Kevin Sweet, MS, CGC
Phone:  614-293-6694
Fax: 614-293-2314
kevin.sweet@osumc.edu   

Publications

Refereed Articles

1.      Zhang, Y., Sweet, K. and Belli, J.  An Enhanced Ability for Transforming Adriamycin into a Noncytotoxic Form in a Multidrug Resistant Cell Line (LZ-8).  Biochem Pharmacol 1992; 44(9): 1869-77.

2.      Sognier, M., Zhang, Y., Sweet, K. and Belli, J.  Interaction Between Radiation and Drug Damage in Mammalian Cells.  VI. Radiation and doxorubicin age-response function of doxorubicin-sensitive and -resistant Chinese hamster cells.  Radiat Res 1992; 132(1): 105-11.

3.      Sognier, M., Zhang, Y., Sweet, K. and Belli, J.  Sequestration of Doxorubicin in Vesicles in a Multidrug-resistant Cell Line (LZ-100).  Biochem Pharmacol 1994; 48(2): 391-401.

4.      Sweet, K. and Seaver, L.  Family With Autosomal Dominant Distal Arthrogryposis, Ophthalmoplegia and Elbow Dislocation:  Extending the Spectrum.  Proc. Greenwood Genet. Center 1998; 17: 13-19.

5.      Sweet, K. and Seaver, L.  Autosomal Dominant Transmission of Anodontia.  Proc. Greenwood Genet. Center 1999; 18: 42-46.

6.      Phelan, M, Rogers, R, Saul, R, Sweet, K, and Anderson, G.  A Review of the 22q13.3 Deletion Syndrome.  Proc. Greenwood Genet. Center 2000; 19: 35-43.

7.      Phelan, M., Rogers, C., Saul R., Stapleton, G., Sweet, K., McDermid, H., Shaw, S., Claytor, J., and Kelly, D.  22q13 deletion syndrome.  Am J Med Genet 2001; 101(2): 91-9.

8.      Sweet, K., Martin, E., Eng, C., and Shah, M.  Familial Basal Cell Carcinoma, Melanoma and Skin Hypersensitivity with GIST:  A New Hereditary Neuroendocrine Syndrome Involving the SCF/KIT Pathway?  J Endocrin Genet 2001; 2(3): 161-67.

9.      Sweet, K., Bradley, T., Westman, J.  Identification and referral of families at high risk for cancer susceptibility.  J Clin Oncol 2002; 20(2): 528-37.

10.  Sweet K, Willis, S, Asida, S and Westman, JA.  Use of Fear Appeal Techniques in the Design of Tailored Cancer Risk Communication Messages:  Implications for Health Care Providers.  J Clin Oncol, 2003; 21(18); 3375-3376.

11.  Lynch HT, Coronel SM, Okimoto R, Hampel H, Sweet K, Lynch JF, Barrow A, Fodde R, Wagner A, Wijnen J, van der Klift H, Franken P, de la Chapelle A. An American founder mutation of the MSH2 gene identified in various areas of the United States and possibly accounting for a significant proportion of all Lynch Syndrome.  JAMA, 2004 Feb 11; 291(6):718-24.

12.  Hampel H, Sweet K, Westman JA, Offit K, Eng C. Referral for cancer genetics consultation: a review and compilation of risk assessment criteria.  J Med Genet 41(2):81-91, Feb 2004.

13.  Nagy R, Sweet K, Eng C. Invited Review: Highly penetrant hereditary cancer syndromes. Oncogene, 2004; 23, 6445–6470.

14.  Sweet, K, Lynch, H.  Genetic Aetiology of Diffuse Gastric Cancer: So Near, Yet so Far.  Invited Editorial, J Med Genet, 2004 Jul;41(7):481-3.

15.  Weber, F., Fukino, K., Sawada, T., Williams, N., Sweet, K., Brena, M.A., Plass, C., Caldes, T., Mutter, G.L., Villalona-Calero, M.A., Eng, C.  Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors.  British Journal of Cancer, 2005, May 23;92(10):1922-6.

