410 W 10th Ave
Columbus, OH 43210
Phone: (614) 293-1727
Assistant Professor-Clinical, Pathology
I am a board certified anatomic and surgical pathologist with expertise in gastrointestinal, liver and pancreatico-biliary pathology. I received my medical degree from the University of Cartagena, Colombia, where I pursued an anatomic pathology residency and a fellowship in surgical pathology. I further pursued an anatomic and clinical pathology residency at the Ohio State University (OSU) and a gastrointestinal, liver and pancreaticobiliary pathology fellowship at the Cleveland Clinic in Cleveland, Ohio.
I joined the department of pathology at OSU in July 2006 as a faculty member, and I use an estimated 90% of my appointed time to evaluate, interpret and render diagnoses on biopsy and resection specimens in gastrointestinal, liver and pancreatico-biliary pathology for OSU as well as non-OSU patients. After tissue is accessioned, grossed, and processed, I microscopically examine it and issue a diagnosis confirming and identifying the presence or absence of disease in a narrative report which is included in the patient’s medical record.
Throughout the years I have provided excellent clinical service as an active member of clinical teams of gastroenterologists, hepatologists, surgeons, oncologists and transplant surgeons. Since July of 2011 I have served as the Division Director of liver pathology at the OSU department of pathology and I am an attending pathologist for the OSU idiopathic inflammatory bowel disease center. Even though I spend most of my time in the clinical field, I actively participate as a collaborator in clinical and translational research projects that have resulted in twenty-four publications. In addition to continuing to develop my own expertise in gastrointestinal, liver and pancreaticobiliary pathology, I teach and mentor, on a daily basis, residents, fellows and junior faculty on their pathway to successful private practice and academic careers.
I am engaged in activities that allow me to connect to a wider community outside of the academic setting, as follows:
I am an active supporter of the OSU Wexner Medical Center Pelotonia and have happily supported some of my colleagues by contributing financially to their fundraising efforts since this event was launched. I have wanted to join my colleagues; however I am unable to ride a bicycle for long distances because of hand injuries I sustained in a motor vehicle accident in 1998. I was excited to find out last year that I could be a virtual rider, so, this year I joined my colleagues as a virtual rider supporting the “Path-to-a-cure Peloton.” I am riding for the bone marrow transplant patients at OSU, as well as for two of my Colombian friends who suffer from cancer.
In addition, I am a member of the OSU Wexner Medical Center Hispanic/Latino Network (HLN). I am participating with other members of the network in the Hispanic Heritage Month Celebration that will take place on September the 23rd, 2013. Given my busy clinical assignments, I am unable to take part in the details of planning, but I am promoting and raising awareness of this important event.
Finally, I serve as a teacher for the Primary organization of the Church of Jesus Christ of Latter Day Saints. I team-teach Sunday school lessons to a group of 5 year-old children. Although it seems an easy task, I find this activity to be a very uplifting and refreshing activity in my life, and a challenging one also, as I have to adapt my teaching skills to a totally different age group and subject scope.
Even though my busy clinical service only allows me to dedicate approximately 5% of my appointed effort to research collaboration and to develop my research interests, some of my published works have contributed to the field of gastrointestinal pathology, as evidenced by three of my publications:
My recent publication “Prolapse-Related Changes Are a Confounding Factor in Misdiagnosis of Sessile Serrated Adenomas in the Rectum” appears listed on the front page of the April 2013 issue of the Human Pathology Journal and it was recommended by the Editor. This article was listed among the monthly articles recommended by the United States Rodger Haggitt Gastrointestinal Pathology Society’s “Journal Watch, May of 2013”. In addition, a renowned and well-respected Oxford professor highlighted and supported our findings in a letter to the Editor of Human Pathology. As a result, I was invited to write a reply to the letter to the editor that has been published recently.
“Histologic Features are Associated with Microsatellite Unstable Colorectal Carcinomas but Not with Mutation Status or MLH1 Promoter Methylation.” This article published in Human Pathology highlighted key histologic features for all general pathologists to be aware of to pursue further testing in patients with colorectal cancer to rule out a hereditary condition named Lynch Syndrome. I presented preliminary data at the United States and Canadian Academy of Pathology (USCAP) meeting 2003 before an international audience.
