Das, Hiranmoy PhD

Current OSU Appointments

Associate Professor, Cardiovascular Medicine

Adjunct Professor, Internal Medicine

Books

Nishimura R, Koizumi T, Das H, Takemori M and Hasegawa K. Enzyme immunoassay of urinary ß-core fragment of human chorionic gonadotropin as a tumor marker for ovarian cancer. Totoya, NJ, US|USA: Humana Press, Inc, January 2000.

Lu J, Pompili VJ and Das H.. Genetic engineering of hematopoietic stem cells to enhance functionality. In Stem Cell Engineering Handbook. New York, NY, US|USA: CRC press, January 2010.

Aggarwal R, Lu J, Pompili VJ and Das H.. Role of natural products and bioactive compounds in disease prevention. Development of ischemic diseases and stem cell therapy.. New York, NY, US|USA: Nova Science Publishers, January 2010.

Lu J, Pompili VJ and Das H.. ?d T cells, Tea and cancer. Nutrition, Diet and Cancer.. New York, NY, US|USA: Springer Publishing Co, January 2011.

Lu J, Aggarwal R, Pompili VJ and Das H.. Ex-vivo expanded hematopoietic stem cells for ischemia. Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury.. New York, NY, US|USA: Springer Publishing Co, January 2011.

Kanji S, Pompili VJ and Das H.. Ischemia, reactive radicals, redox signaling and hematopoietic stem cells. Stem cells and human diseases. New York, NY, US|USA: Springer Publishing Co, January 2011.

Chapters in Books

Nishimura R, Koizumi T, Das H, Takemori M and Hasegawa K.. "Enzyme immunoassay of urinary ß-core fragment of human chorionic gonadotropin as a tumor marker for ovarian cancer.." In In Methods in Molecular Medicine, Ovarian Cancer: Methods and Protocols. Vol. 39. Edited by Bartlett JM. 135-141. Totowa, NJ, US|USA: Humana Press, Inc, January 2000.

Kanji S, Pompili VJ and Das H.. "Ischemia, reactive radicals, redox signaling and hematopoietic stem cells." In Stem cells and human diseases. Edited by R. Srivastava. -. New York, NY: Springer Publishing Co, January 2011.

Lu J, Aggarwal R, Pompili VJ and Das H. "Ex-vivo expanded hematopoietic stem cells for ischemia.." In Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury.. Edited by M.A. Hayat. -. New York, NY: Springer Publishing Co, January 2011.

Aggarwal R, Lu J, Pompili VJ and Das H.. "Development of ischemic diseases and stem cell therapy.." In Role of natural products and bioactive compounds in disease prevention. Edited by M E Essa. -. New York, NY: Nova Science Publishers, January 2011.

Lu J, Pompili VJ and Das H.. "?d T Cells, Tea and Cancer.." In Nutrition, Diet and Cancer.. Edited by Sharmila Shankar and Rakesh Srivastava. -. New York, NY: Springer Publishing Co, January 2011.

Journal Articles

Das H and Bhattachartta AK. "Changes in biochemical markers of hyperplastic and malignant prostatic tissues." Archives of Andrology. Vol. 26, (January 1991.): 185-188.

Das H and Bhattacharyya AK.. "The effect of inhibitors; sodium fluoride and L(+) tartrate on purified acid phosphatase from normal and benign hyperplastic prostates.." Journal of Basic and Applied Biomedicine. Vol. 3, (January 1995.): 19-22.

Murayama T, Koizumi T, Das H, Kobayashi Y, Kajimoto K, Sugimoto T, Imoto S, Nishimura R and Nakagawa T. "Soluble fas ligand in natural killer cell lymphoma." American Journal of Hematology. Vol. 62, (January 1999.): 253-255.

Das H, Imoto S, Murayama T, Kajimoto K, Sugimoto T, Isobe T, Nakagawa T, Nishimura R and Koizumi T. "Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patients." British Journal of Haematology. Vol. 104, (January 1999.): 795-800.

Sugimoto T, Das H, Imoto S, Murayama T, Gomyo H, Chakraborty S, Taniguchi R, Isobe T, Nakagawa T, Nishimura R and Koizumi T.. "Quantitation of minimal residual disease in t(8;21)-positive acute myelogenous leukemia patients using real-time quantitative RT-PCR." American Journal of Hematology. Vol. 64, (January 2000.): 101-106.

Imoto S, Oomoto Y, Murata K, Das H, Murayama T, Kajimoto K, Sugimoto T, Gomyo H, Nakagawa T, Nishimura R and Koizumi T.. "Kinetics of serum cytokines after allogeneic bone marrow transplantation: interleukin-5 as a potential marker of acute graft-versus-host disease.." International Journal of Hematology. Vol. 72, (January 2000.): 92-97.

