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2001 Polaris Pkwy
Columbus, OH 43240

Phone: (614) 293-7369

Email: senter-jamieson.1@osu.edu

 

Current OSU Appointment

Associate Professor-Clinical, Human Genetics

 

Academic Advising

2011 - present OSU CSE758 The Ohio State University. Breast Cancer Risk Program
2009 - 2010 Amy Garrison Sarah Lawrence College. Graduated 2010. Consumer Knowledge of GINA
2010 - 2011 Abhilasha Pamarti Brandeis University. Genetic Information Nondiscrimination Act (GINA) and Its Affect on Genetic Counseling Practice: A Survey of Genetic Counselors
 

Certifications

2007 - present Certified Genetic Counselor: American Board of Genetic Counseling
 

Chapters in Books

Steven Erdman and Leigha Senter. "Question 47: “Doctor, I’m worried. My dad died at age 38 of colon cancer and my younger sister just had 3 pre-cancerous polyps removed." In Curbside Consultation in Pediatric GI: 49 Clinical Questions. Edited by Joel Rosh and Athos Bousvaros. -. Torofare, NJ: SLACK, January 2012.

 

Degrees

2001 B.S., The Ohio State University

2003 M.S., University of Pittsburgh

 

Editorial Activities

2004 - 2008 Journal of Medical Genetics
2006 - 2008 Genetics in Medicine
2007 - 2008 Journal of Genetic Counseling
2009 - present Community Oncology
 

Journal Articles

Clendenning M; Hampel H; LaJeunesse J; Lindblom A; Lockman J; Nilbert M; Senter L; Sotamaa K; de la Chapelle A. "Long-range PCR facilitates the identification of PMS2-specific mutations.." Human Mutation. Vol. 27, no. 5. (May 2006.): 490-.

Gururangan S, Frankel W, Broaddus R, Clendenning M, Senter L, McDonald M, Eastwood J, Reardon D, Vredenburgh J, Quinn J, and Friedman H. "Multi-focal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS-2 mutation." Neuro-Oncology. (January 2007.): -.

Senter L, Clendenning M, Sotamaa K, Hampel H, Green J, Potter J, Lindblom A, Lagerstedt K, Thibodeau S, Lindor N, Young J, Winship I, Dowty J, White D, Hopper J, Baglietto L, Jenkins M, de la Chapelle A.. "The clinical phenotype of Lynch syndrome due to germline PMS2 mutations." Gastroenterology. no. 135. (January 2008.): 419-428.

Kelly, K., Senter, L., Leventhal, H., Ozakinci, G., Porter, K.. "Subjective and objective risk of ovarian cancer in women at risk to carry mutations in BRCA1 and BRCA2.." Patient Education and Counseling. no. 70. (January 2008.): 135-142.

Clendenning M, Senter L, Hampel H, Lagerstedt Robinson K, Sun S, Buchanan D, Walsh M, Nilbert M, Green J, Potter J, Lindblom A, de la Chapelle A. "A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome.." Journal of Medical Genetics. no. 45. (January 2008.): 340-345.

Senter,Leigha; Clendenning,Mark; Sotamaa,Kaisa; Hampel,Heather; Green,Jane; Potter,John,D; Lindblom,Annika; Lagerstedt,Kristina; Thibodeau,Stephen,N; Lindor,Noralane,M; Young,Joanne; Winship,Ingrid; Dowty,James,G; White,Darren,M; Hopper,John,L; Baglietto,Laura; Jenkins,Mark,A; de la Chaple,Albert. "The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations." GASTROENTEROLOGY. Vol. 135, no. 2. (August 2008.): 419-428.

Senter, L. and Chun, N.. "Genetic testing: applying scientific discovery to clinical practice." Community Oncology. Vol. 5, no. 12. (December 2008.): 660-664.

Jackson C, Holter S, Pollett A, de la Chapelle A, Clendenning M, Chou S, Senter L, Ramphal R, Gallinger S, Boycott K. "Café-au-lait macules and pediatric malignancy with recessively inherited mutations in the DNA mismatch repair (MMR) gene PMS2: Case report and review of the literature." Pediatric Blood and Cancer. no. 50. (January 2008.): 1268-1270.

