1645 Neil Ave
Columbus, OH 43210
Phone: (614) 293-9873
Associate Professor, Pathology
Associate Professor, SBS-Biomedical Informatics
Associate Professor, Human Genetics
Associate Professor, Pulm,Allergy,Crit Care & Sleep
Academic pathologist specializing in Transfusion Medicine, Coagulation, and Translational/and Basic Research
Currently funded grants/or contracts 1) RO1 HL083478-01 (PI: Dr. Philip Diaz) 2005 – 2010 NIH, NHLBI Title: Alveolar macrophage proteomics in HIV-induced emphysema This longitudinal study applies functional proteomics to understand the pathophysiology of accelerated lung disease occurring in HIV-seropositive smokers. Role: Co-PI (25% effort) Budget: A total of $1,375,000, direct, with 40% of total award allocated to Dr. Wu in Pathology 2)Industrial sponsored research 2006-2008 Ciphergen Biosystems Title: SELDI-TOF-MS-based Diagnostic Test for Thrombotic Thrombocytopenic Purpura: Test Optimization and Preliminary Validation. Role: Principal Investigator (7.5%) Budget: $100,000 with a full indirect (total at $149.500) 3)OSUMC SIG grant 2007 - 2009 Evaluation of Genetic Susceptibility to Chronic Obstructive Pulmonary Disease (COPD) through Proteomics. Role: Principal Investigator Budget: $75,000, direct 4) OSUMC SIG grant 2007 - 2009 Discovery of Biomarker(s) for Surveillance of Thrombotic Thrombocytopenic Purpura (TTP) recurrences. Role: Principal Investigator Budget: $75,000, direct 5)RO1 NIH, NIHLB (PI: Dr. Clay Marsh) 2007 – 2012 Title: Intracellular pathways of monocyte survival Role: Co-I (5%) 6) R01 HL090313 (PI: Dr. Philip Diaz) 2007-2012 Smoking cessation and the natural history of HIV-induced emphysema Role: Co-PI (12%), Budget: A total of $2,745,890, direct, with 20 % of total award allocated to Dr. Wu in Pathology 7)Archemix Corp 2008 Evaluation of Biomarkers in TTP and associated cardiac and cerebral sequelae: clinical trial. Role: Principal Investigator Budget: $33,400, direct. 8)Roche Diagnostics 2008 -2009 Title: Test development and validation for measurement of ADAMTS13 in Primates Role: Principal Investigator Budget: $15,000, direct, for phase 1 and a proposed $80,000, direct, for phase 2.
|2000 - present||Medical License: New York State Medical Board|
|2001 - present||Medical License: State Medical Board of Ohio|
|2001 - present||Board certified: American Board of Pathology|
|2002 - present||Board certified: American Board of Pathology|
Melanie Kennedy and Haifeng Wu. "Transfusion Therapy and Transfusion in Transplantation." In Modern Blood Banking and Transfusion Practices. 5 ed. Edited by D.M. Harmening. 303-321. Philadelphia, PA, US|USA: F.A. Davis Company, January 2005.
|04/01/2001||Directorship of Clinical Coagulation Laboratory|
|04/01/2001||Attending Physician in Transfusion Medicine and Apheresis (Pathology)|
Evaluation and Validation of SELDI-based Diagnostic Test
Evaluation of Biomarkers Corresponding to Cardiac and Cerebral sequelae in Thrombotic Thrombocytopenic Purpura
Wu,H,M; Cataland,S,R; Kennedy,M,S; Lin,S; Jin,M. "Low ADAMTS13 activity in clinical remission predicts the risk of TTP relapses." In TRANSFUSION. (September 2007). 14A-.
Wu,H; Cataland,S. "Clinical utility of ADAMTS13 biomarkers in the evaluation of TTP." In TRANSFUSION. (September 2008). 256A-.
Wu,H; Yang,S. "Relationship Between ADAMTS13 Antibody Property and TTP's Clinical Outcomes." In TRANSFUSION. (September 2010). 14A-.
|1984||M.D., China Medical University|
|1988||M.S., China Medical University|
|present||Journal of COPD|
|present||Clinical and Epidemiology Allergy|
|2003||Davis Medical Research Award. OSUMC.|
|2006||Junior Investigator Award. American Society for Apheresis.|
|2009 - present||Clinical Pathology Teaching Award. Department of Pathology.|
Cohen WM, Wu HF, Featherstone GL, Jenzano JW, Lundblad RL. "Linkage between blood-coagulation and inflammation - stimulation of neutrophil tissue kallikrein by thrombin." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 176, no. 1. (April 1991.): 315-320.