“Re-Interpretation of High-Grade Dysplasia in Barrett’s Esophagus: A multicenter International Phase III Trial in 485 patients.” This published abstract highlighted the pitfalls that frequently lead to the over-diagnosis of Barrett’s esophagus high-grade dysplasia, a diagnosis that all pathologists have to be 100% sure of before surgeons undertake major procedures. This was an eye-opening study and was well-received at the 2006 USCAP meeting where I did a platform presentation for an international audience.
I look forward to continuing to make contributions that will add to the OSU Wexner Medical Center’s mission of improving patient’s lives through research.
I consider our pathology residents part of my family. I care about them and I always seek opportunities to talk to them about the challenges they are facing both in their personal lives and in their profession. I ask them about how they and their peers are doing, and whether the residency program is fulfilling their expectations. I inquire about their professional goals and discuss with them fellowship or job opportunities and how to go about seeking, applying and successfully obtaining the fellowship/job of their choice. It has been quite rewarding to see six of our own residents join our gastrointestinal, hepatic and pancreaticobiliary pathology fellowship, four of whom have joined us as Assistant Professors of Clinical Pathology.
|2009 - present||Ming Jin, The Ohio State University. Graduated 2013.|
|2010 - present||Wei Chen, The Ohio State University.|
|2011 - present||Peter Stanich, The Ohio State University.|
|2013 - present||Rachel Roth, The Ohio State University.|
|2013 - present||Khalid Nhiazi, The Ohio State University.|
|2006 - 2007||James Liu, The Ohio State University. Graduated 2007.|
|2007 - 2008||Jeffrey Kneile, The Ohio State University. Graduated 2008.|
|2006 - 2009||Cristopher South, The Ohio State University. Graduated 2009.|
|2008 - 2009||Andrew Bellizi, The Ohio State University. Graduated 2009.|
|2006 - 2011||XiaoPing Zhou, The Ohio State University. Graduated 2011.|
|2010 - 2011||Clinton Crowder, The Ohio State University. Graduated 2011.|
|2007 - 2012||Jonathan Rock, The Ohio State University. Graduated 2012.|
|2007 - 2012||Chen Cheng The Ohio State University. Graduated 2011.|
|2011 - 2012||Theodore Doukides, The Ohio State University. Graduated 2012.|
|2008 - 2013||Rebecca Ziegler, The Ohio State University. Graduated 2013.|
|2012 - 2013||Margaret Ryan The Ohio State University. Graduated 2013.|
|2012 - 2013||Benjamin Swanson, The Ohio State University. Graduated 2013.|
|2001 - present||Indefinite ECFMG Certificate: ECFMG|
|2005 - present||Permanent Physician License: State Medical Board of Ohio|
|2008 - present||Board Certified: American Board of Pathology|
|07/01/2006||Gastrointestinal, Liver and Pancreatico-Biliary Pathologist (The Ohio State University Wexner Medical Center and James Cancer Center)|
|07/01/2011||Director Liver Pathology Division (The Ohio State University Wexner Medical Center and James Cancer Center)|
|07/01/2012||Pathologist (The Ohio State University Wexner Medical Center Idiopathic Inflammatory Bowel Disease Center)|
|1986||M.D., Universidad de Cartagena School of Medicine|
|2009 - 2010||Anatomic Pathology Residency Faculty Teaching Award. Pathology Residency Program, The Ohio State Wexner Medical Center.|
Milanes-Yearsley M, Hammond ME, Pajak TF, Cooper JS, Chang C, Griffin T, Nelson D, Laramore G, Pilepich M. "Tissue Micro-Array: A Cost and Time-Effective Method for Correlative Studies by Regional and National Cancer Study Groups." MODERN PATHOLOGY. Vol. 15, no. 12. (December 2002.): 1366-.
Reed M, Yearsley M, Krugh D, Kennedy MS. "Severe Hemolysis Due to Passenger Lymphocyte Syndrome After Hematopoietic Stem Cell Transplantation from an HLA-Match Related Donor." ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. Vol. 127, no. 10. (October 2003.): 1366-1368.
