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333 W Tenth Avenue
Columbus, OH 43210

Phone: (614) 292-1597

Email: sadee.1@osu.edu

 

Current OSU Appointments

Chair, SBS-Pharmacology

Professor, COPH -Environmental Health Sci

Professor, Pharm CBO/Coll

Professor, Internal Medicine

Professor, Psychiatry

 

Biographical

Dr. Sadée is Felts Mercer Professor of Medicine and Pharmacology, Chair, Department of Pharmacology, and Director, Program in Pharmacogenomics, College of Medicine, The Ohio State University, Columbus OH. At OSU, he holds adjunct appointments in Pharmacy, Psychiatry, Medical Genetics, and is member of the Comprehensive Cancer Center and the Heart & Lung Research Institute. He studied Pharmacy and received his doctorate in Pharmaceutical Chemistry at the FU Berlin in 1968. After two post-doctoral positions at UCSF and the FU Berlin, he joined USC in Los Angeles as Assistant Professor of Pharmacy and Medicine from 81-83, and subsequently, moved to UCSF, serving as Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California San Francisco until 2002. Dr. Sadée’s research focuses the genetic basis of variable drug response in CNS and cardiovascular diseases, including addiction, and in cancer chemotherapy. He also pursues drug discovery in the treatment of addiction. Dr. Sadée has published over 300 research papers and monographs. He has received the first AAPS Research Achievement Award in Biotechnology, the Paul Dawson Award in Biotechnology from AACP, and the 2001 Distinguished Pharmaceutical Scientist Award from AAPS. He has served as founding editor of Pharmaceutical Research and the open access, on-line AAPS Journal. He teaches pharmacogenomics, pharmacology, and history of health sciences

Books

W. Sadée and G.C.M. Beelen. Drug Level Monitoring. Analytical Techniques, Metabolism, and Pharmacokinetics. New York: John Wiley and Sons, Inc, January 1980.

W. Sadée and G.C.M. Beelen. Drug Level Monitoring: Japanese Translation. Tokyo: Hirokawa Publ. Co, January 1982.

E.T. Lin and W. Sadée. Drug Level Monitoring, Volume II. Analytical Techniques, Metabolism, and Pharmacokinetics.. New York: John Wiley and Sons, January 1986.

G.L. Amidon and W. Sadée. Membrane Transporters as Drug Targets. New York: Plenum Publ. Corp, January 1999.

R.S. Rapaka and W. Sadée. Drug Addiction. From Basic Research to Therapy. New York: Springer and AAPS Press, January 2008.

 

Editorial Activities

1984 - 1994 Pharmceutical Research
1995 - 2005 Pharmaceutical Research
1999 - present European Journal of Pharmaceutical Sciences
1999 - 2004 The AAPS Journal
2000 - 2005 American Journal of PharmacoGenomics
2004 - present Expert Opinion in Pharmacotherapy
2004 - present Current Cancer Therapy Reviews
2005 - present Pharmaceutical Research
2005 - present Molecular Diagnosis and Therapy
2006 - present Turkish Journal of Pharmaceutical Sciences
2007 - present Journal of Epithelial Biology & Pharmacology
2008 - present Open Neuropsychopharmacology Journal
2008 - present Personalized Medicine
 

Honors

1981 Fellow. Humboldt Foundation, Germany.
1991 Research Achievement Award in Biochemistry.
1994 Distinguished Service Award, American Association of Pharmaceutical Scientists.
1994 Certificate of Appreciation as Founding Editor, Pharmaceutical Research, American Association of Pharmaceutical Scientists. as Founding Editor, Pharmaceutical Research.
1996 Paul Dawson Award in Biotechnology, American Association of Colleges of Pharmacy.
1999 Phoenix Wissenschaftspreis.
2001 Distinguished Pharmaceutical Scientist Award, American Association of Pharmaceutical Scientists.
2001 Distinguished Lectureship, The Nagai Foundation Tokyo. The Nagai Foundation Tokyo.
2001 Avis Distinguished Visiting Professor, University of Tennessee.
2002 Distinguished Lecturer, Frontiers in Chemistry, Case Western Reserve University. Frontiers in Chemistry.
2002 Honorary Lecturer, 22nd Annual Graduate Student Symposium in the Pharmacological Sciences and Bio-related Chemistry. University of Michigan. 22nd Annual Graduate Student Symposium in the Pharmacological Sciences and Bio-related Chemistry.
2002 Opening Plenary Speaker, First AAPS National Biotechnology Conference, San Diego. First AAPS National Biotechnology Conference, San Diego.
2003 AAAS Fellow.
2003 47th Annual Julius A. Koch Lecture, University of Pittsburgh. 2003 47th Annual Julius A. Koch Lecture.
2004 Presidential Citation. American Association of Pharmaceutical Scientists.
2005 Service Award.
2005 Plenary Lecturer, 34th Ann. Meeting, New England Pharmacologists.
2007 Keynote Speaker “Celebrating Research Achievements�.
 

Journal Articles

Beyer, K, H; Sadee, W. "[Titration of benzodiazepine derivatives in water-free medium. 3. On the chemistry and analysis of benzodiazepine derivatives]." Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. Vol. 300, no. 8. (January 1967.): 667-73.

Beyer, K, H; Sadee, W. "[Synthesis and analysis of possible nitrazepam-metabolites. 4. Chemistry and analysis of benzodiazepin-derivatives]." Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. Vol. 302, no. 2. (January 1969.): 152-7.

Beyer, K, H; Sadee, W. "[Spectrophotometric determination of 5-phenyl-1,4-benzodiazepine-derivatives and studies on metabolism of nitrazepam. 5. Chemistry and analytics of benzodiazepine-derivatives]." Arzneimittel-Forschung. Vol. 19, no. 12. (January 1969.): 1929-31.

Sadee, W. "[NMR-spectroscopic studies on ring inversion of 1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-on-derivatives]." Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. Vol. 302, no. 10. (January 1969.): 769-74.

Schroder, R; Schuren, K, P; Biamino, G; Meyer, V; Sadee, W. "[Positive-inotropic heart effect of aldadiene-potassium (Aldactone pro injections)]." Klinische Wochenschrift. Vol. 49, no. 19. (January 1971.): 1093-6.

Schroder, R; Schuren, K, P; Biamino, G; Dennert, J; Meyer, V; Sadee, W. "[Effect of aldactone on the dynamics and contractility of the heart]." Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung. Vol. 37, (January 1971.): 438-45.

Sadee, W; Van der Kleijn, E. "Thermolysis of 1,4-benzodiazepines during gas chromatography and mass spectroscopy.." Journal of pharmaceutical sciences. Vol. 60, no. 1. (January 1971.): 135-7.

Sadee, W; Riegelman, S; Johnson, L F. "On the mechanism of steroid fluorescence in sulfuric acid. I. The formation of trienones.." Steroids. Vol. 17, no. 5. (January 1971.): 595-606.

Sadee, W; Garland, W; Castagnoli, N Jr. "Microsomal 3-hydroxylation of 1,4-benzodiazepines.." Journal of medicinal chemistry. Vol. 14, no. 17. (January 1971.): 643-5.

Castagnoli, N Jr; Sadee, W. "Mechanism of the reaction of a 1,4-benzodiazepine N-oxide with acetic anhydride.." Journal of medicinal chemistry. Vol. 15, no. 10. (January 1972.): 1076-8.

Sadee, W; Riegelman, S; Jones, S C. "Plasma levels of spirolactones in the dog.." Journal of pharmaceutical sciences. Vol. 61, no. 7. (January 1972.): 1129-32.

Sadee, W; Riegelman, S; Jones, S C. "Disposition of tritium-labeled spirolactones in the dog.." Journal of pharmaceutical sciences. Vol. 61, no. 7. (January 1972.): 1132-5.

Sadee, W; Dagcioglu, M; Riegelman, S. "Fluorometric microassay for spironolactone and its metabolites in biological fluids.." Journal of pharmaceutical sciences. Vol. 61, no. 7. (January 1972.): 1126-9.

Schmiedek, P; Sadee, W; Baethmann, A. "Cerebral uptake of a 3 H-labelled spirolactone compound in the dog.." European journal of pharmacology. Vol. 21, no. 2. (January 1973.): 238-41.

Sadee, W; Schwandt, H, J; Beyer, K H. "[On the conformation of unsymmetrically substituted 1,4-benzodiazepin-2-ones (author's transl)]." Archiv der Pharmazie. Vol. 306, no. 10. (January 1973.): 751-6.

Sadee, W; Dagcioglu, M; Schroder, R. "Pharmacokinetics of spironolactone, canrenone and canrenoate-K in humans.." The Journal of pharmacology and experimental therapeutics. Vol. 185, no. 3. (January 1973.): 686-95.

Sadee, W; Schroder, R; von Leitner, E; Dagcioglu, M. "Multiple dose kinetics of spironolactone and canrenoate-potassium in cardiac and hepatic failure.." European journal of clinical pharmacology. Vol. 7, no. 3. (January 1974.): 195-200.

Sadee, W; Abshagen, U; Finn, C; Rietbrock, N. "Conversion of spironolactone to canrenone and disposition kinetics of spironolactone and canrenoate-potassium in rats.." Naunyn-Schmiedebergs archives of pharmacology. Vol. 283, no. 3. (January 1974.): 303-18.

Finj, C; Sadee, W. "Determination of 5-fluorouracil (NSC-19893) plasma levels in rats and man by isotope dilution-mass fragmentography.." Cancer chemotherapy reports. Part 1. Vol. 59, no. 2 Pt 1. (January 1975.): 279-86.

Sadee, W; Staroscik, J; Finn, C; Cohen, J. "Determination of (plus or minus)-1, 2-bis(3, 5-dioxopiperazinyl) propane plasma levels in rats, rabbits, and humans by GLC and mass fragmentography.." Journal of pharmaceutical sciences. Vol. 64, no. 6. (January 1975.): 998-1001.

Sadee, W; Finn, A, M; Schmiedek, P; Baethmann, A. "Aldosterone plasma radioimmunoassay interference by a spirolactone metabolite.." Steroids. Vol. 25, no. 3. (January 1975.): 301-11.

Schwandt, H, J; Sadee, W; Beyer, K, H; Hilderbrandt, A G. "Effects of enzyme induction and inhibition on microsomal oxidation of 1,4-benzodiazepines.." Naunyn-Schmiedebergs archives of pharmacology. Vol. 294, no. 1. (January 1976.): 91-7.

Wu, A, T; Schwandt, H, J; Finn, C; Sadee, W. "Determination of ftorafur and 5-fluorouracil levels in plasma and urine.." Research communications in chemical pathology and pharmacology. Vol. 14, no. 1. (January 1976.): 89-102.

Finn, A, M; Finn, C; Sadee, W. "Chemical structure and aldosterone receptor affinity of canrenoate-potassium metabolites in rabbits.." Research communications in chemical pathology and pharmacology. Vol. 15, no. 4. (January 1976.): 613-25.

Cheng, S, C; Suzuki, K; Sadee, W; Harding, B W. "Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.." Endocrinology. Vol. 99, no. 4. (January 1976.): 1097-106.

Shukur, L, R; Powers, J, L; Marques, R, A; Winter, M, E; Sadee, W. "Measurement of procainamide and N-acetylprocainamide in serum by high-performance liquid chromatography.." Clinical chemistry. Vol. 23, no. 4. (January 1977.): 636-8.

Sadee, W; Wong, C G. "Pharmacokinetics of 5-fluorouracil: inter-relationship with biochemical kinetics in monitoring therapy.." Clinical pharmacokinetics. Vol. 2, no. 6. (January 1977.): 437-50.

Chan, K, K; Staroscik, J, A; Sadee, W. "Synthesis of 5-azacytidine-6-13C and -6-14C.." Journal of medicinal chemistry. Vol. 20, no. 4. (January 1977.): 598-600.

Finn, A, M; Brown, R; Sadee, W. "Tissue distribution of 3H-canrenoate potassium in rabbits.." Journal of pharmaceutical sciences. Vol. 66, no. 2. (January 1977.): 275-7.

