Liu, Zhenguo MD

Current OSU Appointments

Associate Professor, Cardiovascular Medicine

Physician, FGP-Cardiovascular Medicine

Biographical

CLINICAL SKILLS Skilled and experienced in performing the whole spectrum of procedures in adult cardiac electrophysiology including complex atrial fibrillation ablation and Bi-V device implantation. RESEARCH EXPERIENCE 2010 - present Associate Professor, Davis Heart & Lung Research Institute, The Ohio State University Medical Center 2004 - 2010 Assistant Professor, Davis Heart & Lung Research Institute, The Ohio State University Medical Center 2001 - 2002 Research Fellow, University of Minnesota Medical School, Minneapolis, MN. United States. 1995 - 1997 Research Fellow, Whitaker Cardiovacular Institute, Boston University Medical Center, Boston, MA 1984 - 1986 Research Assistant Department of Pharmacology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing, China

Certifications

2003 - present	Medicine and Surgery License:
2004 - present	Medicine and Surgery License: State Medical Board of Ohio
2000 - 2003	Medicine and Surgery License:
2000 - 2010	Board Certified: American Board of Internal Medicine
2003 - 2013	Board Certified: American Board of Cardiovascular Medicine
2005 - 2015	Board Certified: American Board of Cardiovascular Medicine

Chapters in Books

Liu ZG, Du LH. "Isolation and Characterization of Bone Marrow Stem Cells (in Chinese)." In Manetic Induction of Hyperthermia for Cancer. Edited by Tong JT. -. Beijing, CN|CHN: People's Medical Publishing House, January 2010.

Liu ZG, Tyler J. "Cardiac Electrophysiology Study: Basic Concepts and Techniques." In Specialty Board Review: Cardiology. Edited by Baliga R. -. Columbus, OH: McGraw-Hill, January 2011.

Degrees

1984	M.D., Hunan Medical University

1992

M.S.,

1995

Ph.D.,

Honors

1984 - 0	First Academic Award.
1994 - 0	Conference Award.
2006 - 0	ASCI/AAP Travel Award. ASCI/AAP.
1990 - 1991	Dean's Award.
1991 - 1992	Graduate Award.
1991 - 1992	Eldon Boyd Fellowship.
1993 - 1995	Studentship.
2001 - 2002	Cardiology Fellows Forum of Excellence. American Heart Association.
2002	ACC Travel Award. American College of Cardiology.
2002	Lillehei Fellowship.
2002	Finalist for Melvin L. Marcus Young Investigator Award in Cardiovascular Science. American Heart Association.

Journal Articles

Liu ZG, Brien JF, Marks GS, McLaughlin BE, Nakatsu K. "Carbon monoxide does not inhibit glyceryl trinitrate biotransformation by or relaxation of aorta." Eur J Pharmacol. Vol. 211, no. 1. (January 1992.): 129-132.

Liu ZG, Nakatsu K, Brien JF, Beaton ED, Marks GS, Maurice DH. "Selective sequestration of nitric oxide by subcellular components of vascular smooth muscle and platelets: relationship to nitric oxide stimulation of the soluble quanylyl cyclase." Can J Physiol Pharmacol. Vol. 71, no. 12. (January 1993.): 938-945.

Liu ZG, Brien JF, Marks GS, McLaughlin BE, Nakatsu K. "Lack of evidence for the involvement of cytochrome P-450 or other hemoproteins in the metabolic activation of glyceryl trinitrate in rabbit aorta." J Pharmacol Exp Ther. Vol. 264, no. 3. (January 1993.): 1432-1439.

Beaton ED, Liu ZG, McLaughlin BE, Brien JF, Nakatsu K, Marks GS. "A novel method for detection of nitric oxide binding sites by using a chemiluminescence-headspace-gas technique." J Pharmacol Toxicol Meth. Vol. 30, no. 4. (December 1993.): 217-222.

Liu ZG, Marks GS, Brien JF, Nakatsu K. "Sulfhydryl involvement in nitric oxide sequestration and nitric oxide induced soluble guanylyl cyclase activation in vascular smooth muscle." Can J Physiol Pharmacol. Vol. 73, no. 8. (January 1995.): 1144-1148.

Liu ZG, Rudd MA, Freedman JE, Loscalzo J. "S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide." J Pharmacol Exp Ther. Vol. 284, no. 2. (January 1998.): 526-534.

Jin X, Xia L, Wang LS, Shi JZ, Zheng Y, Chen WL, Zhang L, Liu ZG, Chen GQ, Fang NY. "Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats." Proteomics. Vol. 6, no. 7. (January 2006.): 2326-2332.

