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1645 Neil Ave
Columbus, OH 43210

Phone: (614) 293-9873

Email: wu.395@osu.edu

 

Current OSU Appointments

Associate Professor, Pathology

Associate Professor, SBS-Biomedical Informatics

Associate Professor, Human Genetics

Associate Professor, Pulm,Allergy,Crit Care & Sleep

Physician, FGP-Pathology

 

Biographical

I am an academic physician who has been fully committed to research, clinical practice, and higher education at the Ohio State University since 2001. For research, I have developed a national/international leading program in the field of thrombotic microangiopathy. My research laboratory has been continuously funded by grants since 2001 and has published more than 50 peer reviewed papers in the top journals in the field. For clinical practice, I have been an attending physician in the blood bank and apheresis services treating patients and educating medical professionals. At same time, I have been directing two clinical laboratories at OSUWMC. For education, I have been actively involved in teaching medical residents, clinical fellows, medical students, postdoctoral fellows, graduate students and mentoring undergraduates, postdoctors and clinical fellows for research. Between 2010 and 2012, I served as the program director for the Transfusion Medicine Fellowship at OSUWMC. I received the teaching award for clinical pathology in 2009.

Clinical Interest

Clinical Pathology, Hematology

Coagulation

Transfusion Medicine

Advising Narrative

Trudy C Wu is an OSU undergraduate student in Biology. She did a research project in my laboratory in the summer of 2012. Trudy presented her research work orally at the annual meeting for American Society of Hematology in 2012 and she received a prestigious Abstract Achievement Award for her presentation. Her research work was later published in the Journal of Thrombosis and Hemostasis (IF of 6.00) with her as the first author.

Postdoctoral / Researcher Advising

1) Ming Jin, MD, PhD. Dr. Jin was trained as a postdoctoral researcher in my laboratory between 2002 and 2008. During her tenure, she published many papers as shown below and now she is a faculty member in the department of Pathology at OSU.



Yang S, Jin M, Lin S, Cataland S, Wu H. ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome. Haematologica, 96(10):1521-7, 2011.



Cataland SR, Scully MA, Paskavitz J, Maruff P, Witkoff L, Jin M, Uva N, Gilbert JC, Wu HM. Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura. Am J Hematol. 2011 Jan;86(1):87-9.



Cataland SR, Scully MA, Paskavitz J, Maruff P, Witkoff L, Jin M, Uva N, Gilbert JC, Wu HM. Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura. Am J Hematol. 2011 Jan;86(1):87-9.



Hofmeister C, Jin M, Cataland SR, Benson D, Wu H. TTP disease course is independent of myeloma treatment and response. American Journal of Hematology, 85(4):304-6, 2010.



Cataland S, Jin M, Lin S, Kraut E, George J, Wu H. Cyclosporine May Be Effective Prophylactic Therapy in Patients with Idiopathic Thrombotic Thrombocytopenic Purpura. Am J Hematology, 83(12):911-5, 2008.



Zhang X, Jin M, Wu H, Harris N, Green-Church K, Nagaraja H, Birmingham DJ, Yu CY, Hebert LA, Rovin BH. Biomarker Discovery for Lupus Nephritis Through Longitudinal Urine Proteomics. Kidney International, 74 (6), 799-807, 2008.



Jin M, Casper TC, Cataland SR, Kennedy MS, Lin S, Li YJ, Wu H. Relationship between ADAMTS13 activity in clinical remission and the risk of TTP relapse. British Journal of Haematology, 141 (5), 651-658, 2008.



Cataland S, Jin M, Lin S, Kennedy M, Kraut E, George J, Wu H. Concurrent Cyclosporine and Plasma Exchange in Idiopathic Thrombotic Thrombocytopenic Purpura: long-term follow-up with serial analysis of ADAMTS13 activity. British Journal of Haematology, 139(3): 486-493, 2007



Cataland S, Jin M, Ferketich A, Kennedy K, Kraut E, George J, Wu H. An Evaluation of Cyclosporine and Corticosteroids Individually as Adjuncts to Plasma Exchange in the Treatment of Thrombotic Thrombocytopenic Purpura. British Journal of Haematology, 136 (1) 146-149, 2007.



Cataland S, Jin M, Wu H. Rapid determination of ADAMTS13 activity improves clinical decision-making (Letter to the editor). Am J Hematol, 82(3), 251, 2007.



Cataland S, Jin M, Smith E, Stanek M, Wu H. Full Evaluation of an Acquired Case of TTP Following the Surgical Resection of Glioblastoma Multiforme. Journal of Thrombosis Haemostasis,. 4(12): 2733-7, 2006.



Jin M, Diaz P, Bourgeois T, Eng C, Marsh C, Wu H. Two-dimensional gel proteome reference map of blood monocytes. Proteome Science, 4(1):16, 2006.