Wu, A, T; Au, J, L; Sadee, W. "Hydroxylated metabolies of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) in rats and rabbits.." Cancer research. Vol. 38, no. 1. (January 1978.): 210-4.

Friedman, M, A; Sadee, W. "The fluoropyrimidines: biochemical mechanisms and design of clinical trials.." Cancer chemotherapy and pharmacology. Vol. 1, no. 2. (January 1978.): 77-82.

Marques, R, A; Stafford, B; Flynn, N; Sadee, W. "Determination of metronidazole and misonidazole and their metabolites in plasma and urine by high-performance liquid chromatography.." Journal of chromatography. Vol. 146, no. 1. (January 1978.): 163-6.

Powers, J, L; Sadee, W. "Determination of quinidine by high-performance liquid chromatography.." Clinical chemistry. Vol. 24, no. 2. (January 1978.): 299-302.

Phillips, T, L; Wasserman, T, H; Wasserman, T, H; Gomer, C, J; Lawrence, G, A; Levine, M, L; Sadee, W; Penta, J, S; Rubin, D J. "The hypoxic cell sensitizer programme in the United States.." The British journal of cancer. Supplement. Vol. 3, (January 1978.): 276-80.

Mullis, K, B; Perry, D, C; Finn, A, M; Stafford, B; Sadee, W. "Morphine persistence in rat brain and serum after single doses.." The Journal of pharmacology and experimental therapeutics. Vol. 208, no. 2. (January 1979.): 228-31.

Chan, K, K; Giannini, D, D; Staroscik, J, A; Sadee, W. "5-Azacytidine hydrolysis kinetics measured by high-pressure liquid chromatography and 13C-NMR spectroscopy.." Journal of pharmaceutical sciences. Vol. 68, no. 7. (January 1979.): 807-12.

Au, J, L; Wu, A, T; Friedman, M, A; Sadee, W. "Pharmacokinetics and metabolism of ftorafur in man.." Cancer treatment reports. Vol. 63, no. 3. (January 1979.): 343-50.

Au, J, L; Sadee, W. "5-Fluorouracil concentrations in human plasma following R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration.." Cancer research. Vol. 39, no. 10. (January 1979.): 4289-90.

Silber, B; Sheiner, L, B; Powers, J, L; Winter, M, E; Sadee, W. "Spironolactone-associated digoxin radioimmunoassay interference.." Clinical chemistry. Vol. 25, no. 1. (January 1979.): 48-50.

Wasserman, T, H; Phillips, T, L; Johnson, R, J; Gomer, C, J; Lawrence, G, A; Sadee, W; Marques, R, A; Levin, V, A; VanRaalte, G. "Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer.." International journal of radiation oncology, biology, physics. Vol. 5, no. 6. (January 1979.): 775-86.

Finn, C; Schwandt, H, J; Sadee, W. "Determination of uracil and thymine and their nucleosides and nucleotides in picomole amounts by gas chromatography mass spectrometry selected ion monitoring.." Biomedical mass spectrometry. Vol. 6, no. 5. (January 1979.): 194-9.

Maybaum, J; Ullman, B; Mandel, H, G; Day, J, L; Sadee, W. "Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.." Cancer research. Vol. 40, no. 11. (January 1980.): 4209-15.

Maybaum, J; Klein, F, K; Sadee, W. "Determination of pyrimidine ribotide and deoxyribotide pools in cultured cells and mouse liver by high-performance liquid chromatography.." Journal of chromatography. Vol. 188, no. 1. (January 1980.): 149-58.

Au, J, L; Sadee, W. "Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone.." Cancer research. Vol. 40, no. 8 Pt 1. (January 1980.): 2814-9.

Sadee, W. "Antineoplastic agents: high-dose methotrexate and citrovorum factor rescue.." Therapeutic drug monitoring. Vol. 2, no. 2. (January 1980.): 177-85.

Perry, D, C; Mullis, K, B; Oie, S; Sadee, W. "Opiate antagonist receptor binding in vivo: evidence for a new receptor binding model.." Brain research. Vol. 199, no. 1. (January 1980.): 49-61.

Cohen, M, B; Maybaum, J; Sadee, W. "Analysis of purine ribonucleotides and deoxyribonucleotides in cell extracts by high-performance liquid chromatography.." Journal of chromatography. Vol. 198, no. 4. (January 1980.): 435-41.

Canfell, C; Sadee, W. "Methotrexate and 7-hydroxymethotrexate: serum level monitoring by high-performance liquid chromatography.." Cancer treatment reports. Vol. 64, no. 1. (January 1980.): 165-9.

Au, J, L; Sadee, W. "The pharmacology of ftorafur (R, S-1-(tetrahydro-2-furanyl)-5-fluorouracil.." Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. Vol. 76, (January 1981.): 100-14.

Au, J, L; Sadee, W. "Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil).." Cancer chemotherapy and pharmacology. Vol. 7, no. 1. (January 1981.): 55-9.

Maybaum, J; Cohen, M, B; Sadee, W. "In vivo rates of pyrimidine nucleotide metabolism in intact mouse T-lymphoma (s-49) cells treated with 5-fluorouracil.." The Journal of biological chemistry. Vol. 256, no. 5. (January 1981.): 2126-30.

Day, J, L; Maybaum, J; Sadee, W. "Determination of 5-fluoro-2'-deoxyuridine[6-3H] as an impurity in 5-fluoro-uracil[6-3H] by high-performance liquid chromatography.." Journal of chromatography. Vol. 206, no. 2. (January 1981.): 407-9.

Cohen, M, B; Maybaum, J; Sadee, W. "Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells.." The Journal of biological chemistry. Vol. 256, no. 16. (January 1981.): 8713-7.

El Sayed, Y, M; Sadee, W. "Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway.." Biochemical pharmacology. Vol. 31, no. 18. (January 1982.): 3006-8.

Rosenbaum, J, S; Sadee, W. "Demonstration of opiate receptor sub-types in vivo.." Life sciences. Vol. 31, no. 12-13. (January 1982.): 1299-301.

Rosenbaum, J, S; Kurowski, M; Aman, R, A; Sadee, W. "Partial loss of opiate receptor regulation by GPP(NH)P evident in vitro.." Life sciences. Vol. 31, no. 16-17. (January 1982.): 1667-70.

Kurowski, M; Rosenbaum, J, S; Perry, D, C; Sadee, W. "[3H]-etorphine and [3H]-diprenorphine receptor binding in vitro and in vivo: differential effect of Na+ and guanylyl imidodiphosphate.." Brain research. Vol. 249, no. 2. (January 1982.): 345-52.

Pfeiffer, A; Sadee, W; Herz, A. "Differential regulation of the mu-, delta-, and kappa-opiate receptor subtypes by guanyl nucleotides and metal ions.." The Journal of neuroscience : the official journal of the Society for Neuroscience. Vol. 2, no. 7. (January 1982.): 912-7.

Perry, D, C; Rosenbaum, J, S; Sadee, W. "In vivo binding of 3H-etorphine in morphine-dependent rats.." Life sciences. Vol. 31, no. 12-13. (January 1982.): 1405-8.

Perry, D, C; Rosenbaum, J, S; Kurowski, M; Sadee, W. "[3H]Etorphine receptor binding in vivo. Small fractional occupancy elicits analgesia.." Molecular pharmacology. Vol. 21, no. 2. (January 1982.): 272-9.

Sadee, W; Rosenbaum, J, S; Herz, A. "Buprenorphine: differential interaction with opiate receptor subtypes in vivo.." The Journal of pharmacology and experimental therapeutics. Vol. 223, no. 1. (January 1982.): 157-62.

Sadee, W; Pfeiffer, A; Herz, A. "Opiate receptor: multiple effects of metal ions.." Journal of neurochemistry. Vol. 39, no. 3. (January 1982.): 659-67.

Sadee, W; Perry, D, C; Rosenbaum, J, S; Herz, A. "[3H]diprenorphine receptor binding in vivo and in vitro.." European journal of pharmacology. Vol. 81, no. 3. (January 1982.): 431-40.

El Sayed, Y, M; Sadee, W. "Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes.." Cancer research. Vol. 43, no. 9. (January 1983.): 4039-44.

Cohen, M, B; Sadee, W. "Contributions of the depletions of guanine and adenine nucleotides to the toxicity of purine starvation in the mouse T lymphoma cell line.." Cancer research. Vol. 43, no. 4. (January 1983.): 1587-91.

Nguyen, B, T; Cohen, M, B; Sadee, W. "Guanine ribonucleotide depletion in mammalian cells. A target of purine antimetabolites.." Cancer chemotherapy and pharmacology. Vol. 11, no. 2. (January 1983.): 117-9.

Grevel, J; Sadee, W. "An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans.." Science. Vol. 221, no. 4616. (January 1983.): 1198-201.

Sadee, W; Richards, M, L; Grevel, J; Rosenbaum, J S. "In vivo characterization of four types of opioid binding sites in rat brain.." Life sciences. Vol. 33 Suppl 1, (January 1983.): 187-9.

Rosenbaum, J, S; Sadee, W. "Opiate receptor binding affected by guanine nucleotide. Partial loss of sensitivity to guanosine-5'-(beta,gamma-imido)triphosphate evident in vitro.." The Journal of biological chemistry. Vol. 258, no. 3. (January 1983.): 1419-22.

Yu, V, C; Jacobson, A, E; Rice, K, C; Sadee, W. "Stereospecificity of 4,5-epoxymorphinan binding to the lambda site in rat brain.." European journal of pharmacology. Vol. 101, no. 1-2. (January 1984.): 161-2.

Rosenbaum, J, S; Holford, N, H; Sadee, W. "Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy.." Brain research. Vol. 291, no. 2. (January 1984.): 317-24.

Rosenbaum, J, S; Holford, N, H; Richards, M, L; Aman, R, A; Sadee, W. "Discrimination of three types of opioid binding sites in rat brain in vivo.." Molecular pharmacology. Vol. 25, no. 2. (January 1984.): 242-8.

Nguyen, B, T; El Sayed, Y, M; Sadee, W. "Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells.." Cancer research. Vol. 44, no. 6. (January 1984.): 2272-7.

Sadee, W; Nguyen, B T. "Biological consequences of guanine starvation.." Basic life sciences. Vol. 31, (January 1985.): 233-40.

Rosenbaum, J, S; Holford, N, H; Sadee, W. "In vivo receptor binding of opioid drugs at the mu site.." The Journal of pharmacology and experimental therapeutics. Vol. 233, no. 3. (January 1985.): 735-40.

Richards, M, L; Sadee, W. "In vivo opiate receptor binding of oripavines to mu, delta and kappa sites in rat brain as determined by an ex vivo labeling method.." European journal of pharmacology. Vol. 114, no. 3. (January 1985.): 343-53.

Richards, M, L; Sadee, W. "In vivo binding of benzomorphans to mu, delta and kappa opioid receptors: comparison with urine output in the rat.." The Journal of pharmacology and experimental therapeutics. Vol. 233, no. 2. (January 1985.): 425-32.

Lee, H, J; Pawlak, K; Nguyen, B, T; Robins, R, K; Sadee, W. "Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture.." Cancer research. Vol. 45, no. 11 Pt 1. (January 1985.): 5512-20.

Grevel, J; Yu, V; Sadee, W. "Characterization of a labile naloxone binding site (lambda site) in rat brain.." Journal of neurochemistry. Vol. 44, no. 5. (January 1985.): 1647-56.

Hochhaus, G; Yu, V, C; Sadee, W. "Delta opioid receptors in human neuroblastoma cell lines.." Brain research. Vol. 382, no. 2. (January 1986.): 327-31.

Hochhaus, G; Gibson, B, W; Sadee, W. "Development of a biotin-avidin probe for detecting opioid receptors.." NIDA research monograph. Vol. 75, (January 1986.): 33-6.

Perry, D, C; Sadee, W. "Autoradiography of lambda binding sites in rat brain.." European journal of pharmacology. Vol. 129, no. 1-2. (January 1986.): 147-58.