16.  Sweet, K., Willis, J, Sawada, T, Zhou, X.P., Gallione, C., Alhopuro, P., Khoo, S.K., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T.W., Marchuk, D.A., Frebourg, T., Teh, B.T., Aaltonen, L., Eng, C.  Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.  JAMA, 2005 Nov 16;294(19):2465-73.

17.   Narod, S., Lubinski, J., Ghadirian, P., Lynch, H.T., Moller, P., Foulkes, W., Rosen, B., Kim-Sing, C., Isaacs, C., Domchak, S., Sun, P., Hereditary Breast Cancer Clinical Study Group:  Wagner, T., Ainsworth, P., Chudley, A., Eisen, A., Golcrist, D., Lemire, E., Provencher, D., Pasini, B., Bellati, C., Couch, F., Daly, M., Eng, C., Fishman, D., Karlan, B., McLennan, J., McKinnon, W., Merajver, S., Neuhasen, S., Pasche, B., Olopade, O., Osborne, M., Sweet, K., Saal, H., Tung, N., Weitzel, J., Wood, M.  Screening mammography and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.  Lancet Oncol. 2006 May;7(5):402-6.

18.  Gronwald J, Tung N, Foulkes WD, Offit K, Gershoni R, Daly M, Kim-Sing C, Olsson H, Ainsworth P, Eisen A, Saal H, Friedman E, Olopade O, Osborne M, Weitzel J, Lynch H, Ghadirian P, Lubinski J, Sun P, Narod SA, and the Hereditary Breast Cancer Clinical Study Group:  D Gilchrist, D., Weber, B., Rebbeck, T., Isaacs, C., Neuhausen, S., Garber, J., Karlan, B., Fishman, D., Merajver, S., McKinnon, W., Wood, M., Evans, G., Moller, P., B. Pasini, B., Sweet, K., Eng, E., G. Rennert, G., Couch, F., McLennan, J., and Provencher, D.  Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update.  Int J Cancer. 2006 May 1;118(9):2281-4.

19.   Kelly, K. and Sweet, K.  In Search of a Familial Cancer Risk Assessment Tool.  Invited   Review, Clin Genet 2007: 71:  76-83.

20.  Allain, D., Sweet, K. and Agnese, D.  Management Options After Prophylactic Surgeries in     Mutation Positive BRCA Patients:  A Review.   Cancer Control.  Oct. 2007, Vol. 14, No. 4:   220-227

21.  Kelly A. Metcalfe, Dafna Carmeli, Jan Lubinski, Henry Lynch, Pal Moller, Parviz Ghadirian, William D. Foulkes, Eitan Friedman, Charmaine Kim-Sing, Peter Ainsworth, Barry Rosen, Susan Domchek, Claudine Isaacs, Teresa Wagner, Nadine Tung, Siranoush Manoukian, Fergus Couch, Ping Sun, Steven A. Narod and the Hereditary Breast Cancer Clinical Study Group:  Daly, M., Saal, H.M., Sweet, K., Lyonnet, D., Eisen, A., Rennert, G.,  McLennan, J., Gershoni-Baruch, R., Garber, J., Cummings, S., Weitzel, J.,  Karlan, B., Kurz, R., McKinnon, W., Wood, M., Osborne, M., Fishman, D., Meschino, W.S., Lemire, E., Maugard, C., Mills, G., Merajver, S., Rayson, D.  International Variation in Rates of Uptake of Preventive Options in BRCA1 and BRCA2 Mutation Carriers.  Int J Cancer, Vol 26, No. 7, 2017-2022, March 1, 2008.

22.  Metcalfe, K.A., Lubinski, J., Ghadirian, P., Lynch, H., Kim-Sing, C., Friedman, E., Foulkes, W., Domchek, S., Ainsworth,P., Isaacs, C., Tung, N., Gronwald, J., Wagner,  T., Manoukian, S., Sun, P., Narod, S. and the Hereditary Breast Cancer Clinical Study Group:  Daly, M., Saal, H.M., Sweet, K., Lyonnet, D., Eisen, A., McLennan, J., Gershoni-Baruch, R., Garber, J., Cummings, S., Weitzel, J., Karlan, B.,  Kurz, R., McKinnon, W., Wood, M., Chudley, A., Osborne, M., Meschino, W., Maugard, C., Eng, C., Moller, P., Rosen, B., Armel, S., Couch, F., Pasini, B. and Bellati, C.  Predictors of Contralateral Prophylactic Mastectomy in Women with a BRCA1 or BRCA2 Mutation.  J. Clin. Oncol, 26(7):1093-7, March 1, 2008.

