MD program.)

Academic Advising

Graduate professional ( young faculty): Dr. Efebera; Major accomplishments: CTSA award, R21 submitted as multiple PI (SCORED 13 Impact/priority score NHI ( from 10-90) waiting for NOA), 1 clinical trial undergoing and accruing well, currently working on a K23 and an R01 submission.PhD level: currently supervising and advising 3 people (Ranganathan, Yu and Sandhu). Undergraduate level: 1research assistant (Jessica Hofsteter). I also often have students during summer rotations in my laboratory and provide career advice.

Biographical

Ramiro Garzon is an assistant professor of medicine in the division of Hematology, Department of Internal Medicine and a member of the Molecular Biology and Cancer Genetics program at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA. He received his M.D. from the National University School of Medicine, Cordoba, Argentina. He trained in hematology and oncology at Thomas Jefferson University, Philadelphia, Pennsylvania, USA, and carried out a fellowship in leukemia at The Ohio State University. His research focuses on microRNA (miRNA) expression and function in normal hematopoiesis and leukemia. In particular, he is interested in dissecting the role of miRNAs in aberrant epigenetics and in developing novel miRNA-based therapies. He has made several original contributions in the field of miRNAs and leukemia, including the first evidence that miRNAs target the DNA methylation machinery. In 2008, he received the prestigious Kimmel Translational Award to help develop miRNA-based therapeutics to target aberrant epigenetics in acute myeloid leukemia (AML). More recently he received an R21 and R01 from the NIH. Dr. Garzon was initially appointed as instructor of Medicine in September of 2006 and was promoted to Assistant Professor of Medicine (tenure track) in April of 2007.

Master/Graduate Advising

I participated in 2 thesis dissertations defense as committee member: Dr Tiziana Palumbo (Universidad de Catania, Italy 5/2009 and Dr. Violaine Havelange (University of Louvain, Brussels, Belgium in 5/2012).My participation in undergraduate research is described in detailed below.

Civic Engagement

I provided hematology clinic services to the OHIO correctional facilities from 2007 to 2010.

Noteworthy Graduate Narrative

Sukhinder Sandhu (PhD student): 3 oral presentations about her work under my co-supervision in Annual meetings of the American Association for cancer research (AACR,Washington 2010), American society of Hematology (ASH, Orlando 2010 and the European Hematology association (EHA, Barcelona 2010), published 2 reviews and obtained a travel award to attend ASH meeting.



Marina Vasquez (PhD student): 1 poster presentation at ASH annual meeting in San Diego, 2011.



Tiziana Palumbo (PhD student): 1 poster presentation AACR, Washington 2006, 5 per review original papers as co-author. Currently at Harvard University as post -doc.

Partnership Narrative

During the course of my career here at OSU I have developed collaborations within and outside the university that in my view as been very positive for the university.First, I have helped to establish the OSU miRNA therapeutics group (Drs. Byrd, Chan, Liu, Muthusamy, Lee, Croce, Garzon and Marcucci) that hold meetings in a weekly basis. This group have achieved several milestones like the development of an ELISA based assay for miRNA detection, in vivo animal miRNA therapeutics trials and miRNA nanoparticle delivery systems. A total of 3 R01, 1 RC2 and Ohio grants were awarded from data generated by the group and are supporting his research. Several manuscripts has been published, discoveries made, patents filled (2). A PO1 is now to be submitted. Second I contacted and developed a relationship with Santaris Pharma, the only pharmaceutical company in the world which has clinical trials using miRNAs therapies in humans. the goal is to develop miRNA therapies for acute leukemia. I have coordinated MTA process, collaborative process,, patent solving conflicts, and co develop with Tim Wright a drug development plan and lead discussions of partnership for miRNA therapy development.Third, I have established research collaborations with outside researchers such as Drs. Blazar (univ of Minnesota )and Weiss (UPENN) that have resulted in publications and grant applications. More importantly b doing so i have brought to the institution expertise in an area that is currently lacking (GVHD and normal hematopoiesis biology).

Academic Advising

2007 - present Violaine Havelange Université Catholique de Louvain. Graduated 2012.
2009 - present Sukhinder Sandhu The Ohio State University. Graduated 2011. Role of miR-155 in B cell malignancies
2010 - present Parvathi Rangananthan The Ohio State University. Graduated 2010.
2010 - present Jason Mendler The Ohio State University.
2011 - present Xueyan Yu The Ohio State University. Graduated 2005.
2006 - 2008 Tiziana Palumbo University of Catania. Graduated 2009. MicroRNA gene expression during ATRA differentiation of human APL
2006 - 2008 Tiziana Palumbo University of Catania.
2008 - 2009 Andrew Lee The Ohio State University.
2009 Coleen Valencia University of Notre Dame.
2008 - 2010 Nicole Stauffer The Ohio State University.
2007 - 2011 Catherine E. The Ohio State University.
2009 - 2011 Eugene KOh The Ohio State University. Graduated 2011.
2009 - 2011 Marina Lipkin The Ohio State University. Graduated 2011.
2007 - 2012 Violaine Havelange Université Catholique de Louvain. MicroRNAs: new actors in AML
2010 - 2012 Caroline Na The Ohio State University.
 

Chapters in Books

Sandhu S and Garzon R. "MicroRNAS in hematopoiesis." In MIcroRNAS in Medicine. Edited by Charles Lawrie- Wiley-Blackwell. -. January 0.

Ranganathan P and Garzon R.. "MicroRNAs as therapeutic targets." In Targeted therapy in AML. Edited by Michael Andreeff- Springer. -. January 0.

Reinhold Munker, Ramiro Garzon, and Kerry Atkinson. "Therapeutic decision making in BMT/SCT for acute myeloid leukemia." In Therapeutic decision making in BMT/SCT for acute myeloid leukemia. 2nd Edition ed. Edited by Munker, Reinhold ; Lazarus, Hillard M. ; Atkinson, Kerry. 23-40. Cambridge: Cambridge University Press, January 2009.

Jack Erter and Ramiro Garzon. "Hematology Board Review manual." In Current Approach to treating Chronic Myeloid Leukemia. Edited by Turner-white. 2-12. Philadelphia, PA, US|USA: Turner-White, January 2009.

 

Clinical Trials

Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia

 

Conferences

Casas JP, Lopez AM, Palacio S, Lucero C, Robles A, Zeppa G, Abbona H, Garzon R. "Sleep apnea: value of history and complementary studies." In Congress proceedings. (October 1997). 126 C-24.

Garzon R, Lucero C, Palacio S, Lopez AM, Robles A, Casas P.. "Acquired Micrognatia associated with Sleep Obstructive Apnea." In Congress Proceedings. (October 1997). 234-P24.

Urbano L, Garzon R, Mendez JL, Achavla A Heinzman M.. "Coronary artery and cerebrovascular disease: a common association.." In Congress proceedings. (October 1997). 93-C.