Pawlak, K; Lawi-Berger, C; Sadee, W. "Incorporation of nucleotide tracers into nucleic acids in permeabilized cells and cellular homogenates.." The Biochemical journal. Vol. 238, no. 1. (January 1986.): 13-21.

Nguyen, B, T; Sadee, W. "Compartmentation of guanine nucleotide precursors for DNA synthesis.." The Biochemical journal. Vol. 234, no. 2. (January 1986.): 263-9.

Day, J, L; Sadee, W. "Determination of 5-fluorouridine diphosphate glucose as a metabolite of 5-fluorouracil in mouse T-lymphoma (S-49) cells using high-performance liquid chromatography.." Journal of chromatography. Vol. 356, no. 3. (January 1986.): 445-9.

Yu, V, C; Sadee, W. "Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors.." Neuroscience letters. Vol. 71, no. 2. (January 1986.): 219-23.

Yu, V, C; Richards, M, L; Sadee, W. "A human neuroblastoma cell line expresses mu and delta opioid receptor sites.." The Journal of biological chemistry. Vol. 261, no. 3. (January 1986.): 1065-70.

Richards, M, L; Sadee, W. "In vivo binding of putative delta-selective opioid antagonists to central opiate receptors.." European journal of pharmacology. Vol. 126, no. 3. (January 1986.): 313-6.

Richards, M, L; Sadee, W. "Human neuroblastoma cell lines as models of catechol uptake.." Brain research. Vol. 384, no. 1. (January 1986.): 132-7.

Klinz, F, J; Yu, V, C; Sadee, W; Costa, T. "Differential expression of alpha-subunits of G-proteins in human neuroblastoma-derived cell clones.." FEBS letters. Vol. 224, no. 1. (January 1987.): 43-8.

Duan, D, S; Sadee, W. "Distinct effects of adenine and guanine starvation on DNA synthesis associated with different pool sizes of nucleotide precursors.." Cancer research. Vol. 47, no. 15. (January 1987.): 4047-51.

Sadee, W; Yu, V, C; Richards, M, L; Preis, P, N; Schwab, M, R; Brodsky, F, M; Biedler, J L. "Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line.." Cancer research. Vol. 47, no. 19. (January 1987.): 5207-12.

Levi, V; Scott, J, C; White, P, F; Sadee, W. "Improved radioreceptor assay of opiate narcotics in human serum: application to fentanyl and morphine metabolism.." Pharmaceutical research. Vol. 4, no. 1. (January 1987.): 46-9.

Hochhaus, G; Sadee, W. "A biotin-avidin-based enzyme immunoassay for beta h-endorphin.." Pharmaceutical research. Vol. 5, no. 4. (January 1988.): 232-5.

Hochhaus, G; Patthy, A; Schwietert, R; Santi, D, V; Sadee, W. "[Biocytin13]dynorphin A 1-13 amide: a potential probe for the kappa-opioid receptor.." Pharmaceutical research. Vol. 5, no. 12. (January 1988.): 790-4.

Hochhaus, G; Gibson, B, W; Sadee, W. "Biotinylated human beta-endorphins as probes for the opioid receptor.." The Journal of biological chemistry. Vol. 263, no. 1. (January 1988.): 92-7.

Cheng, H, W; Armstrong, R, D; Sadee, W. "Modulation of 6-thioguanine activity by guanine in human promyelocytic leukemia HL-60 cells.." Cancer research. Vol. 48, no. 13. (January 1988.): 3648-51.

Sadee, W. "Genes and the pharmaceutical sciences.." Pharmaceutical research. Vol. 5, no. 4. (January 1988.): 199-200.

Preis, P, N; Saya, H; Nadasdi, L; Hochhaus, G; Levin, V; Sadee, W. "Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A.." Cancer research. Vol. 48, no. 22. (January 1988.): 6530-4.

Yu, V, C; Sadee, W. "Efficacy and tolerance of narcotic analgesics at the mu opioid receptor in differentiated human neuroblastoma cells.." The Journal of pharmacology and experimental therapeutics. Vol. 245, no. 1. (January 1988.): 350-5.

Yu, V, C; Hochhaus, G; Chang, F, H; Richards, M, L; Bourne, H, R; Sadee, W. "Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid.." Journal of neurochemistry. Vol. 51, no. 6. (January 1988.): 1892-9.

Sadee, W; Yu, V, C; Hochhaus, G. "Effects of opioid peptides on human neuroblastoma cells.." NIDA research monograph. Vol. 87, (January 1988.): 111-7.

Duan, D, S; Sadee, W. "Guanine for DNA synthesis. A compulsory route through ribonucleotide reductase.." The Biochemical journal. Vol. 255, no. 3. (January 1988.): 1045-8.

Waschek, J, A; Muller, J, M; Duan, D, S; Sadee, W. "Retinoic acid enhances VIP receptor expression and responsiveness in human neuroblastoma cell, SH-SY5Y.." FEBS letters. Vol. 250, no. 2. (January 1989.): 611-4.

Muller, J, M; Lolait, S, J; Yu, V, C; Sadee, W; Waschek, J A. "Functional vasoactive intestinal polypeptide (VIP) receptors in human neuroblastoma subclones that contain VIP precursor mRNA and release VIP-like substances.." The Journal of biological chemistry. Vol. 264, no. 7. (January 1989.): 3647-50.

Farsam, H; Eiger, S; Lameh, J; Rezvani, A; Gibson, B, W; Sadee, W. "Morphine impurity with opioid activity is identified as 10 alpha-hydroxymorphine.." Pharmaceutical research. Vol. 7, no. 11. (January 1990.): 1205-7.

Maeda, S; Lameh, J; Mallet, W, G; Philip, M; Ramachandran, J; Sadee, W. "Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop.." FEBS letters. Vol. 269, no. 2. (January 1990.): 386-8.

Lameh, J; Cone, R, I; Maeda, S; Philip, M; Corbani, M; Nadasdi, L; Ramachandran, J; Smith, G, M; Sadee, W. "Structure and function of G protein coupled receptors.." Pharmaceutical research. Vol. 7, no. 12. (January 1990.): 1213-21.

Yu, V, C; Eiger, S; Duan, D, S; Lameh, J; Sadee, W. "Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.." Journal of neurochemistry. Vol. 55, no. 4. (January 1990.): 1390-6.

Sadee, W. "Publish or perish, and the Journal glut.." Pharmaceutical research. Vol. 7, no. 4. (January 1990.): 433-4.

Duan, D, S; Nagashima, T; Hoshino, T; Waldman, F; Pawlak, K; Sadee, W. "Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.." The Biochemical journal. Vol. 268, no. 3. (January 1990.): 725-31.

Duan, D, S; Farmer, D; Rayner, A, A; Sadee, W. "Cytotoxicity of lymphokine-activated killer cells against human neuroblastoma cells: modulation by neuroblast differentiation.." Medical and pediatric oncology. Vol. 18, no. 4. (January 1990.): 339-44.

Cone, R, I; Lameh, J; Sadee, W. "Rapid agonist-induced loss of 125I-beta-endorphin opioid receptor sites in NG108-15, but not SK-N-SH neuroblastoma cells.." Life sciences. Vol. 49, no. 19. (January 1991.): PL147-52.

Oh, Doo-Man; Amidon, Gordon L.; Sadee, Wolfgang. "Endogenous peptide transporter and exogenous proton-peptide cotransporter expressed in Xenopus oocytes." Pharmaceutical Research (New York). Vol. 9, no. 10 SUPPL.. (January 1992.): S82-.

Duan, D, S; Smith, W; Sadee, W; Cowan, M J. "Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.." Thymus. Vol. 19, no. 1. (January 1992.): 1-11.

Drubbisch, Volkmar; Lameh, Jelveh; Philip, Mohan; Sharma, Yogesh K.; Sadee, Wolfgang. "Mapping the ligand binding pocket of the human muscarinic cholinergic receptor Hm1: Contribution of tyrosine-82." Pharmaceutical Research (New York). Vol. 9, no. 12. (January 1992.): 1644-1647.

Drubbisch, V; Lameh, J; Philip, M; Sharma, Y, K; Sadee, W. "Mapping the ligand binding pocket of the human muscarinic cholinergic receptor Hm1: contribution of tyrosine-82.." Pharmaceutical research. Vol. 9, no. 12. (January 1992.): 1644-7.

Lameh, J; Philip, M; Sharma, Y, K; Moro, O; Ramachandran, J; Sadee, W. "Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop.." The Journal of biological chemistry. Vol. 267, no. 19. (January 1992.): 13406-12.

Lameh, J; Eiger, S; Sadee, W. "Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells.." European journal of pharmacology. Vol. 227, no. 1. (January 1992.): 19-24.

Cone, R, I; Rosenfeld, S; Lameh, J; Sadee, W. "125I-beta-endorphin binding to neuroblastoma X glioma NG108-15 cells: distribution of delta opioid receptors.." Life sciences. Vol. 51, no. 22. (January 1992.): PL219-24.

Moro, Osamu; Lameh, Jelveh; Sadee, Wolfgang. "Molecular domain of the Hm1 muscarinic cholinergic receptor involved in agonist induced internalization." Pharmaceutical Research (New York). Vol. 9, no. 10 SUPPL.. (January 1992.): S83-.

Cook, J, S; Wolsing, D, H; Lameh, J; Olson, C, A; Correa, P, E; Sadee, W; Blumenthal, E, M; Rosenbaum, J S. "Characterization of the RDC1 gene which encodes the canine homolog of a proposed human VIP receptor. Expression does not correlate with an increase in VIP binding sites.." FEBS letters. Vol. 300, no. 2. (January 1992.): 149-52.

Cone, Ric I.; Rosenfeld, Stuart; Lameh, Jelveh; Sadee, Wolfgang. "Iodine-125 beta-endorphin binding to neuroblastoma C glioma Ng108-15 cells: Distribution of delta opioid receptors." Life Sciences. Vol. 51, no. 22. (January 1992.): PL-219.

Arden, J. R.; Nagata, O.; Shockley, M. S.; Philip, M.; Lameh, J.; Sadee, Wolfgang. "Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the Hm1 muscarinic receptor." Biochemical and Biophysical Research Communications. Vol. 188, no. 3. (January 1992.): 1111-1115.

Arden, J, R; Nagata, O; Shockley, M, S; Philip, M; Lameh, J; Sadee, W. "Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor.." Biochemical and biophysical research communications. Vol. 188, no. 3. (January 1992.): 1111-5.

Wang, Zaijie; Sadee, Wolfgang. "Constitutively activated mu opioid receptors: A novel drug target for treatment of narcotic addiction." Pharmaceutical Research (New York). Vol. 10, no. 10 SUPPL.. (January 1993.): A122-.

Sadee, Wolfgang. "Aaps (american Association of Pharmaceutical Scientists) Eighth Annual Meeting and Exposition, Orlando, Florida, Usa, November 14-18, 1993." Pharmaceutical Research (New York). Vol. 10, no. 10 SUPPL.. (January 1993.): S3-S420.

Moro, Osamu; Lameh, Jelveh; Sadee, Wolfgang. "Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors." Journal of Biological Chemistry. Vol. 268, no. 10. (January 1993.): 6862-6865.

Moro, Osamu; Lameh, Jelveh; Hogger, Petra; Sadee, Wolfgang. "Hydrophobic amino acid in the i2 loop plays a key role in receptor-g protein coupling." Journal of Biological Chemistry. Vol. 268, no. 30. (January 1993.): 22273-22276.

Moro, O; Lameh, J; Sadee, W. "Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.." The Journal of biological chemistry. Vol. 268, no. 10. (January 1993.): 6862-5.

Moro, O; Lameh, J; Hogger, P; Sadee, W. "Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.." The Journal of biological chemistry. Vol. 268, no. 30. (January 1993.): 22273-6.