23.  Sturm, A., Sweet, K., Koenig, K., Schwirian, P., Westman, J., and Kelly, K. Lessons Learned While Developing a Cancer Family History Public Health Campaign in the Columbus, Ohio Metropolitan Area.  Community Genet. 2008;11(5):304-10. Epub 2008 May 20.

24.  Spearman, A., Sweet, K.,  Xiao-Ping Zhou, X.P., McClennan, J., Couch, F.J., Toland, A.E.  Clinically applicable models for the characterization of BRCA1 and BRCA2 variants of uncertain significance.  J. Clin Oncol, September 29, 2008 (Epub).

25.   Kotsopoulos, J., Lubinski, J., Gronwald, J., Kim-Sing, C., Ghadirian, P., Lynch, H.T., Moller, P., Foulkes, W.D., Randall, S., Manoukian, S., Pasini, B., Tung, N., Ainsworth, P.,  Cummings, S., Ping Sun, P., Narod. S.A. and the Hereditary Breast Cancer Clinical Study Group: Horsman, D., B. Rosen, B., Isaacs, C., Domchek, S., Gershoni-Baruch, R., Eisen, A., Olopade, O.I., Friedman, E., Saal, H.M., Neuhausen, S., Daly, M., Karlan, B., Kurz,R., Bellati, C., Eng, C., Sweet, K., Wagner, T., D. Provencher, D., Maugard, C., McKinnon, W., Osborne, M., McLennan, J., Pasche, B., Fallen, T., Lemire, E., Chudley, A., Weitzel, J.,  Meschino, W.S., Rayson, D.,  G. Evans, G., and Olsson, H.  Infertility, Treatment of Infertility and the Risk of Breast Cancer Among Women With BRCA1 and BRCA2 Mutations.  Cancer Causes Control. 2008 Dec;19(10):1111-9. Epub 2008 May 29.

26.  Eisen, A., Lubinski, J., Gronwald, J. Moller, P., Lynch, H.T., Klijn, J., Kim- Sing, C., Neuhausen, S.L., Foulkes, W.D., Ghadirian, P., Manoukian, S., Gad Rennert, G., Eitan Friedman, E., Claudine Isaacs, C., Barry Rosen, B., Mary Daly, M., Ping Sun, P., Narod, S.A. and the Hereditary Breast Cancer Clinical Study Group (Olopade, O., Cummings,  S., Nadine Tung, N., Couch, F., Domchek, S., Stoppa-Lyonnet, D., Ruth Gershoni-Baruch, R., Horsman, D., Wagner, T., Saal, H., Warner, E., Meschino, W., Offit, K., Trivedi, A., Robson, M.,  Osborne, M., Gilchrist, D., Eng, C., Weitzel, J., McKinnon, W., Wood, M., Maugard, C., Barbari Pasini, B., Bellati, C., Ainsworth, P., Osborne, M., Sweet, K., Pasche, B., Karlan, B., Nedelcu, R., Armel, S., Tulman, A., Gilchrist, D., Lemire, E., Mclennan, J., Evans, G., Byrski, T., Huzarski, T.  Hormone replacement therapy and the risk of breast cancer in BRCA1 mutation carriers.  J Natl Cancer Inst. 2008 Oct 1;100(19):1361-7. Epub 2008 Sep 23