Das H, Koizumi T, Sugimoto T, Yamaguchi S, Hasegawa K, Tenjin Y and Nishimura R.. "Induction of apoptosis and manganese superoxide dismutase gene by photodynamic therapy in cervical carcinoma cell lines.." International Journal of Clinical Oncology. Vol. 5, (January 2000.): 97-103.

Das H, Koizumi T, Sugimoto T, Chakraborty S, Ichimura T, Hasegawa K and Nishimura R. "Quantitation of Fas and Fas ligand gene expression in human ovarian, cervical and endometrial carcinomas using real-time quantitative RT-PCR.." British Journal of Cancer. Vol. 82, (January 2000.): 1682-1688.

Taniguchi R, Koizumi T, Das H, Chakraborty S, Sugimoto T, Hasegawa K, Kono M and Nishimura R.. "Trophoblastic cells expressing human chorionic gonadotropin genes in peripheral blood of patients with trophoblastic disease.." Life Sciences. Vol. 66, (January 2000.): 1593-1601.

Das H, Imoto S, Murayama T, Kajimoto K, Sugimoto T, Isobe T, Nakagawa T, Nishimura R and Koizumi T.. "Kinetic analysis of cytokine gene expression during development of human graft versus host disease after donor lymphocyte transfusion.." Bone Marrow Transplantation. Vol. 27, (January 2001.): 373-380.

Das H, Groh V, Kuijl C, Sugita M, Morita C T, Spies T and Bukowski JF. "MICA engagement by human Vγ2Vδ2 T cells enhances their antigen-dependent effector function.." Immunity. Vol. 15, (January 2001.): 83-93.

Das H, Wang L, Kamath A and Bukowski JF. "Vγ2Vδ2 T cell receptor-mediated recognition of aminobisphosphonates." Blood. Vol. 98, (January 2001.): 1616-1618.

Wang L, Kamath A, Das H, Li L and Bukowski JF. "Antibacterial effect of human Vγ2Vδ2 T cells in vivo." Journal of Clinical Investigation. Vol. 108, (January 2001.): 1349-1357.

Wang L, Das H, Kamath A and Bukowski JF.. "Human Vγ2Vδ2 T cells produce IFN-γ and TNF-α with an on/off/on cycling pattern in response to live bacterial product.." Journal of Immunology. Vol. 167, (January 2001.): 6195-6201.

Wang L, Das H, Kamath A, Li L and Bukowski JF. "Human Vγ2Vδ2 T cells augment MIF secretion, and counteract the inhibitory effect of glucocorticoids on IL-1β and TNF-α production." Journal of Immunology. Vol. 168, (January 2002.): 4889-4896.

Narazaki H, Watari E, Shimizu M, Owaki A, Das H, Fukunaga Y, Takahashi H and Sugita M.. "Perforin-dependent killing of tumor cells by Vγ1Vδ1-bearing T cells." Immunology Letters. Vol. 86, (January 2002.): 113-119.

Leslie DS, Vincent MS, Spada FM, Das H, Sugita M, Morita CT and Brenner MB. "CD1-mediated γδ T cell maturation of dendritic cells.." Journal of Experimental Medicine. Vol. 196, (January 2002.): 1575-1584.

Kamath AB, Wang L, Das H, Li L, Reinhold VN and Bukowski JF. "Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses.." Proceedings of the National Academy of Sciences. Vol. 100, (January 2003.): 6009-6014.

Das H, Sugita M and Brenner MB. "Mechanisms of Vδ1 γδ T cell activation by microbial components." Journal of Immunology. Vol. 172, (January 2004.): 6578-6586.

Bukowski JF, Dascher CC, Das H. "Alternative bisphosphonate targets and mechanisms of action (review)." Biochemical and Biophysical Research Communications. Vol. 328, (January 2005.): 746-750.

Sen-banerjee S, Mir S, Lin Z, Hamik A, Atkins GB, Das H, Banerjee P, Kumar A and Jain MK.. "Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.." Circulation. Vol. 112, (January 2005.): 720-726.

Das H, Kumar A, Lin Z, Patino WD, Hwang PM, Feinberg MW, Majumder PK and Jain MK.. "Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes.." Proceedings of the National Academy of Sciences. Vol. 103, (January 2006.): 6653-6658.