Kameyama, Kimihiko; Haga, Kazuko; Haga, Tatsuya; Moro, Osamu; Sadee, Wolfgang. "Activation of a Gtp-binding protein and a Gtp-binding-protein-coupled receptor kinase (beta-adrenergic-receptor kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites." European Journal of Biochemistry. Vol. 226, no. 2. (January 1994.): 267-276.

Kameyama, K; Haga, K; Haga, T; Moro, O; Sadee, W. "Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase (beta-adrenergic-receptor kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites.." European journal of biochemistry / FEBS. Vol. 226, no. 2. (January 1994.): 267-76.

Graul, Richard C.; Babbitt, Patricia C.; Sadee, Wolfgang. "Evolution of G protein coupled receptors from ancient gene fragments." Pharmaceutical Research (New York). Vol. 11, no. 10 SUPPL.. (January 1994.): S77-.

Wang, Zaijie; Segredo, Veronica; Sadee, Wolfgang. "Constitutive mu opioid receptor activation as a regulatory mechanism in narcotic tolerance and dependence." FASEB Journal. Vol. 8, no. 4-5. (January 1994.): A379-.

Wang, Zaijie; Segredo, Veronica; Arden, Jim R.; Sadee, Wolfgang. "Molecular basis of a novel pharmacodynamic model for narcotic dependence and tolerance." Pharmaceutical Research (New York). Vol. 11, no. 10 SUPPL.. (January 1994.): S333-.

Wang, Zaijie; Bilsky, Edward J.; Porreca, Fran; Sadee, Wolfgang. "Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence." Life Sciences. Vol. 54, no. 20. (January 1994.): PL339-PL350.

Wang, Zaijie; Arden, James R.; Segredo, Veronica; Sadee, Wolfgang. "Agonist induced constitutive activation of the mu opioid receptor by phosphorylation." Regulatory Peptides. Vol. 54, no. 1. (January 1994.): 323-324.

Wang, Z; Bilsky, E, J; Porreca, F; Sadee, W. "Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence.." Life sciences. Vol. 54, no. 20. (January 1994.): PL339-50.

Sadee, Wolfgang. "Ninth Annual Meeting of the American Association of Pharmaceutical Scientists, San Diego, California, Usa, November 6-10, 1994." Pharmaceutical Research (New York). Vol. 11, no. 10 SUPPL.. (January 1994.): S3-S451.

Moro, Osamu; Shockley, Melinda S.; Lameh, Jelveh; Sadee, Wolfgang. "Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration." Journal of Biological Chemistry. Vol. 269, no. 9. (January 1994.): 6651-6655.

Moro, O; Shockley, M, S; Lameh, J; Sadee, W. "Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration.." The Journal of biological chemistry. Vol. 269, no. 9. (January 1994.): 6651-5.

Arden, James R.; Segredo, Veronica; Wang, Zaijie; Lameh, Jelveh; Sadee, Wolfgang. "Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in Hek 293 cells." Journal of Neurochemistry. Vol. 65, no. 4. (January 1995.): 1636-1645.

Arden, J, R; Segredo, V; Wang, Z; Lameh, J; Sadee, W. "Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells.." Journal of neurochemistry. Vol. 65, no. 4. (January 1995.): 1636-45.

Sadee, Wolfgang; Drubbisch, Volkmar; Amidon, Gordon L.. "Biology of membrane transport proteins." Pharmaceutical Research (New York). Vol. 12, no. 12. (January 1995.): 1823-1837.

Sadee, W; Wang, Z. "Agonist induced constitutive receptor activation as a novel regulatory mechanism. Mu receptor regulation.." Advances in experimental medicine and biology. Vol. 373, (January 1995.): 85-90.

Sadee, W; Drubbisch, V; Amidon, G L. "Biology of membrane transport proteins.." Pharmaceutical research. Vol. 12, no. 12. (January 1995.): 1823-37.

Sadee, W. "Quo vadis, pharmaceutical sciences, and AAPS?." Pharmaceutical research. Vol. 12, no. 10. (January 1995.): 1393-4.

Oh, Doo-Man; Amidon, Gordon L.; Sadee, Wolfgang. "Functional expressions of endogenous dipeptide transporter and exogenous proton/peptide cotransporter in Xenopus oocytes." Archives of Pharmacal Research (Seoul). Vol. 18, no. 1. (January 1995.): 12-17.

Hogger, Petra; Shockley, Melinda S.; Lameh, Jelveh; Sadee, Wolfgang. "Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors." Journal of Biological Chemistry. Vol. 270, no. 13. (January 1995.): 7405-7410.

Hogger, P; Shockley, M, S; Lameh, J; Sadee, W. "Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors.." The Journal of biological chemistry. Vol. 270, no. 13. (January 1995.): 7405-10.

Segredo, Veronica; Arden, James; Lameh, Jelveh; Sadee, Wolfgang. "Role of the C-terminal tail in the agonist induced regulation of the mu opioid receptors." FASEB Journal. Vol. 9, no. 3. (January 1995.): A96-.

Wang, Zaijie; Arden, James; Sadee, Wolfgang. "Basal phosphorylation of mu opioid receptor is agonist modulated and Ca-2+-dependent." FEBS Letters. Vol. 387, no. 1. (January 1996.): 53-57.

Wang, Z; Arden, J; Sadee, W. "Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent.." FEBS letters. Vol. 387, no. 1. (January 1996.): 53-7.

Segredo, Veronica; Burford, Neil T.; Lameh, Jelveh; Sadee, Wolfgang. "A constitutively recycling mutant of the mu opioid receptor." Society for Neuroscience Abstracts. Vol. 22, no. 1-3. (January 1996.): 822-.

Quillan, J. Mark; Sadee, Wolfgang. "Structure-based search for peptide ligands that cross-react with melanocortin receptors." Pharmaceutical Research (New York). Vol. 113, no. 11. (January 1996.): 1624-1630.

Quillan, J, M; Sadee, W. "Structure-based search for peptide ligands that cross-react with melanocortin receptors.." Pharmaceutical research. Vol. 13, no. 11. (January 1996.): 1624-30.

Sadee, Wolfgang. "Structure-function of G protein coupled receptors. Novel concepts in drug design." Pharmaceutical Research (New York). Vol. 13, no. 9 SUPPL.. (January 1996.): S551-.

Lin, Kedan; Lameh, Jelveh; Sadee, Wolfgang. "Overexpression of beta-adrenergic receptor kinase attenuates muscarinic M1 coupling in Hek 293 cells." Molecular Biology of the Cell. Vol. 7, no. SUPPL.. (January 1996.): 360A-.

Covitz, Kuang-Ming Y.; Walter, Elke; Amidon, Gordon L.; Sadee, Wolfgang. "Development and characterization of a cell line stably transfected with the human dipeptide transporter hpept1." Pharmaceutical Research (New York). Vol. 13, no. 9 SUPPL.. (January 1996.): S244-.

Covitz, Kuang-Ming Y.; Amidon, Gordon L.; Sadee, Wolgang. "Human dipeptide transporter, hpept1, stably transfected into Chinese hamster ovary cells." Pharmaceutical Research (New York). Vol. 113, no. 11. (January 1996.): 1631-1634.

Covitz, K, M; Amidon, G, L; Sadee, W. "Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.." Pharmaceutical research. Vol. 13, no. 11. (January 1996.): 1631-4.

Bilsky, Edward J.; Inturrisi, Charles E.; Sadee, Wolfgang; Hruby, Victor J.; Porreca, Frank. "Competitive and non-competitive Nmda antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice." Pain. Vol. 68, no. 2-3. (January 1996.): 229-237.

Bilsky, Edward J.; Bernstein, Robert N.; Wang, Zaijie; Sadee, Wolfgang; Porreca, Frank. "Effects of naloxone and D-phe-cys-tyr-d-trp-arg-thr-pen-thr-nh-2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice." Journal of Pharmacology and Experimental Therapeutics. Vol. 277, no. 1. (January 1996.): 484-490.

Bilsky, E, J; Inturrisi, C, E; Sadee, W; Hruby, V, J; Porreca, F. "Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.." Pain. Vol. 68, no. 2-3. (January 1996.): 229-37.

Bilsky, E, J; Bernstein, R, N; Wang, Z; Sadee, W; Porreca, F. "Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.." The Journal of pharmacology and experimental therapeutics. Vol. 277, no. 1. (January 1996.): 484-90.

Lin, Kedan; Lameh, Jelveh; Sadee, Wolfgang. "Overexpression of beta-adrenergic receptor kinase attenuates muscarinic m1 receptor coupling in Hek 293 cells." Life Sciences. Vol. 60, no. 13-14. (January 1997.): 1185-.

Surendran, Narayanan; Bigge, Christopher F.; Williamson, Rufus M.; Covitz, Kuang-Ming Y.; Sadee, Wolfgang; Stewart, Barbra H.. "Evidence for overlapping substrate specificity between large neutral amino acid transporter (lnaa) and dipeptide transporter (hpept1) for an Nmda antagonist." Pharmaceutical Research (New York). Vol. 14, no. 11 SUPPL.. (January 1997.): S30-.

Graul, Richard C.; Sadee, Wolfgang. "Sequence alignments of the H+-dependent oligopeptide transporter family Ptr: Inferences on structure and function of the intestinal Pet1 transporter." Pharmaceutical Research (New York). Vol. 14, no. 4. (January 1997.): 388-400.

Graul, Richard C.; Sadee, Wolfgang. "Evolutionary relationships among proteins probed by an iterative neighborhood cluster analysis (inca): Alignment of bacteriorhodopsins with the yeast sequence Yro2." Pharmaceutical Research (New York). Vol. 14, no. 11. (January 1997.): 1533-1541.

Graul, R, C; Sadee, W. "Sequence alignments of the H(+)-dependent oligopeptide transporter family PTR: inferences on structure and function of the intestinal PET1 transporter.." Pharmaceutical research. Vol. 14, no. 4. (January 1997.): 388-400.

Graul, R, C; Sadee, W. "Evolutionary relationships among proteins probed by an iterative neighborhood cluster analysis (INCA). Alignment of bacteriorhodopsins with the yeast sequence YRO2.." Pharmaceutical research. Vol. 14, no. 11. (January 1997.): 1533-41.

Shockley, Melinda S.; Burford, Neil T.; Sadee, Wolfgang; Lameh, Jelveh. "Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor." Journal of Neurochemistry. Vol. 68, no. 2. (January 1997.): 601-609.

Shockley, M, S; Burford, N, T; Sadee, W; Lameh, J. "Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.." Journal of neurochemistry. Vol. 68, no. 2. (January 1997.): 601-9.

Segredo, Veronica; Burford, Neil T.; Lameh, Jelveh; Sadee, Wolfgang. "A constitutively internalizing and recycling mutant of the mu-opioid receptor." Journal of Neurochemistry. Vol. 68, no. 6. (January 1997.): 2395-2404.

Segredo, V; Burford, N, T; Lameh, J; Sadee, W. "A constitutively internalizing and recycling mutant of the mu-opioid receptor.." Journal of neurochemistry. Vol. 68, no. 6. (January 1997.): 2395-404.

Quillan, J. Mark; Sadee, Wolfgang. "Dynorphin peptides: Antagonists of melanocortin receptors." Pharmaceutical Research (New York). Vol. 14, no. 6. (January 1997.): 713-719.

Quillan, J, M; Sadee, W. "Dynorphin peptides: antagonists of melanocortin receptors.." Pharmaceutical research. Vol. 14, no. 6. (January 1997.): 713-9.

Han, H; de Vrueh, R, L; Rhie, J, K; Covitz, K, M; Smith, P, L; Lee, C, P; Oh, D, M; Sadee, W; Amidon, G L. "5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.." Pharmaceutical research. Vol. 15, no. 8. (January 1998.): 1154-9.

Covitz, Kuang-Ming Y.; Amidon, Gordon L.; Sadee, Wolfgang. "Membrane topology of the human dipeptide transporter, hpept1, determined by epitope insertions." Biochemistry. Vol. 37, no. 43. (January 1998.): 15214-15221.