Pieckenstainer R, Moroz S, Avakian A, Garzon R.. "Determination of LDL by calculated Friedewald formula versus laboratory determination in diabetic patients.." In Congress Proceedings. (October 1997). 102-C.

Salvador DF, Lopez AM, Romero E, Robles A, Garzon R, Pickensteiner R. "Acute eosinophilic pneumonia: A case report.." In Congress proceedings. (October 1998). P-23.

Garzon R, Ricci B, Abichain P, Turrado R, Rossi N, Sturich A, Palazzo E.. "Myelodisplastics syndromes: A clinic-cytogenetic correlation of 40 cases." In Congress proceedings. (October 1998). 108-C13.

Garzon R, Mindru C, Fanek HE, Braza F, Kloss R.. "Merkel cell carcinoma as a second tumor in a patient with multiple myeloma.." In ACP proceedigs. (May 2000). 34-.

Palumbo TM, Garzon R, Pichiorri F, Cimmino A, Iuliano R, Volinia S, Wojcik S, Calin GA, Liu C-G, Croce CM. "MicroRNAs expression in acute promyelocitic leukemia upon ATRA treatment.." In AACR proceeding abstracts. (May 2006). abstract 3251-.

Garzon,Ramiro; Volinia,Stefano; Liu,Chang,G; Pichiorri,Flavia; Palumbo,Tiziana; Fabbri,Muller; Cimmino,Amelia; Alder,Hansjuerg; Flomenberg,Neal; Coombes,Kevin,R; Calin,George,A; Andreeff,Michael; Croce,Carlo,M. "MicroRNA signatures associated with cytogenetics and outcome in acute myeloid leukemia.." In BLOOD. (November 2006). 49A-49A.

Garzon R, Pichiorri F, Calin G, Marcucci G, Kornblau S, Andreeff M and Croce, C.. "MiRNA-29b targets MCL-1 and is down-regulated in chemotherapy-resistant Acute myeloid leukemia (AML).." In Blood. (December 2007). 717-.

Garzon,Ramiro; Liu,Shujun; Fabbri,Muller; Liu,Zhongfa; Pang,Jiuxia; Muthusamy,Natarajan; Blum,William; Chan,Kenneth; Byrd,John,C; Croce,Carlo,M; Marcucci,Guido. "MicroRNA (miRNA)-29b targets DNMT3A and B and induces re-expression of the hypermethylated ESR1 and p15 genes in acute myeloid leukemia (AML).." In BLOOD. (November 2007). 220A-220A.

Garzon R, Volinia S, Falini B, Croce, CM. "A unique microRNA signature associated with nucleophosmin mutations in normal karyotype acute myeloid leukemia.." In Journal of Clinical Oncology. (June 2008). 360-.

Xie Z, Liu Z, Chiu M, Dunkerson S, Muthusamy N, Garzon R, Liu S, Croce C, Byrd J, Marcucci G Chan K.. "A validated ultrasensitive hybridization-ELISA assay for synthetic microRNAs in mouse plasma and human leukemia cells and its mouse pharmacokinetics.." In AACR proceedings abstracts. (May 2008). 4418-.

Wang H, Garzon R, Sun H, Ladner K, Singh R, Cheng A, Hall B, Qualman S, Chandler D, Croce C, Guttridge D.. "NF-kB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and Rhabdomyosarcoma.." In AACR proceedings abstracts. (May 2008). LB-99.

Liu S, Pang J, Liu Z, Xie Z, Yu J, Ding H, Huynh L, Klisovic RB, Baiocchi RA, Garzon R, Perrotti D, Chan KK, Wu L-C, Blum W, Marcucci G.. "The proteasome inhibitor bortezomib alters epigenetic profiling through impairing Sp1/NF-kB-dependent DNA methyltransferase activity in acute myeloid leukemia." In AACR proceeding abstracts. (May 2008). 2622-.

Garzon,Ramiro; Heaphy,Catherine,EA; Liu,Chang,Gong; Calin,George,A; Croce,Carlo,M. "Ultraconserved Genomic Regions (UCRs) Expression in Hematopoiesis.." In BLOOD. (November 2008). 855-855.

Blum,William; Klisovic,Rebecca; Liu,Shujun; Garzon,Ramiro; Kefauver,Cheryl; Liu,Zhongfa; Mickle,Jon; Devine,Hollie; Devine,Steve; Grever,Michael,R; Chan,Kenneth,K; Villalona-Calero,Miguel; Byrd,John,C; Marcucci,Guido. "Preliminary Results of a Phase II Study of Low Dose Decitabine as a Single Agent in Older Patients (age >= 60) with Previously Untreated Acute Myeloid Leukemia (AML)." In BLOOD. (November 2008). 1016-1016.

Chen,Ping; Blum,William; Aimiuwu,Josephine; Upadhyayula,Vijayasarathi; Liu,Zhongfa; Liu,Shujun; Pang,Jiuxia; Walker,Alison; Klisovic,Rebecca,B; Garzon,Ramiro; Grever,Michael,R; Villalona-Calero,Miguel; Byrd,John,C; Chan,Kenneth,K; Marcucci,Guido. "Quantification of Intracellular Decitabine-Triphosphate with A Novel, Highly Sensitive and Specific LC-MS/MS Assay in Acute Myeloid Leukemia Patients Treated with Low Dose Decitabine." In BLOOD. (November 2009). 1454-1455.

Chandler,Jason,C; Klisovic,Rebecca,B; Phelps,Mitch,A; Walker,Alison; Garzon,Ramiro; Yang,Xiaoxia; Schaaf,Larry; Schwind,Sebastian; Becker,Heiko; Liu,Shujun; Hickey,Chris; Kefauver,Cheryl; Mickle,Jon; Devine,Steven,M; Grever,Michael,R; Byrd,John,C; Marcucci,Guido; Blum,William. "Phase I Study of Lenalidomide in Acute Leukemia: Remissions in Post-Allogeneic Relapse of Acute Myeloid Leukemia." In BLOOD. (November 2009). 346-347.

Hickey,Christopher; Schwind,Sebastian; Becker,Heiko; Alachkar,Houda; Garzon,Ramiro; Wu,Yue-Zhong; Liu,Shujun; Perrotti,Danilo; Marcucci,Guido. "MicroRNA-181a Targets TEL/AML1 Expression and Impairs Cell Proliferation in t(12;21) Acute Lymphocytic Leukemia (ALL) Cells." In BLOOD. (November 2009). 318-318.

Eiring,Anna,M; Harb,Jason; Neviani,Paolo; Oaks,Joshua; Liu,Shujun; Spizzo,Riccardo; Schwind,Sebastian; Santhanam,Ramasamy; Hickey,Christopher; Becker,Heiko; Chandler,Jason,C; Andino,Raul; Cortes,Jorge; Hokland,Peter; Huettner,Claudia; Bhatia,Ravi; Roy,Denis-Claude; Liebhaber,Stephen; Caligiuri,Michael,A; Marcucci,Guido; Garzon,Ramiro; Croce,Carlo,M; Calin,George,A; Perrotti,Danilo. "Suppression of RISC-Independent Decoy and RISC-Mediated mRNA Base-Pairing Activities of MicroRNA-328 Is Required for Differentiation-Arrest and Enhanced Survival of Blast Crisis CML Progenitors." In BLOOD. (November 2009). 351-352.