Fisch S, Gray S, Heymans S, Halder S, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto Y, Liao R and Jain MK.. "Kruppel-like factor 15 is a novel regulator of cardiomyocyte hypertrophy." Proceedings of the National Academy of Sciences. Vol. 104, (January 2007.): 7074-7079.

George JC, Goldberg J, Joseph M, Abdulhameed N, Crist J, Das H* and Pompili VJ*.. "Transvenous Intramyocardial Cellular Delivery Increases Retention in Comparison to Intracoronary Delivery in a Porcine Model of Acute Myocardial Infarction.." Journal of Interventional Cardiology. Vol. 21, (January 2008.): 424-431.

Das H*, George JC, Joseph M, Das M, Abdulhameed N, Blitz, A, Sakthivel R, Mao HQ, Hoit BD, Kuppusamy P and Pompili VJ.. "Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.." PLoS One. Vol. 4, no. 10. (January 2009.): e7325-.

Das H*, Abdulhameed N, Joseph M, Sakthivel R, Mao HQ and Pompili VJ*.. "Ex-vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis.." Cell Transplantation. Vol. 18, no. 3. (January 2009.): 305-318.

Lu J, Pompili VJ and Das H*. Stem Cells and Cloning: Advances and Applications; 3: 57-68. (January 2010.): -.

Lu J, Aggarwal R, Pompili VJ and Das H*.. Recent Patents on Nanotechnology; 4: 125-134.. (January 2010.): -.

Aggarwal R, Pompili VJ and Das H*.. Frontiers in Bioscience 15: 854-871.. (January 2010.): -.

Adler DS, Lazarus H, Nair R, Goldberg JL, Greco, NJ, Lassar T, Laughlin MJ, Das H* and Pompili VJ*.. "Safety and efficacy of bone marrow-derived autologous CD133+ stem cell therapy." Frontiers in Bioscience. no. 3. (January 2010.): 506-514.

Lu J, Pompili VJ and Das H*. Cell Biochemistry and Biophysics 2010 -in press. (January 2010.): -.

Lu J, Aggarwal R, Kanji S, Das M, Joseph M, Pompili VJ and Das H.. "Human Ovarian Tumor Cells Escape γδ T Cell Recognition Partly by Down Regulating Surface Expression of MICA and Limiting Cell Cycle Related Molecules.." PLoS One. no. 6(9): e23348. doi:10.1371/journal.pone.0023348.. (January 2011.): -.

Das M, Lu J, Joseph M, Aggarwal R, Kanji S, McMichael B, Lee BS, Agarwal S, Ray-Chaudhury A, Iwenofu, OH, Kuppusamy P, Pompili VJ, Jain MK and Das H. "Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis.." Current Molecular Medicine. no. -in press. (January 2011.): -.

Aggarwal R, Lu J, Pompili VJ and Das H.. "Hematopoietic Stem Cells: Transcriptional Regulation, Ex vivo Expansion and Clinical Application (Invited review, peer reviewed)." Current Molecular Medicine. no. -in press. (January 2011.): -.

Kanji S, Pompili VJ and Das H.. "Recent advances in hematopoietic stem cell-mediated regeneration (Invited review, peer reviewed).." Recent Patents on Regenerative Medicine. Vol. 1, (January 2011.): 195-206.

Kanji S, Pompili VJ and Das H.. "Plasticity and maintenance of hematopoietic stem cells during development (Invited review, peer reviewed)." Recent Patents on Biotechnology. Vol. 5, (January 2011.): 40-53.

Kanji S, Pompili VJ and Das H.. no. 1: 195-206. (January 2011.): -.

Kanji S, Pompili VJ and Das H.. (January 2011.): -.

Lu J, Pompili VJ and Das H.. "Neovascularization and hematopoietic stem cells (Invited review, peer reviewed).." Cell Biochemistry and Biophysics. no. -in press. (January 2011.): -.