Covitz, K, M; Amidon, G, L; Sadee, W. "Membrane topology of the human dipeptide transporter, hPEPT1, determined by epitope insertions.." Biochemistry. Vol. 37, no. 43. (January 1998.): 15214-21.

Schmidt, Maria Christiane; Rothen-Rutishauser, Barbara; Rist, Beate; Beck-Sickinger, Annette; Wunderli-Allenspach, Heidi; Rubas, Werner; Sadee, Wolfgang; Merkle, Hans Peter. "Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane." Biochemistry. Vol. 37, no. 47. (January 1998.): 16582-16590.

Schmidt, M, C; Rothen-Rutishauser, B; Rist, B; Beck-Sickinger, A; Wunderli-Allenspach, H; Rubas, W; Sadee, W; Merkle, H P. "Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane.." Biochemistry. Vol. 37, no. 47. (January 1998.): 16582-90.

Tsuga, Hirofumi; Kameyama, Kimihiko; Haga, Tatsuya; Honma, Takeshi; Lameh, Jelveh; Sadee, Wolfgang. "Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2." Journal of Biological Chemistry. Vol. 273, no. 9. (January 1998.): 5323-5330.

Tsuga, H; Kameyama, K; Haga, T; Honma, T; Lameh, J; Sadee, W. "Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2.." The Journal of biological chemistry. Vol. 273, no. 9. (January 1998.): 5323-30.

Sadee, Wolfgang. "Genomics and drugs: Finding the optimal drug for the right patient." Pharmaceutical Research (New York). Vol. 15, no. 7. (January 1998.): 959-963.

Sadee, W. "Genomics and drugs: finding the optimal drug for the right patient.." Pharmaceutical research. Vol. 15, no. 7. (January 1998.): 959-63.

Quillan, J. Mark; Sadee, Wolfgang; Wei, Edward T.; Jimenez, Charles; Ji, Li; Chang, J.-K.. "A synthetic human Agouti-related protein-(83-132)-nh2 fragment is a potent inhibitor of melanocortin receptor function." FEBS Letters. Vol. 428, no. 1-2. (January 1998.): 59-62.

Quillan, J, M; Sadee, W; Wei, E, T; Jimenez, C; Ji, L; Chang, J K. "A synthetic human Agouti-related protein-(83-132)-NH2 fragment is a potent inhibitor of melanocortin receptor function.." FEBS letters. Vol. 428, no. 1-2. (January 1998.): 59-62.

Burford, Neil T.; Tolbert, Lara M.; Sadee, Wolfgang. "Specific G protein activation and mu-opioid receptor internalization caused by morphine, Damgo and endomorphin I." European Journal of Pharmacology. Vol. 342, no. 1. (January 1998.): 123-126.

Burford, N, T; Tolbert, L, M; Sadee, W. "Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I.." European journal of pharmacology. Vol. 342, no. 1. (January 1998.): 123-6.

Okamoto, Curtis T.; Mahlin, E. Denny; Basu, Sujit K.; Kuang-Ming; Covitz, Y.; Sadee, Wolfgang; Lee, Vincent H. L.. "Localization of Pept1 to lysosomes." FASEB Journal. Vol. 12, no. 4. (January 1998.): A442-.

Lu, Yi-Feng; Xu, Heng; Liu-Chen, Lee-Yuan; Chen, Chongguang; Partilla, John S.; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Sadee, Wolfgang; Rothman, Richard B.. "Opioid peptide receptor studies: 7. The methylfentanyl congener Rti-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor." Synapse (New York). Vol. 28, no. 2. (January 1998.): 117-124.

Lu, Y, F; Xu, H; Liu-Chen, L, Y; Chen, C; Partilla, J, S; Brine, G, A; Carroll, F, I; Rice, K, C; Lai, J; Porreca, F; Sadee, W; Rothman, R B. "Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.." Synapse. Vol. 28, no. 2. (January 1998.): 117-24.

Gonzalez, Deborah E.; Covitz, Kuang-Ming Y.; Sadee, Wolfgang; Mrsny, Randall J.. "An oligopeptide transporter is exposed at high levels in the pancreatic carcinoma cell lines Aspc-1 and Capan-2." Cancer Research. Vol. 58, no. 3. (January 1998.): 519-525.

Gonzalez, D, E; Covitz, K, M; Sadee, W; Mrsny, R J. "An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2.." Cancer research. Vol. 58, no. 3. (January 1998.): 519-25.

Lin, Kedan; Sadee, Wolfgang; Quillan, J. Mark. "Rapid measurements of intracellular calcium using a fluorescence plate reader." Biotechniques. Vol. 26, no. 2. (January 1999.): 318-326.

Lin, K; Sadee, W; Quillan, J M. "Rapid measurements of intracellular calcium using a fluorescence plate reader.." BioTechniques. Vol. 26, no. 2. (January 1999.): 318-22, 324.

Wang, Zaijie; Bilsky, Edward J.; Wang, Danxin; Porreca, Frank; Sadee, Wolfgang. "3-isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice." European Journal of Pharmacology. Vol. 371, no. 1. (January 1999.): 1-9.

Wang, Z; Bilsky, E, J; Wang, D; Porreca, F; Sadee, W. "3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice.." European journal of pharmacology. Vol. 371, no. 1. (January 1999.): 1-9.

Surendran, Narayanan; Covitz, Kuang-Ming Y.; Han, Hyo-kyung; Sadee, Wolfgang; Oh, Doo-Man; Amidon, Gordon L.; Williamson, Rufus M.; Bigge, Christopher F.; Stewart, Barbra H.. "Evidence for overlapping substrate specificity between large neutral amino acid (lnaa) and dipeptide (hpept1) transporters for Pd 158473, an Nmda antagonist." Pharmaceutical Research (New York). Vol. 16, no. 3. (January 1999.): 391-395.

Surendran, N; Covitz, K, M; Han, H; Sadee, W; Oh, D, M; Amidon, G, L; Williamson, R, M; Bigge, C, F; Stewart, B H. "Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist.." Pharmaceutical research. Vol. 16, no. 3. (January 1999.): 391-5.

Pang, D, C; Amidon, G, L; Preusch, P, C; Sadee, W. "Second AAPS-NIH frontier symposium 1999: membrane transporters and drug therapy. American Association of Pharmaceutical Scientists.." AAPS pharmSci [electronic resource]. Vol. 1, no. 2. (January 1999.): E7-.

Shockley, Melinda S.; Tolbert, Lara M.; Tobin, Andrew B.; Nahorski, Stefan R.; Sadee, Wolfgang; Lameh, Jelveh. "Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain." European Journal of Pharmacology. Vol. 377, no. 1. (January 1999.): 137-146.

Shockley, M, S; Tolbert, L, M; Tobin, A, B; Nahorski, S, R; Sadee, W; Lameh, J. "Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain.." European journal of pharmacology. Vol. 377, no. 1. (January 1999.): 137-46.

Serkova, Natalie; Litt, Lawrence; James, Thomas L.; Sadee, Wolfgang; Leibfritz, Dieter; Benet, Leslie Z.; Christians, Uwe. "Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear Nmr spectroscopy." Journal of Pharmacology and Experimental Therapeutics. Vol. 289, no. 2. (January 1999.): 800-806.

Serkova, N; Litt, L; James, T, L; Sadee, W; Leibfritz, D; Benet, L, Z; Christians, U. "Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.." The Journal of pharmacology and experimental therapeutics. Vol. 289, no. 2. (January 1999.): 800-6.

Ito, Kazumitsu; Haga, Tatsuya; Lameh, Jelveh; Sadee, Wolfgang. "Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5." European Journal of Biochemistry. Vol. 260, no. 1. (January 1999.): 112-119.

Ito, K; Haga, T; Lameh, J; Sadee, W. "Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5.." European journal of biochemistry / FEBS. Vol. 260, no. 1. (January 1999.): 112-9.

Wang, Danxin; Sadee, Wolfgang; Quillan, J. Mark. "Calmodulin binding to G protein-coupling domain of opioid receptors." Journal of Biological Chemistry. Vol. 274, no. 31. (January 1999.): 22081-22088.

Wang, D; Sadee, W; Quillan, J M. "Calmodulin binding to G protein-coupling domain of opioid receptors.." The Journal of biological chemistry. Vol. 274, no. 31. (January 1999.): 22081-8.

Sadee, W; Graul, R, C; Lee, A Y. "Classification of membrane transporters.." Pharmaceutical biotechnology. Vol. 12, (January 1999.): 29-58.

Felder, C, B; Graul, R, C; Lee, A, Y; Merkle, H, P; Sadee, W. "The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors.." AAPS pharmSci [electronic resource]. Vol. 1, no. 2. (January 1999.): E2-.

Wang, D; Tolbert, L, M; Carlson, K, W; Sadee, W. "Nuclear Ca2+/calmodulin translocation activated by mu-opioid (OP3) receptor.." Journal of neurochemistry. Vol. 74, no. 4. (January 2000.): 1418-25.

Wang, D; Surratt, C, K; Sadee, W. "Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell.." Journal of neurochemistry. Vol. 75, no. 2. (January 2000.): 763-71.

Choi, Doo-Sup; Wang, Danxin; Tolbert, Lara; Sadee, Wolfgang. "Basal signaling activity of human dopamine D2l receptor demonstrated with an ecdysone-inducible mammalian expression system." Journal of Neuroscience Methods. Vol. 94, no. 2. (January 2000.): 217-225.

Choi, D, S; Wang, D; Tolbert, L; Sadee, W. "Basal signaling activity of human dopamine D2L receptor demonstrated with an ecdysone-inducible mammalian expression system.." Journal of neuroscience methods. Vol. 94, no. 2. (January 2000.): 217-25.

Mancinelli, L; Cronin, M; Sadee, W. "Pharmacogenomics: the promise of personalized medicine.." AAPS pharmSci [electronic resource]. Vol. 2, no. 1. (January 2000.): E4-.

Kassack, M, U; Hogger, P; Gschwend, D, A; Kameyama, K; Haga, T; Graul, R, C; Sadee, W. "Molecular modeling of G-protein coupled receptor kinase 2: docking and biochemical evaluation of inhibitors.." AAPS pharmSci [electronic resource]. Vol. 2, no. 1. (January 2000.): E2-.

Yan, Q; Sadee, W. "Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics.." AAPS pharmSci [electronic resource]. Vol. 2, no. 3. (January 2000.): E20-.

Burford, Neil T.; Wang, Danxin; Sadee, Wolfgang. "G-protein coupling of mu-opioid receptors (op3): Elevated basal signalling activity." Biochemical Journal. Vol. 348, no. 3. (January 2000.): 531-537.

Wang, Zaijie; Sadee, Wolfgang. "Tolerance to morphine at the mu-opioid receptor differentially induced by camp-dependent protein kinase activation and morphine." European Journal of Pharmacology. Vol. 389, no. 2-3. (January 2000.): 165-171.

Wang, Z; Sadee, W. "Tolerance to morphine at the mu-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine.." European journal of pharmacology. Vol. 389, no. 2-3. (January 2000.): 165-71.

Wang, Z; Sadee, W. "Dissociation of morphine-induced cyclic AMP-upregulation and mu-opioid receptor desensitization.." Proceedings of the Western Pharmacology Society. Vol. 43, (January 2000.): 9-10.

Wang, Danxin; Tolbert, Lara M.; Carlson, Kurt W.; Sadee, Wolfgang. "Nuclear Ca2+/calmodulin translocation activated by mu-opioid (op3) receptor." Journal of Neurochemistry. Vol. 74, no. 4. (January 2000.): 1418-1425.

Wang, Danxin; Surratt, Christopher K.; Sadee, Wolfgang. "Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (op3) in morphine-pretreated cells." Journal of Neurochemistry. Vol. 75, no. 2. (January 2000.): 763-771.

Botka, C, W; Wittig, T, W; Graul, R, C; Nielsen, C, U; Higaka, K; Amidon, G, L; Sadee, W. "Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics.." AAPS pharmSci [electronic resource]. Vol. 2, no. 2. (January 2000.): E16-.