Blum,William; Klisovic,Rebecca,B; Walker,Alison; Garzon,Ramiro; Liu,Shujun; Schaaf,Larry,J; Humphries,Kristina; Grever,Michael,R; Devine,Steven,M; Byrd,John,C; Marcucci,Guido. "Epigenetic Targeting Via Transcriptional Inhibition of DNA Methyltransferase: a Phase I Study of Bortezomib in Combination with 5-Azacytidine in Adults with Relapsed or Refractory Acute Myeloid Leukemia (AML)." In BLOOD. (November 2009). 815-816.

Fabbri M, Adaeu B, Wernicke D, Garzon R,et al.. "MicroRNA 29 family restores estrogen receptor and selective estrogen receptors regulators (SERMs) sensitivity in breast cancer.." In AACR proceedings abstracts. (May 2009). 1374-.

Hamadani,M; Benson,D,M; Porcu,P; Elder,P; Andritsos,L; Hofmeister,C,C; Krugh,D; Garzon,R; Lin,T; Marcucci,G; Blum,W; Devine,S,M. "EVALUATION OF RABBIT ANTITHYMOCYTE GLOBULIN (RATG) DOSE-INTENSITY IN PATIENTS UNDERGOING ALLOGENEIC STEM CELL TRANSPLANTATION (ASCT) FOLLOWING REDUCED INTENSITY CONDITIONING (RIC) WITH FLUDARABINE, BUSULFAN AND RATG (FBA)." In BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. (February 2009). 5-5.

Garzon,R; Heaphy,E; Croce,C. "ULTRACONSERVED GENOMIC REGIONS EXPRESSION IN HEMATOPOIESIS." In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. (June 2009). 3-3.

Garzon,R; Heaphy,C,EA; Havelange,V; Kornblau,S; Marcucci,G; Andreeff,M; Croce,C,M. "MICRORNA 29B FUNCTIONS IN ACUTE MYELOID LEUKEMIA." In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. (June 2009). 219-220.

Garzon,Ramiro; Heaphy,Catherine,EA; Stauffer,Nicole; Havelange,Violaine; Volinia,Stefano; Andreeff,Michael; Croce,Carlo,M. "Discovery and Functional Implications of a Novel Mir-29b/Mir-29a Polymorphism in Acute Myeloid Leukemia." In BLOOD. (November 2009). 781-782.

Liu,Shujun; Wu,Lai,Chu; Pang,Jiuxia; Santhanam,Ramasamy; Schwind,Sebastian; Wu,Yue-Zhong; Hickey,Christopher; Yu,Jianhua; Mishra,Anjali; Becker,Heiko; Li,Chenglong; Briesewitz,Roger; Baiocchi,Robert,A; Chan,Kenneth,K; Caligiuri,Michael,A; Byrd,John,C; Perrotti,Danilo; Garzon,Ramiro; Marcucci,Guido. "Evidence of MicroRNA-29b and Sp1/NF kappa B-HDAC Regulatory Network for KIT Expression in KIT-Driven Acute Myeloid Leukemia (AML): Biologic and Therapeutic Implications." In BLOOD. (November 2009). 387-387.

Havelange,Violaine; Volinia,Stefano; Andreeff,Michael; Marcucci,Guido; Croce,Carlo,M; Garzon,Ramiro. "Functional Implications of miRNAs in Acute Myeloid Leukemia (AML) by miRNA-mRNA Expression Profiling.." In BLOOD. (November 2009). 653-653.

Volinia,S; Galasso,M; Costinean,S; Tagliavini,L; Gamberoni,G; Drusco,A; Marchesini,J; Mascellani,N; Sana,M,E; Abu,Jarour,R; Desponts,C; Teitell,M; Baffa,R; Aqeilan,R; Iorio,M; Taccioli,C; Garzon,R; Di Leva,G; Fabbri,M; Catozzi,M; Previati,M; Ambs,S; Palumbo,T; Garofalo,M; Veronese,A; Bottoni,A; Gasparini,P; Harris,C,C; Visone,R; Pekarsky,Y; de la Chapelle,A; Bloomston,M; Dillhoff,M; Rassenti,L,Z; Kipps,T,J; Huebner,K; Pichiorri,F; Lenze,D; Cairo,S; Buendia,M,A; Pineau,P; Dejean,A; Zanesi,N; Rossi,S; Calin,G,A; Liu,C,G; Palatini,J; Negrini,M; Vecchione,A; Rosenberg,A; Croce,C,M. "Reprogramming of miRNA networks in cancer and leukemia." In EUROPEAN JOURNAL OF MEDICAL RESEARCH. (October 2010). 152-152.

Ma,Wencai; Davis,R,Eric; Jacamo,Rodrigo; Konopleva,Marina; Garzon,Ramiro; Croce,Carlo,M; Andreeff,Michael. "Mesenchymal Stromal Cells From AML Bone Marrow Are Abnormal by Gene Expression Profiling." In BLOOD. (November 2010). 463-463.

Shukhinder,S; Costinean,S; Neinast,R; Parthum,M; Croce,C; Garzon,R. "MIRNA-155 TARGETS BCL6 AND HDAC4 IN A MURINE B-CELL LEUKEMIA MODEL: A PARADIGM SHIFT IN THE ONCOGENIC MECHANISMS OF MICRORNAS." In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. (June 2010). 227-227.

Sukhinder K. Sandhu, Stefan Costinean, Reid Neinast, Mark Parthun, Ramiro Garzon, and Carlo Croce. "OncomiR-155 targets oncogenes HDAC4 and BCL6 in a murine B cell leukemia model: A paradigm shift in the oncogenic mechanisms of microRNAs." In Cancer research. (April 2010). 3-.

Stauffer,Nicole; Hamadani,Sayed,Mehdi; Heaphy,Catherine; Santhanam,Ramasamy; Sandhu,Sukhinder; Costinean,Stefan; Nuovo,Jerry; Perrotti,Danilo; Croce,Carlo,M; Hadley,Greg; Marcucci,Guido; Devine,Steven,M; Garzon,Ramiro. "Regulation of Acute Graft-Versus-Host Disease by MicroRNA-155." In BLOOD. (November 2010). 113-113.

Mishra,Anjali; Liu,Shujun; Sams,Gregory,H; Curphey,Douglas,P; Santhanam,Ramasamy; Rush,Laura,J; Schaefer,Deanna; Falkenberg,Lauren,G; Sullivan,Laura; Jaroncyk,Laura; Zou,Xunchang; Fisk,Harold; Labanowska,Jadwiga; Caserta,Enrico; Wu,Lai-Chu; Becker,Heiko; Schwind,Sebastian; Chandler,Jason,C; Wu,Yue-Zhong; Heerema,Nyla,A; Porcu,Pierluigi; Garzon,Ramiro; Marcucci,Guido; Caligiuri,Michael,A. "Interleukin-15 Is a Proto-Oncogene In Acute Large Granular Lymphocyte Leukemia." In BLOOD. (November 2010). 311-311.