Cosio FG, Nuovo M, Delgado L, Yearsley M, Porcu P, Caligiuri M, Pelletier RP, Nuovo GJ. "EBV Kidney Allograft Infection: Possible Relationship with a Peri-Graft Localization of PTLD." AMERICAN JOURNAL OF TRANSPLANTATION. Vol. 4, no. 1. (January 2004.): 116-123.
Yearsley MM, Diaz PT, Knoell D, Nuovo GJ. "Correlation of HIV-1 Detection and Histology in AIDS-Associated Emphysema." DIAGNOSTIC MOLECULAR PATHOLOGY. Vol. 14, no. 1. (March 2005.): 48-52.
Yearsley MM, Nuovo GJ. "Histologic Correlates of Fatal Herpes Virus Infection." ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. Vol. 129, no. 4. (April 2005.): 547-576.
de Macedo FC, Nicol AF, Cooper LD, Yearsley M, Pires ARC, Nuovo GJ. "Histologic, Viral, and Molecular Correlates of Dengue Fever Infection of the Liver Using Highly Sensitive Immunohistochemistry." DIAGNOSTIC MOLECULAR PATHOLOGY. Vol. 15, no. 4. (December 2006.): 223-228.
Yearsley M, Hampel H, Lehman A, Nakagawa H, de la Chapelle A, Frankel WL. "Histologic Features Distinguish Microsatellite-High From Microsatellite-Low and Microsatellite-Stable Colorectal Carcinomas, but Do Not Differentiate Germline Mutations from Methylation of the MLH1 Promoter." HUMAN PATHOLOGY. Vol. 37, no. 7. (July 2006.): 831-838.
Kahwash E, Bauer P, Yearsley M. "A Case of Hereditary Elliptocytosis." LABORATORY HEMATOLOGY. Vol. 13, no. 3. (January 2007.): 113-114.
Colonna J, Plaza JA, Frankel WL, Yearsley M, Bloomston M, Marsh WL. "Serous Cystadenoma of the Pancreas: Clinical and Pathological Features in 33 Patients." PANCREATOLOGY. Vol. 8, no. 2. (January 2008.): 135-141.
Rice TW, Goldblum JR, Yearsley MM, Shay SS, Reznik SI, Murthy SC, Mason DP, Blackstone EH. "Myenteric Plexus Abnormalities Associated with Epiphrenic Diverticula." EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. Vol. 35, no. 1. (January 2009.): 22-27.
Marsh WL, Colonna J, Yearsley M, Bloomston M, Frankel WL. "Calponin is Expressed in Serous Cystadenomas of the Pancreas but not in Adenocarcinomas or Endocrine Tumors." APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY. Vol. 17, no. 3. (May 2009.): 216-219.
Sun J, Okumura H, Yearsley M, Frankel W, Fong LY, Druck T, Huebner K. "Nit1 and Fhit Tumor Suppressor Activities are Additive." JOURNAL OF CELLULAR BIOCHEMISTRY. Vol. 107, no. 6. (August 2009.): 1097-1106.
Meyer MM, Levine E, Kirkpatrick RB, Yearsley MM. "Post-transplant Rectal Lymphoma after Subtotal Colectomy for Lynch Syndrome-Associated Colorectal Adenocarcinoma." GASTROENTEROLOGY & HEPATOLOGY. Vol. 5, no. 9. (September 2009.): 633-636.
South CD, Yearsley M, Martin E, Arnold M, Frankel W, Hampel H. "Immunohistochemistry Staining for the Mismatch Repair Proteins in the Clinical Care of Patients with Colorectal Cancer." GENETICS IN MEDICINE. Vol. 11, no. 11. (November 2009.): 812-817.
Haubert L, Yearsley M, Bloomston M. "Hepatocellular Carcinoma Arising Within Focal Nodular Hyperplasia." AMERICAN SURGEON. Vol. 76, no. 3. (March 2010.): 335-336.
Liu K, Anthony BA, Yearsley MM, Hamadani M, Gaughan A, Wang JJ, Devine SM, Hadley GA. "CD103 Deficiency Prevents Graft-versus-Host Disease but Spares Graft-versus-Tumor Effects Mediated by Alloreactive CD8 T Cells." PLOS ONE. Vol. 6, no. 7. (July 2011.): e21968-.