Reference Works

January 1989	Das H and Bhattacharyya AK."Biochemical parameters in prostatic tissues of patients with benign prostatic hyperplasia and carcinoma" . : 160
January 1990	Das H and Bhattacharyya AK."Purification of acid phosphatase from normal and benign human prostate" . : 134
January 1993	Das H and Bhattacharyya AK."Identification of an extra sub unit of acid phosphatase in benign hyperplastic human prostate" . : 343
January 1994	Das H and Bhattacharyya AK."Inhibitory effects of sodium fluoride and L(+)tartrate on purified acid phosphatase from normal and benign hyperplastic prostates" .
January 1997	Koizumi T, Das H, Yamaguchi S, Nakagawa T, Hasegawa K, Tenjin Y, Nishimura R and Gotoh T."Induction of apoptosis and Mn-SOD gene expression in human cervical cancer cells by photodynamic therapy" . : 668
January 1998	Nishimura R, Koizumi T, Das H, Nakagawa T, Gotoh T and Hasegawa K."Ectopic production of B-subunit of human chorionic gonadotropin by non-tropoblastic tumors and its clinical relevance" . : 17
January 1998	Murayama T, Koizumi T, Kobayashi Y, Das H, Kajimoto K, Sugimoto T, Imoto S, Nishimura R and Nakagawa T."GVHD and cytokine; analysis of mRNA" . : 228
January 1998	Koizumi T, Imoto S, Murayama T, Das H, Kajimoto K, Sugimoto T, Nishimura R and Nakagawa T.."Serum FasL level and expression of FasL mRNA in GVHD patients" . : 248
January 1998	Koizumi T, Das H, Imoto S, Murayama T, Gotoh T, Nakagawa T and Nishimura R.."Expression of cytokine genes during the development of human graft versus host disease" . : 37
January 1998	Das H, Koizumi T, Nakagawa T, Gotoh T, Hasegawa K and Nishimura R."Photodynamic therapy induces apoptosis and Mn-SOD gene expression in human cervical cancer cell lines" . : 61
January 2000	Das H, Wang L, Kamath A and Bukowski JF."Recognition of non-peptide antigens and the role of human gamma delta T-cells in innate and adaptive immunity" . : 107
January 2003	Das H and Bukowski JF."A new mechanism for osteoclast and myeloma cell elimination" . : S48
January 2004	Fisch SM, Gray SG, SenBanerjee S, Lin Z, Kumar A, Das H, Petersen CA, Burleigh BA, Jain MK."KLF15 is a novel regulator of cardiomyocyte gene expression" . : III
January 2005	SenBanerjee S, Mir S, Lin Z, Hamik A, Atkins GB, Das H, Banerjee P, Kumar A, and Jain MK.."KLF2 as a novel mediator of statin effects in endothelial cells" . : 369
January 2006	Fisch SM, Gray SG, Heymans S, Wang B, Haldar S, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen C, Mende U, Burleigh B, Zhu Y, Pinto Y, Liao R, and Jain MK. The kruppel like factor KLF15 is a novel regulator of cardiomyocyte hypertrophy."The kruppel like factor KLF15 is a novel regulator of cardiomyocyte hypertrophy" . : II
January 2007	Das H., Joseph M., Abdulhameed N., Mao HQ. and Pompili VJ.."Successful surface aminated nanofiber expansion of human umbilical cord derived CD133+ cells leads to augmentation of angiogenic functionality in vitro and in vivo" . : II
January 2008	Das H., Abdulhameed N., Joseph M., Sakthivel R., Mao HQ. and Pompili VJ.."Ex-vivo nanofiber expansion and genetic modification of human cord blood-derived stem cells enhances vasculogenesis" . : S
January 2009	Kanji S, Aggarwal R, Lu J, Joseph M, Das M, Agarwal S, Pompili VJ and Das H.."Neural differentiation of hematopoietic stem cells for stroke-mediated ischemia therapy." .
January 2009	Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz, A, Sakthivel R, Mao HQ, Hoit BD, Kuppusamy P and Pompili VJ.."Overexpression of VEGF and PDGF on nanofiber-expanded human cord blood-derived stem cells improves heart function by upregulating cardiac tissue connexin 43 and proangiogenic molecules" . : 27
January 2009	Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz, A, Sakthivel R, Mao HQ, Hoit BD, Kuppusamy P and Pompili VJ.."Overexpression of VEGF and PDGF on stem cells improves heart function in a rat infarct model" .
January 2009	Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Agarwal S, Pompili VJ and Das H.."Osteoblastic differentiation of hematopoietic stem cells for the treatment of osteoporosis." .
January 2009	Lu J, Aggarwal R, Kanji S, Joseph M, Das M, Agarwal S, Guan J, Pompili VJ and Das H.."Hematopoietic stem cell differentiation to early cardiomyocytes and optimization of hydrogel as a vehicle for myocardial ischemia therapy." .
January 2010	Das H*, Joseph M, Das M, Merte K, Blau HM, Mao HQ and Pompili VJ.."Genetically modified nanofiber-mediated re-expanded human cord blood-derived stem cells restore blood flow in hind limb ischemia murine model" .
January 2010	Das H*."Combination therapy of stem cell and genes for ischemic diseases. International Conference on Recent Advances in Free radical Research, Natural Products, Antioxidants and Radioprotectors in Health and 9th Annual Conference of Society for Free Radical Rese" .
January 2011	Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Noble G, McMichael B, Hart R, Sun Z, Jackson R, Mao HQ, Pompili V and Das H.."Regulation of osteoblasts and osteoclasts by human umbilical cord blood derived CD34 stem cells in osteoporotic NOD/SCID mice." .
January 2011	Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Agarwal S, Noble G, Hart R, Sun Z, Jackson R, Pompili V, Mao HQ and Das H.."Hematopoietic stem cells heal bone in osteoporosis model" .

