400 W Twelfth Ave
Rm 252N Wiseman Hall
Columbus, OH 43210
Phone: (614) 292-1396
Assistant Professor, Ophthalmology
My most prominent research accomplishment is the characterization of a novel hereditary cancer predisposition syndrome caused by germline mutation in the BAP1 gene. This new hereditary cancer syndrome is associated with multiple different cancers including uveal melanoma, cutaneous melanoma, renal cell carcinoma and potentially other cancers.
Our manuscript describing the BAP1-Tumor Predisposition Syndrome (BAP1-TPDS) has been selected as the editor's choice and has already 108 citations (only 2 self) in less than 4 years. The article is cited by OMIM as 1 of the 4 references describing the BAP1-TPDS (OMIM # 614327)
My expertise in BAP1 is well recognized in the field and so far I have been invited to reviewed three international grants and several manuscripts on BAP1. I was also invited to give two national an one international lectures on the topic.
Based on our well recognized expertise in BAP1 and familial uveal melanoma we have received patients' referral from all over the US (total patients accrued from US outside OSU: 88) and from several foreign countries including Italy, Canada, Belgium, UK, Ireland, Australia, Netherlands and Jordan (total patients accrued from foreign countries: 23 patients). Also based on such strong national and international reputation we were able to accrue 24 patients with familial uveal melanoma (there are less than 100 patients reported Worldwide). This was well recognized by the reviewers of my funded R21 NCI grant who noted that our patient cohort is one of the largest for familial uveal melanoma collected in the World.
Several of my other manuscripts appeared in highly ranked journals such as JMG, JCO, CCR, IOVS. Although, publications in the field of ocular oncology usually don't receive large number of citations, contrary to other common cancers, my publications have been cited 346 times (291 since 2010) and my current H index is 10 (9 since 2010).
One of my papers (MET oncogene inhibition as a potential target of therapy for uveal melanomas, IOVS 2010: 51,7: 3333-9) provided important data for one of the ongoing adjuvant clinical trials for uveal melanoma (NCT02223819).
Another highly cited paper is our work on PTEN in uveal melanoma.
Clinical Medical Genetics
I am a strong believer of investing in undergraduate students' research especially for highly talented candidates. My strategy is to select one or two students/year who I train and give independent research project. I try to limit the number of students rotating in the lab at any time to maximum of two students so I can have sufficient time for mentoring. Although working with undergraduate students is rather challenging I find it highly rewarding.
In addition to the long term projects carried out by selected undergraduate students I accept other undergraduate and medical students for shorter rotations depending on their expertise and research interests. .
Since the start of my faculty appointment at OSU in 2009 I mentored four undergraduate students Benjamin Christopher, Omar Saqr, Samidha Dutta and Tiffany Wang each for more than a year. I also mentored three medical students research projects Benjamin Romney, Kareem Saleh and Muneeb Rehman. Currently I am mentoring one undergraduate student Timothy Grosel but haven't assigned a research project for him yet.
I have been on the advising committee of several graduate students in Egypt. Two of my graduate students from Egypt (Ahmad Agour and Asmaa Abdel-Maksood) obtained scholarships and came to OSU for part of their training.
The doctorate candidate student Eman Adbelsamee, MD is currently a junior faculty (lecturer) at Menoufiya University.
Samira Abdelwehab. MD is currently a fellow (assistant lecturer) at Menoufiya University. She finished her residency training and obtained a master degree in hepatology. She is currently pursuing her doctorate degree.
I currently mentor 4 PhD students from Egypt (1 from Menoufiya University, 1 from Cairo Universality and 2 from Sadat University. Two of them Ahmed A. Agour, MD, MSc and Asmaa Mosbah, MSc obtained scholarships and came to my laboratory at OSU for 3 months to carry out part of their training.
|2013 - present||Elaine M The Ohio State University. Analysis of BAP1 germline gene mutation in young uveal melanoma patients|
|2014 - present||Muneeb Rehman The Ohio State University. Study of a Novel Candidate Gene for Hereditary Predisposition to Uveal Melanoma|
|2013||Omar Saqr The Ohio State University. Graduated 2013. Study of germline BAP1 and VHL mutation in uveal melanoma patients with personal and or family history of renal cell carcinoma|
|2014||Kareem Saleh The Ohio State University. Molecular Genetics of Choroidal Nevi|
|1992 - present||Unrestricted Medical License: Egyptian Ministry of Health|
|1992 - present||General Medical Practitioner: Egyptian Ministry of Health|
|1998 - present||ECFMG: Educational Commission for Foreign Medical Graduates|
|2007 - present||Histopathology Consultant: Egyptian Medical Syndicate|
|2007 - present||Consultant Histopathology: Egyptian Medical Syndicate|
|2009 - present||Unrestricted Medical License: State Medical Board of Ohio|
|07/01/2007||Pathology Practice (Menoufiya, Egypt)|
Yang,Y; Meadows,S; Li,P,K; Davidorf,F,H; Abdel-Rahman,M,H. "Anti-angiogenic effect of Linomide analogue." In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (January 2005). 4166-.