Klisovic,B; Blum,W; Chen,P; Xie,Z; Liu,S; Walker,A; Devine,S; Garzon,R; Byrd,J; Wetzler,M; Sayar,H; Damon,L; Grosskreutz,C; Solomon,S; Murray,P; Chan,K; Marcucci,G. "A PHASE II STUDY OF GTI-2040, AN ANTISENSE TO RIBONUCLEOTIDE REDUCTASE IN COMBINATION WITH HIGH-DOSE CYTARABINE IN RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA." In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. (June 2010). 27-27.

Garzon,R; Gamberroni,G; Visone,R; Pekarsky,Y; Galasso,M; Calin,G; Andreeff,M; Croce,C. "MICRORNA NETWORKS IN LEUKEMIA." In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. (June 2010). 248-248.

Houda Alachkar, Shujun Liu, Sebastian Schwind, Heiko Becker, Klaus H. Metzeler, Christopher Hickey, Jiuxia Pang, Susan P. Whitman, Kenneth K. Chan, Ramiro Garzon, David M. Lucas, Danilo Perrotti, Lai-Chu Wu, Michael R. Grever, A D. Kinghorn, and Guido Marcucci. "The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells." In Cancer Research. (April 2010). 3558-.

Anna M. Eiring, Jason Harb, Paolo Neviani, Joshua J. Oaks, Shujun Liu, Riccardo Spizzo, Sebastian Schwind, Ramasamy Santhanam, Christopher Hickey, Heiko Becker, Jason C. Chandler, Raul Andino, Jorge Cortes, Peter Hokland, Claudia S. Huettner, Ravi Bhatia, Denis C. Roy, Stephen Liebhaber, Michael A. Caligiuri, Guido Marcucci, Ramiro Garzon, Carlo M. Croce, George A. Calin, and Danilo Perrotti. "Suppression of RISC-independent decoy and RISC-mediated RNA-pairing activities of microRNA-328 is required for maturation-arrest and enhanced survival of blast crisis CML progenitors." In Cancer research. (April 2010). 1950-.

Blum,William; Klisovic,Rebecca,B; Garzon,Ramiro; Walker,Alison; Schwind,Sebastian; Liu,Shujun; Schaaf,Larry; Garr,Celia; Devine,Steven,M; Greyer,Michael,R; Byrd,John,C; Marcucci,Guido. "Phase 1 Trial of Decitabine and Bortezomib in High Risk Acute Myeloid Leukemia (AML)." In BLOOD. (November 2010). 1349-1349.

Sandhu,Sukhinder; Neinast,Reid; Balatti,Veronica; Lovat,Francesca; Volinia,Stefano; Garzon,Ramiro; Pekarsky,Yuri; Croce,Carlo,M. "B-Cell Lymphoma In Eu-Mir-17 similar to 92 Transgenic Mice." In BLOOD. (November 2010). 340-340.

Vasquez,Marina,Lipkin; Zanesi,Nicola; Volinia,Stefano; Garzon,Ramiro; Cazzaniga,Giovanni; Croce,Carlo,M; Biondi,Andrea. "MiR-125b Cooperates with BCR-ABL and Enhances Therapy Resistance in Childhood Ph plus ALL." In BLOOD. (November 2011). 37-37.

Anjali Mishra, Gregory H. Sams, Jessica Johns, Douglas P. Curphey, Laura A. Sullivan, Lauren G. Falkenberg, Heather Gibson, Shujun Liu, Laura Jaroncyk, William Carson, Samuel K. Kulp, Ching-Shih Chen, Henry K. Wong, Krista La Perle, Pierluigi Porcu, Ramiro Garzon, Guido Marcucci, and Michael A. Caligiuri. "A novel mouse model for cutaneous T-cell lymphoma reveals a role for IL-15 and activity of a new oral HDAC inhibitor." In Cancer Research. (April 2011). 2858-.

Ranganathan P, Stauffer N, Hamadani M, Heaphy CE, Santhanam R, Sandhu S, Constinean S, Nuovo J, Perrotti D, Croce CM, Hadley G, Marcucci G, Devine S, Garzon R. "Regulation of GVHD by microRNAs." In Haematologica. (June 2011). 0499-.

Walker,Alison,R; Metzeler,Klaus,H; Geyer,Susan; Becker,Heiko; Schwind,Sebastian; Whitman,Susan,P; Curfman,John; Wu,Yue-Zhong; Perrotti,Danilo; Klisovic,Rebecca,B; Garzon,Ramiro; Blum,William; Marcucci,Guido. "Impact of DNMT3A mutations on Clinical Response to the Hypomethylating Agent Decitabine in Older Patients (pts) with Acute-Myeloid Leukemia (AML)." In BLOOD. (November 2011). 430-430.

Huang,Xiaomeng; Schwind,Sebastian; Yu,Bo; Pang,Jiuxia; Santhanam,Ramasamy; Chan,Kenneth,K; Garzon,Ramiro; Blum,William; Bloomfield,Clara,D; Liu,Shujun; Perrotti,Danilo; Lee,Robert,J; Byrd,John,C; Muthusamy,Natarajan; Lee,L,James; Marcucci,Guido. "Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML)." In BLOOD. (November 2011). 39-39.

Aboomar,R; Saridakis,S; Santhanam,R; O'Rourke,J,R; Racke,F; Garzon,R; Olson,E,N; Croce,C,M; Costinean,S. "Decreased Hematopoiesis in miR29ab1 Deficient Mice." In MODERN PATHOLOGY. (February 2012). 320A-320A.

Huang X, Schwind S, Eisfeld AK, Yu B, Hickey CJ, Pang J, Santhanam R, Chan K, Perrotti D, Muthusamy N, Byrd JC, Blum W, Bloomfield CD, Liu S, Garzon R, Lee RJ, Lee LJ, Marcucci G.. "Synthetic microRNA (miR)-181a Nanoparticles (NP) Target RAS and Sensitize Cells to Daunorubicin (DNR) in Acute Myeloid Leukemia (AML)." In Cancer Research. (May 2012). 1111-.

Sebastian Schwind, William Blum, Shujun Liu, Somayeh Samadzadeh Tarighat, Susan Geyer, Rebecca Klisovic, Ann-Kathrin Eisfeld, Alison Walker, Susan Whitman, Santhanam Ramasamy, Yue-Zhong Wu, Samson Jacob, Michael Caligiuri, Michael Grever, Danilo Perrotti, John Byrd, Clara Bloomfield, Ramiro Garzon, and Guido Marcucci. "The combination of bortezomib (BOR) and decitabine (DEC): A phase I trial in patients (pts) with acute myeloid leukemia (AML) targeting FLT3 expression." In Cancer Research. (April 2012). CT-06.