Cataland S, Jin M, Zheng L, George J, Wu H. An Evaluation of Cyclosporine Alone For the Treatment of Early Recurrences of TTP. Journal of Thrombosis and Hemostasis, 4, 1162-1164, 2006



Jin M, Cataland S, Bissell M, Wu H. A rapid test for the diagnosis of Thrombotic Thrombocytopenic Purpura using surface enhanced laser desorption and ionization time-of-flight mass spectrometry. Journal of Thrombosis and Hemostasis, 4: 333–338. 2006



Jin M, Drwal G, Bourgeois T, Saltz J and Wu H: Distinct Proteome Features of Plasma Microparticles. Proteomics, 5(7): 1940-1952. 2005.



Jin M, Opalek J, Marsh C, and Wu H: Proteome Comparison of Alveolar Macrophages with Monocytes Reveals Distinct Protein Characteristics. American Journal of Respiratory Cell and Molecular Biology, 31(3):322-9. 2004.



2) Shangbin Yang, Ph.D. Dr. Yang was trained as a postdoctoral researcher in my laboratory between 2007 and 2012. He is now a research faculty in the Department of Pathology at OSU. He has published many papers during his training in my laboratory.



Jennifer Yui, V. Michael Holers, Shangbin Yang, Haifeng M. Wu, and Spero R Cataland. Clinical Utility of Complement Biomarkers in the Diagnosis and Treatment of Acute Thrombotic Microangiopathies. British Journal of Haematology, in press 2014



Wu N, Liu J, Yang S, Kellett E, Cataland SR, Li H, Wu HM. Diagnostic and prognostic values of ADAMTS13 activity measured during daily plasma exchange therapy in patients with acquired TTP. Transfusion, in press 2014.



Cataland SR, Holers VM, Yang S, Wu HM. Biomarkers of the alternative pathway and terminal complement activity at presentation confirms the clinical diagnosis of aHUS and differentiates aHUS from TTP. Blood 2014 Apr 2 [Epub ahead of print]



Wood KL, Diaz PT, Rahmanian SD, King M, Wu H, Yang S, Lin S, Horne A. Gender Differences in Pulmonary Function, Respiratory Symptoms and Macrophage Proteomics among HIV-Infected Smokers. Journal of COPD. 2014, In press



Wu TC, Yang S, Haven S, Holers VM, Lundberg AS, Wu H, Cataland SR. Complement Activation and Mortality During an Acute Episode of Thrombotic Thrombocytopenic Purpura. J Thromb Haemost. 11(10):1925-7, 2013.



Lotta LA, Wu HM, Mackie IJ, Noris M, Veyradier A, Scully MA, Remuzzi G, Coppo P, Liesner R, Donadelli R, Loirat C, Gibbs RA, Horne A, Yang S, Garagiola I, Musallam KM, Peyvandi F. Residual plasmatic activity of ADAMTS13 correlates with phenotype severity in congenital thrombotic thrombocytopenic purpura. Blood. 2012, 120(2):440-8



Cataland SR, Peyvandi F, Mannucci PM, Lämmle B, Kremer Hovinga JA, Machin SJ, Scully M, Rock G, Gilbert JC, Yang S, Wu H, Jilma B, Knoebl P. Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura. Am J Hematol. 87(4):430-2, 2012



Cataland SR, Yang SB, Wu HM. The Use of ADAMTS13 Activity, Platelet Count, and the Serum Creatinine to Differentiate Acquired TTP from other Thrombotic Microangiopathies. British Journal of Haematology, 157(4):501-3, 2012.



Yang S, Jin M, Lin S, Cataland S, Wu H. ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome. Haematologica, 96(10):1521-7, 2011.



Raman R, Yang S, Wu HM, Cataland SR. ADAMTS13 Activity and the Risk of Thrombotic Thrombocytopenic Purpura Relapse in Pregnancy. British Journal of Heamatology, 153(2):277-9, 2011.



Yang SB, Xu LH, Wu H. Rapid Genotyping of SNPs Influencing Warfarin Drug Response by SELDI-TOF Mass Spectrometry. Journal of Molecular Diagnostics, 12(2),162-8, 2010. PMID: 20075209



Yang SB, Xu LH, Wu H. Rapid Multiplexed Genotyping for Hereditary Thrombophilia by SELDI-TOF Mass Spectrometer. Diagnostic Molecular Pathology, 19(1):54-61, 2010. PMID: 20186013



Cataland S, Yang, S, Witkoff, L, Lin S, Kraut E, George J, Wu H. Demographic and ADAMTS13 Biomarker Data as Predictors of Early Recurrences of Idiopathic Thrombotic Thrombocytopenic Purpura. European Journal of Hematology, 83(6):559-64, 2009

Academic Advising

2013 - present Jian Chen The Ohio State University.
2000 - 2001 Joseph Woods The Ohio State University. Graduated 2001.
2001 - 2002 Barrie Siegfried The Ohio State University. Graduated 2002.
2002 - 2003 Maria Reed The Ohio State University. Graduated 2003.
2003 - 2004 Nada Rikabi The Ohio State University. Graduated 2004.
2005 - 2006 Nawwar Swedan The Ohio State University. Graduated 2006.
2008 - 2010 Byeong Ha The Ohio State University. Graduated 2010.
2009 - 2012 Sara Haven The Ohio State University.
2011 - 2012 Beth Biller The Ohio State University. Graduated 2012.
2012 - 2013 Trudy C The Ohio State University. Graduated 2014.
2013 Nan Wu The Ohio State University.
2013 - 2014 Irmeen Siddiqui The Ohio State University. Graduated 2014.
 