Wu HF, White GC, Workman EF, Jenzano JW, Lundblad RL. "Affinity-chromatography of platelets on immobilized thrombin - retention of catalytic activity by platelet-bound thrombin." THROMBOSIS RESEARCH. Vol. 67, no. 4. (August 1992.): 419-427.
Lundblad RL, Tsai J, Wu HF, Jenzano JW, White GC, Connolly TM. "Hydrophobic affinity-chromatography of human thrombin." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 302, no. 1. (April 1993.): 109-112.
Wu HF, Xu LH, Jenzano JW, Rinehart CA, Kaufman DG, Lundblad RL. "Expression of tissue kallikrein in normal and SV40-transfected human endometrial stromal cells." PATHOBIOLOGY. Vol. 61, no. 3-4. (May 1993.): 123-127.
Wu HF, Venezie RD, Cohen WM, Jenzano JW, Featherstone GL, Lundblad RL. "Identification of tissue kallikrein messenger-RNA in human neutrophils." AGENTS AND ACTIONS. Vol. 38, no. 1-2. (January 1993.): 27-31.
Wu HF, Lundblad RL, Church FC. "Neutralization of heparin activity by neutrophil lactoferrin." BLOOD. Vol. 85, no. 2. (January 1995.): 421-428.
Wu HF, Monroe DM, Church FC. "Characterization of the glycosamineoglycan-binding region of lactoferrin." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 317, no. 1. (February 1995.): 85-92.
Crago AM, Wu KF, Hoffman M, Church FC. "Monocytes chemoattractant activity of SER(195)-]ALA active-site mutant recombinant alpha-thrombin." EXPERIMENTAL CELL RESEARCH. Vol. 219, no. 2. (August 1995.): 650-656.
Wu HFM, Church FC. "Arginine 25 and arginine 28 of lactoferrin are critical for effective heparin neutralization in blood." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 412, no. 1. (April 2003.): 121-125.
Jin M, Opalek JM, Marsh CB, Wu HFM. "Proteome comparison of alveolar macrophages with monocytes reveals distinct protein characteristics." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 31, no. 3. (September 2004.): 322-329.
Wu HFM, Jin M, Marsh CB. "Toward functional proteomics of alveolar macrophages." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 288, no. 4. (April 2005.): L585-L595.
Cataland SR, Wu HM. "Immunotherapy for thrombotic thrombocytopenic purpura." CURRENT OPINION IN HEMATOLOGY. Vol. 12, no. 5. (September 2005.): 359-363.
Jin M, Drwal G, Bourgeois T, Saltz J, Wu HFM. "Distinct proteome features of plasma microparticles." PROTEOMICS. Vol. 5, no. 7. (May 2005.): 1940-1952.
Cataland SR, Jin M, Smith E, Stanek M, Wu HM. "Full evaluation of an acquired case of thrombotic thrombocytopenic purpura following the surgical resection of glioblastoma multiforme." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 4, no. 12. (December 2006.): 2733-2737.
Jin M, Cataland S, Bissell M, Wu HM. "A rapid test for the diagnosis of thrombotic thrombocytopenic purpura using surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF)-mass spectrometry." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 4, no. 2. (February 2006.): 333-338.
Wu HM, Cataland SR, Bissell M, Jin M. "Application of SELDI-TOF mass spectrometry in clinical evaluation of thrombotic thrombocytopenic purpura." SPECTROSCOPY. Vol. 20, no. 5-6. (January 2006.): 219-227.
Cataland SR, Jin M, Zheng XL, Georges JN, Wu HM. "An evaluation of cyclosporine alone for the treatment of early recurrences of thombotic thrombocytopenic purpura." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 4, no. 5. (May 2006.): 1162-1164.
Jin M, Diaz PT, Bourgeois T, Eng C, Marsh CB, Wu HM. "Two-dimensional gel proteome reference map of blood monocytes." PROTEOME SCIENCE. Vol. 4, (September 2006.): 16-.
Cataland SR, Jin M, Wu HM. "Rapid determination of ADAMTS13 activity improves clinical decision-making." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 82, no. 3. (March 2007.): 251-251.
Cataland SR, Jin M, Lin S, Kennedy MS, Kraut EH, George JN, Wu HM. "Ciclosporin and plasma exchange in thrombotic thrombocytopenic purpura: long-term follow-up with serial analysis of ADAMTS13 activity." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 139, no. 3. (November 2007.): 486-493.