Alice S. Mims, Alison R. Walker, Pia Hoellerbauer, Xiaomeng Huang, Kenneth K. Chan, Rebecca B. Klisovic, Danilo Perrotti, Michael A. Caligiuri, John C. Byrd, Ching-Shih Chen, William Blum, Ramiro Garzon, Sebastian Schwind, and Guido Marcucci. "AR42, a histone deacetylase inhibitor (HDACI), increases microRNA (miR)-29b and sensitizes cells to decitabine (DAC) treatment: A novel epigenetic-targeting approach in acute myeloid leukemia (AML)." In Cancer Research. (April 2012). 119-.

Ranganathan P, Yu X, Na C, Santhanam R, Shachman S, Kauffman M, Marcucci G, Garzon R.. "Pre-clinical activity of a novel CRM1 inhibitor in AML.." In Haematologica. (June 2012). 2057-.

 

Editorial Activities

2008 BMC cancer
2008 - 2012 MCB
2008 - 2012 Blood
2009 - present Journal of Nucleic Acid Investigation (JNAI)
2009 Journal of experimental and clinic research
2009 BMC genomics
2010 Seminars in Oncology
2010 Journal of Cellular and Molecular Medicine
2010 - 2011 Stem Cells and Development
2010 - 2011 Cancer Research
2010 - 2012 Leukemia Research
2010 - 2012 Leukemia
2010 - 2012 Clinical Cancer research
2010 - 2012 British journal of cancer
2010 - 2012 PLOS one
2010 - 2012 Molecular Cancer therapeutics
2010 - 2012 Heamatologica
2010 - 2012 Oncogene
2011 Cell death and differentiation
2011 British Journal of Hematology
2011 Leukemia and Lymphoma
2011 - 2012 EMBO
2012 - present PLOS ONE
2012 - present Datasets Papers in Imunology
 

Honors

2007 - 2008 Lauri Strauss Discovery award. Lauri Strauss Foundation.
2008 - 2009 Second highest patient satisfaction score in the OSU medical center (2008-2009). The Ohio State University.
2008 - 2010 Kimmel Translational Award. Kimmel Foundation for Cancer Research.
2009 - 2011 Leukemia SPORE Career Development award. NIH (NCI).
2010 - 2011 CAPS preceptorship recognition for dedicated service in the college of Medicine Educational Programs. College of Medicine.
2011 Molecular Biology and Cancer Genetics Program, Member. Molecular Biology and Cancer Genetics.
2011 Thompson Reuters KOL expert. Thompson Reuters.
 

Journal Articles

Robles A, Casas JP, Pereyra MA, Garzon R and Lopez AM. "Acute eosinophilic pneumonia. Case report and review of the literature.." Medicina. Vol. 60, no. 5. (January 2000.): 605-608.

Mirza I, Garzon R, Burns J, Edwards L, Fernandez-Cymering C, Kloss R.. "Myelodisplastic syndromes: A community hospital based study of prognostic factors and international scoring system.." Connecticut Medicine. Vol. 65, no. 8. (January 2001.): 455-463.

Garzon R. and Murphy JM. "Acute bulbar muscle dysfunction in hyperthyroidism.." Connecticut medicine. Vol. 66, no. 1. (January 2002.): 3-6.

Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu C-G, Kipps TJ, Negrini M, Croce CM.. "A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.." The New England journal of medicine. Vol. 353, no. 17. (January 2005.): 1793-1801.

Garzon R, Pichiorri F, Palumbo T, Iuliano R, Cimmino A, Aqeilan R, Volinia S, Bhatt D, Alder H, Marcucci G, Calin GA, Liu, C-G, Bloomfield CD, Andreeff M, Croce CM. "MicroRNA fingerprints during human megakaryocytopoiesis.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 13. (January 2006.): 5078-5083.

Garzon R, Fabbri, M., Cimmino A., Calin G.A., Croce, C.M. "MicroRNAs expression and function in cancer.." Trends in Molecular Medicine. Vol. 12, no. 12. (October 2006.): 580-587.

Calin GA, Garzon R, Cimmino A, Fabbri M and Croce CM.. "MicroRNAs and leukemias: how strong is the connection.." Leukemia Research. Vol. 30, no. 30. (January 2006.): 651-652.

Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto-Perez FJ, Davuluri R, Liu C-G, Croce CM, Negrini M, Calin GA, Ivan MA. "A microRNA signature of hypoxia.." Molecular and cellular biology. Vol. 27, no. 5. (January 2007.): 1859-1867.

Fabbri M*, Garzon R*, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, Calin GA, Huebner K, Croce CM.. "MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 40. (August 2007.): 15805-15810.

Garzon R, Pichiorri F, Palumbo T, Visentini M, Aqeilan R, Cimmino A, Wang H, Sun H, Volinia S, Alder H, Calin GA, Liu C-G, Andreeff M, Croce CM.. "MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia.." Oncogene. Vol. 26, no. 28. (January 2007.): 4148-57.

Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu C-G, Kipps TJ, Negrini M, Croce CM. "MiR-15a and miR-16-1 cluster functions in human leukemia.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 105, no. 13. (April 2008.): 5166-71.

Liu S, Liu Z, Xie Z, Pang J, Yu J, Lehmann E, Huynh L, Vukosavljevic T, Takeki M, Klisovic RB, Baiocchi RA, Blum W, Porcu P, Garzon R, Byrd JC, Perrotti D, Caligiuri MA, Chan KK, Wu L-C, Marcucci G.. "Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.." Blood. Vol. 111, no. 4. (February 2008.): 2364-73.

Hamadani M, Benson DM, Blum W, Garzon R, Devine SM. "Pulmonary Nocardia and Aspergillus co-infection in a patient with chronic graft-versus-host disease.." Transplant infectious disease. Vol. 10, no. 1. (January 2008.): 24-6.

Fabbri M, Garzon R, Andreeff M, Kantarjian H, Garcia-Manero G and Calin GA. "MicroRNAs and noncoding RNAs in hematological malignancies: molecular, clinical and therapeutic implications.." Leukemia. Vol. 22, no. 6. (March 2008.): 1095-1105.

Marcucci G, Radmacher MD, Maharry K, Mrozek K, Ruppert AS, Paschka P, Vukosavljevic T, Whitman, SP , Baldus CD, Langer C, Liu C-G, Carroll A J, Powell BL, Garzon R, Croce CM, Kolitz JE, Caligiuri MA, Larson RA, Bloomfield CD.. "MicroRNA expression in cytogenetically normal acute myeloid leukemia.." The New England journal of medicine. Vol. 358, no. 18. (May 2008.): 1919-28.

Garzon R and Croce CM. "MicroRNAs in normal and malignant hematopoiesis." Current opinions of Hematology. Vol. 15, no. 4. (January 2008.): 352-358.

Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC. "NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.." Cancer Cell. Vol. 14, no. 5. (October 2008.): 369-381.

Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B.. "Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 105, no. 10. (June 2008.): 3945-50.