Liu ZG, Jiang Y, Hao H, Gupta K, Xu J, Chu L, McFalls E, Zweier J, Verfaillie C, Bache RJ. "Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells." Am J Physiol Heart Circ Physiol. Vol. 293, no. 3. (January 2007.): H1760-H1765.

Xu,J; Liu,X; Jiang,Y; Chu,L; Hao,H; Liua,Z; Verfaillie,C; Zweier,J; Gupta,K; Liu,Z. "MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol. 12, no. 6A. (December 2008.): 2395-2406.

Daoud,Emie,G; Hummel,John,D; Houmsse,Mahmoud; Hart,David,T; Weiss,Raul; Liu,Zhenguo; Augostini,Ratph; Kalbfleisch,Steven; Smith,Macy,C; Mehta,Rohit; Gangasani,Ashish; Raman,Subha,V. "Comparison of computed tomography imaging with intraprocedural contrast esophagram: implications for catheter ablation of atrial fibrillation." Heart Rhythm. Vol. 5, no. 7. (July 2008.): 975-980.

Chu,Ling; Jiang,Yuehua; Hao,Hong; Xia,Yong; Xu,Jian; Liu,Zehao; Verfaillie,Catherine,M; Zweier,Jay,L; Liu,Zhenguo. "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." EUROPEAN JOURNAL OF PHARMACOLOGY. Vol. 591, no. 1-3. (September 2008.): 59-65.

Mehta R, Hart DT, Nagra BS, Liu ZG, Kantharia BK. "Successful ablation of focal left atrial tachycardia using Stereotaxis Niobe remote magnetic navigation system." Europace. Vol. 10, no. 3. (January 2008.): 280-283.

Nagra B, Liu ZG, Mehta R, Hart D, Kantharia B. "Verapamil-sensitive left posterior fascicular ventricular tachycardia after myocardial infarction." J Interv Card Electrophysiol. Vol. 21, no. 1. (January 2008.): 59-63.

Xu,Jian; Liu,Xinfeng; Chen,Jieli; Zacharek,Alex; Cui,Xu; Savant-Bhonsale,Smita; Liu,Zhenguo; Chopp,Michael. "Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via Notch signaling pathway." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. Vol. 296, no. 3. (March 2009.): C535-C543.

Liu,Dezhi; Ge,Song; Zhou,Guangyi; Xu,Gelin; Zhang,Renliang; Zhu,Wusheng; Liu,Zhenguo; Cheng,Songming; Liu,Xinfeng. "Montelukast inhibits matrix metalloproteinases expression in atherosclerotic rabbits." CARDIOVASCULAR DRUGS AND THERAPY. Vol. 23, no. 6. (December 2009.): 431-437.

Liu,Zehao; Lei,Minxiang; Jiang,Yuehua; Hao,Hong; Chu,Ling; Xu,Jian; Luo,Min; Verfaillie,Catherine,M; Zweier,Jay,L; Liu,Zhenguo. "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol. 13, no. 9b. (September 2009.): 3427-3436.

Feng,Chuan; Zhu,Jing; Zhao,Lili; Lu,Tiewei; Zhang,Wen; Liu,Zhenguo; Tian,Jie. "Suberoylanilide hydroxamic acid promotes cardiomyocyte differentiation of rat mesenchymal stem cells." EXPERIMENTAL CELL RESEARCH. Vol. 315, no. 17. (October 2009.): 3044-3051.

Zhao,Xue; Zhang,Jiayou; Mei,Xiang; Liao,Dening; Hu,Jianqiang; Li,Li; Liu,Zhenguo; Zweier,Jay,L. "Pulmonary vein electric shunting for therapy of atrial fibrillation." MEDICAL HYPOTHESES. Vol. 72, no. 4. (April 2009.): 474-475.

Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators (Liu ZG).. "Dabigatran versus warfarin in patients with atrial fibrillation.." N Engl J Med.. Vol. 361, no. 12. (January 2009.): 1139-1151.

Xu,Jian; Liu,Xinfeng; Chen,Jieli; Zacharek,Alex; Cui,Xu; Savant-Bhonsale,Smita; Chopp,Michael; Liu,Zhenguo. "Cell-Cell Interaction Promotes Rat Marrow Stromal Cell Differentiation Into Endothelial Cell via Activation of TACE/TNF-alpha Signaling." Cell Transplantation. Vol. 19, no. 1. (January 2010.): 43-53.