Certifications

2000 - present Medical License: New York State Medical Board
2001 - present Medical License: State Medical Board of Ohio
2001 - present Board certified: American Board of Pathology
2002 - present Board certified: American Board of Pathology
 

Chapters in Books

Melanie Kennedy and Haifeng Wu. "Transfusion Therapy and Transfusion in Transplantation." In Modern Blood Banking and Transfusion Practices. 5 ed. Edited by D.M. Harmening. 303-321. Philadelphia, PA, US|USA: F.A. Davis Company, January 2005.

 

Clinical Services

04/01/2001 Directorship of Clinical Coagulation Laboratory (OSUMC)
04/01/2001 Attending Physician in Transfusion Medicine and Apheresis (Pathology)
08/01/2007 Director of Biomarker Reference Laboratory (OSUMC)
07/01/2010 - 07/01/2012 Program director of Transfusion Medicine Fellowship (OSUMC)

Conferences

Cataland SR, George JN, Kraut EH, Bourgeois TT, Ferketich AK, Kennedy MS, Caligiuri MA, Wu HFM. "Improved Clinical Outcome and ADAMTS13 Activity Following Cyclosporine Therapy in Patients with TTP." In BLOOD. (November 2004). 243A-.

Jin M, Drwal G, Bourgeois T, Saltz J, Wu HM. "Distinct Proteome Features of Plasma Microparticles." In MOLECULAR & CELLULAR PROTEOMICS. (October 2004). S219-.

Drwal G, Jin M, Marsh C, Wu H. "Proteomics and Phosphoproteomics Generate New Directions in the Study of Macrophage Function and Differentiation." In MOLECULAR & CELLULAR PROTEOMICS. (October 2004). S24-.

Leuenberger,K,P; Cataland,S; Jin,M; Orr,C; Marcucci,G; Kraut,E,H; Wu,HM. "Distinguishing Antiphospholipid Antibodies from an Acquired Factor Inhibitor: A Novel Laboratory Approach." In BLOOD. (November 2005). 608A-.

Cataland SR, Jin M, Ferketich AK, Kraut EH, George JN, Wu HM. "Cyclosporine and Plasma Exchange is Superior to Corticosteroids and Plasma Exchange as Initial Therapy of TTP." In BLOOD. (November 2005). 359A-.

Cataland SR, Jin M, Ferketich AK, Zheng XL, George JN, Wu HM. "Cyclosporine Alone for the Treatment of Early Recurrences of TTP." In BLOOD. (November 2005). 359A-360A.

Wu HF, Cataland S, Bissell M, Jin M. "A Rapid Test for the Diagnosis of Thrombotic Thrombocytopenic Purpura using SELDI-TOF-mass Spectrometry." In BLOOD. (November 2005). 746A-747A.

Cataland SR, Kraut EH, Benson D, Ferketich AK, Horne A, Jin M, George JN, Wu HM. "Improved Clinical Outcome and ADAMTS13 Activity After Concurrent Cyclosporine and Plasma Exchange in TTP." In BLOOD. (November 2006). 314A-.

Cataland SR, Jin M, Lin S, Kennedy M, Kraut EH, George JN, Wu HM. "ADAMTS13 Antigen Levels and the Risk of Relapse during Long-term Clinical Follow Up of Patients with Idiopathic Thrombotic Thrombocytopenic Purpura." In BLOOD. (November 2007). 940A-941A.

Cataland SR, Jin M, Lin S, Horne A, Kraut EH, George JN, Wu HM. "Cyclosporine is Effective Prophylactic Therapy in Preventing Recurrences of TTP." In TRANSFUSION. (September 2007). 51A-52A.

Wu HM, Cataland SR, Kennedy MS, Lin S, Jin M. "Low ADAMTS13 Activity in Clinical Remission Predicts the Risk of TTP Relapses." In TRANSFUSION. (September 2007). 14A-.

Wu HM, Casper TC, Cataland SR, Lin S, Kennedy M, Jin M. "Low ADAMTS13 Activity in Clinical Remission Predicts the Risk of TTP Relapses." In BLOOD. (November 2007). 73B-.

Cataland S, Yang S, Horne A, Lin S, George J, Wu H. "Lower ADAMTS13 Activity and Higher Bethesda Units of Antibody Inhibitor in Early Remission Are Associated with a Higher Probability of TTP Exacerbation.." In BLOOD. (November 2008). 802-.

Wu H, Cataland S. "Clinical Utility of ADAMTS13 Biomarkers in the Evaluation of TTP." In TRANSFUSION. (September 2008). 256A-.