Phillips, K, A; Veenstra, D, L; Sadee, W. "Implications of the genetics revolution for health services research: pharmacogenomics and improvements in drug therapy.." Health services research. Vol. 35, no. 5 Pt 3. (January 2000.): 128-40.

Wang, Danxin; Raehal, Kirsten M.; Bilsky, Edward J.; Sadee, Wolfgang. "Inverse agonists and neutral antagonists at mu opioid receptor (mor): Possible role of basal receptor signaling in narcotic dependence." Journal of Neurochemistry. Vol. 77, no. 6. (January 2001.): 1590-1600.

Wang, D; Raehal, K, M; Bilsky, E, J; Sadee, W. "Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.." Journal of neurochemistry. Vol. 77, no. 6. (January 2001.): 1590-600.

Belcheva, M, M; Szucs, M; Wang, D; Sadee, W; Coscia, C J. "mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation.." The Journal of biological chemistry. Vol. 276, no. 36. (January 2001.): 33847-53.

Wang, Danxin; Quillan, J. Mark; Winans, Katharine; Lucas, Julie L.; Sadee, Wolfgang. "Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding." Journal of Biological Chemistry. Vol. 276, no. 37. (January 2001.): 34624-34630.

Wang, D; Quillan, J, M; Winans, K; Lucas, J, L; Sadee, W. "Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding.." The Journal of biological chemistry. Vol. 276, no. 37. (January 2001.): 34624-30.

Graul, R, C; Sadee, W. "Evolutionary relationships among G protein-coupled receptors using a clustered database approach.." AAPS pharmSci [electronic resource]. Vol. 3, no. 2. (January 2001.): E12-.

Belcheva, Mariana M.; Szucs, Maria; Wang, Danxin; Sadee, Wolfgang; Coscia, Carmine J.. "mu-opioid receptor-mediated Erk activation involves calmodulin-dependent epidermal growth factor receptor transactivation." Journal of Biological Chemistry. Vol. 276, no. 36. (January 2001.): 33847-33853.

Urtti, A; Johns, S, J; Sadee, W. "Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant.." AAPS pharmSci [electronic resource]. Vol. 3, no. 1. (January 2001.): E6-.

Raehal, Kirsten M.; Bilsky, Edward J.; Wang, Danxin; Sadee, Wolfgang. "6beta-naltrexol, a nonpeptidic neutral opioid antagonist, precipitates less severe withdrawal than the inverse agonists naloxone and naltrexone: Implications for treating opioid dependence." FASEB Journal. Vol. 15, no. 4. (January 2001.): A513-.

Wei, Edward T.; Quillan, J. Mark; Sadee, Wolfgang; Vlasov, Guennady P.. "Melanocortin receptor antagonists and modulations of melanocortin receptor activity." Official Gazette of the United States Patent and Trademark Office Patents. Vol. 1246, no. 2. (January 2001.): -.

Sadee, Wolfgang. Abstracts of Papers American Chemical Society. Vol. 222, no. 1-2. (January 2001.): MEDI298-.

Sadee, Wolfgang. "Methods for anti-addictive narcotic analgesic treatments." Official Gazette of the United States Patent and Trademark Office Patents. Vol. 1249, no. 1. (January 2001.): -.

Sadee, W; Hoeg, E; Lucas, J; Wang, D. "Genetic variations in human G protein-coupled receptors: implications for drug therapy.." AAPS pharmSci [electronic resource]. Vol. 3, no. 3. (January 2001.): E22-.

Lucas, J, L; DeYoung, J, A; Sadee, W. "Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene.." AAPS pharmSci [electronic resource]. Vol. 3, no. 4. (January 2001.): E31-.

Phillips, Kathryn A.; Veenstra, David L.; Oren, Eyal; Lee, Jane K.; Sadee, Wolfgang. "Potential role of pharmacogenomics in reducing adverse drug reactions." JAMA (Journal of the American Medical Association). Vol. 286, no. 18. (January 2001.): 2270-2279.

Phillips, KA; Veenstra, DL; Oren, E; Lee, JK; Sadee W. "Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review." JAMA: Journal of the American Medical Association. Vol. 286, no. 18. (January 2001.): 2270-9, 2337.

Phillips, K, A; Veenstra, D, L; Oren, E; Lee, J, K; Sadee, W. "Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review.." JAMA : the journal of the American Medical Association. Vol. 286, no. 18. (January 2001.): 2270-9.

Carlson, Kurt W.; Nawy, Susan Stair; Wei, Edward T.; Sadee, Wolfgang; Filov, Vladimir A.; Rezsova, Valentina V.; Slominski, Andrzej; Quillan, J. Mark. "Inhibition of mouse melanoma cell proliferation by corticotropin-releasing hormone and its analogs." Anticancer Research. Vol. 21, no. 2A. (January 2001.): 1173-1180.

Carlson, K, W; Nawy, S, S; Wei, E, T; Sadee, W; Filov, V, A; Rezsova, V, V; Slominski, A; Quillan, J M. "Inhibition of mouse melanoma cell proliferation by corticotropin-releasing hormone and its analogs.." Anticancer research. Vol. 21, no. 2A. (January 2001.): 1173-9.

Lin, Kedan; Wang, Danxin; Sadee, Wolfgang. "Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2.." The Journal of biological chemistry. Vol. 277, no. 43. (January 2002.): 40789-98.

Salvi, Aline; Quillan, J Mark; Sadee, Wolfgang. "Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5-chloromethylfluorescein.." AAPS pharmSci. Vol. 4, no. 4. (January 2002.): E21-.

Sadee, Wolfgang. "Pharmacogenomics: the implementation phase.." AAPS pharmSci. Vol. 4, no. 2. (January 2002.): E5-.

Lin, Kedan; Wang, Danxin; Sadee, Wolfgang. "Serum response factor activation by muscarinic receptors via Rhoa. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2." Journal of Biological Chemistry. Vol. 277, no. 43. (January 2002.): 40789-40798.

Quillan, J Mark; Carlson, Kurt, W; Song, Chunyan; Wang, Danxin; Sadee, Wolfgang. "Differential effects of mu-opioid receptor ligands on Ca(2+) signaling.." The Journal of pharmacology and experimental therapeutics. Vol. 302, no. 3. (January 2002.): 1002-12.

Zahn, Katrin; Eckstein, Niels; Trankle, Christian; Sadee, Wolfgang; Mohr, Klaus. "Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist.." The Journal of pharmacology and experimental therapeutics. Vol. 301, no. 2. (January 2002.): 720-8.

Zahn, Katrin; Eckstein, Niels; Trankle, Christian; Sadee, Wolfgang; Mohr, Klaus. "Allosteric modulation of muscarinic receptor signaling: Alcuronium-induced conversion of pilocarpine from an agonist into an antagonist." Journal of Pharmacology and Experimental Therapeutics. Vol. 301, no. 2. (January 2002.): 720-728.

Kassack, Matthias, U; Hofgen, Barbara; Lehmann, Jochen; Eckstein, Niels; Quillan, J Mark; Sadee, Wolfgang. "Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader.." Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. Vol. 7, no. 3. (January 2002.): 233-46.

Kassack, Matthias U.; Hoefgen, Barbara; Lehmann, Jochen; Eckstein, Niels; Quillan, J. Mark; Sadee, Wolfgang. "Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader." Journal of Biomolecular Screening. Vol. 7, no. 3. (January 2002.): 233-246.

Quillan, J. Mark; Carlson, Kurt W.; Song, Chunyan; Wang, Danxin; Sadee, Wolfgang. "Differential effects of mu-opioid receptor ligands on Ca2+ signaling." Journal of Pharmacology and Experimental Therapeutics. Vol. 302, no. 3. (January 2002.): 1002-1012.

Huang, Ying; Sadee, Wolfgang. "Drug sensitivity and resistance genes in cancer chemotherapy: a chemogenomics approach.." Drug discovery today. Vol. 8, no. 8. (January 2003.): 356-63.

Huang, Ying; Sadee, Wolfgang. "Drug sensitivity and resistance genes in cancer chemotherapy: A chemogenomics approach.." Drug Discovery Today. Vol. 8, no. 8. (January 2003.): 356-363.

Tammler, Ursula; Quillan, J. Mark; Lehmann, Jochen; Sadee, Wolfgang; Kassack, Matthias U.. "Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor.." European Journal of Medicinal Chemistry. Vol. 38, no. 5. (January 2003.): 481-493.

Tammler, Ursula; Quillan, J Mark; Lehmann, Jochen; Sadee, Wolfgang; Kassack, Matthias U. "Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor.." European journal of medicinal chemistry. Vol. 38, no. 5. (January 2003.): 481-93.

Pinsonneault, Julia; Sadee, Wolfgang. "Pharmacogenomics of multigenic diseases: sex-specific differences in disease and treatment outcome.." AAPS pharmSci. Vol. 5, no. 4. (January 2003.): E29-.

Phan, Dana, D; Chin-Hong, Peter; Lin, Emil, T; Anderle, Pascale; Sadee, Wolfgang; Guglielmo, B Joseph. "Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor.." Antimicrobial agents and chemotherapy. Vol. 47, no. 7. (January 2003.): 2351-3.

Phan, Dana D.; Chin-Hong, Peter; Lin, Emil T.; Anderle, Pascale; Sadee, Wolfgang; Guglielmo, B. Joseph. "Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hpept1 inhibitor.." Antimicrobial Agents and Chemotherapy. Vol. 47, no. 7. (January 2003.): 2351-2353.

Lucas, Julie L.; Wang, Danxin; Sadee, Wolfgang. "Interaction between calmodulin and the i3 loop of muscarinic acetylcholine receptors.." FASEB Journal. Vol. 17, no. 4-5. (January 2003.): Abstract No. 394.11-.

Huang, Ying; Barbacioru, Catalin; Anderle, Pascale; Bussey, Kimberly; Pinsonneault, Julie; Papp, Audrey; Weinstein, John; Sadee, Wolfgang. "Expression of transporter genes identified chemo-sensitivity and -resistance markers in human cancer cells.." Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 44, (January 2003.): 797-.

Han, G; Quillan, J, M; Carlson, K; Sadee, W; Hruby, V J. "Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist.." Journal of medicinal chemistry. Vol. 46, no. 5. (January 2003.): 810-9.

Brown, Shoshana; Chang, Jean, L; Sadee, Wolfgang; Babbitt, Patricia C. "A semiautomated approach to gene discovery through expressed sequence tag data mining: discovery of new human transporter genes.." AAPS pharmSci [electronic resource]. Vol. 5, no. 1. (January 2003.): E1-.

Anderle, Pascale; Rakhmanova, Vera; Woodford, Katie; Zerangue, Noa; Sadee, Wolfgang. "Messenger RNA expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines.." Pharmaceutical research. Vol. 20, no. 1. (January 2003.): 3-15.

Anderle, Pascale; Rakhmanova, Vera; Woodford, Katie; Zerangue, Noa; Sadee, Wolfgang. "Messenger Rna expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines.." Pharmaceutical Research (Dordrecht). Vol. 20, no. 1. (January 2003.): 3-15.

Papp, Audrey, C; Pinsonneault, Julia, K; Cooke, Glen; Sadee, Wolfgang. "Single nucleotide polymorphism genotyping using allele-specific PCR and fluorescence melting curves.." BioTechniques. Vol. 34, no. 5. (January 2003.): 1068-72.

Papp, Audrey C.; Pinsonneault, Julia K.; Cooke, Glen; Sadee, Wolfgang. "Single nucleotide polymorphism genotyping using allele-specific Pcr and fluorescence melting curves.." BioTechniques. Vol. 34, no. 5. (January 2003.): 1068-1072.

Wang, Danxin; Raehal, Kirsten, M; Lin, Emil, T; Lowery, John, J; Kieffer, Brigitte, L; Bilsky, Edward, J; Sadee, Wolfgang. "Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence.." The Journal of pharmacology and experimental therapeutics. Vol. 308, no. 2. (January 2004.): 512-20.