Cataland SR, Wu HM. "Targeting the inhibitor of ADAMTS13 in thrombotic thrombocytopenic purpura." EXPERT OPINION ON PHARMACOTHERAPY. Vol. 8, no. 4. (March 2007.): 437-444.
Cataland SR, Jin M, Ferketich AK, Kennedy MS, Kraut EH, George JN, Wu HM. "An evaluation of ciclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpura." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 136, no. 1. (January 2007.): 146-149.
Varker KA, Biber JE, Kefauver C, Jensen R, Lehman A, Young D, Wu H, Lesinski GB, Kendra K, Chen HX, Walker MJ, Carson WE. "A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma." ANNALS OF SURGICAL ONCOLOGY. Vol. 14, no. 8. (August 2007.): 2367-2376.
Zhang X, Jin M, Wu H, Harris N, Green-Church K, Nagaraja H, Birmingham DJ, Yu C-Y, Hebert LA, Rovin BH. "Biomarker discovery for lupus nephritis through longitudinal urine proteomics." Kidney International. Vol. 74, no. 6. (January 2008.): 799-807.
Cataland SR, Jin M, Lin S, Kraut EH, George JN, Wu HM. "Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenicc purpura." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 83, no. 12. (December 2008.): 911-915.
Wu H, Birmingham DJ, Rovin B, Hackshaw KV, Haddad N, Haden D, Yu CY, Hebert LA. "D-dimer level and the risk for thrombosis in systemic lupus erythematosus." CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 3, no. 6. (November 2008.): 1628-1636.
Jin M, Casper TC, Cataland SR, Kennedy MS, Lin S, Li YJ, Wu HM. "Relationship between ADAMTS13 activity in clinical remission and the risk of TTP relapse." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 141, no. 5. (June 2008.): 651-658.
Cataland SR, Yang SB, Witkoff L, Kraut EH, Lin S, George JN, Wu HM. "Demographic and ADAMTS13 biomarker data as predictors of early recurrences of idiopathic thrombotic thrombocytopenic purpura." EUROPEAN JOURNAL OF HAEMATOLOGY. Vol. 83, no. 6. (December 2009.): 559-564.
Zheng XL, Wu HM, Shang D, Falls E, Skipwith CG, Cataland SR, Bennett CL, Kwaan HC. "Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura." HAEMATOLOGICA. Vol. 95, no. 9. (September 2010.): 1555-1562.
Viswanathan S, Rovin BH, Shidham GB, Raman SV, Weinberg M, Allenby P, George JN, Wu HM, Cataland SR. "Long-term, sub-clinical cardiac and renal complications in patients with multiple relapses of thrombotic thrombocytopenic purpura." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 149, no. 4. (May 2010.): 623-625.
Brodsky SV, Collins M, Park E, Rovin BH, Satoskar AA, Nadasdy G, Wu H, Bhatt U, Nadasdy T, Hebert LA. "Warfarin therapy that results in an International Normalization Ratio above the therapeutic range Is associated with accelerated progression of chronic kidney disease." NEPHRON CLINICAL PRACTICE. Vol. 115, no. 2. (January 2010.): C142-C146.
Hofmeister CC, Jin M, Cataland SR, Benson DM, Wu HM. "TTP disease course is independent of myeloma treatment and response." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 85, no. 4. (April 2010.): 304-306.
Wu HM, Xu L, Sedmak DD, Marsh CB, Wurster MW. "Personalized healthcare in clotting disorders." PERSONALIZED MEDICINE. Vol. 7, no. 1. (January 2010.): 65-73.
Yang S, Xu L, Wu HM. "Rapid multiplexed genotyping for hereditary thrombophilia by SELDI-TOF mass spectrometry." DIAGNOSTIC MOLECULAR PATHOLOGY. Vol. 19, no. 1. (March 2010.): 54-61.
Prescott HC, Wu HM, Cataland SR, Baiocchi RA. "Eculizumab therapy in an adult with plasma exchange-refractory atypical hemolytic uremic syndrome." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 85, no. 12. (December 2010.): 976-977.
Yang S, Xu L, Wu HM. "Rapid genotyping of single nucleotide polymorphisms influencing warfarin drug response by surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) mass spectrometry." JOURNAL OF MOLECULAR DIAGNOSTICS. Vol. 12, no. 2. (March 2010.): 162-168.