Shang D, Wu H, Cataland S, Bennett CL, Kwaan HC, Zheng XL. "Multiple Non-Linear Epitopes of ADAMTS13 Were Targeted by Anti-ADAMTS13 IgG in Patients with Acquired Idiopathic Thrombotic Thrombocytopenic Purpura." In BLOOD. (November 2008). 109-.

Zhang X, Jin M, Wu H, Nadasdy T, Nadasdy G, Harris N, Green-Church K, Nagaraja H, Birmingham DJ, Yu CY, Hebert LA, Rovin BH. "Biomarkers of lupus nephritis determined by serial urine proteomics." In KIDNEY INTERNATIONAL. (September 2008). 799-807.

Cataland SR, Yang S, Jin M, Gilbert J, Wu HM. "S100 beta as a Sensitive Biomarker for Acute and Chronic Neurologic Injury in TTP Patients." In TRANSFUSION. (September 2009). 74A-.

Jin M, Yang S, Wu H. "Novel Application of SELDI-TOF Mass Spectrometer in Genotyping and Personalized Medicine." In MODERN PATHOLOGY. (February 2010). 434A-.

Jin M, Yang S, Wu HM. "Relationship Between ADAMTS13 Antibody Property and Thrombotic Thrombocytopenic Purpura's Clinical Outcomes." In AMERICAN JOURNAL OF CLINICAL PATHOLOGY. (October 2010). 674-675.

Yang S, Haven S, Jin M, Geyer S, Cataland SR, Wu H. "Longitudinal Analysis of VWF Multimerization Patterns In a well-defined TTP Cohort.." In BLOOD. (November 2010). 1748-.

Wu H, Biller E, Yang S, Kraut EH, Cataland S, Geyer S. "Comparison of Clinical Outcomes Between Initial and Relapsed Events of Thrombotic Thrombocytopenic Purpura In a Large TTP Cohort.." In BLOOD. (November 2010). 617-.

Wu H, Yang S. "Relationship Between ADAMTS13 Antibody Property and TTP's Clinical Outcomes." In TRANSFUSION. (September 2010). 14A-.

Cataland SR, Peyvandi F, Mannucci PM, Laemmle B, Kremmer Hovinga JA, Machin SJ, Scully M, Rock G, Gilbert J, Knoebl P, Yang S, Wu H, Jilma B. "A Randomized, Double-Blind, Placebo-Controlled, Clinical Outcome Study of ARC1779 In Patients with Thrombotic Thrombocytopenic Purpura (TTP)." In BLOOD. (November 2010). 320-.

Lotta LA, Wu HM, Scully MA, Noris M, Veyradier A, Mackie IJ, Remuzzi G, Coppo P, Liesner R, Donadelli R, Loirat C, Gibbs RA, Horne A, Yang S, Palla R, Peyvandi F. "Residual Plasmatic Activity of ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura Correlates with Disease Phenotype." In BLOOD. (November 2011). 966-966.

Jin M, Leuenberger K, Cataland S, Orr C, Wu H. "Differentiating Lupus Anticoagulant from an Acquired Factor Inhibitor Using Special Mixing Study." In MODERN PATHOLOGY. (February 2011). 303A-304A.

Wu TC, Yang S, Haven S, Holers VM, Lundberg AS, Wu H, Cataland SR. "Mortality From Thrombotic Thrombocytopenic Purpura Is Related to Complement Hyperactivation." In BLOOD. (November 2012). 0-.

Yang S, Cataland SR, Holers VM, Lundberg AS, Wu H. "Complement Activation in Patients with Acquired Thrombotic Thrombocytopenic Pupura (TTP)." In BLOOD. (November 2012). abstract-.

Cataland SR, Yang S, Wu H. "Pretreatment ADAMTS13 antibody concentration and age predicts relapse in patients with newly diagnosed acquired thrombotic thrombocytopenic pupura (TTP)." In JOURNAL OF THROMBOSIS AND HAEMOSTASIS. (December 2013). 72-73.

 

Degrees

1984 M.D., China Medical University

1988 M.S., China Medical University

 

Editorial Activities

2006 Proteomics
2007 Chest
2007 Cancer Research
2008 Clinical and Epidemiological Allergy
2009 - present Blood
2009 Circulation
2009 Journal of COPD
2010 - present Journal of Thrombosis and Hemostasis
2013 - present Haematologica
 

Honors

2006 Junior Investigator Award. American Society for Apheresis.
2009 - present Clinical Pathology Faculty Teaching Award. Department of Pathology.
 

Journal Articles

Cohen WM, Wu HF, Featherstone GL, Jenzano JW, Lundblad RL. "Linkage between blood-coagulation and inflammation - stimulation of neutrophil tissue kallikrein by thrombin." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 176, no. 1. (April 1991.): 315-320.

