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Xia, Yong MD


473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-5709

Email: xia.34@osu.edu

 

Current OSU Appointments

Professor, Cardiovascular Medicine

Professor, SBS-Molec & Cellular Biochem

 

Chapters in Books

Xia, Y., and Zweier, J.L.. "Superoxide anion release from inducible nitric oxide synthase.." In Progress in Inflammation Research: Nitric Oxide and Inflammation. Edited by D. Salvemini, T.R. Billiar, and Y. Vodovotz. -. Basel, CH|CHE: Birkhauser Publishing, January 2002.

Forbes, S.P., Xia, Y., and Cardounel, A.J.. "Endogenous regulation of nitric oxide synthase activity and free radical generation.." In The Oxidative Stress: Clinical and Biomedical Implications.. Edited by B.M. Matata.. 203-226. New York, NY, US|USA: NOVA Scientific Publishers, January 2007.

 

Degrees

1989 M.D., Tongji Medical University

1992 M.S., Tongji Medical University

 

Editorial Activities

1998 - present Biotechniques
1998 - present American Journal of Physiology-Cell Physiology
1999 - present Neuroscience Letter
1999 - present Circulation Research
1999 - present Atherosclerosis
2000 - present Circulation
2000 - present British Journal of Pharmacology
2004 - present Journal of Biological Chemistry
2005 - present Thrombosis and Vascular Biology
2006 - present Pharmacology Biochemistry and Behavior
2007 - present Journal of Cellular and Molecular Medicine
2007 - present Antioxidants & Redox Signaling
2007 - present Journal of Pharmacology and Experimental Therapeutics
 

Honors

1986 Student Research Merit Prize. Tongji Medical University.
1991 Young Investigator Award for Excellence in Research. Chinese Society of Pharmacology.
1994 Young Investigator Award for Excellence in Research. Chinese Society of Pathophysiology.
1996 Trainee Investigator Award for Excellence in Research. Association of American Physicians.
1996 Caroline tum Suden/Frances A. Hellenbrandt Professional Award. American Physiological Society.
1997 Caroline tum Suden/Frances A. Hellebrandt Professional Award. American Physiological Society.
1997 Research Fellowship Award. Researcher for Harry & Jane W. Alburger Trust.
1997 Trainee Investigator Certificate of Achievement for Outstanding Abstract at Biomedicine 97 Meeting. AAP, ASCI and AFMR.
1997 The Pharmacia and Upjohn Award for Young Investigators. International Society for Heart Research..
1998 Mentored Clinical Scientist Award. National Institute on Aging.
 

Journal Articles

Xia, Y., Qian, J.Q., and Wang, X.L. "Effects of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on membrane currents of single ventricular myocyte of rats." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 47-52.

Xia, Y., and Qian, J.Q.. "Effect of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on the heart conductive system in anesthetized rabbits.." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 53-58.

Xia, Y., and Qian, J.Q. "Effects of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on the action potential of isolated sinoatrial node cells of rabbits." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 59-62.

Xia, Y., and Han, C.. "ATP-sensitive potassium channels in cardiovascular system.." Pharmacol. Bulletin. Vol. 9, (January 1993.): 410-413.

Xia, Y., Zhang, J., Qian, J.Q., and Zeng, G.Y. "Antihypertensive effect of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on conscious renal hypertensive canines.." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 16-20.

Xia, Y., and Han, C.. "Role of K+ channels in neuropeptide Y-induced vasoconstriction in rabbit cerebral basilar artery.." Eur. J. Pharmacol.. Vol. 255, (January 1994.): 67-72.

Xia, Y., and Zweier, J.L.. "Substrate control of free radical generation from xanthine oxidase in the postischemic heart.." J. Biol. Chem.. Vol. 270, (January 1995.): 18797-18803.

Xia, Y., Khatchikian, G., and Zweier, J.L.. "Adenosine deaminase inhibition prevents free radical mediated injury in the postischemic heart.." J. Biol. Chem.. Vol. 271, (January 1996.): 10096-10102.