Zighelboim I, Powell MA, Babb SA, Whelan AJ, Schmidt AP, Clendenning M, Senter L, Thibodeau SN, de la Chapelle A, Goodfellow PJ.. "Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch Syndrome." Familial Cancer. Vol. 4, no. 8. (January 2009.): 501-504.

Senter, L and Friedman, S. "Mixed Blessings: Genetic Counselor Perspective." Community Oncology. Vol. 6, no. 1. (January 2009.): 46-48.

Vahteristo, P; Koski, TA; Naatsaari, L; Kiuru, M; Karhu, A; Herva, R; Sallinen, SL; Vierimaa, O; Bjorck, E; Richard, S; Gardie, B; Bessis, D; Van Glabeke, E; Blanco, I; Houlston, R; Senter, L; Hietala, M; Aittomaki, K; Aaltonen, LA; Launonen, V; Lehtonen, R. "No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome." FAMILIAL CANCER. Vol. 9, no. 2. (June 2010.): 245-251.

Weissman S, Burt R, Church J, Erdman S, Hampel H, Holter S, Jasperson K, Kalady M, Haidle J, Lynch H, Palaniappan S, Wise P, Senter L. "NSGC Practice Guidelines for the Genetics Management of Lynch Syndrome." Journal of Genetic Counseling. (December 2011.): -.

Riley B, Culver J, Skrzynia C, Senter L, Peters J, Costalas J, Callif-Daley F, Grumet S, Hunt K, Nagy R, McKinnon W, Petrucelli N, Bennett R, Trepanier A. "Essential Elements of Genetic Cancer Risk Assessment, Counseling, and Testing: Updated Recommendations of the National Society of Genetic Counselors." Journal of Genetic Counseling. (December 2011.): -.

McGee J, Kotsopoulos J, Lubinski J, Lynch H, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes W, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, and Narod SA. "Anthropometric Measures and Risk of Ovarian Cancer Among BRCA1 and BRCA2 Mutation Carriers." Obesity. (January 2011.): -.

Mavaddat N, Barrowdale D, AndrulisIL, Domchek SM, Eccle D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O’Malley F, John EM, Janavicius R, Tihomirova L, O Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Benítez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, HEBON, EMBRACE1, Peock S, Frost S, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, Weaver J, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schönbuchner I, Gevensleben H, GEMO Study Collaborators, Stoppa-Lyonnet D, Belotti M, Barjhoux L, Isaacs C, Peshkin BN, Caldes T, de al Hoya M, Cañadas C, Heikkinen T, Heikkilä P, Aittomäki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D’Andrea E, Yan M, Fox S, kConFab Investigators, Rebbeck TR Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, SWE-BRCA Collaborators, Steele L, Neuhausen SL, Nussbaum B, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC on behalf of the Consortium of Investigators of Modifiers of BR. "Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results for the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)." Epi, Biomarkers, and Prevention. (January 2011.): -.

Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, Lambrechts D, Despierre E, Barrowdale D, McGuffog L, Healey S, Easton DF, Sinilnikova O, Benitez J, Garcia MJ, Neuhausen S, Gail MH, Hartge P, Peock S, Frost D, Evans G, Eeles R, Godwin AK, Daly MB, Kwong A, Ma ESK, Lazaro C, Blanco I, Montagna M, D’Andrea E, Nicoletto O, Johnatty SE, Kjaer SK, Jensen A, Hogdall E, Goode EL, Fridley BL, Loud JT, Greene MH, Mai PL, Chetrit A, Lubin FC, Hirsh-Yechezkel G, Blendon G, Andrulis IL, Toland AE, Senter, L, Gore ME, Gourley C, Michie CO, Song H, Tyrer J, Whittemore AS, McGuire V, Sieh W, Kristoffersson U, Olsson H, Borg A, Levine DA, Steele L, Beattie MS, Chan S, Nussbaum RL, Moysich KB, Gross J, Cass I, Walsh C, Li AJ, Leuchter R, Gordon O, Garcia-Closas M, Gayther S, Chanock SJ, Antoniou AC, and Pharoah PDP. "Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer." JAMA. (January 2012.): -.