Wu HF, White GC, Workman EF, Jenzano JW, Lundblad RL. "Affinity-chromatography of platelets on immobilized thrombin - retention of catalytic activity by platelet-bound thrombin." THROMBOSIS RESEARCH. Vol. 67, no. 4. (August 1992.): 419-427.

Lundblad RL, Tsai J, Wu HF, Jenzano JW, White GC, Connolly TM. "Hydrophobic affinity-chromatography of human thrombin." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 302, no. 1. (April 1993.): 109-112.

Wu HF, Xu LH, Jenzano JW, Rinehart CA, Kaufman DG, Lundblad RL. "Expression of tissue kallikrein in normal and SV40-transfected human endometrial stromal cells." PATHOBIOLOGY. Vol. 61, no. 3-4. (May 1993.): 123-127.

Wu HF, Venezie RD, Cohen WM, Jenzano JW, Featherstone GL, Lundblad RL. "Identification of tissue kallikrein messenger-RNA in human neutrophils." AGENTS AND ACTIONS. Vol. 38, no. 1-2. (January 1993.): 27-31.

Wu HF, Lundblad RL, Church FC. "Neutralization of heparin activity by neutrophil lactoferrin." BLOOD. Vol. 85, no. 2. (January 1995.): 421-428.

Wu HF, Monroe DM, Church FC. "Characterization of the glycosamineoglycan-binding region of lactoferrin." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 317, no. 1. (February 1995.): 85-92.

Crago AM, Wu KF, Hoffman M, Church FC. "Monocytes chemoattractant activity of SER(195)-]ALA active-site mutant recombinant alpha-thrombin." EXPERIMENTAL CELL RESEARCH. Vol. 219, no. 2. (August 1995.): 650-656.

Wu HFM, Church FC. "Arginine 25 and arginine 28 of lactoferrin are critical for effective heparin neutralization in blood." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Vol. 412, no. 1. (April 2003.): 121-125.

Jin M, Opalek JM, Marsh CB, Wu HFM. "Proteome comparison of alveolar macrophages with monocytes reveals distinct protein characteristics." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 31, no. 3. (September 2004.): 322-329.

Wu HFM, Jin M, Marsh CB. "Toward functional proteomics of alveolar macrophages." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 288, no. 4. (April 2005.): L585-L595.

Cataland SR, Wu HFM. "Immunotherapy for thrombotic thrombocytopenic purpura." CURRENT OPINION IN HEMATOLOGY. Vol. 12, no. 5. (September 2005.): 359-363.

Ping PP, Vondriska TM, Creighton CJ, Gandhi TKB, Yang ZP, Menon R, Kwon MS, Cho SY, Drwal G, Kellmann M, Peri S, Suresh S, Gronborg M, Molina H, Chaerkady R, Rekha B, Shet AS, Gerszten RE, Wu HF, Raftery M, Wasinger V, Schulz-Knappe P, Hanash SM, Paik YK, Hancock WS, States DJ, Omenn GS, Pandey A. "A functional annotation of subproteomes in human plasma." PROTEOMICS. Vol. 5, no. 13. (August 2005.): 3506-3519.

Jin M, Drwal G, Bourgeois T, Saltz J, Wu HFM. "Distinct proteome features of plasma microparticles." PROTEOMICS. Vol. 5, no. 7. (May 2005.): 1940-1952.

Cataland SR, Jin M, Smith E, Stanek M, Wu HM. "Full evaluation of an acquired case of thrombotic thrombocytopenic purpura following the surgical resection of glioblastoma multiforme." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 4, no. 12. (December 2006.): 2733-2737.

Wu HM, Cataland SR, Bissell M, Jin M. "Application of SELDI-TOF mass spectrometry in clinical evaluation of thrombotic thrombocytopenic purpura." SPECTROSCOPY. Vol. 20, no. 5-6. (January 2006.): 219-227.

Jin M, Cataland S, Bissell M, Wu HM. "A rapid test for the diagnosis of thrombotic thrombocytopenic purpura using surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF)-mass spectrometry." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 4, no. 2. (February 2006.): 333-338.

Cataland SR, Jin M, Zheng XL, Georges JN, Wu HM. "An evaluation of cyclosporine alone for the treatment of early recurrences of thombotic thrombocytopenic purpura." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 4, no. 5. (May 2006.): 1162-1164.

Jin M, Diaz PT, Bourgeois T, Eng C, Marsh CB, Wu HM. "Two-dimensional gel proteome reference map of blood monocytes." PROTEOME SCIENCE. Vol. 4, (September 2006.): 16-.

Cataland SR, Jin M, Wu HM. "Rapid determination of ADAMTS13 activity improves clinical decision-making." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 82, no. 3. (March 2007.): 251-251.

Cataland SR, Jin M, Lin S, Kennedy MS, Kraut EH, George JN, Wu HM. "Cyclosporin and plasma exchange in thrombotic thrombocytopenic purpura: long-term follow-up with serial analysis of ADAMTS13 activity." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 139, no. 3. (November 2007.): 486-493.