Xia, Y., Dawson, V.L., Dawson, T.M., Snyder, S.H., and Zweier, J.L.. "Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite mediated cellular injury.." Proc. Natl. Acad. Sci. USA. Vol. 93, (January 1996.): 6770-6774.

Xia, Y., and Zweier, J.L.. "Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages.." Proc. Natl. Acad. Sci. USA. Vol. 94, (January 1997.): 6954-6958.

Xia, Y., and Zweier, J.L.. "Measurement of myeloperoxidase in leukocyte-containing tissues.." Anal. Biochem.. Vol. 245, (January 1997.): 93-96.

Xia, Y., and Zweier, J.L.. "Direct measurement of nitric oxide generation from nitric oxide synthase.." Proc. Natl. Acad. Sci. USA. Vol. 94, (January 1997.): 12705-12710.

Giraldez, R.R., Panda, A., Xia, Y., Saunders, S.P., and Zweier, J.L.. "Decreased nitric oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart.." J. Biol. Chem.. Vol. 272, (January 1997.): 21420-21426.

Irani, K., Xia, Y., Zweier, J.L., Sollott, S.J., Der C.J., Fearon, E.R., Sundaresan M., Finkel, T., and Goldschmidt-Clermont, P.J.. "Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.." Science. Vol. 275, (January 1997.): 1649-1652.

Polyak K, Xia, Y., Zweier J.L., Kinzler, K.W., and Vogelstein B.. "A model for p53-induced apoptosis.." Nature. Vol. 389, (January 1997.): 300-305.

Hu, Q., Xia Y., Corda, S., Zweier, J.L., and Ziegelstein, R.C.. "Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange.." Circ. Res.. Vol. 83, (January 1998.): 644-651.

Xia, Y., Tsai, A.L., Berka, V., and Zweier, J.L.. "Superoxide generation from endothelial nitric oxide synthase: a Ca2+/calmodulin dependent and tetrahydrobiopterin regulatory process.." J. Biol. Chem.. Vol. 273, (January 1998.): 25804-25808.

Xia, Y., Roman L.J., Masters B.S.S., and Zweier, J.L.. "Inducible nitric oxide synthase generates superoxide from the reductase domain.." J. Biol. Chem.. Vol. 273, (January 1998.): 22635-22639.

Xia, Y., Cardounel, A.J., Vanin, A.F., and Zweier, J.L.. "Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron distinguishes nitric oxide and nitroxyl in a redox dependent manner: applications in identifying nitrogen monoxide products from nitric oxide synthase.." Free Radic. Biol. Med.. Vol. 29, (January 2000.): 793-797.

Song, Y., Zweier, J.L., and Xia, Y.. "Determination of the enhancing action of Hsp90 on neuronal nitric oxide synthase by EPR spectroscopy.." American J. Physiology-Cell Physiology. Vol. 281, (January 2001.): C1819-C1824.

Song, Y., Zweier, J.L., and Xia, Y. "Heat shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding.." Biochem. J.. Vol. 355, (January 2001.): 357-360.

Biondi, R., Xia, Y., Rossi, R., Paolocci N, Ambrosio G, and Zweier JL.. "Detection of hydroxyl radicals by D-phenylalanine hydroxylation: a specific assay of hydroxyl radical generation in biological systems.." Anal. Biochem. Vol. 290, (January 2001.): 138-145.

Paolocci N, Biondi, R., Bettini M, Berlowitz, C.O., Rossi R, Xia Y, Ambrosio G, Labbate A, Kass D, Zweier JL.. "Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart.." J Mol Cell Cardiol. Vol. 33, (January 2001.): 671-679.

Song, Y., Cardounel, A.J., Zweier, J.L., and Xia Y.. "Heat shock protein 90 prevents superoxide generation from neuronal nitric oxide synthase: implications in NOS regulation.." Biochemistry. Vol. 41, (January 2002.): 10616-10622.

Yoshida, M., and Xia, Y.. "Heat shock protein 90 as an endogenous protein enhancer of inducible nitric oxide synthase.." J. Biol. Chem.. Vol. 278, (January 2003.): 36953-36958.