Muller F and Garzon R. "Implications of MicroRNAs in normal hematopoiesis and human leukemias." Clinical leukemia. Vol. 2, no. 2. (May 2008.): 96-101.

Garzon R, Volinia S, Liu C-G, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM. "MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.." Blood. Vol. 111, no. 6. (May 2008.): 3183-9.

Havelange V, Heaphy CEA, Garzon R.. "MicroRNAs in the diagnosis, prognosis and treatment of cancer.." Oncology Reviews. Vol. 2, no. 2. (October 2008.): 201-211.

Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP, Munker R, Volinia S, Boccadoro M, Garzon R, Palumbo A, Aqeilan RI, Croce CM. "MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 105, no. 35. (June 2008.): 12885-90.

Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB.. "Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation." J Biol Chem. Vol. 23, no. 284. (June 2009.): 15676-15684.

Hamadani M, Blum W, Phillips G, Elder P, Andritsos L, Hofmeister C, O’Donnell L, Klisovic R, Penza S, Garzon R, Krugh D, Lin TS, Benson DM, Byrd JC, Marcucci G, and Devine SM.. "Improved non-relapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced intensity conditioning allogeneic transplantation for hematologic malignancies.." Biol Blood Marrow Transplant. Vol. 15, no. 11. (November 2009.): 1422-1430.

Hamadani M, Benson DM, Hofmesiter CC, Elder P, Blum W, Porcu PG, Garzon R, Blum KA, Lin TS, Marcucci G, Devine SM. "Allogeneic stem cell transplantation for patients with relapsed chemorefractory aggressive non-hodgkin lymphomas." Biol Blood Marrow Transplant. Vol. 15, no. 5. (May 2009.): 547-553.

Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CEA, Callegari E, Schwind S, Pang Ji, Yu J, Muthusamy N, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Byrd JC, Chan KK, Wu LC, Croce CM and Marcucci G.. "MicroRNA- 29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.." Blood. Vol. 25, no. 113. (June 2009.): 6411-6418.

Havelange V, Garzon R, and Croce CM.. "MicroRNAS: new players in acute myeloid leukemia." British Journal of Cancer. Vol. 101, no. 5. (July 2009.): 743-748.

Garzon R, Calin G and Croce C.. "MicroRNAs in Cancer." Annuals review of medicine. Vol. 60, no. 60. (January 2009.): 167-179.

Garzon R. "MicroRNA profiling of megakaryocytes." Methods Mol Biol. Vol. 496, (January 2009.): 293-298.

Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, and Croce CM. "MicroRNA 29b functions in acute myeloid leukemia." Blood. Vol. 114, (December 2009.): 5331-5341.

Havelange V and Garzon R. "MicroRNAs: Emerging Key Regulators of Hematopoiesis." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 85, no. 12. (December 2010.): 935-942.

Blum W, Klisovic R, Becker H, Rozewski D, Xiaoxia Y, Phelps M, Garzon R, Walker A, Chandler JC, Whitman SP, Curfman J, Liu S, Schaaf L, Mickle J, Kefauver C, Devine SM, Grever MR, Marcucci G, Byrd JC.. "Dose escalation of lenalidomide in relapsed or refractory acute leukemias." JCO. Vol. 28, no. 33. (November 2010.): 4919-4925.

Blum W, Garzon R, Klisovic RB, Schwind S, Walker A, Geyer S, Liu S, Havelange V, Becker H, Schaaf L, Mickle J, Devine H, Kefauver C, Devine SM, Chan KK, Heerema NA, Bloomfield,CD Grever MR, Byrd JC, Villalona-Calero M, Croce CM, and Marcucci G.. "Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine.." PNAS. Vol. 107, no. 16. (January 2010.): 7473-7478.

Schwind S, Maharry K, Radmacher M, Mrozek Krzysztof, Holland Kelsi, Whitman S, Hickey C, Becker H, Metzeler K, Pascka P, Baldus CD, Liu S, Garzon R,Powell BL, Kolitz JE, Carroll AJ, Caligiuri MA, Larson RA, Marcucci G, Bloomfield CD.. "Prognostic Significance of Expression of a Single microRNA, miR-181a, in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study.." JCO. Vol. 28, no. 36. (December 2010.): 5257-5264.

Garzon R, Marcucci G and Croce CM. "Targeting microRNAs in cancer: rationale, strategies and challenges." NATURE REVIEWS DRUG DISCOVERY. Vol. 9, no. 10. (October 2010.): 775-789.

Eiring AM¸ Neviani P, Garton C, Spizzo R, Liu S, Oaks JJ, Hickey C, Santhanam R, Harb JG, Chandler JD, Andino R, Cortes J, Hokland P, Huettner CS, Bhatia R, Roy DC, Caligiuri MA, Marcucci G, Garzon R, Croce CM, Calin GA, Perrotti D. "miR-328 functions as an RNA decoy to modulate hnRNP-E2 regulation of mRNA translation of leukemic blasts.." Cell. Vol. 140, no. 5. (March 2010.): 652-665.

Erter J, Alinari L, Darabi K, Gurcan M, Garzon R, Marcucci G, Bechtel MA, Wong H, Porcu P. "New Targets of Therapy in T-Cell Lymphomas." CURRENT DRUG TARGETS. Vol. 11, no. 4. (April 2010.): 482-493.

Chan KK, Liu Z, Xie Z, Chiu M, Wang H, Chen P, Dunkerson S, Chiu M, Liu S, Triantafillou G, Garzon R, Croce CM, Byrd JC, Muthusamy N, Marcucci G.. "A Novel Ultrasensitive Hybridization-Based ELISA Method for 2-Methoxyphosphorothiolate MicroRNAs and Its In vitro and In vivo Application.." AAPS J. Vol. 12, no. 4. (December 2010.): 556-568.

Volinia S, Galasso M, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Jarour RA, Desponts C, Teitell M , Baffa R, Aqeilan R, Nickoloff B, Taccioli C, Garzon R, Di Leva G, Fabbri M, Catozzi1M, Previati M, Ambs S, Palumbo T, Harris CC, Visone R, Pekarsky Y, Pichiorri F, Zanesi N, Calin G, Liu C-G, Palatini J, Negrini M, Vecchione A, Rosenberg A & Croce CM.. "Reprogramming of miRNA networks in cancer and leukemia.." Genome Research. Vol. 20, no. 5. (January 2010.): 589-599.

Liu S, Wu L-C, Pang J, Santhanam R, Schwind S, Wu Y-Z, Hickey C, Yu J, Becker H, Maharry K, Radmacher MD, Li C, Whitman SP, Eiring AM, Briesewitz R, Baiocchi RA, Chan KK, Paschka P, Caligiuri MA, Byrd JC, Croce CM, Bloomfield CD, Perrotti D, Garzon R and Marcucci GM. "Sp1/NF kappa B/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia." CANCER CELL. Vol. 17, no. 4. (April 2010.): 333-347.