Cataland SR, Wu HM. "Targeting the inhibitor of ADAMTS13 in thrombotic thrombocytopenic purpura." EXPERT OPINION ON PHARMACOTHERAPY. Vol. 8, no. 4. (March 2007.): 437-444.

Cataland SR, Jin M, Ferketich AK, Kennedy MS, Kraut EH, George JN, Wu HM. "An evaluation of ciclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpura." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 136, no. 1. (January 2007.): 146-149.

Varker KA, Biber JE, Kefauver C, Jensen R, Lehman A, Young D, Wu H, Lesinski GB, Kendra K, Chen HX, Walker MJ, Carson WE. "A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma." ANNALS OF SURGICAL ONCOLOGY. Vol. 14, no. 8. (August 2007.): 2367-2376.

Cataland S, Jin M, Lin S, Kraut EH, George JN, Wu HM. "Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenic purpura." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 83, no. 12. (December 2008.): 911-915.

Wu H, Birmingham DJ, Rovin B, Hackshaw KV, Haddad N, Haden D, Yu CY, Hebert LA. "D-dimer level and the risk for thrombosis in systemic lupus erythematosus." CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 3, no. 6. (November 2008.): 1628-1636.

Zhang X, Jin M, Wu H, Nadasdy T, Nadasdy G, Harris N, Green-Church K, Nagaraja H, Birmingham DJ, Yu CY, Hebert LA, Rovin BH. "Biomarkers of lupus nephritis determined by serial urine proteomics." KIDNEY INTERNATIONAL. Vol. 74, no. 6. (September 2008.): 799-807.

Jin M, Casper TC, Cataland SR, Kennedy MS, Lin S, Li YJ, Wu HM. "Relationship between ADAMTS13 activity in clinical remission and the risk of TTP relapse." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 141, no. 5. (June 2008.): 651-658.

Cataland SR, Yang SB, Witkoff L, Kraut EH, Lin S, George JN, Wu HM. "Demographic and ADAMTS13 biomarker data as predictors of early recurrences of idiopathic thrombotic thrombocytopenic purpura." EUROPEAN JOURNAL OF HAEMATOLOGY. Vol. 83, no. 6. (December 2009.): 559-564.

Viswanathan S, Rovin BH, Shidham GB, Raman SV, Weinberg M, Allenby P, George JN, Wu HM, Cataland SR. "Long-term, sub-clinical cardiac and renal complications in patients with multiple relapses of thrombotic thrombocytopenic purpura." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 149, no. 4. (May 2010.): 623-625.

Brodsky SV, Collins M, Park E, Rovin BH, Satoskar AA, Nadasdy G, Wu H, Bhatt U, Nadasdy T, Hebert LA. "Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease." NEPHRON CLINICAL PRACTICE. Vol. 115, no. 2. (January 2010.): C142-C146.

Hofmeister CC, Jin M, Catalano SR, Benson DM, Wu HM. "TTP disease course is independent of myeloma treatment and response." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 85, no. 4. (April 2010.): 304-306.

Wu HM, Xu L, Sedmak DD, Marsh CB, Wurster MW. "Personalized healthcare in clotting disorders." PERSONALIZED MEDICINE. Vol. 7, no. 1. (January 2010.): 65-73.

Zheng XL, Wu HM, Shang D, Falls E, Skipwith CG, Cataland SR, Bennett CL, Kwaan HC. "Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura." HAEMATOLOGICA. Vol. 95, no. 9. (September 2010.): 1555-1562.

Yang S, Xu L, Wu HM. "Rapid multiplexed genotyping for hereditary thrombophilia by SELDI-TOF mass spectrometry." DIAGNOSTIC MOLECULAR PATHOLOGY. Vol. 19, no. 1. (March 2010.): 54-61.

Prescott HC, Wu HM, Cataland SR, Baiocchi RA. "Eculizumab therapy in an adult with plasma exchange-refractory atypical hemolytic uremic syndrome." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 85, no. 12. (December 2010.): 976-977.

Yang S, Xu L, Wu HM. "Rapid genotyping of single nucleotide polymorphisms influencing warfarin drug response by surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) mass spectrometry." JOURNAL OF MOLECULAR DIAGNOSTICS. Vol. 12, no. 2. (March 2010.): 162-168.

Birmingham DJ, Irshaid F, Nagaraja HN, Zou X, Tsao BP, Wu H, Yu CY, Hebert LA, Rovin BH. "The complex nature of serum C3 and C4 as biomarkers of lupus renal flare." LUPUS. Vol. 19, no. 11. (October 2010.): 1272-1280.

Raman R, Yang S, Wu HM, Cataland SR. "ADAMTS13 activity and the risk of thrombotic thrombocytopenic purpura relapse in pregnancy." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 153, no. 2. (April 2011.): 277-278.

Brodsky SV, Nadasdy T, Rovin BH, Satoskar AA, Nadasdy GM, Wu HM, Bhatt UY, Hebert LA. "Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate." KIDNEY INTERNATIONAL. Vol. 80, no. 2. (July 2011.): 182-190.

