Tushar Patel

Recent Publications


Meng F, Henson R, Patel T.
Chemotherapeutic stress selectively activates NF-kappaB dependent Akt and VEGF expression in liver cancer derived endothelial cells.
Am J Physiol Cell Physiol. 2007 In press.  doi:10.1152/ajpcell.00537.2006

Meng F, Henson R, Wehbe-Janek, Ghoshal K, Jacob S, Patel T.
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular carcinoma.
Gastroenterology 2007 In press.   doi:10.1053/j.gastro.2007.05.022

Hanje AJ, Patel T.
Preoperative evaluation of patients with liver disease.
Nat Clin Pract Gastroenterol Hepatol. 2007 May;4(5):266-76. 

Patel T, Singh P.
Cholangiocarcinoma: emerging approaches to a challenging cancer.
Curr Opin Gastroenterol. 2007 May;23(3):317-23.

Meng F, Henson R, Wehbe-Janek H, Smith H, Ueno Y, Patel T.
The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling
in malignant human cholangiocytes.
J Biol Chem. 2007 Mar 16;282(11):8256-64. Epub 2007 Jan 12.

Wehbe H, Henson R, Meng F, Mize-Berge J, Patel T.
Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant
promoter methylation and gene expression.
Cancer Res. 2006 Nov 1;66(21):10517-24.

Naus PJ, Henson R, Bleeker G, Wehbe H, Meng F, Patel T.
Tannic acid synergizes the cytotoxicity of chemotherapeutic drugs in human
cholangiocarcinoma by modulating drug efflux pathways.
J Hepatol. 2007 Feb;46(2):222-9. Epub 2006 Oct 6.

McLean L, Patel T.
Racial and ethnic variations in the epidemiology of intrahepatic
cholangiocarcinoma in the United States.
Liver Int. 2006 Nov;26(9):1047-53.

Wehbe H, Henson R, Lang M, Meng F, Patel T.
Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein
kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant
cholangiocytes.
J Pharmacol Exp Ther. 2006 Dec;319(3):1153-61. Epub 2006 Sep 18.

Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J,
Schmittgen TD, Patel T.
Involvement of human micro-RNA in growth and response to chemotherapy in human
cholangiocarcinoma cell lines.
Gastroenterology. 2006 Jun;130(7):2113-29.

Singh P, Patel T.
Advances in the diagnosis, evaluation and management of cholangiocarcinoma.
Curr Opin Gastroenterol. 2006 May;22(3):294-9. Review.

Reddy SB, Patel T.
Current approaches to the diagnosis and treatment of cholangiocarcinoma.
Curr Gastroenterol Rep. 2006 Feb;8(1):30-7. Review.

Patel T, Dangell C, Maheshwari S.
Impact of age on screening and surveillance for primary liver cancer.
Am J Gastroenterol. 2006 Apr;101(4):768-74. Epub 2006 Feb 22.

Meng F, Yamagiwa Y, Ueno Y, Patel T.
Over-expression of interleukin-6 enhances cell survival and transformed cell
growth in human malignant cholangiocytes.
J Hepatol. 2006 Jun;44(6):1055-65. Epub 2005 Dec 13.

Patel T.
Cholangiocarcinoma.
Nat Clin Pract Gastroenterol Hepatol. 2006 Jan;3(1):33-42. Review.

Yamagiwa Y, Meng F, Patel T.
Interleukin-6 decreases senescence and increases telomerase activity in
malignant human cholangiocytes.
Life Sci. 2006 Apr 18;78(21):2494-502. Epub 2005 Dec 5.