Marcucci G, Mrozek K, Radmacher MD, Garzon R, Bloomfield CD. "The Prognostic and Functional Role of MicroRNAs in Acute Myeloid Leukemia." Blood. Vol. 117, no. 4. (November 2011.): 1121-1129.

Garzon R and Croce CM. "MIcroRNAs and Cancer." Seminars in Oncology. Vol. 38, no. 6. (December 2011.): 721-723.

Havelange V, Heaphy CE, Stauffer N, Volinia S, Andreeff M, Marcucci G, Croce CM and Garzon R. "Functional Implications of MicroRNAs in Acute Myeloid Leukemia by Integrating MicroRNA and Messenger RNA Expression Profiling." Cancer. Vol. 117, no. 20. (October 2011.): 4696-4706.

Sandhu S, Croce CM and Garzon R.. "MicroRNAs in Lymphomas." Advances in hematology. Vol. 2011, (March 2011.): 347137-.

Hamadani M, Craig M, Phillips GS, Abraham J, Tse W, Cumpston A; Gibson L, Remick SC, Bunner P, Leadmon S, Elder P, Hofmeister C, Penza S, Efebera Y, Andritsos L, Garzon R, Benson DM, Blum W, Devine SM. "Higher busulfan dose intensity does not improve outcomes of patients undergoing allogeneic haematopoietic cell transplantation following fludarabine, busulfan-based reduced toxicity conditioning." HEMATOLOGICAL ONCOLOGY. Vol. 29, no. 4. (December 2011.): 202-210.

Sandhu S and Garzon R. "Potential applications of micrornas in cancer diagnosis, prognosis and treatment." Seminars in Oncology. Vol. 38, no. 6. (December 2011.): 781-787.

Ranganathan P, Yu X, Na C, Santhanam R, Shacham S, Kauffman M, Walker A, Klisovic R, Blum W, Caligiuri M, Croce CM, Marcucci GM and Garzon R. "Pre-clinical Activity of a novel CRM1 inhibitor in Acute Myeloid Leukemia.." Blood. Vol. 120, (August 2012.): 1765-1773.

Metzeler KH, Walker A, Geyer S, Garzon R, Klisovic RB, Bloomfield CD, Blum W. and Marcucci G. "DNMT3A Mutations and Response to the Hypomethylating Agent Decitabine in Acute Myeloid Leukemia." Leukemia. Vol. 26, no. 5. (January 2012.): 1106-1107.

Ranganathan P, Heaphy CEA, Costinean S, Stauffer N, Na C, Hamadani M, Santhanam R, Mao C, Taylor PA, Sandhu S, He G, Shana'ah A, Nuovo GJ, Lagana A, Cascione L, Obad S, Broom O, Kauppinen S, Byrd JC, Caligiuri M, Perrotti D, Hadley GA, Marcucci G, Devine SM, Blazar BR, Croce CM, Garzon R. "Regulation of acute graft-versus-host disease by microRNA-155." BLOOD. Vol. 119, no. 20. (May 2012.): 4786-4797.

Yan P, Frankhouser D, Murphy M, Tam HH, Rodriguez B, Curfman J, Trimarchi M, Geyer S, Wu YZ, Whitman SP, Metzeler K, Walker A, Klisovic R, Jacob S, Grever MR, Byrd JC, Bloomfield CD, Garzon R, Blum W, Caligiuri MA, Bundschuh R, Marcucci G. "Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia.." Blood. Vol. 120, no. 12. (September 2012.): 2466-74.

Garzon R and Marcucci G.. "Potential of mIcroRNAs for cancer diagnosis, prognostication and therapy." Currents Opinion of Oncology. Vol. 24, no. 6. (November 2012.): 655-9.

Blum W, Schwind S, Tarighat SS, Geyer S, Eisfeld A-K, Whitman S, Walker A, Klisovic R, Byrd JC, Santhanam R, Wang H, Curfman JP, Devine SM, Jacob S, Garr C, Kefauver C, Perrotti D, Chan KK, Bloomfield CD, Caligiuri MA, Grever MR, Garzon R*, and Marcucci G*. "Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.." Blood. Vol. 119, no. 25. (May 2012.): 6025-31.

Wang H, Ming C, Xie Z, Chiu M, Liu Z, Chen P, Liu S, Byrd JC, Muthusamy N, Garzon R, Croce CM, Marcucci G, Chan KK. "Synthetic MicroRNA Cassette Dosing: Pharmacokinetics, Tissue Distribution and Bioactivity." MOLECULAR PHARMACEUTICS. Vol. 9, no. 6. (June 2012.): 1638-1644.

Mishra A, Liu S, Sams GH, Curphey D, Santhanam R, Rush LJ, Schaefer D, Falkenberg LG, Sullivan L, Jaroncyk L, Yang X, Fisk H, Wu L, Chandler JC, Wu YZ, Heerema NA, Chan KK, Perrotti D, Zhang J, Porcu P, Hickey C, Racke FK Garzon R, Lee R, Marcucci G, Caligiuri M.. "Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation." Cancer Cell. -.

Sukhinder K. Sandhu, Stefano Volinia , Stefan Costinean, Reid Neinast, Ramasamy, Santhanam, Mark Parthun, Ramiro Garzon *, Carlo M. Croce* (* equal senior contribution).. "By targeting HDAC4 and causing a loss of BCL6, miRNA-155 induces a block in B cell differentiation and acute leukemia." PNAS. -.

Hongyan Wang, Ping Chen,Jiang Wang,Ramasamy Santhanam, Josephine Aimiuwu, Vijaya Saradhi UV, Zhongfa Liu, Sebastian Schwind, Alice Mims, Rebecca Klisovic, Alison Walker, Michael R. Grever, Miguel A. Villalona-Calero, Clara D. Bloomfield, John C. Byrd, Ramiro Garzon, William Blum, Kenneth K. Chan, Guido Marcucci, MD. "In vivo Quantification of Active Decitabine-Triphosphate Metabolite: a Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia." AAPS. -.

Christopher Hickey, Hanna Radomska, Sebastian Schwind, Ramasay Santhanam, Anjali Mishra, Yue-Zhong Wu, Houda Alachkar, Kati Maharry, Krzysztof Mrózek, Alison Walker, Anna Eiring, Susan Whitman, Heiko Becker, Danilo Perrotti, Lai-Chu Wu, Xi Zhao, Todd A Fehniger, ravi vij, John C Byrd, William Blum, L James Lee, Michael A Caligiuri, Clara D Bloomfield, Ramiro Garzon, and Guido Marcucci. "Lenalidomide-mediated enhanced translation of the C/EBPα-p30 protein upregulates expression of miR-181a in acute myeloid leukemia." Blood. -.

 

Reference Works

March 2012 Mishra A, Liu S, Pang J, Yang X, Garzon R, Lee R, Marcucci G, and Caligiuri M.."Interleukin (IL)-15 and miR-29b leukemogenic interplay: a novel therapeutic target for large granular lymphocytic leukemia" Columbus.