Cataland SR, Scully MA, Paskavitz J, Maruff P, Witkoff L, Jin M, Uva N, Gilbert JC, Wu HM. "Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 86, no. 1. (January 2011.): 87-89.

Yang S, Jin M, Lin S, Cataland S, Wu H. "ADAMTS13 activity and antigen during therapy and follow-up of patients with idiopathic thrombotic thrombocytopenic purpura: correlation with clinical outcome." HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. Vol. 96, no. 10. (October 2011.): 1521-1527.

Ware K, Brodsky P, Satoskar AA, Nadasdy T, Nadasdy G, Wu H, Rovin BH, Bhatt U, Von Visger J, Hebert LA; Brodsky SV. "Warfarin-related nephropathy modeled by nephron reduction and excessive anticoagulation." JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 22, no. 10. (October 2011.): 1856-1862.

Cataland SR, Wu HM. "Practical issues in ADAMTS13 testing and emerging therapies in thrombotic thrombocytopenic purpura." SEMINARS IN HEMATOLOGY. Vol. 48, no. 4. (October 2011.): 242-250.

Cataland SR, Peyvandi F, Mannucci PM, Laemmle B, Kremer Hovinga JA, Machin SJ, Scully M, Rock G, Gilbert JC, Yang S, Wu H, Jilma B, Knoebl P. "Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura." AMERICAN JOURNAL OF HEMATOLOGY. Vol. 87, no. 4. (April 2012.): 430-432.

Cataland SR, Yang S, Wu HM. "The use of ADAMTS13 activity, platelet count, and serum creatinine to differentiate acquired thrombotic thrombocytopenic purpura from other thrombotic microangiopathies." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 157, no. 4. (May 2012.): 501-503.

Lotta LA, Wu HM, Mackie IJ, Noris M, Veyradier A, Scully MA, Remuzzi G, Coppo P, Liesner R, Donadelli R, Loirat C, Gibbs RA, Horne A, Yang S, Garagiola I, Musallam KM, Peyvandi F. "Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura." BLOOD. Vol. 120, no. 2. (July 2012.): 440-448.

Cataland SR, Wu HM. "Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Clinically differentiating the thrombotic microangiopathies." EUROPEAN JOURNAL OF INTERNAL MEDICINE. Vol. 24, no. 6. (September 2013.): 486-491.

Wu TC, Yang S, Haven S, Holers VM, Lundberg AS, Wu H, Cataland SR. "Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpura." JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 11, no. 10. (October 2013.): 1925-1927.

Lotta LA, Wu HM, Musallam KM, Peyvandi F. "The emerging concept of residual ADAMTS13 activity in ADAMTS13-deficient thrombotic thrombocytopenic purpura." BLOOD REVIEWS. Vol. 27, no. 2. (March 2013.): 71-76.

Lotta LA, Wu HM, Cairo A, Bentivoglio G, Peyvandi F. "Drop of residual plasmatic activity of ADAMTS13 to undetectable levels during acute disease in a patient with adult-onset congenital thrombotic thrombocytopenic purpura." BLOOD CELLS MOLECULES AND DISEASES. Vol. 50, no. 1. (January 2013.): 59-60.

Ryan M, Ware K, Qamri Z, Satoskar A, Wu H, Nadasdy G, Rovin B, Hebert L, Nadasdy T, Brodsky SV. "Warfarin-related nephropathy is the tip of the iceberg: direct thrombin inhibitor dabigatran induces glomerular hemorrhage with acute kidney injury in rats." NEPHROLOGY DIALYSIS TRANSPLANTATION. Vol. Epub ahead of print, (September 2013.): 1-.

Cataland SR, Wu HM. "Diagnosis and management of complement mediated thrombotic microangiopathies." BLOOD REVIEWS. Vol. 28, no. 2. (March 2014.): 67-74.

Rahmanian SD, Wood KL, Lin S, King MA, Horne A, Yang S, Wu HM, Diaz PT. "Gender differences in pulmonary function, respiratory symptoms, and macrophage proteomics among HIV-infected smokers." SCIENTIFICA. Vol. 2014, (January 2014.): 613689-.

Cataland SR, Holers VM, Geyer S, Yang S, Wu HM. "Biomarkers of the alternative pathway and terminal complement activity at presentation confirms the clinical diagnosis of aHUS and differentiates aHUS from TTP." BLOOD. Vol. 1, (April 2014.): Epub ahead of print (9.90)-.

Cataland SR, Wu HM. "How I treat: the clinical differentiation and initial treatment of adult patients with atypical hemolytic uremic syndrome." BLOOD. Vol. 123, no. 16. (April 2014.): 2478-2484.

Wu N, Liu J, Yang S, Kellett E, Cataland SR, Li H, Wu HM. "Diagnostic and prognostic values of ADAMTS13 activity measured during daily plasma exchange therapy in patients with acquired TTP." TRANSFUSION 2014. -.