Almadani B, Sood N, Yearsley M, Lee WM. "Life-Threatening Variceal Hemorrhage in a Woman with Severe Pulmonary Arterial Hypertension.." GASTROENTEROLOGY & HEPATOLOGY. Vol. 8, no. 6. (June 2012.): 404-407.
Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, Weng YI, Huang T, Tichelaar J, Yearsley M, Stoner GD, Huang YW. "Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells." NUTRITION AND CANCER. Vol. 65, no. 1. (January 2013.): 118-125.
Yearsley M, Frankel WL, Zhou XP, Zhao W, Huang C. "Left-Sided Sessile Serrated Polyps/Adenomas-Reply." HUMAN PATHOLOGY. Vol. 44, no. 9. (September 2013.): 1960-1961.
Stanich P, Yearsley M, Meyer M. "Olmesartan-Associated Sprue-like Enteropathy." JOURNAL OF CLINICAL GASTROENTEROLOGY. Vol. Epub ahead of print, (June 2013.): 1-.
Huang C, Frankel WL, Doukides T, Zhou XP, Zhao W, Yearsley MM. "Prolapse-Related Changes are a Confounding Factor in Misdiagnosis of Sessile Serrated Adenomas in the Rectum." HUMAN PATHOLOGY. Vol. 44, no. 4. (April 2013.): 480-486.
Jin M, Hampel H, Zhou X, Schunemann L, Yearsley M, Frankel WL. "BRAF V600E Mutation Analysis Simplifies the Testing Algorithm for Lynch Syndrome.." AMERICAN JOURNAL OF CLINICAL PATHOLOGY. Vol. 140, no. 2. (August 2013.): 177-183.
Swanson BJ, Limketkai BN, Liu TC, Montgomery E, Nazari K, Park J, Santangelo WC, Torbenson MS, Voltaggio L, Yearsley MM, Arnold CA. "Renvela Crystals in the Gastrointestinal Tract (GIT): A New Entity Associated with Mucosal Injury." AMERICAN JOURNAL OF SURGICAL PATHOLOGY. -.
Chen W, Rock JB, Yearsley MM, Ferrell LD, Frankel WL. "Different Collagen Types Show Distinct Rates of Increase from Early to Late Stages of Hepatitis-C Related Liver Fibrosis." HUMAN PATHOLOGY. -.
|February 2001||Milanes-Yearsley M, Hammond ME, Pajack T."Tissue Micro-Array Technique: A Time and Cost-Effective Method for RTOG Tissue Bank Correlative Studies" Augusta. : 123|
|January 2003||Hampel H, Yearsley MM, Nakagawa H, Lehman A, de la Chapelle A, Frankel WL."Histologic Features in Microsatellite Unstable and Stable Endometrial Carcinomas" Augusta. : 191A|
|February 2003||Yearsley MM, Hampel H, Lehman A, Nakagawa H, de la Chapelle A, Frankel WL."Histological Features Are Associated with Microsatellite Unstable Colorectal Carcinomas But Not Mutation Status or MLH1 Promoter Methylation" Augusta. : 125|
|January 2003||Yearsley MM, Nuovo GJ."HIV Infection and Matrix Metalloproteinase in HIV-Associated Emphysema" Augusta. : 265A|
|January 2005||Yearsley MM, Aguilera I, Frankel WL, Prior TW."Correlation Between Hereditary Hemochromatosis Genotypes and Phenotypes" Augusta. : 290A|
|January 2006||Yearsley MM, Rice TW, Resnik S, Shay S, Goldblum J."Are All Esophageal Diverticula Secondary to an Underlying Esophageal Motility Disorder (EMD)?" Augusta. : 125A|
|January 2006||Lagwinski N, Bennett A, Goldblum JR, Henricks W, Skacel M, Yearsley M, Yerian L, Bauer T, Bronner MP."Microsatellite Instability (MSI) in Colorectal Carcinomas - Prospective Correlation of Clinicopathologic Features with MSI Status" Augusta. : 112A|
|January 2006||Yearsley MM, Haggitt RC, Taylor RSL, Overholt BG, Depot M, Emond MJ, Bronner M."Reinterpretation of High-Grade Dysplasia in Barrett's Esophagus: A Multicenter International Phase III Trial in 485 Patients" Augusta. : 125A|