27.   Ginsburg, O., Ghadirian, P., Lubinski, J., Lynch, H., Neuhausen, S., Charmaine Kim-Sing, C., Mark Robson, M., Susan Domchek, S., Claudine Isaacs, C., Jan Klijn, J., Armel, S., Foulkes, W.D., Tung, N., Moller, P., Sun, P., Narod^, S.A. and the Hereditary Breast Cancer Clinical Study Group:  Horsman, D., B. Rosen, B., Isaacs, C., Domchek, S., Gershoni-Baruch, R., Eisen, A., Olopade, O.I., Friedman, E., Saal, H.M., Neuhausen, S., Daly, M., Karlan, B., Kurz,R., Bellati, C., Eng, C., Sweet, K., Wagner, T., D. Provencher, D., Maugard, C., McKinnon, W., Osborne, M., McLennan, J., Pasche, B., Fallen, T., Lemire, E., Chudley, A., Weitzel, J.,  Meschino, W.S., Rayson, D.,  G. Evans, G., and Olsson, H.  Smoking and the Risk of Breast Cancer in BRCA1 and BRCA2 carriers: an Update.  Breast Cancer Res Treat. 2008 May 16. [Epub ahead of print]

28.  Spearman, A.D., Sweet, K., Toland, A.E.  Methylation as a “second hit” in tumors with germline BRCA mutations.  Submission, November 2008, Oncogene.

29.   Buchanan, D., Sweet, K., Drini, M., Jenkins, M., Gattas, M., McKeone, D., Roberts, A., Clendenning, M., Walters, R., Arnold, S., Walsh, M., Young, A., Hampel, H., Hopper, J., Goldblatt, J., George, J., Suthers, G.K., Phillips, K., Young, G.P., Chow, E., Parry, S., Tucker K., Muir, A., Field, M., Greening, S., Chapelle, A.D.L., Macrae, F., Jass, J.R., Young, J.P.  Ethnicity, Smoking and Family History of Cancer in Individuals with Multiple Serrated Polyps.  Submission, GUT, November 2008.

30. Kelly, K., Ferketick, A., Sturm, A., Koenig, C., Sweet, K., Kemp, K., Schwirian, P. and Westman, J.   Cancer Risk and Risk Communication in Urban, Lower-Income Neighborhoods.  Submission, November 2008, Journal of the National Medical Association

31.  Vicus, D., Rosen, B., Lubinski^, J, Domchek, S, Kauff, N, Lynch, H., Issacs, C. Tung, N. Sun, P., Narod, S, ²Daly, M. Olopade, O, Neuhausen, S., Foulkes, W., Gilchrist, D., Karlan, B., Lyonnet, S., Sweet, K.,  Gershoni-Baruch, R., Rayson, D., Ainsworth, P., Weitzel, J., Bordeleau, L., Cybulski, C. and Gronwald, J. Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers.  Submission, November 2008, Gynecologic Oncology

32.  Sweet, K. and Agnese, D.  Surgical management of cancer risk in female BRCA mutation carriers in a single institution.  Manuscript in preparation.

Books and Other Monographs

1.      Sweet, K., Phelan, M., Tarleton, J., Crawford, E., Christensen, B., Schroer, R. and Taylor, H.  Counseling Aids for Geneticists, 3^rd Edition.  Greenwood Genetic Center, 1995.

2.      Saul, R.A., Phelan, M.C., Geer, J.S., Seaver, L.H., and Sweet, K.M.  Growth References:  Third Trimester to Adulthood, 2^nd Edition.  Greenwood Genetic Center, 1998.

3.      Calendar, A., Morrision, C., Komminoth, P., Scoazec, J.Y., Sweet, K., Teh, B.T.  Multiple Endocrine Neoplasia type 1 (MEN 1). In: DeLellis R, Heitz PU, Lloyd R, Eng C, eds, Pathology and Molecular Genetics of Endocrine Tumours (WHO Classification of Tumours of Endocrine Organs), IARC Press, Lyon (2004)

4.      Gimm, O., Morrison, C., Komminoth, P., Suster, S., Sweet, K., Mulligan, L.  Endocrine Neoplasia type 2 (MEN 2). In: DeLellis R, Heitz PU, Lloyd R, Eng C, eds, Pathology and Molecular Genetics of Endocrine Tumours (WHO Classification of Tumours of Endocrine Organs), IARC Press, Lyon (2004)

5.      Carpten, J., Morrison, C., Sweet, K., Teh, B.T. Hyperparathyroidism Jaw Tumour Syndrome. In: DeLellis R, Heitz PU, Lloyd R, Eng C, eds, Pathology and Molecular Genetics of Endocrine Tumours (WHO Classification of Tumours of Endocrine Organs), IARC Press, Lyon (2004)