Wood KL, Diaz PT, Rahmanian SD, King M, Wu H, Yang S, Lin S, Horne A. "Gender differences in pulmonary function, respiratory symptoms and macrophage proteomics among HIV-infected smokers." JOURNAL OF COPD 2014. -.

Yui J, Holers VM, Yang S, Wu HM, Cataland SR. "Clinical utility of complement biomarkers in the diagnosis and treatment of acute thrombotic microangiopathies." BRITISH JOURNAL OF HAEMATOLOGY 2014. -.

 

Inventions and Patents

Haifeng Wu, Shangbin Yang and Lihui Xu. "SNP Genotyping by Surface Enhanced Laser Desorption and Ionization (SELDI) mass spectrometer." Filed March 2010.

Haifeng M. Wu, Ming Jin, Spero Cataland, Michael Bissell. "A diagnosis test for Thrombotic Thrombocytopenic Purpura using SEDLI-TOF-mass spectrometer." Filed January 2007.

Haifeng Wu and Frank C. Church. "Use of lactoferrin to modulate and/or neutralize heparin activity." Filed May 1995.

 

Presentations

"Disease proteomics of plasma microparticles." Presented at Human Proteome Organization 3rd Annual World Congress, Beijing, CN|CHN. (October 2004)

"Disease Proteomics of mononuclear phagocytes and plasma microparticles." Presented at Seminar at Nebraska University Medical Center, Omaha, NE, US|USA. (April 2005)

"Clinical Proteomics." Presented at Presentation at the University of Illinois at Chicago, Chicago, IL, US|USA. (April 2006)

"Rapid determination of ADAMTS13 activity and autoantibody titers by SELDI-TOF mass spectrometer." Presented at College of American Pathologists, San Diego, CA, US|USA. (September 2006)

"Clinical proteomics: From technologies to discoveries, and ultimately to the patient bedside." Presented at Presentation at BD Biosciences, Franklin Lakes, NJ, US|USA. (October 2006)

"Clinical management of thrombotic thrombocytopenic purpura: yesterday, today, and tomorrow." Presented at Special Seminar at American Association of Blood Banks, San Diego, CA, US|USA. (June 2007)

"SELDI-based tests for diagnosis and clinical evaluation of TTP." Presented at Lecture sponsored by Quest Diagnostics, Chantilly, VA, US|USA. (September 2007)

"Chronic kidney disease (CKD) biomarker develeopment and validation." Presented at NIDDK CKD Biomarker Consortium Meeting, Washington DC, DC, US|USA. (January 2010)

"Translational research of thrombotic thrombocytopenic purpura." Presented at University of Florida, Gainesville, FL, US|USA. (August 2010)

"Autoimmune thrombotic thrombocytopenic purpura: Diagnosis, prognosis, and immune-based therapies." Presented at BIT's 2nd Annual World Congress of Immunodiseases and Therapy, Quangzhou, CN|CHN. (November 2011)

"Therapeutic monitoring of heparin therapy." Presented at International Conference of Laboratory Hematology, Hangzhou, CN|CHN. (September 2011)

"Differentiating TMA to accurately diagnose aHUS and optimize patient outcomes." Presented at Lecture Sponsored by Alexion Pharmaceuticals, Columbus, OH, US|USA. (November 2012)

"Translational study for improving clinical outcomes in thrombotic thrombocytopenic purpura." Presented at Clinical Pathology Grand Rounds, Philadelphia, PA, US|USA. (November 2012)

"Pathogenesis of TTP and complement activation." Presented at Lecture sponsored by Alexion Pharmaceuticals, Cambridge, MA, US|USA. (May 2012)

"Heparin-induced thrombocytopenia: laboratory diagnosis and connection to therapy." Presented at Northeastern Regional Symposium, Columbus, OH, US|USA. (June 2013)

"Translational study for improving clinical outcomes in acquired thrombotic thrombocytopenic purpura (TTP)." Presented at Grand Rounds, Indianapolis, IN, US|USA. (June 2013)

 

Professional Activities

present Advisory Board for Thrombotic Microangiopathy, Alexion Pharmaceuticals. Alexion Pharmaceuticals.
present Advisory Board for Thrombotic Thrombocytopenic Purpura/Atypical Hemolytic Uremic Syndrome. Alexion Pharmaceuticals.
- 2012 Advisory Board for Apheresis. Alexion Pharmaceuticals.
 

Unpublished Works

Yang, S, Cataland, SR, and Wu, HM. Differential Diagnosis of thrombotic microangiopathies by complement biomarkers.

Yang, S, McGookey, M, Cataland, SR, and Wu, HM. Effect of blood sampling, processing, and storage on the measurement of complement activation biomarkers. June 2014.

Yang, S, Cataland, SR, and Wu, HM. Longitudinal characterization of complement activities in a TTP cohort.

Yang, S and Wu, HM. Relationship between VWF multimer patterns and complement activities in TTP patients during clinical remission.

Wu, YY and Wu, HM. How I Treat HUS.