Lu,Tiewei; Pelacho,Beatriz; Hao,Hong; Luo,Min; Zhu,Jing; Verfaillie,Catherine,M; Tian,Jie; Liu,Zhenguo. "Cardiomyocyte Differentiation of Rat Bone Marrow Multipotent Progenitor Cells Is Associated with Downregulation of Oct-4 Expression." Tissue Engineering Part A. Vol. 16, no. 10. (October 2010.): 3111-3117.

Chu,Ling; Hao,Hong; Luo,Min; Huang,Yu; Chen,Zhenyu; Lu,Tiewei; Zhao,Xue; Verfaillie,Catherine,M; Zweier,Jay,L; Liu,Zhenguo. "Ox-LDL modifies the behavior of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol. 15, no. 2. (February 2011.): 423-432.

Yan,Limei; Hao,Hong; Elton,Terry,S; Liu,Zhenguo; Ou,Hesheng. "Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling." MOLECULAR AND CELLULAR BIOCHEMISTRY. Vol. 357, no. 1-2. (November 2011.): 9-19.

Maffett S, Boyd JM, Love C, Daoud EG, Weiss R, Augostini R, Hasan A, Liu ZG, Hummel JD, Houmsse M, Kalbfleisch S.. "Pacemaker and implantable cardioverter-defibrillator implantation during chronic anticoagulation: continuation of warfarin versus bridging with heparin." The Journal of Innovations in Cardiac Rhythm Management. Vol. 1, no. 1. (January 2011.): 1-5.

Yang,Ge; Tian,Jie; Feng,Chuan; Zhao,Li-Li; Liu,Zhenguo; Zhu,Jing. "Trichostatin A Promotes Cardiomyocyte Differentiation of Rat Mesenchymal Stem Cells After 5-Azacytidine Induction or During Coculture With Neonatal Cardiomyocytes Via a Mechanism Independent of Histone Deacetylase Inhibition." CELL TRANSPLANTATION. Vol. 21, no. 5. (January 2012.): 985-996.

Lu,Tiewei; Parthasarathy,Sampath; Hao,Hong; Luo,Min; Ahmed,Shabnam; Zhu,Jing; Luo,Suxin; Kuppusamy,Periannan; Sen,Chandan,K; Verfaillie,Catherine,M; Tian,Jie; Liu,Zhenguo. "Reactive Oxygen Species Mediate Oxidized Low-Density Lipoprotein-Induced Inhibition of Oct-4 Expression and Endothelial Differentiation of Bone Marrow Stem Cells." ANTIOXIDANTS & REDOX SIGNALING. -.