Dai, Zunyan; Huang, Ying; Sadee, Wolfgang. "Growth factor signaling and resistance to cancer chemotherapy.." Current topics in medicinal chemistry. Vol. 4, no. 13. (January 2004.): 1347-56.

Dai, Zunyan; Huang, Ying; Sadee, Wolfgang. "Growth factor signaling and resistance to cancer chemotherapy." Current Topics in Medicinal Chemistry. Vol. 4, no. 13. (January 2004.): 1347-1356.

Bartlett, Jeffrey, L; Lavoie, Nicholas, R; Raehal, Kirsten, M; Sadee, Wolfgang; Bilsky, Edward J. "In vivo studies with 6 beta -naltrexamide, a peripherally selective opioid antagonist that has less inverse agonist activity than naltrexone and naloxone." FASEB Journal. Vol. 18, no. 4-5. (January 2004.): Abst. 399.15-.

Wang, Danxin; Raehal, Kirsten M.; Lin, Emil T.; Lowery, John J.; Kieffer, Brigitte L.; Bilsky, Edward J.; Sadee, Wolfgang. "Basal signaling activity of mu opioid receptor in mouse brain: Role in narcotic dependence.." Journal of Pharmacology and Experimental Therapeutics. Vol. 308, no. 2. (January 2004.): 512-520.

Sadee, Wolfgang; Wang, Danxin. "Neutral antagonists and use thereof in treating drug abuse." Official Gazette of the United States Patent and Trademark Office Patents. Vol. 1280, no. 5. (January 2004.): -.

Pinsonneault, Julia; Nielsen, Carsten Uhd; Sadee, Wolfgang. "Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions.." The Journal of pharmacology and experimental therapeutics. Vol. 311, no. 3. (January 2004.): 1088-96.

Pinsonneault, Julia; Nielsen, Carsten Uhd; Sadee, Wolfgang. "Genetic variants of the human H+/dpeptide transporter Pept2: Analysis of haplotype functions." Journal of Pharmacology and Experimental Therapeutics. Vol. 311, no. 3. (January 2004.): 1088-1096.

Yang, Chihae; Blower, Paul E.; Cross, Kevin; Myatt, Glenn; Sadee, Wolfgang; Huang, Ying. "Linking chemical scaffolds to gene families to help elucidate molecular mechanisms.." Abstracts of Papers American Chemical Society. Vol. 227, no. Part 1. (January 2004.): U678-U679.

Landowski, Christopher, P; Anderle, Pascale; Sun, Duxin; Sadee, Wolfgang; Amidon, Gordon L. "Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies.." The AAPS journal. Vol. 6, no. 3. (January 2004.): e21-.

Huang, Ying; Anderle, Pascale; Bussey, Kimberly, J; Barbacioru, Catalin; Shankavaram, Uma; Dai, Zunyan; Reinhold, William, C; Papp, Audrey; Weinstein, John, N; Sadee, Wolfgang. "Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance.." Cancer research. Vol. 64, no. 12. (January 2004.): 4294-301.

Huang, Ying; Anderle, Pascale; Bussey, Kimberly J.; Barbacioru, Catalin; Shankavaram, Uma; Dai, Zunyan; Reinhold, William C.; Papp, Audrey; Weinstein, John N.; Sadee, Wolfgang. "Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance." Cancer Research. Vol. 64, no. 12. (January 2004.): 4294-4301.

Bhamidipati, Castigliano, M; Lowery, John, J; Bourgault, Terry; Turcato, Nina; Sadee, Wolfgang; Bilsky, Edward J. "6 beta -naltrexol produces long-lasting antagonism of Cns-mediated effects of morphine with decreased withdrawal in mice compared to naltrexone." FASEB Journal. Vol. 18, no. 4-5. (January 2004.): Abst. 635.1-.

Anderle, Pascale; Huang, Ying; Sadee, Wolfgang. "Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays.." European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. Vol. 21, no. 1. (January 2004.): 17-24.

Anderle, Pascale; Huang, Ying; Sadee, Wolfgang. "Intestinal membrane transport of drugs and nutrients: Genomics of membrane transporters using expression microarrays.." European Journal of Pharmaceutical Sciences. Vol. 21, no. 1. (January 2004.): 17-24.

Zhang, Ying; Wang, Danxin; Johnson, Andrew, D; Papp, Audrey, C; Sadee, Wolfgang. "Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.." The Journal of biological chemistry. Vol. 280, no. 38. (January 2005.): 32618-24.

Xiao, Jim, J; Huang, Ying; Dai, Zunyan; Sadee, Wolfgang; Chen, Jiyun; Liu, Shujun; Marcucci, Guido; Byrd, John; Covey, Joseph, M; Wright, John; Grever, Michael; Chan, Kenneth K. "Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell." The Journal of pharmacology and experimental therapeutics. Vol. 314, no. 1. (January 2005.): 467-75.

Xiao, Jim, J; Foraker, Amy, B; Swaan, Peter, W; Liu, Shujun; Huang, Ying; Dai, Zunyan; Chen, Jiyun; Sadee, Wolfgang; Byrd, John; Marcucci, Guido; Chan, Kenneth K. "Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.." The Journal of pharmacology and experimental therapeutics. Vol. 313, no. 1. (January 2005.): 268-76.

Xiao, Jim J.; Huang, Ying; Dai, Zunyan; Sadee, Wolfgang; Chen, Jiyun; Liu, Shujun; Marcucci, Guido; Byrd, John; Covey, Joseph M.; Wright, John; Grever, Michael; Chan, Kenneth K.. "Chemoresistance to depsipeptide Fk228 [(e)-(1s,4s,10s,21r)-7-[(z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible Mdr1 induction in human cancer cell lines." Journal of Pharmacology and Experimental Therapeutics. Vol. 314, no. 1. (January 2005.): 467-475.

Xiao, Jim J.; Foraker, Amy B.; Swaan, Peter W.; Liu, Shujun; Huang, Ying; Dai, Zunyan; Chen, Jiyun; Sadee, Wolfgang; Byrd, John; Marcucci, Guido; Chan, Kenneth K.. "Efflux of depsipeptide Fk228 (fr901228, Nsc-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein." Journal of Pharmacology and Experimental Therapeutics. Vol. 313, no. 1. (January 2005.): 268-276.

Raehal, Kirsten, M; Lowery, John, J; Bhamidipati, Castigliano, M; Paolino, Ryan, M; Blair, Jennifer, R; Wang, Danxin; Sadee, Wolfgang; Bilsky, Edward J. "In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice.." The Journal of pharmacology and experimental therapeutics. Vol. 313, no. 3. (January 2005.): 1150-62.

Zhang, Ying; Wang, Danxin; Sadee, Wolfgang. "Calmodulin interaction with peptides from G-protein coupled receptors measured with S-Tag labeling.." Biochemical and biophysical research communications. Vol. 333, no. 2. (January 2005.): 390-5.

Zhang, Ying; Wang, Danxin; Sadee, Wolfgang. "Calmodulin interaction with peptides from G-protein coupled receptors measured with S-tag labeling." Biochemical and Biophysical Research Communications. Vol. 333, no. 2. (January 2005.): 390-395.

Wei, Edward T.; Quillan, J. Mark; Sadee, Wolfgang; Vlasov, Guennady P.; Chang, Jaw Kang. "Melanocortin receptor antagonists and modulations of melanocortin receptor activity." Official Gazette of the United States Patent and Trademark Office Patents. (January 2005.): -.

Wang, Danxin; Johnson, Andrew D.; Papp, Audrey C.; Kroetz, Deanna L.; Sadee, Wolfgang. "Multidrug resistance polypeptide 1 (mdr1, Abcb1) variant 3435c > T affects mrna stability." Pharmacogenetics and Genomics. Vol. 15, no. 10. (January 2005.): 693-704.

Wang, Danxin; Sun, Xiaochun; Bohn, Laura, M; Sadee, Wolfgang. "Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer.." Molecular pharmacology. Vol. 67, no. 6. (January 2005.): 2173-84.

Wang, Danxin; Sun, Xiaochun; Bohn, Laura M.; Sadee, Wolfgang. "Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer." Molecular Pharmacology. Vol. 67, no. 6. (January 2005.): 2173-2184.

Wang, Danxin; Johnson, Andrew, D; Papp, Audrey, C; Kroetz, Deanna, L; Sadee, Wolfgang. "Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.." Pharmacogenetics and genomics. Vol. 15, no. 10. (January 2005.): 693-704.

Sadee, Wolfgang; Wang, Danxin; Bilsky, Edward J.. "Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities." Life Sciences. Vol. 76, no. 13. (January 2005.): 1427-1437.

Sadee, Wolfgang; Wang, Danxin; Bilsky, Edward J. "Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities.." Life sciences. Vol. 76, no. 13. (January 2005.): 1427-37.

Sadee, Wolfgang; Dai, Zunyan. "Pharmacogenetics/genomics and personalized medicine.." Human molecular genetics. Vol. 14 Spec No. 2, (January 2005.): R207-14.

Sadee, Wolfgang; Dai, Zunyan. "Pharmacogenetics/genomics and personalized medicine." Human Molecular Genetics. Vol. 14, no. Sp. Iss. 2. (January 2005.): R207-R214.

Raehal, Kirsten M.; Lowery, John J.; Bhamidipati, Castigliano M.; Paolino, Ryan M.; Blair, Jennifer R.; Wang, Danxin; Sadee, Wolfgang; Bilsky, Edward J.. "In vivo characterization of 6 beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice." Journal of Pharmacology and Experimental Therapeutics. Vol. 313, no. 3. (January 2005.): 1150-1162.

Johnson, Andrew, D; Wang, Danxin; Sadee, Wolfgang. "Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.." Pharmacology & therapeutics. Vol. 106, no. 1. (January 2005.): 19-38.

Johnson, Andrew D.; Wang, Danxin; Sadee, Wolfgang. "Polymorphisms affecting gene regulation and mrna processing: Broad implications for pharmacogenetics." Pharmacology & Therapeutics. Vol. 106, no. 1. (January 2005.): 19-38.

Bahadduri, Praveen, M; D'Souza, Vanessa, M; Pinsonneault, Julia, K; Sadee, Wolfgang; Bao, Shenying; Knoell, Daren, L; Swaan, Peter W. "Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium.." American journal of respiratory cell and molecular biology. Vol. 32, no. 4. (January 2005.): 319-25.

Bahadduri, Praveen M.; D'Souza, Vanessa M.; Pinsonneault, Julia K.; Sadee, Wolfgang; Bao, Shenying; Knoell, Daren L.; Swaan, Peter W.. "Functional characterization of the peptide transporter Pept2 in primary cultures of human upper airway epithelium." American Journal of Respiratory Cell and Molecular Biology. Vol. 32, no. 4. (January 2005.): 319-325.

Huang, Ying; Dai, Zunyan; Barbacioru, Catalin; Sadee, Wolfgang. "Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance.." Cancer research. Vol. 65, no. 16. (January 2005.): 7446-54.

Huang, Ying; Dai, Zunyan; Barbacioru, Catalin; Sadee, Wolfgang. "Cystine-glutamate transporter Slc7a11 in cancer chemosensitivity and chemoresistance." Cancer Research. Vol. 65, no. 16. (January 2005.): 7446-7454.

Huang, Y; Blower, P, E; Yang, C; Barbacioru, C; Dai, Z; Zhang, Y; Xiao, J, J; Chan, K, K; Sadee, W. "Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1.." The pharmacogenomics journal. Vol. 5, no. 2. (January 2005.): 112-25.

Zhang, Ying; Wang, Danxin; Johnson, Andrew D.; Papp, Audrey C.; Sadee, Wolfgang. "Allelic expression imbalance of human mu opioid receptor (oprm1) caused by variant A118g (vol 280, pg 32618, 2005)." Journal of Biological Chemistry. Vol. 280, no. 46. (January 2005.): 38888-.