Abdel-Rahman MH, Hedges D, Pilarski R, Boru G, Massengill JB, Rai K, Davidorf FH, Cebulla CM. "Whole genome exome sequencing to identify novel candidates for hereditary predisposition to UM uveal melanoma.." In abstracts.ashg.org. (October 2014). 2014: 3484T-.
Pilarski R, Boru G, Saqr OH, Rai K, Massengill JB, Cebulla CM, Abdel-Rahman MH.. "Germline epigenetic inactivation of BAP1 in a subset of patients with uveal melanoma.." In abstracts.ashg.org. (October 2014). 2014: 3485T-.
Cebulla CM, Pilarski R, Rai K, Massengill JB, Boru G, Davidorf FH, Abdel-Rahman MH.. "Two novel germline BAP1 mutations in two unrelated families with features of the BAP1 Tumor Predisposition Syndrome.." In abstracts.ashg.org. (October 2014). 2014: 3485S-.
Kim B, Kusibati R, Binkley E, Abdel-Rahman MH, Cebulla CM.. "Up-Regulation of VEGF by Hyaluronic Acid in Microglia." In ARVO meetinabstracts. (April 2014). 2014 55:2261-.
Binkley EM, Cebulla CM, Pilarski R, Massengill JB, Marino MJ, Singh AD, Abdel-Rahman MH.. "Lack of BAP1 germline gene mutation in patients with early onset uveal melanoma." In ARVO meeting abstracts. (April 2014). 2014 55:5077-.
|1990||M.D., Cairo University|
|1996||M.S., Menoufiya University|
|2002||Ph.D., The Ohio State University|
|present||Dove Medical Publications|
|present||Clinical Cancer Research|
|2009 - present||Investigatve Ophthalmology and Visual Sciences|
|2000||Loes Jones Endowment for cancer research fellowship award. Comprehensive Cancer Center.|
|2001||Travel Fellowship. 10th International Congress of Human Genetics.|
|2010||Junior Investigator Award. Ocular Melanoma Foundation.|
Pilarski,Robert; Cebulla,Colleen,M; Massengill,James,B; Rai,Karan; Rich,Thereasa; Strong,Louise; McGillivray,Barbara; Asrat,Mary-Jill; Davidorf,Frederick,H; Abdel-Rahman,Mohamed,H. "Expanding the Clinical Phenotype of Hereditary BAP1 Cancer Predisposition Syndrome, Reporting Three New Cases." GENES CHROMOSOMES & CANCER. Vol. 53, no. 2. (February 2014.): 177-182.
Abdel-Rahman MH, Agour AA and El-Azab DS. "Tissue microarray as a research tool to study non-eoplastic liver diseases." Egyptian Liver Journal. Vol. 4, no. 3. (July 2014.): 69-74.
"The Practice of Clinical Cancer Genetics." Presented at 1St International Scientific Conference, Children’s Cancer Hospital, Egypt, Cairo, EG|EGY. (July 2009)
"Hereditary predisposition to uveal melanoma." Presented at Great Lake Ocular Oncology Seminar, Michigan. (October 2012)
"Clinical cancer genetics; ophthalmology perspective." Presented at OSU postgraduate course in Ophthalmolgy, Columbus, OH, US|USA. (February 2014)
"Lessons learned from the genetics of a rare eye tumor." Presented at Biology Seminar Series, American University Cairo, Cairo, EG|EGY. (September 2014)
|2012 - present||Establishing a bio-repository research laboratory and program in molecular genetics in Egypt. Sustainable Sciences Institute & Menoufiya University.|
|2014 - present||Tumor Cancer Genome Atlas Uveal Melanoma Analysis Working Group. National Cancer Institute.|
|- 2009||Denman Undergraduate Research Forum. The Ohio State University.|
|- 2010||OSUMC researc day. College of Medicine, The Ohio State University.|
|- 2010||Denman Undergraduate research forum. The Ohio State University.|
|- 2010||Invited speaker. Children's Cancer Hospital of Egypt.|
|- 2010||Educational workshop. Children's Cancer Hospital of Egypt.|
|- 2011||OSUMC research day 2011. College of Medicine, The Ohio State University.|
|- 2011||Denman Undergadutae Research Forum. The Ohio State University.|
|- 2011||Non compensated spokesperson. American Cancer Society.|
Boru, G, Cebulla, CM, Olencki T, Carson W III, Davidorf, FH, Abdel-Rahman, MH.. Heterogeneity in MAPK activation and GNAQ and GNA11 somatic mutations in uveal melanomas, potential impact for therapy.