Bellcross CA; Bedrosian SR; Daniels E; Duquette D; Hampel H; Jasperson K; Joseph DA; Kaye C; Lubin I; Meyer LJ; Reyes M; Scheuner MT; Schully SD; Senter L; Stewart SL; St Pierre J; Westman J; Wise P; Yang VW; Khoury MJ. "Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.." Genetics In Medicine: Official Journal Of The American College Of Medical Genetics. Vol. 14, no. 1. (January 2012.): 152-.

 

Reference Works

January 2007 Senter L, Stephens J, Agnese D."Predictors of progression to malignancy or BI-RADS 4: Can we determine what BI-RADS 3 lesions should be biopsied?" .
January 2007 Senter L, Clendenning M, Hampel H, Sotamaa K, de la Chapelle A.."Clinical phenotype of individuals with germline mutations in the PMS2 gene." . : 31
January 2007 S Holter, A Pollett, G Zogopoulos, H Kim, K Boycott, CC Jackson, S Chou, L Senter, M Clendenning, A de la Chapelle, S Gallinger.."Hepatic Adenomas caused by TCF1 Mutations in Patients with Biallelic Germline Mismatch Repair Gene Mutations" .
January 2007 Boycott KM, Jackson C-C, Chou S, Ramphal R, Pollett A, Holter S, Senter L, Clendenning M, Gallinger S.."Cafe-au-lait macules and malignancy with recessively inherited mutations in DNA mismatch repair (MMR) genes: Case report and review of the literature." . : 72
January 2008 L Senter, M Clendenning, S Sun, J Panescu, S Gallinger, J Mackay, J Larsen Haidle, M Greenblatt, J Young, A de la Chapelle.."Founder Mutations in PMS2." .
January 2010 Senter L, Sweet K, Gnanadesikan S, Newman D, Toland AE."VUS Predict: a web-based toll for classifying BRCA variants of uncertain significance" Dallas.
January 2010 Senter L, Sweet K, Gnanadesikan S, Newman D, Toland AE."VUS Predict: a web-based tool for classifying BRCA variants of uncertain significance" Washington DC.
January 2011 Jarvinen TM, Liyanarachchi S, Comeras I, Senter L, Lozanski G, Hertlein E, Byrd JC, de la Chapelle A.."Linkage study suggests common genetic determinants for chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis" .
January 2011 Pamarti AK, Lerner B, Roche P, Senter L.."Genetics Information Nondiscrimination Act (GINA) and Its Affect on Genetic Counseling Practice: A Survey of Genetic Counselors" .

Presentations

"PMS2: Differences between monoallelic and biallelic mutation carriers." Presented at National Society of Genetic Counselors Annual Education Conference, Los Angeles, CA, US|USA. (October 2008)

"Hot Topics: Clinical Sciences." Presented at Collaborative Group of the Americas-Inherited Colorectal Cancer (CGA-ICC) Annual Meeting, Honolulu, HI, US|USA. (October 2009)

"GINA: Process and Implications." Presented at American Society of Human Genetics Annual Meeting, Honolulu, HI, US|USA. (October 2009)

"Cancer Family History: Basics." Presented at National Society of Genetic Counselors Online Course, . (July 2010)

"Implementing IHC at Your Insitution." Presented at Collaborative Group of the Americas-Inherited Colorectal Cancer Annual Meeting, Dallas, TX, US|USA. (November 2010)

"GINA: The Process and Implications." Presented at National Society of Genetic Counselors Annual Education Conference, Dallas, TX, US|USA. (November 2010)

 

Professional Activities

2007 - present Expedited Reviewer, Biomedical Institutional Review Board. The Ohio State University.
2009 - 2010 Chair, Audrey Heimler Special Projects Committee. National Society of Genetic Counselors.
2009 - 2010 Certification Examination Item Writer. American Board of Genetic Counseling.
2006 - 2011 Member, Biomedical Institutional Review Board. The Ohio State University.