Zhang, Ying; Wang, Danxin; Johnson, Andrew D.; Papp, Audrey C.; Sadee, Wolfgang. "Allelic expression imbalance of human mu opioid receptor (oprm1) caused by variant A118g." Journal of Biological Chemistry. Vol. 280, no. 38. (January 2005.): 32618-32624.

Frank, Natasha, Y; Margaryan, Armen; Huang, Ying; Schatton, Tobias; Waaga-Gasser, Ana Maria; Gasser, Martin; Sayegh, Mohamed, H; Sadee, Wolfgang; Frank, Markus H. "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.." Cancer research. Vol. 65, no. 10. (January 2005.): 4320-33.

Frank, Natasha Y.; Margaryan, Armen; Huang, Ying; Schatton, Tobias; Waaga-Gasser, Ana Maria; Gasser, Martin; Sayegh, Mohamed H.; Sadee, Wolfgang; Frank, Markus H.. "Abcb5-mediated doxorubicin transport and chemoresistance in human malignant melanoma." Cancer Research. Vol. 65, no. 10. (January 2005.): 4320-4333.

Becker, Jill, B; Arnold, Arthur, P; Berkley, Karen, J; Blaustein, Jeffrey, D; Eckel, Lisa, A; Hampson, Elizabeth; Herman, James, P; Marts, Sherry; Sadee, Wolfgang; Steiner, Meir; Taylor, Jane; Young, Elizabeth. "Strategies and methods for research on sex differences in brain and behavior.." Endocrinology. Vol. 146, no. 4. (January 2005.): 1650-73.

Becker, Jill B.; Arnold, Arthur P.; Berkley, Karen J.; Blaustein, Jeffrey D.; Eckel, Lisa A.; Hampson, Elizabeth; Herman, James P.; Marts, Sherry; Sadee, Wolfgang; Steiner, Meir; Taylor, Jane; Young, Elizabeth. "Strategies and methods for research on sex differences in brain and behavior." Endocrinology. Vol. 146, no. 4. (January 2005.): 1650-1673.

Huang, Ying; Blower, Paul E.; Barbacioru, Catalin; Dai, Zunyan; Green, Bridgette; Wise, Carolyn; Lyn-Cook, Beverly D.; Kadlubar, Fred F.; Sadee, Wolfgang. "Pharmacogenomic analysis reveals determinants of sensitivity and resistance to geldanamycin analogs: the role of membrane transporters.." Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 47, (January 2006.): 737-.

Dai, Zunyan; Liu, Shujun; Marcucci, Guido; Sadee, Wolfgang. "5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).." Biochemical and biophysical research communications. Vol. 351, no. 2. (January 2006.): 455-61.

Dai, Zunyan; Liu, Shujun; Marcucci, Guido; Sadee, Wolfgang. "5-aza-2 '-deoxycytidine and depsipeptide synergistically induce expression of Bik (bcl2-interacting killer)." Biochemical and Biophysical Research Communications. Vol. 351, no. 2. (January 2006.): 455-461.

Lim, J-E; Papp, A; Pinsonneault, J; Sadee, W; Saffen, D. "Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR.." Molecular psychiatry. Vol. 11, no. 7. (January 2006.): 649-62.

Wang, Yonghui; Dai, Zunyan; Sadee, Wolfgang; Hancock, William S.. "A pharmacoproteomics study of the cancer cell line Ekvx using capillary-lc/ms/ms." Molecular Pharmaceutics. Vol. 3, no. 5. (January 2006.): 566-578.

Wang, Yonghui; Dai, Zunyan; Sadee, Wolfgang; Hancock, William S. "A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS.." Molecular pharmaceutics. Vol. 3, no. 5. (January 2006.): 566-78.

Wang, Danxin; Sadee, Wolfgang. "Searching for polymorphisms that affect gene expression and mRNA processing: example ABCB1 (MDR1).." The AAPS journal. Vol. 8, no. 3. (January 2006.): E515-20.

Huang, Ying; Sadee, Wolfgang. "Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells.." Cancer letters. Vol. 239, no. 2. (January 2006.): 168-82.

Huang, Ying; Sadee, Wolfgang. "Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells." Cancer Letters. Vol. 239, no. 2. (January 2006.): 168-182.

Dai, Zunyan; Barbacioru, Catalin; Huang, Ying; Sadee, Wolfgang. "Prediction of anticancer drug potency from expression of genes involved in growth factor signaling.." Pharmaceutical research. Vol. 23, no. 2. (January 2006.): 336-49.

Dai, Zunyan; Barbacioru, Catalin; Huang, Ying; Sadee, Wolfgang. "Prediction of anticancer drug potency from expression of genes involved in growth factor signaling." Pharmaceutical Research (Dordrecht). Vol. 23, no. 2. (January 2006.): 336-349.

Pinsonneault, Julia, K; Papp, Audrey, C; Sadee, Wolfgang. "Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors.." Human molecular genetics. Vol. 15, no. 17. (January 2006.): 2636-49.

Pinsonneault, Julia K.; Papp, Audrey C.; Sadee, Wolfgang. "Allelic mrna expression of X-linked monoamine oxidase a (maoa) in human brain: dissection of epigenetic and genetic factors." Human Molecular Genetics. Vol. 15, no. 17. (January 2006.): 2636-2649.

Sadee, Wolfgang; Bohn, Laura. "How specific are "target-specific" drugs? Celecoxib as a case in point.." Molecular interventions. Vol. 6, no. 4. (January 2006.): 196-8.

Lucas, Julie, L; Wang, Danxin; Sadee, Wolfgang. "Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors.." Pharmaceutical research. Vol. 23, no. 4. (January 2006.): 647-53.

Lucas, Julie L.; Wang, Danxin; Sadee, Wolfgang. "Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors." Pharmaceutical Research (Dordrecht). Vol. 23, no. 4. (January 2006.): 647-653.

Krejsa, Cecile; Rogge, Mark; Sadee, Wolfgang. "Protein therapeutics: new applications for pharmacogenetics.." Nature reviews. Drug discovery. Vol. 5, no. 6. (January 2006.): 507-21.

Johnson, Andrew D.; Papp, Audrey C.; Lesinski, Amanda; Binkley, Philip; Sadee, Wolfgang. "Allelic expression imbalance analysis in heart failure samples finds novel cis-acting alleles in Ace and Sod2." Circulation. Vol. 114, no. 18, Suppl. S. (January 2006.): 590-.

Anderle, Pascale; Nielsen, Carsten Uhd; Pinsonneault, Julia; Krog, Pernille Lindskov; Brodin, Birger; Sadee, Wolfgang. "Genetic variants of the human dipeptide transporter PEPT1.." The Journal of pharmacology and experimental therapeutics. Vol. 316, no. 2. (January 2006.): 636-46.

Anderle, Pascale; Nielsen, Carsten Uhd; Pinsonneault, Julia; Krog, Pernille Lindskov; Brodin, Birger; Sadee, Wolfgang. "Genetic variants of the human dipeptide transporter Pept1." Journal of Pharmacology and Experimental Therapeutics. Vol. 316, no. 2. (January 2006.): 636-646.

Lim, J-E; Pinsonneault, J; Sadee, W; Saffen, D. "Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.." Molecular psychiatry. Vol. 12, no. 5. (January 2007.): 491-501.

Dai, Zunyan; Huang, Ying; Sadee, Wolfgang; Blower, Paul. "Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.." Journal of medicinal chemistry. Vol. 50, no. 8. (January 2007.): 1896-1906.

Huang, Ying; Blower, Paul, E; Liu, Ruqing; Dai, Zunyan; Pham, Anh-Nhan; Moon, Hojin; Fang, Jialong; Sadee, Wolfgang. "Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1.." Pharmaceutical research. Vol. 24, no. 9. (January 2007.): 1702-1712.

Blower, Paul, E; Verducci, Joseph, S; Lin, Shili; Zhou, Jin; Chung, Ji-Hyun; Dai, Zunyan; Liu, Chang-Gong; Reinhold, William; Lorenzi, Philip, L; Kaldjian, Eric, P; Croce, Carlo, M; Weinstein, John, N; Sadee, Wolfgang. "MicroRNA expression profiles for the NCI-60 cancer cell panel.." Molecular cancer therapeutics. Vol. 6, no. 5. (January 2007.): 1483-1491.

Beitelshees, Amber, L; Gong, Yan; Wang, Danxin; Schork, Nicholas, J; Cooper-Dehoff, Rhonda, M; Langaee, Taimour, Y; Shriver, Mark, D; Sadee, Wolfgang; Knot, Harm, J; Pepine, Carl, J; Johnson, Julie, A; Johnson, Julie A. "KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST).." Pharmacogenetics and genomics. Vol. 17, no. 9. (January 2007.): 719-729.

Wang, Danxin; Sun, Xiaochun; Sadee, Wolfgang. "Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.." The Journal of pharmacology and experimental therapeutics. Vol. 321, no. 2. (January 2007.): 544-552.

Zhang, Ying; Bertolino, Alessandro; Fazio, Leonardo; Blasi, Giuseppe; Rampino, Antonio; Romano, Raffaella; Lee, Mei-Ling, T; Xiao, Tao; Papp, Audrey; Wang, Danxin; Sadee, Wolfgang. "Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 51. (January 2007.): -.

Cao, Xianhua; Fang, Lanyan; Gibbs, Seth; Huang, Ying; Dai, Zunyan; Wen, Ping; Zheng, Xincheng; Sadee, Wolfgang; Sun, Duxin. "Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia.." Cancer chemotherapy and pharmacology. Vol. 59, no. 4. (January 2007.): 495-505.

Cao, Xianhua; Fang, Lanyan; Gibbs, Seth; Huang, Ying; Dai, Zunyan; Wen, Ping; Zheng, Xincheng; Sadee, Wolfgang; Sun, Duxin. "Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia." Cancer Chemotherapy and Pharmacology. Vol. 59, no. 4. (January 2007.): 495-505.

Blower PE; Chung JH; Verducci JS; Lin S; Park JK; Dai Z; Liu CG; Schmittgen TD; Reinhold WC; Croce CM; Weinstein JN; Sadee W. "MicroRNAs modulate the chemosensitivity of tumor cells.." Molecular Cancer Therapeutics. Vol. 7, no. 1. (January 2008.): 1-.

Dai Z; Papp AC; Wang D; Hampel H; Sadee W. "Genotyping panel for assessing response to cancer chemotherapy.." BMC Medical Genomics. Vol. 1, (January 2008.): 24-.

Besecker B; Bao S; Bohacova B; Papp A; Sadee W; Knoell DL. "The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.." American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 294, no. 6. (June 2008.): L1127-.

Johnson AD; Zhang Y; Papp AC; Pinsonneault JK; Lim JE; Saffen D; Dai Z; Wang D; Sadée W. "Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.." Pharmacogenetics And Genomics. Vol. 18, no. 9. (September 2008.): 781-.

Alachkar H; Kataki M; Scharre DW; Papp A; Sadee W. "Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.." Neuroscience Letters. Vol. 448, no. 1. (December 2008.): 120-.

Wang D; Chen H; Momary KM; Cavallari LH; Johnson JA; Sadée W. "Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.." Blood. Vol. 112, no. 4. (August 2008.): 1013-.

Sadee W. "Drug therapy and personalized health care: pharmacogenomics in perspective.." Pharmaceutical Research. Vol. 25, no. 12. (December 2008.): 2713-.

Bertolino A; Fazio L; Di Giorgio A; Blasi G; Romano R; Taurisano P; Caforio G; Sinibaldi L; Ursini G; Popolizio T; Tirotta E; Papp A; Dallapiccola B; Borrelli E; Sadee W. "Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.." The Journal Of Neuroscience: The Official Journal Of The Society For Neuroscience. Vol. 29, no. 4. (January 2009.): 1224-.

Johnson AD; Gong Y; Wang D; Langaee TY; Shin J; Cooper-Dehoff RM; Schork NJ; Binkley P; Pepine CJ; Johnson JA; Sadee W. "Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension.." Clinical Pharmacology And Therapeutics. Vol. 85, no. 1. (January 2009.): 36-.