|October 2007||Colonna JE, Yearsley MM, Morrison C, Suster S, Frankel WL."CD31 Immunoreactivity in Non-Small Cell Carcinomas: A Tissue Microarray Study of 613 Cases" Chicago. : 683|
|January 2007||Yearsley MM, Hampel H, Marsh WL, Cook SS, Frankel WL."Routine Use of Immunohistochemistry for the Mismatch Repair Proteins on Unselected CRC: An Initial Experience" Augusta. : 132A|
|January 2007||Colonna J, Yearsley MM, Marsh WL, Bloomston M, Frankel WL."Calponin is Strongly Expressed in Serous Adenomas of the Pancreas but not in Adenocarcinomas or Endocrine Tumors" Augusta. : 278A|
|June 2008||Rice T, Yearsley MM, Reznik SI, Shay SS, Mason DP, Murthy SC, Goldblum JR."Epinephric Diveritculum: A Clinical and Pathologic Study" Bologna.|
|January 2008||Yearsley M, Liu J, Marsh W, Frankel WL."Correlation of H&E Features, Immunohistochemical Expression of Neuroendocrine Markers, and Microsatellite Status in 149 Colorectal Carcinomas" Augusta. : 142A|
|September 2008||Yan M, Zhang J, Hall N, Carlton M, Mojzisick C, Yearsley MM, Knopp M, Martin E."Potential Utility of Micro PER Imaging in Assessment of Surgical Margins of Hepatic Metastasis to Liver-A Case Based Feasibility Study" Nice.|
|September 2008||South C, Yearsley M, Hampel H, Frankel W."Prospective Evaluation of Mismatch Repair Protein Expression in Primary Colorectal Cancer" New York, NY. : S169|
|September 2008||Manitsas S, South C, Panchal P, Yearsley M."Mycobacterial Spindle Cell Pseudotumor of the Colon: A Case Report" New York, NY. : S235|
|January 2009||Yearsley MM, Bellizzi AM, South CD, Hampel H, Marsh WL, Frankel WL."Routine Mismatch Repair Protein Immunostaining in Colorectal Carcinomas - Equivocal MSH6 Staining Is a Challenge" Augusta. : 153A|
|January 2009||Liu JJ, Bloomston M, Dilhoff M, Yearsley MM, Frankel WL."Esophageal Adenocarcinomas Overexpress MicroRNA-21: A Tissue Microarray Study of 64 Cases Using In-Situ Hybridization" Augusta. : 138A|
|October 2010||Zhou XP, Huebner K, Frankel WL, Yearsley MM.."Frequent FHIT Tumor Suppressor but not NIT-1 Expression is Lost in Barrett's Esophagus and Esophageal Adenocarcinomas" San Francisco.|
|October 2010||Macedo FC, Nicol FC, Yearsley M, Pires ARC, Nuovo GJ."Histologic Viral and Molecular Correlates of Dengue Fever Infection of the Liver Using Highly Sensitive Immunohistochemistry" Hoboken, NJ. : 177|
|January 2011||Kuo C, Stoner K, Huang Y, Yu J, Huang T, Yearsley M, Yang G, Jin V, Stoner G, Wang L."Effects of Dietary Black Raspberries on DNA Methylation in Ulcerative Colitis-Induced Carcinogenesis in IL-10 Knock-Out Mice" Philadelphia. : S15|
|February 2011||Ziegler RM, Wenzke JT, Lehman A, Frankel WL, Yearsley MM."The Clinical Significance of Active Ileitis and Chronic Active Ileitis: Clinicopathologic Study of 72 Cases" Augusta. : 174A|
|February 2011||Zhou X, Yearsley MM, Jones KS, Frankel WL."Hepatocellular Carcinomas Occasionally Express Neuroendocrine Markers While Neukroendocrine Tumors Metastatic to the Liver Do Not Show Hepatocellular Expression" Augusta. : 378A|