Inventions and Patents

Sakthivel R, Brown DJ, Mao HQ, Douay L, Pompili VJ, Mclntosh K, Das H, Zhao Y. "Methods and systems for expanding AC133+ cells and directing differentiation." Filed November 2009.

Presentations

"Nanofiber-expansion, genetic modification & function of progenitor stem cells." Presented at Japan Society for Promotional Science-The Ohio State University, Columbus, OH, US|USA. (May 2008)

"Nanofiber-expansion, genetic modification & function of progenitor stem cells.." Presented at Stem Cell Group. OSUMC, Columbus, OH, US|USA. (July 2008)

"Preclinical use of nanofiber-expandedh stem cells." Presented at Retinoic acid group, Dept of Neurosciences and Opthalmology, Columbus, OH, US|USA. (November 2008)

"Ex-vivo nanofiber expansion and genetic modification of human cord blood-derived stem cells enhances vasculogenesis." Presented at Annual Conference of American Heart Association, New Orleans, LA, US|USA. (November 2008)

"Stem cell for future cardiovascular therapy: An overview of preclinical studies.." Presented at Oral biology program. School of Dentistry, Columbus, OH, US|USA. (October 2008)

"Phenotypic and functional characterization of nanofiber-expanded hematopoietic stem cells,." Presented at DHLRI Retreat., Columbus, OH, US|USA. (October 2008)

"Genetic modification of hematopoietic stem cells: preclinical study.." Presented at IBGP graduate program, Columbus, OH, US|USA. (October 2008)

"Nanofiber expanded hematopoietic stem cells: a bright future for degenerative diseases." Presented at Dept of Food and Nutrition Graduate Program, Columbus, OH, US|USA. (February 2009)

"Genetically modified nanofiber expanded hematopoietic stem cells: future of regenerative medicine." Presented at DHLRI, Research in progress, Columbus, OH, US|USA. (February 2009)

"Stem cell modification, and its clinical application." Presented at Cardiothorasic Surgery, University of Utah, Salt Lake City, Utah, Salt Lake City, UT, US|USA. (May 2009)

"Overexpression of VEGF and PDGF on stem cells improves cardiac function in a rat infarct model." Presented at International Society on Oxygen Transport to Tissue (ISOTT), Cleveland, OH, US|USA. (July 2009)

"Stem cell therapy for osteoporosis." Presented at Osteoarthritis research group, Columbus, OH, US|USA. (October 2010)

"Hematopoietic stem cells improve bone mineral density and and bone remodeling in murine osteoporosis model.." Presented at National Center for Regenerative Medicine retreat, Cleveland, OH, US|USA. (November 2010)

"Stem cell therapy for human diseases." Presented at Tripura University (Central University), Agartala, Tripura, India, . (January 2010)

"Monocyte/macrophage-mediated regulation of inflammatory disease via transcriptional factor KLF2.." Presented at Bone and Joint interest group (BJIG), The Ohio State University, Columbus, OH, . (January 2010)

"Kruppel like factor (KLF) 2-mediated regulation of monocytes /macrophages in various inflammatory diseases.." Presented at Center of Molecular Neurobiology,? Comprehensive Cancer Center,?The Ohio State University, Columbus, Ohio, . (January 2010)

"Genetically modified stem cell therapy for ischemic diseases: how far we are." Presented at Cardiology grand round, Department of Medicine, The Ohio State University, Columbus, Ohio, . (January 2010)

"Genetically modified stem cell therapy for ischemic diseases and beyond.." Presented at Chittaranjan National Cancer Institute, Calcutta, India, . (January 2010)

"Gene directed hematopoietic stem cell therapy for ischemic diseases." Presented at Klassen Research Day, The Ohio State University, Columbus, OH, . (January 2010)

"Combination therapy of stem cells and genes for ischemic diseases.." Presented at Annual meeting of Society for Free Radical Research (SFRR) held at Hyderabad, India, . (January 2010)

"Cell-based therapy for degenerative diseases using genetically modified hematopoietic stem cells." Presented at Biomedical Engineering, The Ohio State University, Columbus, OH, . (January 2010)