Wei, Q., and Xia, Y.. "Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric oxide synthase phosphorylation and function by heat shock protein 90.." J. Biol. Chem.. Vol. 280, (January 2005.): 18081-18086.

Cardounel, A.J., Xia Y., and Zweier, J.L.. "Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.." J. Biol. Chem.. Vol. 280, (January 2005.): 7540-7549.

Wei, Q., and Xia, Y.. "Proteasome inhibition down-regulates endothelial nitric oxide synthase phosphorylation and function.." J. Biol. Chem.. Vol. 281, (January 2006.): 21652-21659.

Xia, Y, Berlowitz, C.O.. "PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase.." Biochimica et Biophysica Acta. Vol. 1760, (January 2006.): 1445-1449.

Joshi, M.S., Julian, M.W., Huff, J.E., Bauer, J.A., Xia, Y., and Crouser, E.D.. "Calcineurin regulates myocardial function during acute endotoxemia.." Am. J. Respir. Crit. Care Med.. Vol. 173, (January 2006.): 999-1007.

Dumitrescu C, Biondi R, Xia Y, Cardounel AJ, Druhan LJ, Ambrosio G, Zweier JL. "Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.." Proc Natl Acad Sci USA. Vol. 104, no. 38. (January 2007.): -.

Pope AJ, Druhan L, Guzman JE, Forbes SP, Murugesan V, Lu D, Xia Y, Chicoine LG, Parinandi NL, Cardounel AJ. "Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.." Am J Physiol Cell Physiol. Vol. 293, no. 5. (November 2007.): C1679-86.

Jiang, J.G., Chen, R.J., Xiao, B., Yang, S., Wang, J.N., Wang, Y., Cowart, L.A., Xiao, X., Wang, D.W., and Xia, Y.. "Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to expoyeicosatrienoic acids.." Prostaglandins Other Lipid Mediat.. Vol. 82, (January 2007.): 162-174.

Xia Y. "Superoxide generation from nitric oxide synthases.." Antioxid Redox Signal. Vol. 9, no. 10. (October 2007.): 1773-8.

Xia, Y.. "Superoxide generation from nitric oxide synthase.." Vol. 9, (January 2007.): 1771-1778.

Hu Z, Chen J, Wei Q, Xia Y. "Bidirectional actions of hydrogen peroxide on endothelial nitric oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK." J. Biol. Chem. Vol. 283, (January 2008.): 25256-25263.

Chu L, Jiang Y, Hao H, Xia Y, Xu J, Liu Z, Verfaillie CM, Liu Z. "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." Eur. J. Pharmacol. Vol. 591, (January 2008.): 59-65.

Moens. A.L., Arkenbout, E.K., Yang, H., Bedja, D., Gabrielson, K.; Chen, J., Xia, Y., Champion, H.C., Halushka, M., Barker, N., Wuyts, F.L., Kaminski, P.S., Wolin, M.S., Kass, D.A., Barouch, L.A. "Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.." J. Mol. Cell Cardiol. Vol. 47, (January 2009.): 576-585.

Yong Xia. "How does Viagra protect the ischemic heart? Focus on “ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice�." Am J Physiol Heart Circ Physiol. Vol. 296, (January 2009.): H1209-H1210.

Pope, A.J., Karuppiah, K., Kearns, P.N., Xia, Y., and Cardounel, A.J.. "Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production.." J. Biol. Chem.. Vol. 284, (January 2009.): 35338-35347.

Li, X., Wang, P., Xu, X., Wang, Y., Xia, Y., and Wang D.W. "Simvastatin Increases the Activity of Endothelial Nitric Oxide Synthase via Enhancing Phosphorylation.." J. Huazhong Univ. Sci. Technol.-Med. Sci. Vol. 29, (January 2009.): 286-290.

 

Reference Works

January 2007 Chen, J., Qin, H., Chiang, P.Y., Lu, D., and Xia, Y.."Loss of Endothelial NO Synthase Serine 1179 Phosphorylation and Function in ER stress." . : 308

Professional Activities

2003 - 2005 Director of protein expression Core laboratory. Davis Heart and Lung Research Institute, the Ohio State University Medical Center.. Columbus, OH.