|February 2011||Huang C, Frankel WL, Doukides T, Zhao W, Yearsley MM."Prolapse-Type Changes Can Lead to Overdiagnosis of Sessile Serrated Adenomas of the Rectum: A Histopathologic Study of 75 Rectal Polyps" Augusta. : 152A|
|January 2011||Stoner K, Kuo C, Huang YW, Huang TH, Montrose D, Horelik N, Madigan J, Rosenberg D, Yearsley M, Jin V, Stoner GD, Wang LS."Dietary Black Raspberries-Modulated DNA Methylation in Dextran Sodium Sulfate (DSS)-Induced Ulcerative Colitis" Philadelphia. : S25|
|July 2011||Ziegler R, Wenzke J, Lehman A, Frankel WL, Yearsley MM."Paneth Cell Hyperplasia in Inflammed Terminal Ileum is a Feature of Chronic Mucosal Injury: A Histopathologic Study of 88 Cases" Chicago. : A241|
|February 2012||Rock JB, Yearsley MM, Hanje AJ, Frankel WL."Collagen Immunohistochemical Stains in the Liver Are Useful in Differentiating Capsular from Septal Fibrosis" Augusta. : 422A|
|February 2013||Jin M, Hampel H, Zhou X, Schunemann L, Yearsley MM, Frankel WL."BRAFV600E Mutation Analysis Simplifies the Testing Algorithm for Lynch Syndrome" Augusta. : 158A|
|February 2013||Chen W, Rock JB, Yearsley MM, Farrell LD, Frankel WL."Different Collagen Types Show Variable Increases from Early to Late Stages of Hepatitis-C Related Liver Fibrosis" Augusta. : 399A|
|February 2013||Arnold CA, Limketkai BN, Liu TC, Montgomery E, Nazari K, Torbenson MS, Yearsley MM, Lam-Himlin D."Renvela Crystals in the Gastrointestinal (GI) Tract: A New Entity" Augusta. : 144A|
|Chen W, Frankel WL, Yearsley MM."The Significance of Paneth Cell Metaplasia in Barrett's Esophagus: Morphologic and Clinicopathologic Study of 757 Cases" .|
"Hereditary Non-Polyposis Colon Cancer Immunohistochemistry - Round Table." Presented at OSU Annual Pathology Update Course, Columbus, OH, US|USA. (September 2009)
"Fulminant Liver Failure." Presented at OSU Annual Pathology Update Course, Columbus, OH, US|USA. (October 2010)
"Diagnostic Challenges Slide Seminar." Presented at OSU Pathology Update Course, Columbus, OH, US|USA. (October 2011)
"Pathologic Aspects of Liver Transplantation." Presented at Transplant Surgery Team Conference, Columbus, OH, US|USA. (December 2012)
"Idiopathic Inflammatory Bowel Disease-Associated Dysplasia: A Case Presentation." Presented at Gastroenterology, Hepatology and Nutrition Conference, Columbus, OH, US|USA. (December 2012)
"Pattern Approach to Liver Pathology Interpretation." Presented at Invited Guest Lecture, Akron, OH, US|USA. (January 2012)
"Liver Pathology Microscope Session." Presented at Invited Guest Conference, Akron, OH, US|USA. (January 2012)
"Practical Approach to Liver Masses." Presented at Invited Guest Conference, Akron, OH, US|USA. (January 2013)
"Liver Pathology Microscope Session." Presented at Invited Guest Conference, Akron, OH, US|USA. (January 2013)
|2007 - present||Mentoring. OSU Wexner Medical Center Pathology Department. Columbus, OH.|
Wang LS, Kuo CT, Stoner K, Yearsley MM, Yu J, Huang JW, Stoner G. Dietary Black Raspberries Modulate DNA Methylation in Dextran Sodium Sulfate (DSS)-Induced Ulcerative Colitis. August 2013.
Chen W, Rock JB, Yearsley MM, Hanje AJ, Frankel WL. Collagen Immunostains Can Distinguish Capsular Fibrous Tissue from Septal Fibrosis and May Help Stage Liver Fibrosis. August 2013.