Amanda Toland, PhD
Department of Molecular Virology, Immunology, & Medical Genetics
Department of Internal Medicine's Division of Human Genetics
998 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210
Dr. Toland joined The Ohio State University in July 2005. She holds a joint appointment in the Department of Molecular Virology, Immunology, & Medical Genetics and the Department of Internal Medicine's Division of Human Genetics.
Human tumor susceptibility genes
Dr. Toland's research focuses on the search for human tumor susceptibility genes. Environmental factors and a combination of inherited cancer susceptibility and resistance genes determine cancer risk in humans. Identification of tumor resistance and susceptibility genes in humans will lead to a better understanding of the mechanism of tumorigenesis and may, in the future, help to calculate cancer risk estimates for individuals who would benefit from cancer prevention interventions. Unfortunately these genes can be difficult to identify using human populations due to low penetrance of these genes, genetic heterogeneity and inconsistent results through case/control studies. In addition, most studies looking at low penetrance cancer susceptibility genes focus on examining the effects of one variation at a time. Each individual has a unique combination of genetic variations. It is likely that some variants may act in different ways depending on the genetic context (sum of all the other variants), and because of this, it is important to develop ways to look at combinations of variants for better determination of individual cancer risk.
PhD, Human Genetics, University of Utah, 1996
BA, Biology, Franklin and Marshall College, Lancaster PA, 1990