Reference Works

January 1987	Liu ZG, Zhang T, Duan CG, Xiu RJ."Preliminary study on the inhibitory action of compound 24 on antiogenesis induced by S-180 in chicken chario-allantoic membrane" . : 67
January 1994	Liu ZG, Marks GS, Brien JF, Maurice DH, Nakatsu K."Characteristics of nitric oxide sequestration by bovine vascular smooth muscle" . : A360
January 1996	Liu ZG, Rudd MA, Loscalzo J."Transnitrosation reactions in the metabolism of nitric oxide and their relationship to the biological actions of nitric oxide" . : I521
January 1997	Liu ZG, Zai A, Scribner AW, Loscalzo J."S-Transnitrosation reactions involving plasma membrane thiol groups are mechanistic determinants of the biological effects of S-nitrosothiols" . : I675
January 1997	Rudd MA, Liu ZG, Zai A, Loscalzo J."Platelet membrane thiols regulate cellular entry and activity of nitric oxide" . : I547
January 2002	Liu ZG, Jiang Y, Gupta K, Hao H, Sikora J, Blackstad M, McFalls E, Verfaillie CM, Bache RJ."Developmental expression of nitric oxide synthase during stem cell differentiation into endothelial cells" . : II
January 2004	Liu ZG, Lou R, Jiang Y, Gupta K, Verfaillie C, Bache RJ."Dimerization of mitogen-activated protein kinase and auto-phosphorylation of Akt occur in the newly differentiated endothelial-like cells from adult bone marrow stem cells in vitro" . : 498A
January 2006	Chu L, Jiang Y, Hao H, Wei Q, Xia Y, Verfaillie C, Zweier J, Liu ZG."Oct-4 expression and differentiation of bone marrow stem cells into endothelial cells are independent of the inhibition of nitric oxide synthase in vitro" . : A1126
January 2007	Chu L, Jiang Y, Hao H, Verfaillie C, Zweier J, Liu ZG."Exogenous nitric oxide increases the expression of Oct-4 and may modify bone marrow stem cell differentiation into endothelial cells in vitro" . : 401A
January 2007	Xu J, Liu XF, Gupta K, Jiang Y, Hao H, Vergaillie C, Zweier J, Liu ZG."Phosphorylated Akt is critical to the differentiation of bone marrow stem cells into endothelial cells" . : 385A
January 2007	Xu J, Liu XF, Gupta K, Jiang Y, Hao H, Verfaillie CM, Zweier J, Liu ZG."STAT-3 and p42/44 MAPK are dynamically phosphorylated during bone marrow stem cell differentiation into endothelial cells" . : A1427
January 2009	Doshi AA, Fitzpatrick A, Love CJ, Daoud EG, Kalbfleisch SJ, Augostini RS, Houmsse M, Hart DT, Liu ZG, Weiss R, Rooney T, Schilling K, Danker J, Rhodes T, Gangasani A, Hummel JD."Identification of a Novel Mechanism for Inappropriate Accelerometer Activation during Diagnostic Fluoroscopy" . : S190
January 2010	Doshi A, Stohr E, Dutro M, Daoud EG, Weiss R, Augostini RS, Love CJ, Kalbfleisch SJ, Houmsse M, Hart DT, Hasan A, Liu ZG, Rhodes T, Tyler J, Rhine D, Rooney T, Hummel JD."Initial Performance Data of a Defibrillation Lead Utilizing the Draft IS4 Connection System" . : S21
January 2010	Boyd JM, Southall R, Augostini RS, Daoud EG, Hart D, Houmsse M, Kalbfleisch SJ, Liu ZG, Love CJ, Weiss R, Hummel JD."Evaluation of Complications During Planned Inpatient Initiation of Antiarrhythmic Medications" . : S280
May 2011	Snider MJ, Boyd JM, Hirsch A, Houmsse M, Daoud EG, Hummel JD, Kalbfleisch SJ, Augostini RS, Weiss R, Hart DT, Love CJ, Liu ZG, Rhodes TE, Porter K, Carnes CA."Dronedarone: Real Life Experience And Follow Up" .
May 2011	Bittenbender PM, Parekh A, Stephens J, Tyler J, Amin A, Rhine D, Tsai S, Hamam I, Rhodes TE, Hart DT, Houmsse M, Kalbfleisch SJ, Liu ZG, Love CJ, Augostini RS, Hummel JD, Daoud EG, Weiss R."Outcomes with Remote Magnetic Navigation for Ablation of Atrial Fibrillation" .
May 2011	Hamam IR, Daoud EG, Tsai S, Rhine D, Tyler J, Weiss R, Houmsse M, Love CJ, Kalbfleisch SJ, Augostini RS, Hart DT, Rhodes TE, Liu ZG, Hummel JD."Impact of Elevated International Normalized Ratio and Activated Clotting Time on Unfractionated Heparin Dosing for Ablation of Atrial Fibrillation" .

Presentations

"Nitric oxide release following glyceryl trinitrate interaction with vascular smooth muscle is not mediated by hemoprotein." Presented at Fifth World Conference on Clinical Pharmacology and Therapeutics, Yokohama, JP|JPN. (January 1992)

"Approaches to the identification of nitric oxide receptors in vascular smooth muscle." Presented at 36th Annual Meeting of the Canadian Federal Biological Society, Ontario, CA|CAN. (January 1993)

"Mechanisms of Ventricular Tachycardia and Management." Presented at Shanghai Second Medical University Department of Medicine, Shanghai, CN|CHN. (September 2004)

"Cardiovascular Diseases and Stroke." Presented at Ministry of Health, P.R of China, CN|CHN. (September 2004)

"Sudden Cardiac Death: Mechanisms and Management." Presented at The Ohio State University Medical Center, Columbus, OH. (November 2004)

"Evaluation and Management of Syncope." Presented at Chillicothe VA Medical Center, Chillicothe, OH. (March 2005)

"Unique Biological Behaviors of the Newly Differentiated Endothelial Cells from Bone Marrow Stem Cells and Possible Mechanisms." Presented at Central Society for Clinical Research, Midwestern Section American Federation for Medical Research, Chicago, IL. (April 2005)

"Update on Atrial Fibrillation." Presented at Xiangya Medical College of Central South University, Department of Medicine, Changsha, Hunan, CN|CHN. (June 2005)

"Catheter-Based Approaches to the Treatment of Atrial Fibrillation." Presented at Shanghai Second Medical University, Department of Medicine, Shanghai, CN|CHN. (June 2005)