Inventions and Patents

Carlo Croce and Ramiro Garzon. "Methods and Compositions for Modulating Acute Graft-versus-Host Disease using miR-155 Specific Inhibitors." OSU Medical Shool. Filed March 2012.

Carlo M Croce and Ramiro Garzon. "MicroRNAs associatted with cytogenetics and outcome in acute myeloid leukemia." OSU OSURF 08076. Filed January 2008.

 

Presentations

"Acquired Micrognatia associated with Sleep Obstructive Apnea." Presented at VI National Congress of Medicine, Rosario, AR|ARG. (October 1997)

"Myelodisplastics syndromes: A clinic-cytogenetic correlation." Presented at VII National Congress of Medicine, Buenos Aires, AR|ARG. (October 1998)

"Merkle Cell carcinoma as a second tumor in a patient with multiple myeloma." Presented at American Collegue of Physician Connecticut chapter meeting, Hartford, CT. (January 2001)

"MicroRNA signature associatted with survival and progression of CLL." Presented at 15th Beaumont Clinical Pathology meeting, Royal Oak, MI, US|USA. (February 2006)

"MicroRNA's Signatures associated with cytogenetics and prognosis in AML." Presented at American Society of Hematology annual meeting, Orlando, FL, US|USA. (December 2006)

"MIcroRNAs in AML." Presented at Leukemia retreat 2007, Houston, TX, US|USA. (October 2007)

"A Unique MicroRNA signature associated with Nucleophosmin Mutations in Normal Karyotyape Acute Myeloid Leukemia." Presented at ASCO annual meeting, Chicago, IL, US|USA. (June 2007)

"MicroRNAs in Megakarypoiesis." Presented at Platelet Physioloy and Signaling 2007, Gordon Research Conference, Ventura, CA, US|USA. (March 2007)

"MicroRNAS as predictors of leukemia relapse after transplant." Presented at OSU BMT research meeting, Columbus, OH, US|USA. (March 2007)

"MiRNA-29b Targets MCL-1 and is down-regulated in chemotherapy-resistant Acute Myeloid Leukemia (AML)." Presented at American Society of Hematology Annual meeting, Atlanta, GA, US|USA. (December 2007)

"MicroRNA (miRNA)-29 b Targets DNMT3a and b and induces re-expression of the hypermethylated ESR1 and p15 genes in acute myeloid leukemia (AML)." Presented at American Society of Hematology annual meeting, Atlanta, GA, US|USA. (December 2007)

"Ultraconserved genomic regions in normal hematopoiesis." Presented at American Society of Hematology Annual meeting, San Francisco, US|USA. (December 2008)

"MIcroRNAs in AML." Presented at Seminars in apoptosis, Houston, TX, US|USA. (March 2008)

"MicoRNA Therapeutics." Presented at OSU Phase I/II experimental therapeutics meeting, Columbus, OH, US|USA. (May 2009)

"MICRORNA 29B FUNCTIONS IN ACUTE MYELOID LEUKEMIA." Presented at European Hematology Association in Berlin, Germany 2009., Berlin, DE|DEU. (May 2009)

"MicoRNA Therapeutics." Presented at Massachusetts Institute of technology (MIT) The Barn, Boston, MA, US|USA. (October 2009)

"MIcroRNAs networks in AML." Presented at Seminars in Hematology, Philadelphia, PA, US|USA. (May 2010)

"miRNA-155 targets oncogenes HDAC4 and Bcl6 in a murine B-cell leukemia model.." Presented at European Hematology Association annual meeting, Barcelona, ES|ESP. (June 2010)

"MIcroRNAs networks in AML." Presented at Molecular Biology Seminar, Madrid, ES|ESP. (June 2010)

"Regulation of acute graft versus host disease by microRNA-155." Presented at ASH annual meeting in Orlando, FLA 2010, FLA, US|USA. (December 2010)

"MIcroRNAs in AML." Presented at Eagle Think Tank Meeting at the Annual American Society of Hematology, Orlando, FL, US|USA. (December 2010)

"MicrorNA networks in leukemia." Presented at European hematological association annual meeting 2010, Barcelona, ES|ESP. (June 2010)

"Regulation of GVHD by miR-155." Presented at NCI Translation meeting, Washington, DC, US|USA. (July 2011)

"Targeting microRNAs in AML." Presented at Trasnlational symposium at Alliance Meeting, Chicago, IL, US|USA. (November 2011)

"miR-155 role in AML and aGVHD." Presented at Santaris Pharma, Copenhagen, DK|DNK. (November 2011)

"Regulation of GVHD by micrornas." Presented at European Hematology Association Annual meeting, London, GB|GBR. (June 2011)

"Regulation of GVHD by microRNAs." Presented at CALGB Correlative science spring meeting, Chicago, IL, US|USA. (March 2011)

"Regulation of GVHD by microRNAs." Presented at Midwest Blood group annual meeting, Cinncinatti, OH, US|USA. (April 2011)

"MicroRNAs in T cell development." Presented at Research Meeting at the Ministry of Science and Innovation, Tenerife, ES|ESP. (October 2011)

"MicroRNAS: from the bench to the clinic." Presented at Lowe mini symposium in cancer research, Marburg, DE|DEU. (January 2012)

"Pre-clinical activity of a novel CRM1 inhibitor in AML." Presented at European Hematology Association Annual meeting, Amsterdan, NL|NLD. (June 2012)

"MiRNAS in AML." Presented at Seminars in Hematology, Brussels, BE|BEL. (May 2012)

"MicroRNAs: from the bench to the clinic." Presented at 2nd International Conference" Tanslational Reserach in Oncology: a new approach to Personalized Medicine", Forli, IT|ITA. (May 2012)

 

Professional Activities

2008 - present Consultancy. Reckner mednet.
2009 - present CTSA reviewer. OSU CTSA Pilot Award program. Columbus, OH.
2011 - present ACS OSU Institutional seed grants. American Cancer Society. Columbus, OH.
2011 - present Dr. Yvonne Efebera. OSU-Division of Hematology. Columbus, OH.
2012 - present Grant Reviewer. Association for Internatioal Cancer Research.
2012 - present Grant Reviewer. Cancer Research UK.
2009 Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Austria, Vienna. Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Austria, Vienna.
2009 Proposal reviewer. Hong Kong Research Grants Council.
2010 NHLSRT Development Grant. Medical Research Council of South Africa.
2010 Israeli Science Foundation Grant reviewer. Israeli Science Foundation.
2010 Scientific advisory board. Martell Foundation. Boston, MA.
2011 Grant Reviewer. Italian Association for Cancer Research.
2011 Cariplo Foundation.
2010 - 2012 Proposal review. Bernische Krebsliga.
2010 - 2012 Grant review. Fondazione Cariplo.
2010 - 2012 Dutch Cancer Society. Dutch Cancer Society.
2011 - 2012 Department of Defense (DOD) Discovery awards Blood cancer study section. Department of Defense.
2012 Grant Reviewer. Medical Research Council.
2012 Grant Reviewer. Eropean Research Council.