Birmingham DJ, Irshaid F, Nagaraja HN, Zou X, Tsao BP, Wu H, Yu CY, Hebert LA, Rovin BH. "The complex nature of serum C3 and C4 as biomarkers of lupus renal flare." LUPUS. Vol. 19, no. 11. (October 2010.): 1272-1280.
Raman R, Yang S, Wu HM, Cataland SR. "ADAMTS13 activity and the risk of thrombotic thrombocytopenic purpura relapse in pregnancy." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 153, no. 2. (April 2011.): 277-278.
Brodsky SV, Nadasdy T, Rovin BH, Satoskar AA, Nadasdy GM, Wu HM, Bhatt UY, Hebert LA. "Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate." KIDNEY INTERNATIONAL. Vol. 80, no. 2. (July 2011.): 182-190.
Cataland SR, Scully MA, Paskavitz J, Maruff P, Witkoff L, Jin M, Uva N, Gilbert JC, Wu HM. "Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 86, no. 1. (January 2011.): 87-89.
Yang S, Jin M, Lin S, Cataland S, Wu H. "ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome." HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. Vol. 96, no. 10. (October 2011.): 1521-1527.
Ware K, Brodsky P, Satoskar AA, Nadasdy T, Nadasdy G, Wu H, Rovin BH, Bhatt U, Von Visger J, Hebert LA, Brodsky SV. "Warfarin-related nephropathy modeled by nephron reduction and excessive anticoagulation." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 22, no. 10. (October 2011.): 1856-1862.
Cataland SR, Wu HM. "Practical issues in ADAMTS13 testing and emerging therapies in thrombotic thrombocytopenic purpura." SEMINARS IN HEMATOLOGY. Vol. 48, no. 4. (October 2011.): 242-250.
Cataland SR, Geyer S, Yang S, Wu H. "Pretreatment ADAMTS13 activity predicts clinical outcome in patients with acquired thrombotic thrombocytopenic purpura (TTP)." BLOOD. Vol. 118, no. 21. (November 2011.): 968-969.
Cataland SR, Peyvandi F, Mannucci PM, Laemmle B, Hovinga JAK, Machin SJ, Scully M, Rock G, Gilbert JC, Yang S, Wu H, Jilma B, Knoebl P. "Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 87, no. 4. (April 2012.): 430-432.
Cataland SR, Yang S, Wu HM. "The use of ADAMTS13 activity, platelet count, and serum creatinine to differentiate acquired thrombotic thrombocytopenic purpura from other thrombotic microangiopathies." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 157, no. 4. (May 2012.): 501-503.
Lotta LA, Wu HM, Mackie IJ, Noris M, Veyradier A, Scully MA, Remuzzi G, Coppo P, Liesner R, Donadelli R, Loirat C, Gibbs RA, Horne A, Yang S, Garagiola I, Musallam KM, Peyvandi F. "Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura." BLOOD. Vol. 120, no. 2. (July 2012.): 440-448.
Cataland SR, Wu HM. "Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Clinically differentiating the thrombotic microangiopathies." European Journal of Internal Medicine. Vol. 1, (June 2013.): Epub ahead of print-.
Lotta LA, Wu HM, Musallam KM, Peyvandi F. "The emerging concept of residual ADAMTS13 activity in ADAMTS13-deficient thrombotic thrombocytopenic purpura." BLOOD REVIEWS. Vol. 27, no. 2. (March 2013.): 71-76.
Lotta LA, Wu HM, Cairo A, Bentivoglio G, Peyvandi F. "Drop of residual plasmatic activity of ADAMTS13 to undetectable levels during acute disease in a patient with adult-onset congenital thrombotic thrombocytopenic purpura." BLOOD CELLS MOLECULES AND DISEASES. Vol. 50, no. 1. (January 2013.): 59-60.
Wu TC, Yang S, Haven S, Holers VM, Lundberg AS, Wu H, Cataland SR. "Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpura." Journal of Thrombosis and Haemostasis. Vol. 1, (August 2013.): Epub ahead of print-.
Haifeng Wu and Frank C. Church. "Use of lactoferrin to modulate and/or neutralize heparin activity."
Haifeng M. Wu, Ming Jin, Spero Cataland, Michael Bissell. "A diagnosis test for Thrombotic Thrombocytopenic Purpura using SEDLI-TOF-mass spectrometer." Filed January 2007.
Haifeng Wu, Shangbin Yang and Lihui Xu. "SNP Genotyping by Surface Enhanced Laser Desorption and Ionization (SELDI) mass spectrometer." Filed January 2008.