"Development of New Drugs with Cultured Bone Marrow Stem Cells." Presented at Chinese Academy of Medical Sciences, Research Center for Pharmacology and Toxicology, Beijing, CN|CHN. (July 2005)

"Evaluation and Management of Ventricular Tachycardia." Presented at Chillicothe VA Medical Center, Chillicothe, OH. (August 2005)

"New Strategies in the Management of Atrial Fibrillation." Presented at The Ohio State University Medical Center, Columbus, OH. (May 2005)

"Dyspnea: Cardiac vs Pulmonary." Presented at Chillicothe VA Medical Center, Chillicothe, OH. (November 2006)

"Expression of Akt/MAPK Signal Transduction Pathway during Bone Marrow Stem Cell Differentiation into Endothelial Cell." Presented at Xiangya Medical College of Central South University, Changsha, Hunan, CN|CHN. (July 2006)

"Current Status on the Management of Atrial Fibrillation." Presented at Tong-ji Medical University Department of Cardiology, Wuhan, Hubei, CN|CHN. (July 2006)

"Bone Marrow Stem Cells and Vascular Repair." Presented at Nanhua University College of Life Sciences, Hengyang, Hunan, CN|CHN. (July 2006)

"Rhythm vs Rate Control in the Management of Atrial Fibrillation." Presented at Chillicothe VA Medical Center, Chillicothe, OH. (March 2006)

"Role of the Cardiologist in the Management of Stroke." Presented at The Second International Stroke Summit, Nanjing, CN|CHN. (August 2006)

"Cell differentiation and mechanisms." Presented at Qinghua University Center for Life Sciences, Beijing, CN|CHN. (June 2007)

"Atrial Fibrillation and Other Arrhythmias/Devices." Presented at Pikeville Medical Center, Pikeville, KY. (May 2007)

"Advances in the Modalities and Treatment of Cardiac and Vascular Patients." Presented at Pikeville Medical Center, Pikeville, KY. (May 2007)

"ECG Analysis and Troubleshooting." Presented at IBHRExAM Review Course, Columbus, OH. (August 2007)

"Characteristics of the Newly Differentiated Endothelial Cells from Bone Marrow Stem Cells and Possible Mechanisms." Presented at The Ohio State University Medical Center, Columbus, OH. (November 2007)

"Superventricular tachycardia: evaluation and management." Presented at The Ohio State University Medical Center, Division of Cardiovascular Medicine, Columbus, OH. (May 2008)

"Bradycardia Stored Electrogram." Presented at IBHRExAM Review Course, Columbus, OH. (March 2008)

"PFO and Stroke." Presented at Fourth International Summit for Stroke, Nanjin, CN|CHN. (July 2008)

"Hyperlipidemia and Bone Marrow Stem Cells." Presented at Xiangya Medical College of Central South University, Changsha, Hunan, CN|CHN. (July 2008)

"Impaired endothelial differentiation from bone marrow stem cells: a novel mechanism for cardiovascular diseases." Presented at Shanghai Jiaotong University School of Medicine, Shanghai, CN|CHN. (July 2009)

"Cardiovascular Risk Factors and Bone Marrow Stem Cells." Presented at Chongqing Medical University, Chongqing, CN|CHN. (July 2009)

"Cardiovascular Diseases and Stroke: An Update." Presented at Fifth International Summit for Stroke, Nanjin, CN|CHN. (July 2009)

"Therapies for ventricular arrhythmia:Indications for ICDs." Presented at Cardiac Electrophysiology Fellows Lecture Series, Columbus, OH. (October 2009)

"Ventricular Arrhythmia: Etiology and Management." Presented at The Ohio State University Medical Center East, Columbus, OH. (June 2010)

"Impact of Hyperlipidemia on Bone Marrow Stem Cells: A Novel Mechanism for the Development of Cardiovascualr Diseases in Hyperlipidemic Patients." Presented at Children's Hospital, Chongging Medical University, Chongging, CN|CHN. (January 2010)

"Bone Marrow Stem Cells: Characteristics adn their Potential Clinical Applications." Presented at Hunan University of Chinese Medicine, Changsha, Hunan, CN|CHN. (January 2010)

"Effects of ox-LDL on bone marrow stem cells: A new look at the mechanisms for the development of cardiovascular diseases in hyperlipidemia." Presented at The Ohio State University Medical Center, Department of Surgery 2010 Klassen Research Day, Columbus, OH. (May 2010)